ZA200503598B - Bicomponent monofilament - Google Patents

Info

Publication number

ZA200503598B

ZA200503598B ZA200503598A ZA200503598A ZA200503598B ZA 200503598 B ZA200503598 B ZA 200503598B ZA 200503598 A ZA200503598 A ZA 200503598A ZA 200503598 A ZA200503598 A ZA 200503598A ZA 200503598 B ZA200503598 B ZA 200503598B

Authority

ZA

South Africa

Prior art keywords

groups

substituted

unsubstituted

aryl

alkyl

Prior art date

2002-12-30

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• 125000000217 alkyl group Chemical group 0.000 claims description 229
• 150000003839 salts Chemical class 0.000 claims description 199
• -1 guanidinyl groups Chemical group 0.000 claims description 182
• 125000003118 aryl group Chemical group 0.000 claims description 181
• 150000001875 compounds Chemical class 0.000 claims description 179
• 125000000623 heterocyclic group Chemical group 0.000 claims description 177
• 238000000034 method Methods 0.000 claims description 111
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 98
• 239000000203 mixture Substances 0.000 claims description 97
• 150000003893 lactate salts Chemical class 0.000 claims description 93
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 91
• 125000004103 aminoalkyl group Chemical group 0.000 claims description 64
• 229910052739 hydrogen Inorganic materials 0.000 claims description 55
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 42
• 125000000278 alkyl amino alkyl group Chemical group 0.000 claims description 38
• 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims description 38
• 125000005128 aryl amino alkyl group Chemical group 0.000 claims description 37
• 239000002904 solvent Substances 0.000 claims description 35
• 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 34
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 33
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 32
• 239000008194 pharmaceutical composition Substances 0.000 claims description 31
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 30
• 239000003814 drug Substances 0.000 claims description 28
• 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 27
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 27
• 125000005160 aryl oxy alkyl group Chemical group 0.000 claims description 25
• 125000004430 oxygen atom Chemical group O* 0.000 claims description 25
• 229910052731 fluorine Inorganic materials 0.000 claims description 21
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 20
• 125000003545 alkoxy group Chemical group 0.000 claims description 20
• 239000003112 inhibitor Substances 0.000 claims description 19
• YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 18
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• 238000009472 formulation Methods 0.000 claims description 18
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• 238000010438 heat treatment Methods 0.000 claims description 17
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 17
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• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 12
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• 125000003342 alkenyl group Chemical group 0.000 claims description 12
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• YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 12
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