ZA200709147B - Pyrimidindione derivatives as prokineticin 2 receptor antagonists - Google Patents

Pyrimidindione derivatives as prokineticin 2 receptor antagonists

Info

Publication number
ZA200709147B
ZA200709147B ZA200709147A ZA200709147A ZA200709147B ZA 200709147 B ZA200709147 B ZA 200709147B ZA 200709147 A ZA200709147 A ZA 200709147A ZA 200709147 A ZA200709147 A ZA 200709147A ZA 200709147 B ZA200709147 B ZA 200709147B
Authority
ZA
South Africa
Prior art keywords
pyrimidindione
prokineticin
derivatives
receptor antagonists
antagonists
Prior art date
Application number
ZA200709147A
Other languages
English (en)
Inventor
Tamara A Miskowski
Steven J Coats
Alexey B Dyatkin
He Wei
Lisko Joseph
Janet L Ralbovsky
Mark J Schultz
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA200709147B publication Critical patent/ZA200709147B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200709147A 2005-03-24 2007-10-23 Pyrimidindione derivatives as prokineticin 2 receptor antagonists ZA200709147B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66486505P 2005-03-24 2005-03-24

Publications (1)

Publication Number Publication Date
ZA200709147B true ZA200709147B (en) 2009-08-26

Family

ID=36580484

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200709147A ZA200709147B (en) 2005-03-24 2007-10-23 Pyrimidindione derivatives as prokineticin 2 receptor antagonists

Country Status (16)

Country Link
US (1) US20080045535A1 (fr)
EP (1) EP1869006A1 (fr)
JP (1) JP2008534499A (fr)
KR (1) KR20070116915A (fr)
CN (1) CN101223147A (fr)
AR (1) AR053700A1 (fr)
AU (1) AU2006229791A1 (fr)
BR (1) BRPI0609317A2 (fr)
CA (1) CA2602510A1 (fr)
EA (1) EA200702062A1 (fr)
IL (1) IL186188A0 (fr)
MX (1) MX2007011847A (fr)
NO (1) NO20075406L (fr)
TW (1) TW200716566A (fr)
WO (1) WO2006104713A1 (fr)
ZA (1) ZA200709147B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006004712A2 (fr) 2004-06-29 2006-01-12 United States Postal Service Unite de batterie de boites aux lettres comportant des elements de securite
CA2602576A1 (fr) 2005-03-24 2006-10-05 Janssen Pharmaceutica N.V. Antagonistes du recepteur de prokineticine 1
CA2630517A1 (fr) * 2005-12-06 2007-06-14 Merck & Co., Inc. Antagonistes de recepteur de prokineticine de morpholine-carboxamide
CN101495464B (zh) * 2005-12-29 2014-03-05 詹森药业有限公司 激肽原1受体拮抗剂
CN101405002A (zh) * 2005-12-29 2009-04-08 詹森药业有限公司 激肽原2受体拮抗剂
US8324380B2 (en) * 2007-10-30 2012-12-04 Janssen Pharmaceutica Nv Amino-heteroaryl-containing prokineticin 1 receptor antagonists
WO2010077976A2 (fr) * 2008-12-17 2010-07-08 The Regents Of The University Of California Antagoniste du récepteur de la prokinéticine et ses utilisations
CA2752269C (fr) * 2009-02-13 2016-08-30 Hiroyuki Kai Nouveau derive de triazine et composition pharmaceutique le contenant
BRPI1013561A8 (pt) * 2009-03-26 2015-09-22 Mapi Pharma Ltd processo para a preparação de alogliptina
CA2803545A1 (fr) * 2010-06-28 2012-01-12 Janssen Pharmaceutica Nv Antagonistes du recepteur-1 de la prokineticine pour le traitement de la douleur
US20110319418A1 (en) * 2010-06-28 2011-12-29 Flores Christopher M Prokineticin 1 receptor antagonists for the treatment of pain
WO2012020749A1 (fr) 2010-08-10 2012-02-16 塩野義製薬株式会社 Dérivé de triazine et composition pharmaceutique présentant une activité analgésique à teneur en dérivé de triazine
JP6075621B2 (ja) 2010-08-10 2017-02-08 塩野義製薬株式会社 新規複素環誘導体およびそれらを含有する医薬組成物
WO2013118855A1 (fr) 2012-02-09 2013-08-15 塩野義製薬株式会社 Noyau hétérocyclique et dérivé carbocyclique
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
WO2015099107A1 (fr) 2013-12-26 2015-07-02 塩野義製薬株式会社 Dérivé cyclique à six chaînons contenant de l'azote et composition pharmaceutique le contenant
WO2016171249A1 (fr) 2015-04-24 2016-10-27 塩野義製薬株式会社 Dérivé hétérocyclique à 6 chainons et composition pharmaceutique comprenant celui-ci
CA3039458A1 (fr) 2016-10-17 2018-04-26 Shionogi & Co., Ltd. Derive heterocyclique azote bicyclique et composition pharmaceutique le comprenant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9704272D0 (sv) * 1997-11-21 1997-11-21 Astra Pharma Prod Novel Compounds
AU2003249535A1 (en) * 2002-08-13 2004-02-25 Warner-Lambert Company Llc 1,6-fused uracil derivatives as matrix metalloproteinase inhibitors
WO2004014868A2 (fr) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Derives de pyrimidine 2,4-diones, utilises comme inhibiteurs de metalloproteinase matricielle

