ZA200606409B - Pharmaceutical compositions comprising a proton pump inhibitor and a prokinetic - Google Patents
Pharmaceutical compositions comprising a proton pump inhibitor and a prokinetic Download PDFInfo
- Publication number
- ZA200606409B ZA200606409B ZA200606409A ZA200606409A ZA200606409B ZA 200606409 B ZA200606409 B ZA 200606409B ZA 200606409 A ZA200606409 A ZA 200606409A ZA 200606409 A ZA200606409 A ZA 200606409A ZA 200606409 B ZA200606409 B ZA 200606409B
- Authority
- ZA
- South Africa
- Prior art keywords
- agent
- composition according
- prokinetic agent
- release form
- pharmaceutically acceptable
- Prior art date
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- 229940126409 proton pump inhibitor Drugs 0.000 title claims description 19
- 239000000612 proton pump inhibitor Substances 0.000 title claims description 19
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 14
- 239000002325 prokinetic agent Substances 0.000 claims description 87
- 239000000203 mixture Substances 0.000 claims description 70
- 239000003826 tablet Substances 0.000 claims description 70
- 239000003795 chemical substances by application Substances 0.000 claims description 41
- 230000003111 delayed effect Effects 0.000 claims description 39
- 229960001253 domperidone Drugs 0.000 claims description 35
- FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 claims description 35
- 210000004211 gastric acid Anatomy 0.000 claims description 32
- 238000004519 manufacturing process Methods 0.000 claims description 25
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 25
- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 claims description 24
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 24
- 229960005019 pantoprazole Drugs 0.000 claims description 24
- 150000002148 esters Chemical class 0.000 claims description 19
- 150000004677 hydrates Chemical class 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 19
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- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims description 15
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 14
- 229960004503 metoclopramide Drugs 0.000 claims description 14
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 claims description 14
- 230000002902 bimodal effect Effects 0.000 claims description 12
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 11
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- 239000008120 corn starch Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 1
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 206010060865 duodenogastric reflux Diseases 0.000 description 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical group NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 1
- 229960001596 famotidine Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229960001021 lactose monohydrate Drugs 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 1
- 238000009115 maintenance therapy Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000008185 minitablet Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 229960004085 mosapride Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229960001778 rabeprazole sodium Drugs 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 229940083037 simethicone Drugs 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN21DE2004 | 2004-01-06 | ||
| IN25DE2004 | 2004-01-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200606409B true ZA200606409B (en) | 2008-06-25 |
Family
ID=34751863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200606409A ZA200606409B (en) | 2004-01-06 | 2005-01-05 | Pharmaceutical compositions comprising a proton pump inhibitor and a prokinetic |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20070160664A1 (sr) |
| EP (1) | EP1729743A1 (sr) |
| AP (1) | AP2006003703A0 (sr) |
| AU (1) | AU2005204014B2 (sr) |
| BR (1) | BRPI0506704A (sr) |
| CA (1) | CA2552627A1 (sr) |
| EA (1) | EA012261B1 (sr) |
| NZ (1) | NZ548780A (sr) |
| RS (1) | RS20050796A (sr) |
| WO (1) | WO2005065664A1 (sr) |
| ZA (1) | ZA200606409B (sr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7803817B2 (en) * | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
| US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| ES2511792T3 (es) | 2006-07-25 | 2014-10-23 | Vecta Ltd. | Composiciones y métodos para la inhibición de la secreción de ácido gástrico usando derivados de pequeños ácidos dicarboxílicos en combinación con IBP |
| CN101657436A (zh) | 2007-02-09 | 2010-02-24 | 特兰齐姆制药公司 | 大环生长素释放肽受体调节剂及其使用方法 |
| WO2010038241A2 (en) * | 2008-09-30 | 2010-04-08 | Panacea Biotec Limited | Pharmaceutical compositions comprising of proton pump inhibitor, prokinetic agent and alginic acid |
| EP2563341A1 (en) * | 2010-04-26 | 2013-03-06 | Mahmut Bilgic | Pharmaceutical compositions inducing synergistic effect |
| WO2012018056A1 (ja) * | 2010-08-03 | 2012-02-09 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 圧縮組成物 |
| BRPI1103093A2 (pt) * | 2011-06-03 | 2013-07-02 | Eurofarma Laboratarios Ltda | composiÇço farmacÊutica oral e uso da composiÇço farmacÊutica oral |
| KR20130024644A (ko) * | 2011-08-31 | 2013-03-08 | 한국유나이티드제약 주식회사 | 이토프라이드 염산염을 함유하는 제어 방출성 경구 제제의 조성물 및 그의 제조방법 |
| JP2018518521A (ja) * | 2015-06-26 | 2018-07-12 | コリア ユナイテッド ファーマ． インコーポレーテッド | モサプリドとラベプラゾールの複合製剤 |
| WO2024042540A1 (en) * | 2022-08-24 | 2024-02-29 | Alkem Laboratories Limited | Mesdopetam compositions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7397194A (en) * | 1993-07-06 | 1995-02-06 | Mcneil-Ppc, Inc. | H2 antagonist-gastrointestinal motility agent combinations |
| SE9600072D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients II |
| CA2275604A1 (en) * | 1997-01-03 | 1998-07-09 | Kenneth Iain Cumming | Sustained release cisapride mini-tablet formulation |
| US6521255B2 (en) * | 2000-01-13 | 2003-02-18 | Osmotica Corp. | Osmotic device containing ranitidine and a prokinetic agent |
| WO2004071374A2 (en) * | 2003-02-11 | 2004-08-26 | Torrent Pharmaceuticals Limited | Once a day orally administered pharmaceutical compositions |
-
2005
- 2005-01-05 WO PCT/IN2005/000002 patent/WO2005065664A1/en active Application Filing
- 2005-01-05 ZA ZA200606409A patent/ZA200606409B/en unknown
- 2005-01-05 CA CA002552627A patent/CA2552627A1/en not_active Abandoned
- 2005-01-05 BR BRPI0506704-9A patent/BRPI0506704A/pt not_active IP Right Cessation
- 2005-01-05 AP AP2006003703A patent/AP2006003703A0/xx unknown
- 2005-01-05 RS YUP-2005/0796A patent/RS20050796A/sr unknown
- 2005-01-05 NZ NZ548780A patent/NZ548780A/en unknown
- 2005-01-05 AU AU2005204014A patent/AU2005204014B2/en not_active Ceased
- 2005-01-05 EA EA200601286A patent/EA012261B1/ru not_active IP Right Cessation
- 2005-01-05 EP EP05709158A patent/EP1729743A1/en not_active Withdrawn
-
2006
- 2006-07-06 US US11/482,186 patent/US20070160664A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EA012261B1 (ru) | 2009-08-28 |
| RS20050796A (en) | 2007-08-03 |
| CA2552627A1 (en) | 2005-07-21 |
| NZ548780A (en) | 2008-09-26 |
| WO2005065664A8 (en) | 2005-10-20 |
| EA200601286A1 (ru) | 2007-02-27 |
| AU2005204014B2 (en) | 2008-02-28 |
| EP1729743A1 (en) | 2006-12-13 |
| AU2005204014A1 (en) | 2005-07-21 |
| AP2006003703A0 (en) | 2006-08-31 |
| WO2005065664A1 (en) | 2005-07-21 |
| US20070160664A1 (en) | 2007-07-12 |
| BRPI0506704A (pt) | 2007-05-02 |
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