ZA200504874B - Novel compounds having selective inhibiting effect at GSK3 - Google Patents
Novel compounds having selective inhibiting effect at GSK3 Download PDFInfo
- Publication number
- ZA200504874B ZA200504874B ZA200504874A ZA200504874A ZA200504874B ZA 200504874 B ZA200504874 B ZA 200504874B ZA 200504874 A ZA200504874 A ZA 200504874A ZA 200504874 A ZA200504874 A ZA 200504874A ZA 200504874 B ZA200504874 B ZA 200504874B
- Authority
- ZA
- South Africa
- Prior art keywords
- heterocyclic ring
- independently selected
- phenyl
- compound
- amino
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 143
- 102000001267 GSK3 Human genes 0.000 title claims 5
- 230000002401 inhibitory effect Effects 0.000 title description 5
- 108060006662 GSK3 Proteins 0.000 title 1
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 title 1
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- 238000006243 chemical reaction Methods 0.000 claims description 44
- 125000000217 alkyl group Chemical group 0.000 claims description 43
- 125000000623 heterocyclic group Chemical group 0.000 claims description 43
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 40
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 40
- -1 4-methyl-1-piperazinyl Chemical group 0.000 claims description 39
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- WTIRVOVQNGLJIQ-UHFFFAOYSA-N [4-(4-methylpiperazin-1-yl)sulfonylphenyl]boronic acid Chemical compound C1CN(C)CCN1S(=O)(=O)C1=CC=C(B(O)O)C=C1 WTIRVOVQNGLJIQ-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Landscapes
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Chemical & Material Sciences (AREA)
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Applications Claiming Priority (1)
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| US7704995B2 (en) | 2002-05-03 | 2010-04-27 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| SE0203752D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| SE0203753D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| WO2009130317A1 (en) * | 2008-04-24 | 2009-10-29 | Abbott Gmbh & Co. Kg | 1- (7-(hexahydropyrrolo [3, 4-c] pyrrol-2 (1h) -yl) quin0lin-4-yl) -3- (pyrazin-2-yl) urea derivatives and related compounds as glycogen synthase kinase 3 (gsk-3) |
| EP2438041A4 (en) * | 2009-06-01 | 2012-11-21 | Merck Sharp & Dohme | PYRAZINE-carboxamide-orexin receptor Antagonist |
| US8198285B2 (en) | 2010-01-19 | 2012-06-12 | Astrazeneca Ab | Pyrazine derivatives |
| HRP20211868T1 (hr) | 2016-07-20 | 2022-03-04 | Novartis Ag | Derivati aminopiridina i njihova uporaba kao selektivnih inhibitora za alk-2 |
| BR112022009710A2 (pt) | 2019-11-22 | 2022-08-09 | Incyte Corp | Terapia de combinação compreendendo um inibidor de alk2 e um inibidor de jak2 |
| AU2021292484A1 (en) | 2020-06-16 | 2023-01-19 | Incyte Corporation | ALK2 inhibitors for the treatment of anemia |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5472823A (en) | 1992-01-20 | 1995-12-05 | Hitachi Chemical Co., Ltd. | Photosensitive resin composition |
| JPH10152622A (ja) | 1996-11-26 | 1998-06-09 | Dainippon Ink & Chem Inc | ジスアゾ化合物およびジスアゾ顔料 |
| MA26473A1 (fr) | 1997-03-01 | 2004-12-20 | Glaxo Group Ltd | Composes pharmacologiquement actifs. |
| KR20030031886A (ko) * | 2000-02-16 | 2003-04-23 | 뉴로젠 코포레이션 | 치환된 아릴피라진 |
| BR0108974A (pt) * | 2000-03-07 | 2003-06-03 | Aventis Pharma Gmbh | 3-fenil-5-alcóxi-1,3,4-oxdiazol-2-onas substituìdas e seu uso para a inibição das lipases sensìveis a hormÈnios |
| AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| EP1406884A1 (en) * | 2001-05-11 | 2004-04-14 | Biovitrum Ab | Arylsusfonamide compounds for the treatment of obesity, type ii diabetes and cns-disorders |
| WO2003093297A2 (en) * | 2002-05-03 | 2003-11-13 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| SE0203754D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| SE0203752D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| SE0203753D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
-
2002
- 2002-12-17 SE SE0203753A patent/SE0203753D0/xx unknown
-
2003
- 2003-12-04 TW TW092134210A patent/TW200505905A/zh unknown
- 2003-12-09 AR ARP030104528A patent/AR042343A1/es unknown
- 2003-12-15 PT PT03781206T patent/PT1575942E/pt unknown
- 2003-12-15 DK DK03781206T patent/DK1575942T3/da active
- 2003-12-15 US US10/539,545 patent/US7595321B2/en not_active Expired - Fee Related
- 2003-12-15 CA CA002508045A patent/CA2508045A1/en not_active Abandoned
- 2003-12-15 WO PCT/SE2003/001957 patent/WO2004055009A1/en active IP Right Grant
- 2003-12-15 AT AT03781206T patent/ATE361291T1/de not_active IP Right Cessation
- 2003-12-15 DE DE60313658T patent/DE60313658T2/de not_active Expired - Lifetime
- 2003-12-15 BR BR0317299-6A patent/BR0317299A/pt not_active IP Right Cessation
- 2003-12-15 NZ NZ540450A patent/NZ540450A/en unknown
- 2003-12-15 MX MXPA05006244A patent/MXPA05006244A/es active IP Right Grant
- 2003-12-15 EP EP03781206A patent/EP1575942B1/en not_active Expired - Lifetime
- 2003-12-15 ES ES03781206T patent/ES2285221T3/es not_active Expired - Lifetime
- 2003-12-15 KR KR1020057011135A patent/KR20050084362A/ko not_active Application Discontinuation
- 2003-12-15 JP JP2004560225A patent/JP2006512337A/ja active Pending
- 2003-12-15 CN CNB2003801064833A patent/CN100360522C/zh not_active Expired - Fee Related
- 2003-12-15 AU AU2003287137A patent/AU2003287137B2/en not_active Ceased
-
2005
- 2005-06-14 ZA ZA200504874A patent/ZA200504874B/en unknown
- 2005-07-15 NO NO20053459A patent/NO20053459L/no not_active Application Discontinuation
-
2006
- 2006-01-18 HK HK06100841A patent/HK1080854A1/xx not_active IP Right Cessation
-
2007
- 2007-07-04 CY CY20071100890T patent/CY1106709T1/el unknown
-
2009
- 2009-09-28 US US12/568,266 patent/US20100087396A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CY1106709T1 (el) | 2012-05-23 |
| CN100360522C (zh) | 2008-01-09 |
| US20060116385A1 (en) | 2006-06-01 |
| HK1080854A1 (en) | 2006-05-04 |
| DK1575942T3 (da) | 2007-09-03 |
| CN1726210A (zh) | 2006-01-25 |
| US7595321B2 (en) | 2009-09-29 |
| SE0203753D0 (sv) | 2002-12-17 |
| BR0317299A (pt) | 2005-11-08 |
| US20100087396A1 (en) | 2010-04-08 |
| WO2004055009A8 (en) | 2005-06-30 |
| AU2003287137A1 (en) | 2004-07-09 |
| DE60313658D1 (de) | 2007-06-14 |
| EP1575942B1 (en) | 2007-05-02 |
| NZ540450A (en) | 2007-10-26 |
| JP2006512337A (ja) | 2006-04-13 |
| DE60313658T2 (de) | 2008-01-10 |
| MXPA05006244A (es) | 2005-08-19 |
| AU2003287137B2 (en) | 2007-07-05 |
| EP1575942A1 (en) | 2005-09-21 |
| PT1575942E (pt) | 2007-07-09 |
| CA2508045A1 (en) | 2004-07-01 |
| TW200505905A (en) | 2005-02-16 |
| AR042343A1 (es) | 2005-06-15 |
| NO20053459L (no) | 2005-08-12 |
| KR20050084362A (ko) | 2005-08-26 |
| WO2004055009A1 (en) | 2004-07-01 |
| ES2285221T3 (es) | 2007-11-16 |
| ATE361291T1 (de) | 2007-05-15 |
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