ZA200507161B - Expansion of renewable stem cell populations using modulators of PI 3-kinase - Google Patents

Expansion of renewable stem cell populations using modulators of PI 3-kinase

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Publication number
ZA200507161B
ZA200507161B ZA200507161A ZA200507161A ZA200507161B ZA 200507161 B ZA200507161 B ZA 200507161B ZA 200507161 A ZA200507161 A ZA 200507161A ZA 200507161 A ZA200507161 A ZA 200507161A ZA 200507161 B ZA200507161 B ZA 200507161B
Authority
ZA
South Africa
Prior art keywords
modulators
kinase
expansion
stem cell
cell populations
Prior art date
Application number
ZA200507161A
Other languages
English (en)
Inventor
Tony Peled
Frida Grynspan
Original Assignee
Gamida Cell Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gamida Cell Ltd filed Critical Gamida Cell Ltd
Publication of ZA200507161B publication Critical patent/ZA200507161B/xx

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
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    • C12N2503/00—Use of cells in diagnostics
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    • C12N2510/00—Genetically modified cells
    • G—PHYSICS
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors

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  • General Engineering & Computer Science (AREA)
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  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA200507161A 2003-03-07 2005-09-06 Expansion of renewable stem cell populations using modulators of PI 3-kinase ZA200507161B (en)

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US45254503P 2003-03-07 2003-03-07

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ZA200507161B true ZA200507161B (en) 2006-08-30

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ZA200507161A ZA200507161B (en) 2003-03-07 2005-09-06 Expansion of renewable stem cell populations using modulators of PI 3-kinase

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US (1) US20050054103A1 (enExample)
EP (1) EP1601759A4 (enExample)
JP (1) JP2006521813A (enExample)
AU (1) AU2004217699B2 (enExample)
CA (1) CA2517959A1 (enExample)
WO (1) WO2004078917A2 (enExample)
ZA (1) ZA200507161B (enExample)

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EP1601759A4 (en) 2007-02-14
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AU2004217699A2 (en) 2004-09-16
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AU2004217699A1 (en) 2004-09-16
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