ZA200800116B - New combination of anti-MAdCAM antibody and anti-fibrotic caspase inhibitor to treat liver fibrosis - Google Patents
New combination of anti-MAdCAM antibody and anti-fibrotic caspase inhibitor to treat liver fibrosisInfo
- Publication number
- ZA200800116B ZA200800116B ZA200800116A ZA200800116A ZA200800116B ZA 200800116 B ZA200800116 B ZA 200800116B ZA 200800116 A ZA200800116 A ZA 200800116A ZA 200800116 A ZA200800116 A ZA 200800116A ZA 200800116 B ZA200800116 B ZA 200800116B
- Authority
- ZA
- South Africa
- Prior art keywords
- fibrotic
- liver fibrosis
- new combination
- caspase inhibitor
- madcam antibody
- Prior art date
Links
- 229940123169 Caspase inhibitor Drugs 0.000 title 1
- 230000003510 anti-fibrotic effect Effects 0.000 title 1
- 208000019425 cirrhosis of liver Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69856105P | 2005-07-11 | 2005-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200800116B true ZA200800116B (en) | 2008-12-31 |
Family
ID=37434222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200800116A ZA200800116B (en) | 2005-07-11 | 2008-01-04 | New combination of anti-MAdCAM antibody and anti-fibrotic caspase inhibitor to treat liver fibrosis |
Country Status (15)
Country | Link |
---|---|
US (1) | US20090214527A1 (zh) |
EP (1) | EP1904100A1 (zh) |
JP (1) | JP2007023030A (zh) |
KR (1) | KR20080017094A (zh) |
CN (1) | CN101217980A (zh) |
AR (1) | AR054828A1 (zh) |
AU (1) | AU2006267976B2 (zh) |
BR (1) | BRPI0613459A2 (zh) |
CA (1) | CA2614622A1 (zh) |
IL (1) | IL188397A0 (zh) |
MX (1) | MX2008000659A (zh) |
RU (1) | RU2008101383A (zh) |
TW (1) | TW200730190A (zh) |
WO (1) | WO2007007162A1 (zh) |
ZA (1) | ZA200800116B (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2552523C (en) * | 2004-01-09 | 2019-11-26 | Pfizer Inc. | Monoclonal antibodies to mucosal addressin cell adhesion molecule(madcam) |
US20080070823A1 (en) * | 2006-09-15 | 2008-03-20 | Philip Gorlin | Liquid Detergent Composition |
CA2669849C (en) * | 2006-12-06 | 2012-01-31 | Pfizer Inc. | Crystalline forms of (3s)-3-[n-(n'-(2-tert-butylphenyl)oxamyl)alaninyl]amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-oxopentanoic acid |
WO2008106167A1 (en) * | 2007-02-28 | 2008-09-04 | Conatus Pharmaceuticals, Inc. | Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases |
AU2009292959B2 (en) | 2008-09-19 | 2016-02-25 | Henry Ford Health System | Methods, systems, and compositions for calpain inhibition |
WO2012021800A2 (en) * | 2010-08-13 | 2012-02-16 | Banyan Biomarkers | Caspase inhibitors as therapeutics for neural and organ injury and imaging |
CN108884045B (zh) | 2016-05-11 | 2020-12-04 | 正大天晴药业集团股份有限公司 | Caspase抑制剂及其药物组合物、用途和治疗方法 |
JP7160491B2 (ja) | 2017-07-14 | 2022-10-25 | ファイザー インコーポレイティッド | MAdCAMに対する抗体 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7090845B2 (en) * | 1998-05-13 | 2006-08-15 | Genentech, Inc. | Diagnosis and treatment of hepatic disorders |
US6197750B1 (en) * | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US20010046496A1 (en) * | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
WO2004081049A1 (en) * | 2003-03-10 | 2004-09-23 | Auckland Uniservices Limited | Monoclonal antibodies that recognise mucosal addressin cell adhesion molecule-1 (madcam-1), soluble madcam-1 and uses thereof |
CA2552523C (en) * | 2004-01-09 | 2019-11-26 | Pfizer Inc. | Monoclonal antibodies to mucosal addressin cell adhesion molecule(madcam) |
ATE483732T1 (de) * | 2005-07-08 | 2010-10-15 | Pfizer Ltd | Madcam-antikörper |
-
2006
- 2006-07-03 RU RU2008101383/13A patent/RU2008101383A/ru not_active Application Discontinuation
