ZA200508315B - Compositions containing piperacillin and tazobactam useful for injection - Google Patents
Compositions containing piperacillin and tazobactam useful for injection Download PDFInfo
- Publication number
- ZA200508315B ZA200508315B ZA200508315A ZA200508315A ZA200508315B ZA 200508315 B ZA200508315 B ZA 200508315B ZA 200508315 A ZA200508315 A ZA 200508315A ZA 200508315 A ZA200508315 A ZA 200508315A ZA 200508315 B ZA200508315 B ZA 200508315B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmaceutical composition
- composition according
- piperacillin
- tazobactam
- pharmaceutically acceptable
- Prior art date
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- 229960002292 piperacillin Drugs 0.000 title claims description 49
- LPQZKKCYTLCDGQ-WEDXCCLWSA-N tazobactam Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 0.000 title claims description 33
- 229960003865 tazobactam Drugs 0.000 title claims description 31
- 239000007924 injection Substances 0.000 title claims description 7
- 238000002347 injection Methods 0.000 title claims description 7
- IVBHGBMCVLDMKU-GXNBUGAJSA-N piperacillin Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 IVBHGBMCVLDMKU-GXNBUGAJSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims description 85
- WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 claims description 66
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- FYZXEMANQYHCFX-UHFFFAOYSA-K tripotassium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxymethyl)amino]acetate Chemical compound [K+].[K+].[K+].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O FYZXEMANQYHCFX-UHFFFAOYSA-K 0.000 description 1
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Classifications
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61P31/04—Antibacterial agents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Oncology (AREA)
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- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
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| US46280803P | 2003-04-14 | 2003-04-14 |
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| ZA200508315A ZA200508315B (en) | 2003-04-14 | 2005-10-13 | Compositions containing piperacillin and tazobactam useful for injection |
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| EP (1) | EP1468697B1 (fr) |
| JP (1) | JP4644659B2 (fr) |
| KR (1) | KR100824554B1 (fr) |
| CN (1) | CN1802179B (fr) |
| AR (1) | AR043863A1 (fr) |
| AT (1) | ATE381947T1 (fr) |
| AU (1) | AU2004229407B2 (fr) |
| BR (1) | BRPI0409450B8 (fr) |
| CA (1) | CA2464258C (fr) |
| CH (1) | CH695185A9 (fr) |
| CL (1) | CL2004000782A1 (fr) |
| CO (1) | CO5700796A2 (fr) |
| CR (2) | CR8035A (fr) |
| CY (1) | CY1108064T1 (fr) |
| DE (1) | DE602004010862T2 (fr) |
| DK (1) | DK1468697T3 (fr) |
| EC (1) | ECSP056100A (fr) |
| ES (1) | ES2298672T3 (fr) |
| FR (1) | FR2853547B1 (fr) |
| GB (1) | GB2400557B (fr) |
| HK (1) | HK1069775A1 (fr) |
| IL (1) | IL171337A (fr) |
| MX (1) | MXPA05010996A (fr) |
| MY (1) | MY139099A (fr) |
| NO (1) | NO20054789L (fr) |
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| TW (1) | TWI308069B (fr) |
