ZA200607552B - Identification of self and non-self antigens implicated in autoimmune diseases - Google Patents
Identification of self and non-self antigens implicated in autoimmune diseases Download PDFInfo
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- ZA200607552B ZA200607552B ZA200607552A ZA200607552A ZA200607552B ZA 200607552 B ZA200607552 B ZA 200607552B ZA 200607552 A ZA200607552 A ZA 200607552A ZA 200607552 A ZA200607552 A ZA 200607552A ZA 200607552 B ZA200607552 B ZA 200607552B
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Rehabilitation Therapy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
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|---|---|---|---|
| US10/799,005 US7084247B2 (en) | 2004-03-11 | 2004-03-11 | Identification of self and non-self antigens implicated in autoimmune diseases |
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|---|---|
| ZA200607552B true ZA200607552B (en) | 2008-05-28 |
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|---|---|---|---|
| ZA200607552A ZA200607552B (en) | 2004-03-11 | 2006-09-08 | Identification of self and non-self antigens implicated in autoimmune diseases |
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| US (2) | US7084247B2 (xx) |
| EP (1) | EP1732595A2 (xx) |
| JP (1) | JP2007528422A (xx) |
| KR (1) | KR20070026450A (xx) |
| CN (1) | CN1942202A (xx) |
| AP (1) | AP2006003735A0 (xx) |
| AU (1) | AU2005221712A1 (xx) |
| BR (1) | BRPI0508633A (xx) |
| CA (1) | CA2559065A1 (xx) |
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| MA (1) | MA28525B1 (xx) |
| MX (1) | MXPA06010364A (xx) |
| NO (1) | NO20064610L (xx) |
| TN (1) | TNSN06273A1 (xx) |
| WO (1) | WO2005087261A2 (xx) |
| ZA (1) | ZA200607552B (xx) |
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| US7084247B2 (en) * | 2004-03-11 | 2006-08-01 | Peptimmune, Inc. | Identification of self and non-self antigens implicated in autoimmune diseases |
| EP1945182B1 (en) * | 2005-10-14 | 2010-07-28 | Janssen Pharmaceutica N.V. | Formulations of tipifarnib for intravenous application |
| US20090093016A1 (en) * | 2006-01-17 | 2009-04-09 | N.V. Organon | Selective Enzymatic Hydrolysis of C-Terminal Tert-Butyl Esters of Peptides |
| CA2649296A1 (en) * | 2006-04-13 | 2007-10-25 | Peptimmune, Inc. | Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability |
| JP2009069050A (ja) * | 2007-09-14 | 2009-04-02 | Nec Corp | 化合物のカラム担体への固定化方法 |
| BRPI0817682A2 (pt) * | 2007-10-16 | 2015-04-07 | Peptimmune Inc | Métodos para projetar e preparar vacinas compreendendo composições de polímero de sequência direcionada via a expansão direta de epítopos |
| CA2759118A1 (en) * | 2008-04-17 | 2009-10-22 | Declion Pharmaceuticals, Inc. | Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
| ATE551369T1 (de) | 2008-11-17 | 2012-04-15 | Borealis Ag | Mehrstufiger prozess zur herstellung von polyethylen mit reduzierter gelbildung |
| SG176064A1 (en) * | 2009-05-14 | 2011-12-29 | Oatmeal Biotechnologies Group L L C | Platform technologies for spontaneously occurring diseases |
| GB201112806D0 (en) * | 2011-07-26 | 2011-09-07 | Bauer Johann | Use of epitopes inducing specific tolerance for the prevention of tissue rejection |
| EP2570455A1 (en) | 2011-09-16 | 2013-03-20 | Borealis AG | Polyethylene composition with broad molecular weight distribution and improved homogeneity |
| EP2599828A1 (en) | 2011-12-01 | 2013-06-05 | Borealis AG | Multimodal polyethylene composition for the production of pipes with improved slow crack growth resistance |
| US11458199B2 (en) * | 2012-08-21 | 2022-10-04 | Opko Pharmaceuticals, Llc | Liposome formulations |
| EP2730611B1 (en) | 2012-11-09 | 2017-01-04 | Abu Dhabi Polymers Company Limited (Borouge) | Drip irrigation pipe comprising a polymer composition comprising a multimodal polyethylene base resin |
| EP2730612B1 (en) | 2012-11-09 | 2016-09-14 | Abu Dhabi Polymers Company Limited (Borouge) | Polymer composition comprising a blend of a multimodal polyethylene and a further ethylene polymer suitable for the production of a drip irrigation pipe |
| EP2740761B1 (en) | 2012-12-05 | 2016-10-19 | Borealis AG | Polyethylene composition with improved balance of slow crack growth resistance, impact performance and pipe pressure resistance for pipe applications |
| PL2860202T3 (pl) | 2013-10-10 | 2018-11-30 | Borealis Ag | Polietylen odporny na wysoką temperaturę i sposób jego wytwarzania |
