ZA200603435B - Nucleic acids specifically binding bioactive ghrelin - Google Patents

Nucleic acids specifically binding bioactive ghrelin Download PDF

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Publication number
ZA200603435B
ZA200603435B ZA200603435A ZA200603435A ZA200603435B ZA 200603435 B ZA200603435 B ZA 200603435B ZA 200603435 A ZA200603435 A ZA 200603435A ZA 200603435 A ZA200603435 A ZA 200603435A ZA 200603435 B ZA200603435 B ZA 200603435B
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South Africa
Prior art keywords
ghrelin
nucleic acid
bioactive
detection
nucleic
Prior art date
Application number
ZA200603435A
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English (en)
Inventor
Klussmann Sven
Helmling Steffen
Eulberg Dirk
Maasch Christian
Buchner Klaus
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Noxxon Pharma Ag
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Publication date
Application filed by Noxxon Pharma Ag filed Critical Noxxon Pharma Ag
Publication of ZA200603435B publication Critical patent/ZA200603435B/en

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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    • A61P9/00Drugs for disorders of the cardiovascular system
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

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ZA200603435A 2003-11-10 2006-05-02 Nucleic acids specifically binding bioactive ghrelin ZA200603435B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03025743 2003-11-10

Publications (1)

Publication Number Publication Date
ZA200603435B true ZA200603435B (en) 2007-06-27

Family

ID=34610046

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200603435A ZA200603435B (en) 2003-11-10 2006-05-02 Nucleic acids specifically binding bioactive ghrelin

Country Status (19)

Country Link
US (2) US20070031840A1 (OSRAM)
EP (1) EP1682662A1 (OSRAM)
JP (1) JP4823067B2 (OSRAM)
KR (1) KR20060125743A (OSRAM)
CN (1) CN1894407A (OSRAM)
AP (1) AP2006003618A0 (OSRAM)
AU (1) AU2004291656A1 (OSRAM)
BR (1) BRPI0415872A (OSRAM)
CA (1) CA2544805A1 (OSRAM)
CR (1) CR8388A (OSRAM)
EA (1) EA009376B1 (OSRAM)
EC (1) ECSP066559A (OSRAM)
IL (1) IL175443A0 (OSRAM)
MA (1) MA28153A1 (OSRAM)
NO (1) NO20062663L (OSRAM)
OA (1) OA13282A (OSRAM)
TN (1) TNSN06132A1 (OSRAM)
WO (1) WO2005049828A1 (OSRAM)
ZA (1) ZA200603435B (OSRAM)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003251681A1 (en) * 2002-08-01 2004-02-23 Noxxon Pharma Ag Ghrelin binding nucleic acids
EP2290074B1 (en) * 2004-05-28 2014-12-17 Asuragen, Inc. Methods and compositions involving microRNA
CA2850323A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
UY29460A1 (es) * 2005-04-08 2006-11-30 Noxxon Pharma Ag Acidos nucleicos de union a ghrelin
JP2010510964A (ja) * 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路
CA2664383C (en) * 2006-09-19 2017-08-22 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
CN101627121A (zh) * 2006-12-08 2010-01-13 奥斯瑞根公司 作为治疗干预的靶标的miRNA调控基因和路径
CA2671299A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro rnas
EP2104735A2 (en) * 2006-12-08 2009-09-30 Asuragen, INC. Mir-21 regulated genes and pathways as targets for therapeutic intervention
US20090175827A1 (en) * 2006-12-29 2009-07-09 Byrom Mike W miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090131354A1 (en) * 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
WO2008154333A2 (en) * 2007-06-08 2008-12-18 Asuragen, Inc. Mir-34 regulated genes and pathways as targets for therapeutic intervention
US8361714B2 (en) 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
WO2009070805A2 (en) * 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
WO2009086156A2 (en) * 2007-12-21 2009-07-09 Asuragen, Inc. Mir-10 regulated genes and pathways as targets for therapeutic intervention
US20090263803A1 (en) * 2008-02-08 2009-10-22 Sylvie Beaudenon Mirnas differentially expressed in lymph nodes from cancer patients
EP2268832A2 (en) * 2008-03-06 2011-01-05 Asuragen, INC. Microrna markers for recurrence of colorectal cancer
WO2009154835A2 (en) * 2008-03-26 2009-12-23 Asuragen, Inc. Compositions and methods related to mir-16 and therapy of prostate cancer
EP2990487A1 (en) 2008-05-08 2016-03-02 Asuragen, INC. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
WO2010056737A2 (en) * 2008-11-11 2010-05-20 Mirna Therapeutics, Inc. Methods and compositions involving mirnas in cancer stem cells
JP2013509434A (ja) 2009-10-30 2013-03-14 トランザイム・ファーマ,インコーポレイテッド 大環状グレリン受容体アンタゴニストおよびインバースアゴニストならびにその使用方法
CA2824073A1 (en) * 2011-01-10 2012-07-19 Noxxon Pharma Ag Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614395A (en) * 1988-03-08 1997-03-25 Ciba-Geigy Corporation Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
US5475096A (en) * 1990-06-11 1995-12-12 University Research Corporation Nucleic acid ligands
EP0825997A1 (en) * 1995-05-03 1998-03-04 Whitehead Institute For Biomedical Research Identification of enantiomeric ligands
US5780221A (en) * 1995-05-03 1998-07-14 Whitehead Institute For Biomedical Research Identification of enantiomeric ligands
AU2001259056A1 (en) * 2000-05-17 2001-11-26 Eli Lilly And Company Method for selectively inhibiting ghrelin action
US20030211967A1 (en) * 2001-05-07 2003-11-13 Bryant Henry Uhlman Method for selectively inhibiting ghrelin action
JP2004514651A (ja) * 2000-05-30 2004-05-20 メルク エンド カムパニー インコーポレーテッド グレリン類似体
AU2003251681A1 (en) * 2002-08-01 2004-02-23 Noxxon Pharma Ag Ghrelin binding nucleic acids
UY29460A1 (es) * 2005-04-08 2006-11-30 Noxxon Pharma Ag Acidos nucleicos de union a ghrelin

Also Published As

Publication number Publication date
CA2544805A1 (en) 2005-06-02
US20070031840A1 (en) 2007-02-08
CR8388A (es) 2006-10-17
ECSP066559A (OSRAM) 2006-11-24
JP4823067B2 (ja) 2011-11-24
AP2006003618A0 (en) 2006-06-30
IL175443A0 (en) 2006-09-05
TNSN06132A1 (fr) 2007-11-15
BRPI0415872A (pt) 2007-01-09
KR20060125743A (ko) 2006-12-06
AU2004291656A1 (en) 2005-06-02
MA28153A1 (fr) 2006-09-01
WO2005049828A1 (en) 2005-06-02
EP1682662A1 (en) 2006-07-26
EA009376B1 (ru) 2007-12-28
US20100261291A1 (en) 2010-10-14
NO20062663L (no) 2006-08-09
CN1894407A (zh) 2007-01-10
OA13282A (en) 2007-01-31
JP2007513608A (ja) 2007-05-31
EA200600735A1 (ru) 2006-10-27

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