ZA200503461B - Cohesive coprecipitates of sulfated polyasaccharide and fibrillar protein and use thereof - Google Patents
Cohesive coprecipitates of sulfated polyasaccharide and fibrillar protein and use thereof Download PDFInfo
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- ZA200503461B ZA200503461B ZA200503461A ZA200503461A ZA200503461B ZA 200503461 B ZA200503461 B ZA 200503461B ZA 200503461 A ZA200503461 A ZA 200503461A ZA 200503461 A ZA200503461 A ZA 200503461A ZA 200503461 B ZA200503461 B ZA 200503461B
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- South Africa
- Prior art keywords
- gel
- biocompatible
- cohesive biopolymer
- biopolymer gel
- dextran sulfate
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IL15203002A IL152030A0 (en) | 2002-09-30 | 2002-09-30 | Cohesive biopolymers comprising sulfated polysaccharides and fibrillar proteins and use thereof for tissue repair |
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IL (1) | IL152030A0 (de) |
WO (1) | WO2004029095A2 (de) |
ZA (1) | ZA200503461B (de) |
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WO2005117912A1 (en) | 2004-05-27 | 2005-12-15 | Avigen, Inc. | Methods for treating bleeding disorders using sulfated polysaccharides |
AU2005286097A1 (en) * | 2004-09-21 | 2006-03-30 | Nvr Labs. Ltd. | Compositions and methods for stem cell expansion and differentiation |
FR2881434B1 (fr) * | 2005-02-02 | 2007-05-11 | Coletica Sa | Dispositif de support de culture de cellules |
CN100382772C (zh) * | 2005-09-28 | 2008-04-23 | 南通大学 | 含蚕丝丝素的医用神经移植物的制备方法 |
EP2259803B2 (de) | 2008-02-29 | 2019-03-13 | Ferrosan Medical Devices A/S | Vorrichtung zur förderung von hämostase und/oder wundheilung |
US8546096B2 (en) | 2008-08-22 | 2013-10-01 | Baxter International Inc. | Method for identifying a non-anticoagulant sulfated polysaccharide which enhances blood coagulation dependence on FXI |
DE102008059857A1 (de) * | 2008-12-01 | 2010-06-02 | Forschungsinstitut für Leder und Kunststoffbahnen gGmbH | Mit Kohlenhydrat-Derivaten additivierte Gelatinezusammensetzungen |
EP2384205A1 (de) * | 2009-01-02 | 2011-11-09 | Ramot at Tel-Aviv University Ltd. | Fibrin- und fibrinogen-matrizen und ihre verwendung |
EP2498830B1 (de) * | 2009-11-11 | 2016-09-21 | University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA) | Hydrogels auf Basis von Dextran-Hyaluronsäure |
CA2786758A1 (en) | 2010-01-14 | 2011-07-21 | Baxter International Inc. | Methods and compositions for treating bleeding disorders |
CA2838793C (en) | 2011-07-19 | 2019-08-06 | Baxter International Inc. | Resorption enhancers as additives to improve the oral formulation of non-anticoagulant sulfated polysaccharides |
RU2657955C2 (ru) | 2012-03-06 | 2018-06-18 | Ферросан Медикал Дивайсиз А/С | Контейнер под давлением, содержащий гемостатическую пасту |
JP6394916B2 (ja) | 2012-06-12 | 2018-09-26 | フェロサン メディカル デバイシーズ エイ/エス | 乾燥止血組成物 |
WO2014028382A1 (en) | 2012-08-14 | 2014-02-20 | Baxter International Inc. | Methods and systems for screening compositions comprising non-anticoagulant sulfated polysaccharides |
US9474767B2 (en) * | 2012-11-12 | 2016-10-25 | Warsaw Orthopedic, Inc. | Compositions and methods for inhibiting bone growth |
US9421221B2 (en) * | 2012-11-12 | 2016-08-23 | Warsaw Orthopedic, Inc. | Compositions and methods for inhibiting adhesion formation |
US9724078B2 (en) | 2013-06-21 | 2017-08-08 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
US9981067B2 (en) | 2013-09-30 | 2018-05-29 | Bioactive Regenerative Therapeutics, Inc. | Biomimetic hybrid gel compositions and methods of use |
CA2928963C (en) | 2013-12-11 | 2020-10-27 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
CA2960309A1 (en) | 2014-10-13 | 2016-04-21 | Ferrosan Medical Devices A/S | Dry composition for use in haemostasis and wound healing |
JP6747650B2 (ja) | 2014-12-24 | 2020-08-26 | フェロサン メディカル デバイシーズ エイ/エス | 第1の物質と第2の物質を保持し混合するためのシリンジ |
BR112017027695A2 (pt) | 2015-07-03 | 2018-09-04 | Ferrosan Medical Devices As | seringa para retenção e mistura de primeira e segunda substâncias |
CN112368028A (zh) | 2018-05-09 | 2021-02-12 | 弗罗桑医疗设备公司 | 用于制备止血组合物的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6352707B1 (en) * | 1992-02-24 | 2002-03-05 | Anton-Lewis Usala | Transplant encapsulation in a hydrogel matrix to obscure immune recognition |
US5480644A (en) * | 1992-02-28 | 1996-01-02 | Jsf Consultants Ltd. | Use of injectable biomaterials for the repair and augmentation of the anal sphincters |
US5571166A (en) * | 1992-03-19 | 1996-11-05 | Medtronic, Inc. | Method of making an intraluminal stent |
US5783214A (en) * | 1994-06-13 | 1998-07-21 | Buford Biomedical, Inc. | Bio-erodible matrix for the controlled release of medicinals |
AU737348B2 (en) * | 1994-08-12 | 2001-08-16 | Meadox Medicals, Inc. | Vascular graft impregnated with a heparin-containing collagen sealant |
DE69524501T2 (de) * | 1994-08-12 | 2002-05-29 | Meadox Medicals, Inc. | Mit einen Heparin enhaltendes Kollagendichtmittel imprägniertes Gefässtransplantat |
WO1997041899A1 (en) * | 1996-05-03 | 1997-11-13 | Innogenetics N.V. | New medicaments containing gelatin cross-linked with oxidized polysaccharides |
AU2003215330B2 (en) * | 2002-02-21 | 2008-03-13 | Encelle, Inc. | Immobilized bioactive hydrogel matrices as surface coatings |
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2002
- 2002-09-30 IL IL15203002A patent/IL152030A0/xx unknown
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- 2003-09-30 WO PCT/IL2003/000787 patent/WO2004029095A2/en not_active Application Discontinuation
- 2003-09-30 JP JP2004539417A patent/JP2006506110A/ja not_active Abandoned
- 2003-09-30 EP EP03751222A patent/EP1549295A4/de not_active Withdrawn
- 2003-09-30 US US10/529,830 patent/US20060110426A1/en not_active Abandoned
- 2003-09-30 CA CA002501009A patent/CA2501009A1/en not_active Abandoned
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CA2501009A1 (en) | 2004-04-08 |
AU2003269440A1 (en) | 2004-04-19 |
EP1549295A4 (de) | 2007-08-15 |
WO2004029095A3 (en) | 2004-06-03 |
US20060110426A1 (en) | 2006-05-25 |
JP2006506110A (ja) | 2006-02-23 |
EP1549295A2 (de) | 2005-07-06 |
WO2004029095A2 (en) | 2004-04-08 |
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