| EP2860204B1 (en) | 2013-10-10 | 2018-08-01 | Borealis AG | Polyethylene composition for pipe applications |
| EP2860201A1 (en) | 2013-10-10 | 2015-04-15 | Borealis AG | High temperature resistant polyethylene and process for the production thereof |
| EP2860200B1 (en) | 2013-10-10 | 2017-08-02 | Borealis AG | Polyethylene composition for pipe and pipe coating applications |
| WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
| WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| EP3076992B1 (en) * | 2013-12-06 | 2022-04-06 | The Broad Institute, Inc. | Formulations for neoplasia vaccines |
| KR20230076867A (ko) | 2013-12-20 | 2023-05-31 | 더 브로드 인스티튜트, 인코퍼레이티드 | 신생항원 백신과의 병용 요법 |
| CN113604491A (zh) * | 2014-05-02 | 2021-11-05 | 宾夕法尼亚大学董事会 | 嵌合自身抗体受体t细胞的组合物和方法 |
| US10975442B2 (en) | 2014-12-19 | 2021-04-13 | Massachusetts Institute Of Technology | Molecular biomarkers for cancer immunotherapy |
| WO2016100977A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute Inc. | Methods for profiling the t-cel- receptor repertoire |
| MX2017014700A (es) | 2015-05-20 | 2018-08-15 | Broad Inst Inc | Neoantigenos compartidos. |
| WO2018140391A1 (en) | 2017-01-24 | 2018-08-02 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| EP3873954A1 (en) | 2018-10-31 | 2021-09-08 | Borealis AG | Polyethylene composition for high pressure resistant pipes with improved homogeneity |
| EP3647645A1 (en) | 2018-10-31 | 2020-05-06 | Borealis AG | Polyethylene composition for high pressure resistant pipes |
| US11912838B2 (en) | 2018-11-28 | 2024-02-27 | Borealis Ag | Polyethylene composition for film applications |
| US20220282074A1 (en) | 2019-07-22 | 2022-09-08 | Abu Dhabi Polymers Co. Ltd (Borouge) L.L.C., | Single site catalysed multimodal polyethylene composition |
| EP4019583B1 (en) | 2020-12-28 | 2024-04-10 | ABU DHABI POLYMERS CO. LTD (BOROUGE) - Sole Proprietorship L.L.C. | Polyethylene composition for film applications with improved toughness and stiffness |
Family Cites Families (15)
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|---|---|---|---|---|
| US4973577A (en) * | 1986-04-04 | 1990-11-27 | The Salk Institute For Biological Studies | FSH-releasing peptides |
| US5130297A (en) | 1988-06-23 | 1992-07-14 | Anergen, Inc. | Conjugates useful in ameliorating autoimmunity MHC-II-peptide |
| US5260422A (en) | 1988-06-23 | 1993-11-09 | Anergen, Inc. | MHC conjugates useful in ameliorating autoimmunity |
| US5194425A (en) | 1988-06-23 | 1993-03-16 | Anergen, Inc. | Mhc-mediated toxic conjugates useful in ameliorating autoimmunity |
| AU4948890A (en) | 1989-01-12 | 1990-08-13 | Blood Center Of Southeastern Wisconsin, The | Peptide-mediated modulation of t-cell recognition as a means of affecting immune responses |
| EP0579747A4 (en) | 1991-03-22 | 1994-07-06 | Univ Pennsylvania | Method of modulating mammalian t-cell response |
| WO1993010813A1 (en) | 1991-11-27 | 1993-06-10 | THE UNITED STAES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Nucleotide and amino acid sequence of pemphigus vulgaris antigen and methods of use |
| US5719064A (en) | 1992-08-31 | 1998-02-17 | Oklahoma Medical Research Foundation | Peptide diagnostics and therapeutics for spondyloarthropathies |
| AU4851893A (en) | 1992-09-11 | 1994-04-12 | Washington University | Peptides tolerizing t-cells and compositions thereof |
| EP0726708A1 (en) | 1993-11-05 | 1996-08-21 | Pathogenesis Corporation | Virus associated multiple sclerosis: treatments, prevention and diagnosis thereof |
| US6329499B1 (en) * | 1994-11-18 | 2001-12-11 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein |
| US5874531A (en) * | 1995-03-07 | 1999-02-23 | President And Fellows Of Harvard College | Identification of self and non-self antigens implicated autoimmune disease |
| AU767185B2 (en) * | 1998-03-23 | 2003-11-06 | President And Fellows Of Harvard College | Synthesis of compounds and libraries of compounds |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US7084247B2 (en) * | 2004-03-11 | 2006-08-01 | Peptimmune, Inc. | Identification of self and non-self antigens implicated in autoimmune diseases |
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| WO2005087261A3 (en) | 2005-12-08 |
| MA28525B1 (fr) | 2007-04-03 |
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