- 2006-07-03 CN CNA2006800253085A patent/CN101217980A/zh active Pending
- 2006-07-03 MX MX2008000659A patent/MX2008000659A/es not_active Application Discontinuation
- 2006-07-03 EP EP06765630A patent/EP1904100A1/en not_active Withdrawn
- 2006-07-03 BR BRPI0613459-9A patent/BRPI0613459A2/pt not_active IP Right Cessation
- 2006-07-03 US US11/995,204 patent/US20090214527A1/en not_active Abandoned
- 2006-07-03 CA CA002614622A patent/CA2614622A1/en not_active Abandoned
- 2006-07-03 WO PCT/IB2006/001896 patent/WO2007007162A1/en active Application Filing
- 2006-07-03 KR KR1020087000793A patent/KR20080017094A/ko not_active Application Discontinuation
- 2006-07-03 AU AU2006267976A patent/AU2006267976B2/en not_active Ceased
- 2006-07-10 TW TW095125044A patent/TW200730190A/zh unknown
- 2006-07-10 JP JP2006188775A patent/JP2007023030A/ja not_active Withdrawn
- 2006-07-10 AR ARP060102959A patent/AR054828A1/es not_active Application Discontinuation
-
2007
- 2007-12-25 IL IL188397A patent/IL188397A0/en unknown
-
2008
- 2008-01-04 ZA ZA200800116A patent/ZA200800116B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1904100A1 (en) | 2008-04-02 |
KR20080017094A (ko) | 2008-02-25 |
BRPI0613459A2 (pt) | 2011-01-11 |
IL188397A0 (en) | 2008-08-07 |
RU2008101383A (ru) | 2009-07-20 |
AU2006267976B2 (en) | 2009-12-24 |
AR054828A1 (es) | 2007-07-18 |
MX2008000659A (es) | 2008-03-13 |
TW200730190A (en) | 2007-08-16 |
CA2614622A1 (en) | 2007-01-18 |
WO2007007162A1 (en) | 2007-01-18 |
CN101217980A (zh) | 2008-07-09 |
JP2007023030A (ja) | 2007-02-01 |
AU2006267976A1 (en) | 2007-01-18 |
US20090214527A1 (en) | 2009-08-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA200800116B (en) | New combination of anti-MAdCAM antibody and anti-fibrotic caspase inhibitor to treat liver fibrosis | |
EP1883406A4 (en) | COMPOSITIONS AND METHOD FOR CONTINUOUS RELEASE OF BETA-ALLANINE | |
ZA200802490B (en) | Isoindole-imide compounds and compositions comprising and methods of using the same | |
IL185914A0 (en) | Pyrimidine compounds and methods of use | |
BRPI0615224A2 (pt) | redução de esteróis e de outros compostos em óleos | |
AP2715A (en) | Use of imatinib to treat liver disorders and viralinfections | |
IL189364A0 (en) | Estrogen compositions and therapeutic methods of use thereof | |
EP1940787A4 (en) | NOVEL IDO INHIBITORS AND METHODS OF USE | |
IL191072A0 (en) | Therapeutic compositions and methods | |
EP1951278A4 (en) | METHODS AND COMPOSITIONS FOR DEREPRESSION OF IPA-INHIBITED CASPASE | |
IL187304A0 (en) | Pyrrolopyridine - based inhibitors of dipeptidyl peptidase iv and methods | |
HK1135099A1 (en) | Aza-indolyl compounds and methods of use | |
ZA200805296B (en) | Allergy inhibitor compositions and kits and methods of using the same | |
IL182943A0 (en) | Ovr110 antibody compositions and methods of use | |
HK1099757A1 (en) | Caspase inhibitors and uses thereof | |
IL185309A0 (en) | Isoqunoline compounds and methods of use thereof | |
EP1763346A4 (en) | COMPOSITION AND METHODS RELATING TO INHIBITORS OF PYRIMIDINE SYNTHESIS | |
EP1937075A4 (en) | SYNERGIC COMPOSITION AND METHOD OF USE | |
EP1933805A4 (en) | INFLAMMATORY COMPOSITIONS AND METHODS OF ADMINISTRATION | |
HK1109576A1 (en) | Aequorin-containing compositions and methods of using same | |
EP1912630A4 (en) | COMPOSITIONS AND METHODS FOR REDUCING POSTOPERATIVE PAIN | |
PT2572724T (pt) | Tratamento de fibroses e doenças hepáticas | |
EP1940458A4 (en) | COMPOSITIONS AND METHODS OF INHIBITING GRANZYME B | |
EP1912633A4 (en) | METHODS AND COMPOSITIONS FOR INHIBITING VASCULAR PERMEABILITY | |
EP1887002A4 (en) | CARBOXYLIC AMIDE COMPOUND AND USE THEREOF |