ZA200409848B - Method treating attention deficit hyperactivity disorder - Google Patents
Method treating attention deficit hyperactivity disorder Download PDFInfo
- Publication number
- ZA200409848B ZA200409848B ZA200409848A ZA200409848A ZA200409848B ZA 200409848 B ZA200409848 B ZA 200409848B ZA 200409848 A ZA200409848 A ZA 200409848A ZA 200409848 A ZA200409848 A ZA 200409848A ZA 200409848 B ZA200409848 B ZA 200409848B
- Authority
- ZA
- South Africa
- Prior art keywords
- aminomethyl
- integer
- ligand
- phenyl
- methyl
- Prior art date
Links
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 title claims description 16
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 title claims description 15
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 title description 14
- 238000000034 method Methods 0.000 title description 14
- 239000003446 ligand Substances 0.000 claims description 27
- 150000001875 compounds Chemical class 0.000 claims description 24
- 125000000217 alkyl group Chemical group 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 20
- -1 1H-tetrazol-5-ylmethyl Chemical group 0.000 claims description 15
- 239000001257 hydrogen Substances 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 15
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims description 7
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical group OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 229960002870 gabapentin Drugs 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 150000002367 halogens Chemical class 0.000 claims description 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
- 229960001233 pregabalin Drugs 0.000 claims description 5
- 125000001424 substituent group Chemical group 0.000 claims description 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 5
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical group C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims description 4
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 150000001408 amides Chemical group 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- 150000002431 hydrogen Chemical group 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 229940124530 sulfonamide Drugs 0.000 claims description 4
- 150000003456 sulfonamides Chemical group 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 2
- PPIQMYQQPKTQBZ-UHFFFAOYSA-N n-[2-[1-(aminomethyl)cyclohexyl]ethyl]methanesulfonamide Chemical compound CS(=O)(=O)NCCC1(CN)CCCCC1 PPIQMYQQPKTQBZ-UHFFFAOYSA-N 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims 3
- ONKWZNBXHSMMDK-UHFFFAOYSA-N 2-[2-(aminomethyl)-1,3,3a,4,5,6,7,7a-octahydroinden-2-yl]acetic acid Chemical compound C1CCCC2CC(CN)(CC(O)=O)CC21 ONKWZNBXHSMMDK-UHFFFAOYSA-N 0.000 claims 2
- GSBZRDSCOPXLJJ-UHFFFAOYSA-N 2-[2-(aminomethyl)-3,3a,4,5,6,6a-hexahydro-1h-pentalen-2-yl]acetic acid Chemical compound C1CCC2CC(CN)(CC(O)=O)CC21 GSBZRDSCOPXLJJ-UHFFFAOYSA-N 0.000 claims 2
- 229940100684 pentylamine Drugs 0.000 claims 2
- NDDZVQRQVFTNSN-UHFFFAOYSA-N 2-[3-(aminomethyl)-3-bicyclo[3.2.0]heptanyl]acetic acid Chemical compound C1C(CN)(CC(O)=O)CC2CCC21 NDDZVQRQVFTNSN-UHFFFAOYSA-N 0.000 claims 1
- 101710143136 Enoyl-[acyl-carrier-protein] reductase [NADH] 2 Proteins 0.000 claims 1
