ZA200700745B - Methods and compositions for modulating hepatocyte growth factor activation - Google Patents

Methods and compositions for modulating hepatocyte growth factor activation Download PDF

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Publication number
ZA200700745B
ZA200700745B ZA200700745A ZA200700745A ZA200700745B ZA 200700745 B ZA200700745 B ZA 200700745B ZA 200700745 A ZA200700745 A ZA 200700745A ZA 200700745 A ZA200700745 A ZA 200700745A ZA 200700745 B ZA200700745 B ZA 200700745B
Authority
ZA
South Africa
Prior art keywords
antibody
hgf
molecule
hepsin
polypeptide
Prior art date
Application number
ZA200700745A
Other languages
English (en)
Inventor
Daniel K Kirchhofer
Paul M Moran
Mark D Peek
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ZA200700745B publication Critical patent/ZA200700745B/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475Assays involving growth factors
    • G01N2333/4753Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
ZA200700745A 2004-07-26 2005-07-25 Methods and compositions for modulating hepatocyte growth factor activation ZA200700745B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59133904P 2004-07-26 2004-07-26

Publications (1)

Publication Number Publication Date
ZA200700745B true ZA200700745B (en) 2008-07-30

Family

ID=35094502

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200700745A ZA200700745B (en) 2004-07-26 2005-07-25 Methods and compositions for modulating hepatocyte growth factor activation

Country Status (15)

Country Link
US (3) US7432044B2 (https=)
EP (1) EP1774022B1 (https=)
JP (2) JP5226308B2 (https=)
KR (1) KR101222254B1 (https=)
CN (1) CN101023182B (https=)
AU (1) AU2005269463B2 (https=)
BR (1) BRPI0512482A (https=)
CA (1) CA2570323C (https=)
ES (1) ES2532610T3 (https=)
IL (1) IL179917A0 (https=)
MX (1) MX2007001064A (https=)
NZ (1) NZ551908A (https=)
RU (1) RU2405041C2 (https=)
WO (1) WO2006014928A1 (https=)
ZA (1) ZA200700745B (https=)

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EP2030016B1 (en) * 2006-06-22 2015-03-25 Genentech, Inc. Methods and compositions for modulating hepsin activation of urokinase-type plasminogen activator
WO2008102452A1 (ja) * 2007-02-22 2008-08-28 Kringle Pharma Inc. Hgf製剤
US20110206704A1 (en) * 2009-10-19 2011-08-25 Genentech, Inc. Methods and compositions for modulating hepatocyte growth factor activator
EP2491059B1 (en) * 2009-10-22 2015-02-25 F.Hoffmann-La Roche Ag Anti-hepsin antibodies and methods using same
US8697386B2 (en) 2009-10-22 2014-04-15 Genentech, Inc. Methods and compositions for modulating hepsin activation of macrophage-stimulating protein
WO2011161189A1 (en) 2010-06-24 2011-12-29 F. Hoffmann-La Roche Ag Anti-hepsin antibodies and methods of use
KR20120100027A (ko) 2011-03-02 2012-09-12 한국생명공학연구원 엔도사이토시스 모티프 및 단백질 도입 도메인을 포함하는 암 예방 또는 치료용 약학적 조성물
WO2013070771A1 (en) * 2011-11-07 2013-05-16 Isis Pharmaceuticals, Inc. Administration of factor xi antisense oligonucleotides
US10260089B2 (en) 2012-10-29 2019-04-16 The Research Foundation Of The State University Of New York Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
US11547743B2 (en) 2014-04-28 2023-01-10 Eisai R&D Management Co., Ltd. Lyophilized formulation of HGF
WO2016144654A1 (en) 2015-03-09 2016-09-15 Washington University Inhibitors of growth factor activation enzymes
WO2017147298A1 (en) * 2016-02-23 2017-08-31 The Regents Of The University Of Colorado, A Body Corporate Peptide-based methods for treating neurological injury
ES2894477T3 (es) 2016-03-17 2022-02-14 Eisai R&D Man Co Ltd Método para producir factor de crecimiento de hepatocitos (HGF) activo
JPWO2020158691A1 (ja) * 2019-01-28 2021-12-02 東レ株式会社 肝細胞増殖因子又はその活性断片のポリエチレングリコール修飾体

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Also Published As

Publication number Publication date
HK1100294A1 (en) 2007-09-14
US20060084120A1 (en) 2006-04-20
JP2012196217A (ja) 2012-10-18
MX2007001064A (es) 2007-04-12
JP2008507295A (ja) 2008-03-13
EP1774022B1 (en) 2014-12-31
IL179917A0 (en) 2007-05-15
RU2007106862A (ru) 2008-09-10
AU2005269463B2 (en) 2011-08-18
CA2570323A1 (en) 2006-02-09
ES2532610T3 (es) 2015-03-30
CN101023182A (zh) 2007-08-22
WO2006014928A1 (en) 2006-02-09
US20100209956A1 (en) 2010-08-19
NZ551908A (en) 2009-10-30
BRPI0512482A (pt) 2008-03-11
JP5226308B2 (ja) 2013-07-03
US20090075317A1 (en) 2009-03-19
AU2005269463A1 (en) 2006-02-09
KR101222254B1 (ko) 2013-01-16
CA2570323C (en) 2014-08-26
RU2405041C2 (ru) 2010-11-27
EP1774022A1 (en) 2007-04-18
KR20070037499A (ko) 2007-04-04
US7432044B2 (en) 2008-10-07
CN101023182B (zh) 2013-04-17

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