ZA200609058B - Use of dipyridamole for treatment of resistance to platelet inhibitors - Google Patents
Use of dipyridamole for treatment of resistance to platelet inhibitors Download PDFInfo
- Publication number
- ZA200609058B ZA200609058B ZA200609058A ZA200609058A ZA200609058B ZA 200609058 B ZA200609058 B ZA 200609058B ZA 200609058 A ZA200609058 A ZA 200609058A ZA 200609058 A ZA200609058 A ZA 200609058A ZA 200609058 B ZA200609058 B ZA 200609058B
- Authority
- ZA
- South Africa
- Prior art keywords
- inhibitors
- platelet
- carbonyl
- pyrrolidin
- chloro
- Prior art date
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- YHRXFEUHRJIWLH-AWEZNQCLSA-N n-[(1s)-1-(6-chloro-1h-benzimidazol-2-yl)ethyl]-3-methyl-4-(pyrrolidine-1-carbonyl)benzamide Chemical compound N([C@@H](C)C=1NC2=CC=C(Cl)C=C2N=1)C(=O)C(C=C1C)=CC=C1C(=O)N1CCCC1 YHRXFEUHRJIWLH-AWEZNQCLSA-N 0.000 description 1
- AQKCVIJGQHMSEJ-UHFFFAOYSA-N n-[1-(6-bromo-1h-benzimidazol-2-yl)ethyl]-3-methyl-4-(pyrrolidine-1-carbonyl)benzamide Chemical compound N=1C2=CC(Br)=CC=C2NC=1C(C)NC(=O)C(C=C1C)=CC=C1C(=O)N1CCCC1 AQKCVIJGQHMSEJ-UHFFFAOYSA-N 0.000 description 1
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- KGFYHTZWPPHNLQ-AWEZNQCLSA-N rivaroxaban Chemical compound S1C(Cl)=CC=C1C(=O)NC[C@@H]1OC(=O)N(C=2C=CC(=CC=2)N2C(COCC2)=O)C1 KGFYHTZWPPHNLQ-AWEZNQCLSA-N 0.000 description 1
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- 230000002537 thrombolytic effect Effects 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 229960002528 ticagrelor Drugs 0.000 description 1
- OEKWJQXRCDYSHL-FNOIDJSQSA-N ticagrelor Chemical compound C1([C@@H]2C[C@H]2NC=2N=C(N=C3N([C@H]4[C@@H]([C@H](O)[C@@H](OCCO)C4)O)N=NC3=2)SCCC)=CC=C(F)C(F)=C1 OEKWJQXRCDYSHL-FNOIDJSQSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57059704P | 2004-05-13 | 2004-05-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200609058B true ZA200609058B (en) | 2008-03-26 |
Family
ID=34969445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200609058A ZA200609058B (en) | 2004-05-13 | 2006-10-31 | Use of dipyridamole for treatment of resistance to platelet inhibitors |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090048173A1 (de) |
| EP (1) | EP1747016A2 (de) |
| JP (1) | JP2007537184A (de) |
| KR (1) | KR20070026577A (de) |
| CN (1) | CN101068570A (de) |
| AU (1) | AU2005245271A1 (de) |
| BR (1) | BRPI0511054A (de) |
| CA (1) | CA2566081A1 (de) |
| IL (1) | IL179169A0 (de) |
| MX (1) | MXPA06013157A (de) |
| RU (1) | RU2006143838A (de) |
| WO (1) | WO2005113006A2 (de) |
| ZA (1) | ZA200609058B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008517974A (ja) * | 2004-10-25 | 2008-05-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗血栓薬と併用しての血栓塞栓性疾患の治療および予防のためのジピリダモールの使用 |
| TWI482772B (zh) * | 2006-08-21 | 2015-05-01 | Astrazeneca Ab | 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物 |
| CN103582480B (zh) * | 2011-02-09 | 2016-03-16 | 医药公司 | 治疗肺高压的方法 |
| US20130345262A1 (en) | 2012-06-25 | 2013-12-26 | Boehringer Ingelheim International Gmbh | Method for prevention of stroke |
| US20150306281A1 (en) * | 2014-04-28 | 2015-10-29 | Nalini Marie Rajamannan | Devices and methods for inhibiting stenosis, obstruction, or calcification of a native heart valve, stented heart valve or bioprosthesis |
| US10058630B2 (en) | 2012-10-22 | 2018-08-28 | Concievalve, Llc | Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis |
| TW201503900A (zh) * | 2013-07-29 | 2015-02-01 | ren-zheng Lin | 增強治療急性中風之抗血小板藥物之遞送方法及其組合物 |
| WO2015110952A1 (en) | 2014-01-21 | 2015-07-30 | Wockhardt Limited | Solid oral pharmaceutical compositions comprising ticagrelor or salt thereof |
| WO2015113001A1 (en) * | 2014-01-24 | 2015-07-30 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Materials, methods and devices for altering cell reactivity |
| JP2018516624A (ja) * | 2015-04-15 | 2018-06-28 | コンシーヴァルブ エルエルシー | 自然心臓弁、ステント装着された心臓弁またはバイオプロテーゼの狭窄、閉塞または石灰化を抑制するためのデバイスおよび方法 |
| CN104965017B (zh) * | 2015-06-17 | 2017-06-16 | 广西师范学院 | 水蛭素抗凝血酶活性的测定方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US77729A (en) * | 1868-05-12 | William hall | ||
| US151534A (en) * | 1874-06-02 | Improvement in | ||
| US175831A (en) * | 1876-04-11 | Improvement in jig-saw attachments | ||
| US176469A (en) * | 1876-04-25 | Improvement in carpet-beaters | ||
| US151595A (en) * | 1874-06-02 | Improvement in hand corn-planters | ||
| US107409A (en) * | 1870-09-13 | Improvement in double-shovel plows | ||
