ZA200503039B - Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy - Google Patents

Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy Download PDF

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Publication number
ZA200503039B
ZA200503039B ZA200503039A ZA200503039A ZA200503039B ZA 200503039 B ZA200503039 B ZA 200503039B ZA 200503039 A ZA200503039 A ZA 200503039A ZA 200503039 A ZA200503039 A ZA 200503039A ZA 200503039 B ZA200503039 B ZA 200503039B
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South Africa
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gene
host cell
plasmid
mutation
replication
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ZA200503039A
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English (en)
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Soubrier Fabienne
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Centelion
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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • C07K14/501Fibroblast growth factor [FGF] acidic FGF [aFGF]
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • C12N15/69Increasing the copy number of the vector
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
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  • Neurology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
ZA200503039A 2002-10-11 2005-04-14 Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy ZA200503039B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/268,948 US7279313B2 (en) 1995-09-15 2002-10-11 Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy

Publications (1)

Publication Number Publication Date
ZA200503039B true ZA200503039B (en) 2006-11-29

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ZA200503039A ZA200503039B (en) 2002-10-11 2005-04-14 Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy

Country Status (22)

Country Link
US (3) US7279313B2 (de)
EP (1) EP1549735B1 (de)
JP (2) JP4522861B2 (de)
KR (1) KR101323542B1 (de)
CN (2) CN100491521C (de)
AT (1) ATE521695T1 (de)
AU (2) AU2003287078B2 (de)
BR (1) BR0314512A (de)
CA (1) CA2501851C (de)
CY (1) CY1112110T1 (de)
DK (1) DK1549735T3 (de)
ES (1) ES2372599T3 (de)
HK (2) HK1082761B (de)
IL (1) IL167706A (de)
MX (1) MXPA05003857A (de)
NO (1) NO333932B1 (de)
NZ (2) NZ539311A (de)
PT (1) PT1549735E (de)
RU (1) RU2307870C2 (de)
SI (1) SI1549735T1 (de)
WO (1) WO2004033664A2 (de)
ZA (1) ZA200503039B (de)

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US7279313B2 (en) * 1995-09-15 2007-10-09 Centelion Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
FR2738842B1 (fr) * 1995-09-15 1997-10-31 Rhone Poulenc Rorer Sa Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique
FR2822476B1 (fr) * 2001-03-23 2004-04-02 Aventis Pharma Sa Procedes de purification et de detection de sequences cibles d'adn double brin par interaction triple helice
SI1737945T1 (sl) 2004-04-19 2011-05-31 Aventis Pharma Sa Postopek za čiščenje plazmidne DNA
JP4581851B2 (ja) * 2004-07-27 2010-11-17 セイコーエプソン株式会社 電気光学装置の駆動回路及び駆動方法、電気光学装置並びに電子機器
FR2920158B1 (fr) * 2007-08-24 2010-03-12 Centre Nat Rech Scient Production de plasmides et expression de proteines recombinantes dans des cellules cultivees sans antibiotiques
EP2221066A1 (de) 2009-02-18 2010-08-25 Sanofi-Aventis Verwendung des VgII3-Aktivitätsmodulators zur Modulierung von Adipogenese
EP2471909A1 (de) * 2010-12-30 2012-07-04 SIRION BIOTECH GmbH Nukleinsäuremoleküle zur Herstellung adenoviraler Vektoren
JP5863338B2 (ja) * 2011-08-25 2016-02-16 株式会社東芝 プラスミド型ベクター、遺伝子プロモーター活性の検出方法、及びアッセイキット
WO2014035457A1 (en) 2012-08-29 2014-03-06 Nature Technology Corporation Dna plasmids with improved expression
WO2014077863A1 (en) 2012-11-19 2014-05-22 Nature Technology Corporation Replicative minicircle vectors with improved expression
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US10301672B2 (en) * 2014-11-18 2019-05-28 Japan Science And Technology Agency Method of amplifying circular DNA
US10086089B2 (en) 2015-09-18 2018-10-02 DNARx Systems and methods for nucleic acid expression in vivo
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EP3911749A1 (de) * 2019-01-18 2021-11-24 Janssen Biotech, Inc. Alpha-peptid von beta-galactosidase als nicht-antibiotischer selektionsmarker und dessen verwendungen
WO2023069895A1 (en) * 2021-10-18 2023-04-27 Modernatx, Inc. Markerless dna production
WO2023241567A1 (zh) * 2022-06-13 2023-12-21 南京金斯瑞生物科技有限公司 一种可提高无筛选标签质粒制备效率的野生型-突变体π蛋白切换表达系统

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US7364894B2 (en) * 1995-09-15 2008-04-29 Centelion Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
FR2738842B1 (fr) * 1995-09-15 1997-10-31 Rhone Poulenc Rorer Sa Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique
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Publication number Publication date
US20030161844A1 (en) 2003-08-28
US20090252713A1 (en) 2009-10-08
US7279313B2 (en) 2007-10-09
CN1717476A (zh) 2006-01-04
CA2501851C (en) 2014-03-11
HK1082761B (zh) 2012-05-18
CN100491521C (zh) 2009-05-27
WO2004033664A2 (en) 2004-04-22
RU2005114367A (ru) 2005-12-20
EP1549735A4 (de) 2006-05-03
SI1549735T1 (sl) 2011-12-30
CN101182534A (zh) 2008-05-21
KR101323542B1 (ko) 2013-10-29
IL167706A (en) 2012-05-31
RU2307870C2 (ru) 2007-10-10
NO20052276L (no) 2005-07-06
CN101182534B (zh) 2013-04-24
US20070015282A1 (en) 2007-01-18
US20070141708A2 (en) 2007-06-21
EP1549735B1 (de) 2011-08-24
NO20052276D0 (no) 2005-05-10
US7807444B2 (en) 2010-10-05
AU2003287078B2 (en) 2009-01-15
ATE521695T1 (de) 2011-09-15
JP2010057493A (ja) 2010-03-18
ES2372599T3 (es) 2012-01-24
DK1549735T3 (da) 2011-12-12
MXPA05003857A (es) 2005-06-22
EP1549735A2 (de) 2005-07-06
WO2004033664A3 (en) 2004-12-29
JP2006502714A (ja) 2006-01-26
AU2003287078A1 (en) 2004-05-04
NZ539311A (en) 2008-06-30
HK1082761A1 (en) 2006-06-16
KR20050084847A (ko) 2005-08-29
CY1112110T1 (el) 2015-11-04
AU2009201405A1 (en) 2009-05-07
HK1086297A1 (en) 2006-09-15
NO333932B1 (no) 2013-10-21
BR0314512A (pt) 2005-07-26
PT1549735E (pt) 2011-11-30
JP4522861B2 (ja) 2010-08-11
JP4750203B2 (ja) 2011-08-17
NZ566205A (en) 2009-02-28
CA2501851A1 (en) 2004-04-22

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