| WO (1) | WO2004091666A1 (fr) |
| ZA (1) | ZA200508315B (fr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5591434B2 (ja) | 2002-12-20 | 2014-09-17 | ゼリス ファーマシューティカルズ インコーポレイテッド | 皮内注射方法 |
| PT1468697E (pt) * | 2003-04-14 | 2008-03-05 | Wyeth Corp | Composições contendo piperacilina e tazobactam úteis para injecção |
| EP1799209A1 (fr) * | 2004-10-14 | 2007-06-27 | Wyeth | Préparations contenant de la pipéracilline, du tazobactam et un acide aminocarboxylique dilués dans du lactate de sodium |
| RS51506B (en) * | 2004-12-02 | 2011-06-30 | Venus Remedies Limited H. O&R&D. | BETA-LACTAMASE INTERFERENCE MIXTURES OF MEDIUM RESISTANCE TO ANTIBIOTICS USING BETA-LACTAMASE INHIBITORS USED FOR INJECTION |
| ES2284318B1 (es) * | 2005-04-13 | 2008-11-01 | Labiana Development, S.L. | Procedimiento de obtencion de una mezcla en polvo de una sal sodica de piperaciclina y tazobactama, util para su administracion por via inyectable. |
| ITMI20051630A1 (it) * | 2005-09-02 | 2007-03-03 | Acs Dobfar Spa | Formulazione farmaceutica sterile iniettabile contenente almeno due principi attivi |
| CN1927201B (zh) * | 2006-08-25 | 2011-06-01 | 天津和美生物技术有限公司 | 含哌拉西林的抗生素复方 |
| CN102441169A (zh) * | 2006-08-25 | 2012-05-09 | 天津和美生物技术有限公司 | 含β-内酰胺类抗生素和离子螯合剂的抗生素复方 |
| CN101129382B (zh) | 2006-08-25 | 2013-12-25 | 天津和美生物技术有限公司 | 含β-内酰胺类抗生素和缓冲组分的抗生素复方 |
| CN101129383B (zh) * | 2006-08-25 | 2014-04-02 | 天津和美生物技术有限公司 | 含氨基糖苷类抗生素的抗生素复方 |
| CN102210679B (zh) * | 2006-08-25 | 2013-03-13 | 天津和美生物技术有限公司 | 含哌拉西林的抗生素复方 |
| CN101129381B (zh) * | 2006-08-25 | 2012-02-01 | 天津和美生物技术有限公司 | 含β-内酰胺类抗生素和离子螯合剂的抗生素复方 |
| CN101265263B (zh) * | 2008-05-12 | 2010-06-02 | 海南百那医药发展有限公司 | 哌拉西林钠他唑巴坦钠复方注射剂的生产方法 |
| WO2010013640A1 (fr) * | 2008-07-28 | 2010-02-04 | Yamaguchi Keizo | Potentialisateur d'efficacité thérapeutique sur une maladie infectieuse |
| JP5852316B2 (ja) * | 2010-03-30 | 2016-02-03 | 富山化学工業株式会社 | ピペラシリン含有懸濁液の製造法 |
| US20120046225A1 (en) | 2010-07-19 | 2012-02-23 | The Regents Of The University Of Colorado, A Body Corporate | Stable glucagon formulations for the treatment of hypoglycemia |
| PE20140716A1 (es) | 2010-11-25 | 2014-07-12 | Allecra Therapeutics Gmbh | Compuestos y su usos |
| BR112013023062B1 (pt) | 2011-03-10 | 2022-01-18 | Xeris Pharmaceuticals, Inc | Solução estável para a injeção parenteral e método de fabricação da mesma |
| KR102007057B1 (ko) | 2011-10-31 | 2019-08-02 | 엑스에리스 파머수티클스, 인크. | 당뇨병 치료를 위한 제형물 |
| JP5625081B2 (ja) | 2012-03-26 | 2014-11-12 | 参天製薬株式会社 | ジクアホソル含有点眼液 |
| US9125805B2 (en) | 2012-06-27 | 2015-09-08 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of small molecule drugs |
| US8476425B1 (en) * | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| KR101816798B1 (ko) * | 2012-10-19 | 2018-01-10 | 주식회사유한양행 | 피페라실린 또는 그의 염, 타조박탐 또는 그의 염 및 덱사메타손 포스페이트 또는 그의 염을 포함하는 국소투여용 약학 조성물 |
| US9018162B2 (en) | 2013-02-06 | 2015-04-28 | Xeris Pharmaceuticals, Inc. | Methods for rapidly treating severe hypoglycemia |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| US9320740B2 (en) | 2013-03-15 | 2016-04-26 | Merck Sharp & Dohme Corp. | Ceftolozane-tazobactam pharmaceutical compositions |