| US183519A (en) * | 1876-10-24 | Improvement in cornice-gutters | ||
| US3031450A (en) * | 1959-04-30 | 1962-04-24 | Thomae Gmbh Dr K | Substituted pyrimido-[5, 4-d]-pyrimidines |
| DE3000979A1 (de) * | 1980-01-12 | 1981-07-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue dipyridamol-retardformen und verfahren zu ihrer herstellung |
| DE3124090A1 (de) * | 1981-06-19 | 1983-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue orale dipyridamolformen |
| DE3627423A1 (de) * | 1986-08-13 | 1988-02-18 | Thomae Gmbh Dr K | Arzneimittel enthaltend dipyridamol oder mopidamol und o-acetylsalicylsaeure bzw. deren physiologisch vertraegliche salze, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung der thrombusbildung |
| US5256559A (en) * | 1988-03-04 | 1993-10-26 | Biogen, Inc. | Methods and compositions for inhibiting platelet aggregation |
| US5498613A (en) * | 1994-06-07 | 1996-03-12 | The University Of Southern California | Dipyridamole and analogs thereof in preventing adhesion formation |
| FR2728901B1 (fr) * | 1994-12-28 | 1997-03-28 | Sanofi Sa | Derives de phenyl-4-thiazoles substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
| US6136794A (en) * | 1998-02-02 | 2000-10-24 | Merck & Co., Inc. | Platelet aggregation inhibition using low molecular weight heparin in combination with a GP IIb/IIIa antagonist |
| DE19834751A1 (de) * | 1998-08-01 | 2000-02-03 | Boehringer Ingelheim Pharma | Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
| ATE261934T1 (de) * | 1998-12-16 | 2004-04-15 | Boehringer Ingelheim Pharma | Substituierte aryl- und heteroarylamidinderivate, deren herstellung und deren verwendung als arzneimittel |
| EP1093814A1 (de) | 1999-10-22 | 2001-04-25 | Boehringer Ingelheim Pharma KG | Verwendung von Dipyridamole oder Mopidamol zur Herstellung eines Medikaments für die Behandlung und Vorbeugung von fibrinabhängigen Mikrozirkulationstörungen |
| WO2001031052A1 (en) * | 1999-10-25 | 2001-05-03 | Colorado Coagulation Consultants | Thromboxane b2 metabolite and methods for regulating aspirin-related platelet action |
| FR2809181B1 (fr) * | 2000-05-16 | 2002-10-25 | Biocytex | Monoreactif pour le dosage des microparticules plaquettaires |
| US8519005B2 (en) * | 2000-07-27 | 2013-08-27 | Thomas N. Thomas | Compositions and methods to prevent toxicity of antiinflammatory agents and enhance their efficacy |
| WO2002059623A2 (en) * | 2001-01-24 | 2002-08-01 | Sendx Medical, Inc. | Methods for determining platelet activity with antiplatelet compositions |
| DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| EP1622621A2 (de) | 2003-04-24 | 2006-02-08 | Boehringer Ingelheim International GmbH | Verwendung von dipyridamol oder mopidamol zur behandlung und prävention von thromboembolischen erkrankungen und störungen verursacht durch übermässige bildung von thrombin und/oder erhöhte expression von thrombin-rezeptoren |
-
2005
- 2005-05-10 KR KR1020067026148A patent/KR20070026577A/ko not_active Application Discontinuation
- 2005-05-10 WO PCT/EP2005/005024 patent/WO2005113006A2/en active Application Filing
- 2005-05-10 AU AU2005245271A patent/AU2005245271A1/en not_active Abandoned
- 2005-05-10 RU RU2006143838/14A patent/RU2006143838A/ru not_active Application Discontinuation
- 2005-05-10 EP EP05748279A patent/EP1747016A2/de not_active Withdrawn
- 2005-05-10 BR BRPI0511054-8A patent/BRPI0511054A/pt not_active IP Right Cessation
- 2005-05-10 CA CA002566081A patent/CA2566081A1/en not_active Abandoned
- 2005-05-10 CN CNA2005800236935A patent/CN101068570A/zh active Pending
- 2005-05-10 US US11/568,730 patent/US20090048173A1/en not_active Abandoned
- 2005-05-10 JP JP2007512064A patent/JP2007537184A/ja active Pending
- 2005-05-10 MX MXPA06013157A patent/MXPA06013157A/es not_active Application Discontinuation
-
2006
- 2006-10-31 ZA ZA200609058A patent/ZA200609058B/en unknown
- 2006-11-09 IL IL179169A patent/IL179169A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101068570A (zh) | 2007-11-07 |
| KR20070026577A (ko) | 2007-03-08 |
| JP2007537184A (ja) | 2007-12-20 |
| CA2566081A1 (en) | 2005-12-01 |
| IL179169A0 (en) | 2007-03-08 |
| US20090048173A1 (en) | 2009-02-19 |
| WO2005113006A2 (en) | 2005-12-01 |
| AU2005245271A1 (en) | 2005-12-01 |
| BRPI0511054A (pt) | 2007-11-27 |
| EP1747016A2 (de) | 2007-01-31 |
| WO2005113006A3 (en) | 2007-02-08 |
| RU2006143838A (ru) | 2008-06-20 |
| MXPA06013157A (es) | 2007-02-13 |
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