ZA200710341B - Alpha-(aryl-or heteroaryl-methyl)beta-piperidinopropanoic acid compounds as ORL 1-receptor antagonists - Google Patents

Alpha-(aryl-or heteroaryl-methyl)beta-piperidinopropanoic acid compounds as ORL 1-receptor antagonists

Info

Publication number
ZA200710341B
ZA200710341B ZA200710341A ZA200710341A ZA200710341B ZA 200710341 B ZA200710341 B ZA 200710341B ZA 200710341 A ZA200710341 A ZA 200710341A ZA 200710341 A ZA200710341 A ZA 200710341A ZA 200710341 B ZA200710341 B ZA 200710341B
Authority
ZA
South Africa
Prior art keywords
orl
heteroaryl
beta
aryl
alpha
Prior art date
Application number
ZA200710341A
Other languages
English (en)
Inventor
Hashizume Yoshinobu
Koike Hiroki
Mihara Sachiko
Hirota Masako
Matsumoto Yukari
Nakamura Hiroshi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA200710341B publication Critical patent/ZA200710341B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200710341A 2005-06-17 2007-11-28 Alpha-(aryl-or heteroaryl-methyl)beta-piperidinopropanoic acid compounds as ORL 1-receptor antagonists ZA200710341B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69190505P 2005-06-17 2005-06-17

Publications (1)

Publication Number Publication Date
ZA200710341B true ZA200710341B (en) 2008-10-29

Family

ID=37075616

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710341A ZA200710341B (en) 2005-06-17 2007-11-28 Alpha-(aryl-or heteroaryl-methyl)beta-piperidinopropanoic acid compounds as ORL 1-receptor antagonists

Country Status (12)

Country Link
US (1) US20080207665A1 (xx)
EP (1) EP1896479A1 (xx)
JP (1) JP2008543826A (xx)
KR (1) KR20080012977A (xx)
CN (1) CN101233139A (xx)
AU (1) AU2006257273A1 (xx)
CA (1) CA2611030A1 (xx)
IL (1) IL187654A0 (xx)
MX (1) MX2007016215A (xx)
NO (1) NO20080285L (xx)
WO (1) WO2006134485A1 (xx)
ZA (1) ZA200710341B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
EP3424505A4 (en) 2016-03-04 2019-10-16 Taiho Pharmaceutical Co., Ltd. PREPARATION AND COMPOSITION FOR TREATING MALIGNANT TUMORS
WO2019181876A1 (ja) * 2018-03-19 2019-09-26 大鵬薬品工業株式会社 アルキル硫酸ナトリウムを含む医薬組成物
TW202237143A (zh) 2020-12-10 2022-10-01 南韓商Ｌｇ化學股份有限公司 酸（Ｂｏｒｏｎｉｃ Ａｃｉｄ）化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166209A (en) * 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
US20030078278A1 (en) * 2001-06-26 2003-04-24 Pfizer Inc. Spiropiperidine compounds as ligands for ORL-1 receptor
US7354925B2 (en) * 2004-03-29 2008-04-08 Pfizer Inc. Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists

Also Published As

Publication number Publication date
US20080207665A1 (en) 2008-08-28
CN101233139A (zh) 2008-07-30
IL187654A0 (en) 2008-08-07
WO2006134485A1 (en) 2006-12-21
AU2006257273A1 (en) 2006-12-21
JP2008543826A (ja) 2008-12-04
EP1896479A1 (en) 2008-03-12
CA2611030A1 (en) 2006-12-21
KR20080012977A (ko) 2008-02-12
AU2006257273A8 (en) 2010-01-07
MX2007016215A (es) 2008-03-07
NO20080285L (no) 2008-03-10

Similar Documents

Publication Publication Date Title
IL182828A0 (en) Constrained compounds as cgrp-receptor antagonists
AP2395A (en) New composition containing quinoline compounds.
IL185399A0 (en) Pyridyl acetic acid compounds
EP1758458A4 (en) COMPOSITIONS CONTAINING OPIOIDANT AGONISTS
IL208963A0 (en) Substituted quinoline compounds
IL179888A0 (en) Compounds as ccr5 antagonists
EP1940412A4 (en) NEW OPIOID ANTAGONISTS
ZA200804198B (en) Improved process for the preparation of the salts of 4-(benzimidazolylmethylamino)-benzamides
IL184148A0 (en) Substituted triazole derivatives as oxytocin antagonists
EP1911738A4 (en) PHENOXYALKANSÄUREVERBINDUNG
EP1850870A4 (en) COMPOSITION FOR ADJUVANT CONTAINING POLY-GAMMA-GLUTAMIC ACID
IL185326A0 (en) PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS mGluR5 ANTAGONISTS
EP1945028A4 (en) SUBSTITUTED NICOTINAMIDE COMPOUNDS
IL192308A0 (en) Oxazoloisoquinoline derivatives as thrombin receptor antagonists
ZA200710511B (en) Alpha(aryl- or heteroaryl-methyl)-beta piperidino propanamide compounds as ORL 1-receptor antagonists
IL179912A0 (en) Substituted diketopiperazines as oxytocin antagonists
ZA200803454B (en) Piperazine derivatives useful as CCR5 antagonists
IL184737A (en) Worm remedy
AP2007004227A0 (en) Novel compounds as GLP-1 agonists
ZA200710341B (en) Alpha-(aryl-or heteroaryl-methyl)beta-piperidinopropanoic acid compounds as ORL 1-receptor antagonists
IL195027A0 (en) Constrained compounds as cgrp-receptor antagonists
ZA200809205B (en) Constrained compounds as CGRP-receptor antagonists
EP1750722A4 (en) NEW LYSOPHOSPHIC ACID RECEPTORSELECTIVE ANTAGONISTS
GB0427403D0 (en) Novel compounds I
ZA200605575B (en) Substituted quinoline compounds