| KR102226197B1 (ko) | 2013-03-15 | 2021-03-11 | 머크 샤프 앤드 돔 코포레이션 | 세프톨로잔 항균성 조성물 |
| WO2015035376A2 (fr) | 2013-09-09 | 2015-03-12 | Calixa Therapeutics, Inc. | Traitement d'infections au moyen de ceftolozane/tazobactam chez des sujets ayant une fonction rénale altérée |
| US20150094293A1 (en) | 2013-09-27 | 2015-04-02 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| EP3102200B1 (fr) | 2014-02-07 | 2023-04-05 | Exithera Pharmaceuticals Inc. | Composés et compositions thérapeutiques |
| AU2015300944B2 (en) | 2014-08-06 | 2019-07-11 | Xeris Pharmaceuticals, Inc. | Syringes, kits, and methods for intracutaneous and/or subcutaneous injection of pastes |
| CN106714799A (zh) * | 2014-10-08 | 2017-05-24 | 泽井制药株式会社 | 冷冻干燥制剂的制造方法 |
| US9649364B2 (en) | 2015-09-25 | 2017-05-16 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic formulations in aprotic polar solvents |
| US11590205B2 (en) | 2015-09-25 | 2023-02-28 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents |
| EP3268001A1 (fr) * | 2016-03-31 | 2018-01-17 | Wockhardt Limited | Compositions anti-bactériennes |
| WO2018025248A1 (fr) * | 2016-08-05 | 2018-02-08 | Jodas Expoim Private Limited | Injection d'edta et son procédé de fabrication. |
| CN110709061B (zh) | 2017-06-02 | 2023-09-08 | Xeris药物公司 | 抗沉淀的小分子药物制剂 |
| US11110054B2 (en) * | 2018-05-09 | 2021-09-07 | Slayback Pharma Llc | Ready-to-use injectable pharmaceutical compositions comprising neostigmine and glycopyrrolate |
| CN112618486B (zh) * | 2020-12-24 | 2023-07-18 | 浙江昂利康制药股份有限公司 | 一种注射用混悬油剂及其制备方法 |
| CN113209030B (zh) * | 2021-04-27 | 2023-04-25 | 海南通用康力制药有限公司 | 哌拉西林钠他唑巴坦钠无菌粉针剂的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477452A (en) * | 1981-03-26 | 1984-10-16 | American Cyanamid Company | Composition of matter comprising a lyophilized preparation of a penicillin derivative |
| US4534977A (en) * | 1981-03-26 | 1985-08-13 | American Cyanamid Company | Composition of matter comprising a low bulk density lyophilized preparation of Sodium Piperacillin |
| US4562073A (en) * | 1982-12-24 | 1985-12-31 | Taiho Pharmaceutical Company Limited | Penicillin derivatives |
| US5763480A (en) * | 1994-02-14 | 1998-06-09 | The Jewish Hospital Of St. Louis | Inhibitors of cell-medicated disorders |
| US5580856A (en) * | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
| US6503881B2 (en) * | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US6207661B1 (en) * | 1999-02-22 | 2001-03-27 | Baxter International Inc. | Premixed formulation of piperacillin sodium and tazobactam sodium injection |
| AU2003225073A1 (en) * | 2002-04-18 | 2003-11-03 | The University Of Iowa Research Foundation | Methods of inhibiting and treating bacterial biofilms by metal chelators |
| WO2004098643A1 (fr) * | 2003-04-14 | 2004-11-18 | Wyeth Holdings Corporation | Compositions d'injection contenant piperacilline et tazobactame |
| US6900184B2 (en) * | 2003-04-14 | 2005-05-31 | Wyeth Holdings Corporation | Compositions containing pipercillin and tazobactam useful for injection |
| PT1468697E (pt) * | 2003-04-14 | 2008-03-05 | Wyeth Corp | Composições contendo piperacilina e tazobactam úteis para injecção |
