ZA200801332B - Pentacyclic kinase inhibitors - Google Patents

Pentacyclic kinase inhibitors

Info

Publication number
ZA200801332B
ZA200801332B ZA200801332A ZA200801332A ZA200801332B ZA 200801332 B ZA200801332 B ZA 200801332B ZA 200801332 A ZA200801332 A ZA 200801332A ZA 200801332 A ZA200801332 A ZA 200801332A ZA 200801332 B ZA200801332 B ZA 200801332B
Authority
ZA
South Africa
Prior art keywords
kinase inhibitors
pentacyclic
malignancies
compounds
useful
Prior art date
Application number
ZA200801332A
Other languages
English (en)
Inventor
Thomas E Rawson
Safina Brian
Dotson Jennafer
Aliagas-Martin Ignacio
Halladay Jason
Liang Jun
Rueth Matthias
Zhu Bing-Yan
Brookfield Frederick
Prime Michael
Zhang Birong
Jun M Li
Zhou Aihe
Original Assignee
Genentech Inc F Hoffmann La Ro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc F Hoffmann La Ro filed Critical Genentech Inc F Hoffmann La Ro
Publication of ZA200801332B publication Critical patent/ZA200801332B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200801332A 2005-08-12 2008-02-07 Pentacyclic kinase inhibitors ZA200801332B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70790205P 2005-08-12 2005-08-12

Publications (1)

Publication Number Publication Date
ZA200801332B true ZA200801332B (en) 2009-10-28

Family

ID=37607426

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200801332A ZA200801332B (en) 2005-08-12 2008-02-07 Pentacyclic kinase inhibitors

Country Status (14)

Country Link
US (1) US7749994B2 (fr)
EP (1) EP1919920B1 (fr)
JP (1) JP2009504680A (fr)
KR (1) KR20080035691A (fr)
CN (1) CN101287737A (fr)
AT (1) ATE509933T1 (fr)
AU (1) AU2006279659A1 (fr)
BR (1) BRPI0615141A2 (fr)
CA (1) CA2619276A1 (fr)
IL (1) IL189296A0 (fr)
NO (1) NO20081292L (fr)
RU (1) RU2008108903A (fr)
WO (1) WO2007022102A2 (fr)
ZA (1) ZA200801332B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010007430A (es) * 2008-01-11 2010-12-21 Albany Molecular Res Inc Piridoindoles (1-azinona)-sustituidos como antagonistas de la hormona de concentracion melanina humana.
US8618299B2 (en) * 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2011003021A1 (fr) * 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Antagonistes de mch-1 azabicycloalcane-indoles et azabicycloalcane-pyrrolo-pyridines substitués par azinone, leurs procédés de fabrication et leur utilisation
US8637501B2 (en) * 2009-07-01 2014-01-28 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
WO2011003007A1 (fr) * 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Antagonistes de mch-1 d’azabicycloalcane-indole et d’azabicycloalcane-pyrrolo-pyridine, procédés de préparation, et utilisation de ceux-ci
WO2012088124A2 (fr) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Antagonistes de la mch-1 à base de tétrahydro-azacarboline, leurs procédés de fabrication et leurs utilisations
WO2012088038A2 (fr) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Antagonistes de mch-1 consistant en tétrahydro-carbolines substituées par pipérazinone, leurs procédés de fabrication et utilisations
JP6653573B2 (ja) 2012-05-22 2020-02-26 トラスティーズ・オブ・ダートマウス・カレッジ シクロアルカニル［ｂ］インドール、シクロアルカニル［ｂ］ベンゾフラン、シクロアルカニル［ｂ］ベンゾチオフェンを合成するための方法、化合物および使用の方法
WO2017162661A1 (fr) 2016-03-22 2017-09-28 Bayer Pharma Aktiengesellschaft 1h-benzo[de]isoquinoléine-1,3(2h)-diones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032869A1 (en) * 2003-07-08 2005-02-10 Pharmacia Italia S.P.A. Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2006133885A1 (fr) * 2005-06-15 2006-12-21 F. Hoffmann-La Roche Ag Derives d'indole fusionnes tricycliques et leur utilisation en tant qu'inhibiteurs d'aurora kinase

Also Published As

Publication number Publication date
ATE509933T1 (de) 2011-06-15
CA2619276A1 (fr) 2007-02-22
EP1919920A2 (fr) 2008-05-14
US7749994B2 (en) 2010-07-06
RU2008108903A (ru) 2009-09-20
WO2007022102A2 (fr) 2007-02-22
NO20081292L (no) 2008-05-13
WO2007022102A3 (fr) 2007-05-10
EP1919920B1 (fr) 2011-05-18
IL189296A0 (en) 2008-06-05
CN101287737A (zh) 2008-10-15
KR20080035691A (ko) 2008-04-23
JP2009504680A (ja) 2009-02-05
AU2006279659A1 (en) 2007-02-22
US20070037791A1 (en) 2007-02-15
BRPI0615141A2 (pt) 2009-07-14

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