Also Published As

Publication number Publication date
US20080045535A1 (en) 2008-02-21
EA200702062A1 (ru) 2008-02-28
WO2006104713A1 (fr) 2006-10-05
EP1869006A1 (fr) 2007-12-26
CN101223147A (zh) 2008-07-16
AU2006229791A1 (en) 2006-10-05
AR053700A1 (es) 2007-05-16
IL186188A0 (en) 2008-01-20
BRPI0609317A2 (pt) 2010-03-16
JP2008534499A (ja) 2008-08-28
KR20070116915A (ko) 2007-12-11
MX2007011847A (es) 2008-03-11
NO20075406L (no) 2007-12-14
TW200716566A (en) 2007-05-01
CA2602510A1 (fr) 2006-10-05

Similar Documents

Publication Publication Date Title
ZA200709147B (en) Pyrimidindione derivatives as prokineticin 2 receptor antagonists
IL192426A0 (en) Prokineticin 2 receptor antagonists
IL192424A0 (en) Prokineticin 1 receptor antagonists
AP2008004441A0 (en) Piperdin-4-ylpyrazin-2-ylamine derivatives as fastdissociating dopamine 2 receptor antagonists
ZA200800320B (en) Indol-3-carbonyl-spiro-piperidine derivatives as Via receptor antagonists
ZA200708028B (en) Acetylenyl-pyrazolo-pyrimidine derivatives as mGluR2 antagonists
IL222922A0 (en) Neuropilin antagonists
AP2007004047A0 (en) Substituted triazole derivatives as oxtocin antagonists
IL184233A0 (en) 2,3,4,9-tetrahydro-1h-carbazole derivatives as crth2 receptor antagonists
EP1959959A4 (fr) Antagonistes de recepteur de prokineticine de morpholine-carboxamide
AP1983A (en) Carboxamide derivatives as muscarinic receptor antagonists
AP2006003840A0 (en) Indole-2-carboxamidine derivatives as NMDA receptor antagonists
EP1889848A4 (fr) Dérivé de morphinane substitué par un carbamoyle en position 7 et ayant une insauration en position 6,7
ZA200710169B (en) Piperidin-4-yl-amide derivatives and their use as SST receptor subtype 5 antagonists
ZA200806065B (en) Oxazoloisoquinoline derivatives as thrombin receptor antagonists
PT1912976E (pt) Derivados de indol-3-il-carboni-piperidin-benzimidazole como antagonistas dos receptores v1a
ZA200802339B (en) Indol-3-yl-carbonyl-azaspiro derivatives as vasopressin receptor antagonists
ME01208B (fr) Dérivés de pipéridin-4-yl-pyridazin-3-ylamine en tant qu'antagonistes à dissociation rapide du récepteur 2 de la dopamine
ZA200800516B (en) Indol-3-yl-carbonyl-piperidin-benzoimidazol derivatives as V1a receptor antagonists
GB0518344D0 (en) I c v t 2005