ZA200603435B - Nucleic acids specifically binding bioactive ghrelin - Google Patents

Nucleic acids specifically binding bioactive ghrelin Download PDF

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Publication number
ZA200603435B
ZA200603435B ZA200603435A ZA200603435A ZA200603435B ZA 200603435 B ZA200603435 B ZA 200603435B ZA 200603435 A ZA200603435 A ZA 200603435A ZA 200603435 A ZA200603435 A ZA 200603435A ZA 200603435 B ZA200603435 B ZA 200603435B
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South Africa
Prior art keywords
ghrelin
nucleic acid
bioactive
detection
nucleic
Prior art date
Application number
ZA200603435A
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English (en)
Inventor
Klussmann Sven
Helmling Steffen
Eulberg Dirk
Maasch Christian
Buchner Klaus
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Noxxon Pharma Ag
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Publication date
Application filed by Noxxon Pharma Ag filed Critical Noxxon Pharma Ag
Publication of ZA200603435B publication Critical patent/ZA200603435B/en

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Diabetes (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
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ZA200603435A 2003-11-10 2006-05-02 Nucleic acids specifically binding bioactive ghrelin ZA200603435B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03025743 2003-11-10

Publications (1)

Publication Number Publication Date
ZA200603435B true ZA200603435B (en) 2007-06-27

Family

ID=34610046

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200603435A ZA200603435B (en) 2003-11-10 2006-05-02 Nucleic acids specifically binding bioactive ghrelin

Country Status (19)

Country Link
US (2) US20070031840A1 (xx)
EP (1) EP1682662A1 (xx)
JP (1) JP4823067B2 (xx)
KR (1) KR20060125743A (xx)
CN (1) CN1894407A (xx)
AP (1) AP2006003618A0 (xx)
AU (1) AU2004291656A1 (xx)
BR (1) BRPI0415872A (xx)
CA (1) CA2544805A1 (xx)
CR (1) CR8388A (xx)
EA (1) EA009376B1 (xx)
EC (1) ECSP066559A (xx)
IL (1) IL175443A0 (xx)
MA (1) MA28153A1 (xx)
NO (1) NO20062663L (xx)
OA (1) OA13282A (xx)
TN (1) TNSN06132A1 (xx)
WO (1) WO2005049828A1 (xx)
ZA (1) ZA200603435B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7750140B2 (en) * 2002-08-01 2010-07-06 Noxxon Pharma Ag Ghrelin binding nucleic acids
EP2290070B1 (en) * 2004-05-28 2015-03-25 Asuragen, Inc. Methods and compositions involving microRNA
EP2322616A1 (en) 2004-11-12 2011-05-18 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
WO2008073922A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro rnas
UY29460A1 (es) 2005-04-08 2006-11-30 Noxxon Pharma Ag Acidos nucleicos de union a ghrelin
CA2663962A1 (en) * 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
JP5520605B2 (ja) * 2006-09-19 2014-06-11 アシュラジェン インコーポレイテッド 膵臓疾患で差次的に発現されるマイクロrnaおよびその使用
US20090092974A1 (en) * 2006-12-08 2009-04-09 Asuragen, Inc. Micrornas differentially expressed in leukemia and uses thereof
CA2671294A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Mir-21 regulated genes and pathways as targets for therapeutic intervention
CA2671270A1 (en) * 2006-12-29 2008-07-17 Asuragen, Inc. Mir-16 regulated genes and pathways as targets for therapeutic intervention
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090131354A1 (en) * 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
WO2008154333A2 (en) * 2007-06-08 2008-12-18 Asuragen, Inc. Mir-34 regulated genes and pathways as targets for therapeutic intervention
US8361714B2 (en) 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
WO2009070805A2 (en) * 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
US20090192114A1 (en) * 2007-12-21 2009-07-30 Dmitriy Ovcharenko miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention
US20090263803A1 (en) * 2008-02-08 2009-10-22 Sylvie Beaudenon Mirnas differentially expressed in lymph nodes from cancer patients
US20090233297A1 (en) * 2008-03-06 2009-09-17 Elizabeth Mambo Microrna markers for recurrence of colorectal cancer
WO2009154835A2 (en) * 2008-03-26 2009-12-23 Asuragen, Inc. Compositions and methods related to mir-16 and therapy of prostate cancer
EP2990487A1 (en) 2008-05-08 2016-03-02 Asuragen, INC. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
US20110105389A1 (en) 2009-10-30 2011-05-05 Hoveyda Hamid R Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same
KR20140026357A (ko) * 2011-01-10 2014-03-05 녹손 파르마 아게 목표 분자에 결합력을 갖는 핵산 및 이를 제조하는 방법
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614395A (en) * 1988-03-08 1997-03-25 Ciba-Geigy Corporation Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
JP2763958B2 (ja) * 1990-06-11 1998-06-11 ネクスター ファーマスーティカルズ,インコーポレイテッド 核酸リガンド
US5780221A (en) * 1995-05-03 1998-07-14 Whitehead Institute For Biomedical Research Identification of enantiomeric ligands
CA2218083A1 (en) * 1995-05-03 1996-11-07 Antonius Nicolaas Maria Schumacher Identification of enantiomeric ligands
US20030211967A1 (en) * 2001-05-07 2003-11-13 Bryant Henry Uhlman Method for selectively inhibiting ghrelin action
AU2001259056A1 (en) * 2000-05-17 2001-11-26 Eli Lilly And Company Method for selectively inhibiting ghrelin action
CA2411667A1 (en) * 2000-05-30 2001-12-06 Merck & Co. Inc. Ghrelin analogs
US7750140B2 (en) * 2002-08-01 2010-07-06 Noxxon Pharma Ag Ghrelin binding nucleic acids
UY29460A1 (es) * 2005-04-08 2006-11-30 Noxxon Pharma Ag Acidos nucleicos de union a ghrelin

Also Published As

Publication number Publication date
CR8388A (es) 2006-10-17
NO20062663L (no) 2006-08-09
US20100261291A1 (en) 2010-10-14
EP1682662A1 (en) 2006-07-26
CN1894407A (zh) 2007-01-10
ECSP066559A (xx) 2006-11-24
MA28153A1 (fr) 2006-09-01
KR20060125743A (ko) 2006-12-06
BRPI0415872A (pt) 2007-01-09
WO2005049828A1 (en) 2005-06-02
US20070031840A1 (en) 2007-02-08
AP2006003618A0 (en) 2006-06-30
EA009376B1 (ru) 2007-12-28
CA2544805A1 (en) 2005-06-02
JP2007513608A (ja) 2007-05-31
OA13282A (en) 2007-01-31
JP4823067B2 (ja) 2011-11-24
AU2004291656A1 (en) 2005-06-02
EA200600735A1 (ru) 2006-10-27
TNSN06132A1 (fr) 2007-11-15
IL175443A0 (en) 2006-09-05

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