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2004
- 2004-04-06 PT PT04076075T patent/PT1468697E/pt unknown
- 2004-04-06 PL PL04076075T patent/PL1468697T3/pl unknown
- 2004-04-06 AT AT04076075T patent/ATE381947T1/de active
- 2004-04-06 RU RU2005135135/15A patent/RU2322980C2/ru active
- 2004-04-06 CN CN2004800159296A patent/CN1802179B/zh not_active Expired - Lifetime
- 2004-04-06 ES ES04076075T patent/ES2298672T3/es not_active Expired - Lifetime
- 2004-04-06 EP EP04076075A patent/EP1468697B1/fr not_active Expired - Lifetime
- 2004-04-06 SI SI200430609T patent/SI1468697T1/sl unknown
- 2004-04-06 DK DK04076075T patent/DK1468697T3/da active
- 2004-04-06 DE DE602004010862T patent/DE602004010862T2/de not_active Expired - Lifetime
- 2004-04-07 WO PCT/US2004/010698 patent/WO2004091666A1/fr active Application Filing
- 2004-04-07 NZ NZ543005A patent/NZ543005A/en not_active IP Right Cessation
- 2004-04-07 KR KR1020057019689A patent/KR100824554B1/ko active IP Right Grant
- 2004-04-07 BR BRPI0409450A patent/BRPI0409450B8/pt active IP Right Grant
- 2004-04-07 JP JP2006509780A patent/JP4644659B2/ja not_active Expired - Lifetime
- 2004-04-07 MX MXPA05010996A patent/MXPA05010996A/es active IP Right Grant
- 2004-04-07 US US10/553,139 patent/US7498312B2/en active Active
- 2004-04-07 GB GB0407853A patent/GB2400557B/en not_active Expired - Fee Related
- 2004-04-07 TW TW093109588A patent/TWI308069B/zh not_active IP Right Cessation
- 2004-04-07 AU AU2004229407A patent/AU2004229407B2/en not_active Expired
- 2004-04-08 CA CA002464258A patent/CA2464258C/fr not_active Expired - Lifetime
- 2004-04-09 FR FR0403786A patent/FR2853547B1/fr not_active Expired - Fee Related
- 2004-04-09 MY MYPI20041292A patent/MY139099A/en unknown
- 2004-04-12 CL CL200400782A patent/CL2004000782A1/es unknown
- 2004-04-13 AR ARP040101237A patent/AR043863A1/es active IP Right Grant
- 2004-04-13 CH CH00641/04A patent/CH695185A9/fr not_active IP Right Cessation
- 2004-05-18 SA SA4250119A patent/SA04250119B1/ar unknown
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2005
- 2005-03-16 HK HK05102311A patent/HK1069775A1/xx not_active IP Right Cessation
- 2005-10-07 CR CR8035A patent/CR8035A/es unknown
- 2005-10-10 IL IL171337A patent/IL171337A/en active IP Right Grant
- 2005-10-13 ZA ZA200508315A patent/ZA200508315B/en unknown
- 2005-10-14 EC EC2005006100A patent/ECSP056100A/es unknown
- 2005-10-18 NO NO20054789A patent/NO20054789L/no not_active Application Discontinuation
- 2005-11-09 CO CO05114116A patent/CO5700796A2/es not_active Application Discontinuation
-
2007
- 2007-11-16 RU RU2007142454/15A patent/RU2007142454A/ru not_active Application Discontinuation
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2008
- 2008-03-04 CR CR9792A patent/CR9792A/es not_active Application Discontinuation
- 2008-03-06 CY CY20081100258T patent/CY1108064T1/el unknown
-
2009
- 2009-02-13 US US12/370,794 patent/US7915229B2/en not_active Expired - Lifetime
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2011
- 2011-02-24 US US13/033,861 patent/US8133883B2/en not_active Expired - Fee Related
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