- CJMFUZSVUFPYJR-UHFFFAOYSA-N [2-(aminomethyl)-4-methylpentyl]phosphonic acid Chemical compound CC(C)CC(CN)CP(O)(O)=O CJMFUZSVUFPYJR-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N mono-methylamine Natural products NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 229960001171 acetohydroxamic acid Drugs 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 125000004122 cyclic group Chemical group 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 3
- 208000013403 hyperactivity Diseases 0.000 description 3
- 208000020016 psychiatric disease Diseases 0.000 description 3
- 239000000021 stimulant Substances 0.000 description 3
- QIQWRCNAPQJQLL-COALEZEGSA-N (z)-but-2-enedioic acid;5-[(1r,2r)-2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1h-imidazole Chemical compound OC(=O)\C=C/C(O)=O.CC(C)(C)CCC#C[C@@H]1C[C@H]1C1=CN=CN1 QIQWRCNAPQJQLL-COALEZEGSA-N 0.000 description 2
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 2
- 229960002896 clonidine Drugs 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000005062 synaptic transmission Effects 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- ZONTWIUNHYLDLZ-JTQLQIEISA-N 2-[(1r)-1-(aminomethyl)-3,3-dimethylcyclopentyl]-n-hydroxyacetamide Chemical compound CC1(C)CC[C@](CN)(CC(=O)NO)C1 ZONTWIUNHYLDLZ-JTQLQIEISA-N 0.000 description 1
- BQOLBIIAWFGWEW-HTQZYQBOSA-N 2-[(3r,4r)-1-(aminomethyl)-3,4-dimethylcyclopentyl]-n-hydroxyacetamide Chemical compound C[C@@H]1CC(CN)(CC(=O)NO)C[C@H]1C BQOLBIIAWFGWEW-HTQZYQBOSA-N 0.000 description 1
- RVJMNFWHJKSARF-UHFFFAOYSA-N 2-[1-(aminomethyl)-3,3-dimethylcyclobutyl]-n-hydroxyacetamide Chemical compound CC1(C)CC(CN)(CC(=O)NO)C1 RVJMNFWHJKSARF-UHFFFAOYSA-N 0.000 description 1
- IUVMAUQEZFTTFB-UHFFFAOYSA-N 2-[1-(aminomethyl)-3,4-dimethylcyclopentyl]acetic acid Chemical compound CC1CC(CN)(CC(O)=O)CC1C IUVMAUQEZFTTFB-UHFFFAOYSA-N 0.000 description 1
- UOPIILYKLVDKTK-UHFFFAOYSA-N 2-[1-(aminomethyl)-3-methylcyclohexyl]acetic acid Chemical compound CC1CCCC(CN)(CC(O)=O)C1 UOPIILYKLVDKTK-UHFFFAOYSA-N 0.000 description 1
- HYVKVSAZCPKHDV-UHFFFAOYSA-N 2-[1-(aminomethyl)-3-methylcyclopentyl]acetic acid Chemical compound CC1CCC(CN)(CC(O)=O)C1 HYVKVSAZCPKHDV-UHFFFAOYSA-N 0.000 description 1
- HKBYROVPIYTBLO-UHFFFAOYSA-N 2-[1-(aminomethyl)cyclohexyl]-n-hydroxyacetamide Chemical compound ONC(=O)CC1(CN)CCCCC1 HKBYROVPIYTBLO-UHFFFAOYSA-N 0.000 description 1
- BWBQMUPZKXFEIP-UHFFFAOYSA-N 3-(1-aminoethyl)-5-methylheptanoic acid Chemical compound CCC(C)CC(C(C)N)CC(O)=O BWBQMUPZKXFEIP-UHFFFAOYSA-N 0.000 description 1
- IRQCKMBXGOKUDW-UHFFFAOYSA-N 3-(1-azaniumylethyl)-5-methylhexanoate Chemical compound CC(C)CC(C(C)N)CC(O)=O IRQCKMBXGOKUDW-UHFFFAOYSA-N 0.000 description 1
- AYXYPKUFHZROOJ-UHFFFAOYSA-N 3-(azaniumylmethyl)-5-methylhexanoate Chemical compound CC(C)CC(CN)CC(O)=O AYXYPKUFHZROOJ-UHFFFAOYSA-N 0.000 description 1
- MIZFLIXVZLTPPF-NSHDSACASA-N 3-[[(1r)-1-(aminomethyl)-3,3-dimethylcyclopentyl]methyl]-2h-1,2,4-oxadiazol-5-one Chemical compound C1C(C)(C)CC[C@]1(CN)CC1=NOC(=O)N1 MIZFLIXVZLTPPF-NSHDSACASA-N 0.000 description 1
- MIZFLIXVZLTPPF-LLVKDONJSA-N 3-[[(1s)-1-(aminomethyl)-3,3-dimethylcyclopentyl]methyl]-2h-1,2,4-oxadiazol-5-one Chemical compound C1C(C)(C)CC[C@@]1(CN)CC1=NOC(=O)N1 MIZFLIXVZLTPPF-LLVKDONJSA-N 0.000 description 1
- LDNRKBMOYVWRKL-HTQZYQBOSA-N 3-[[(3r,4r)-1-(aminomethyl)-3,4-dimethylcyclopentyl]methyl]-2h-1,2,4-oxadiazol-5-one Chemical compound C1[C@@H](C)[C@H](C)CC1(CN)CC1=NOC(=O)N1 LDNRKBMOYVWRKL-HTQZYQBOSA-N 0.000 description 1
- RXDXEKHDLCVPDI-HTQZYQBOSA-N 3-[[(3r,4r)-1-(aminomethyl)-3,4-dimethylcyclopentyl]methyl]-2h-1,2,4-oxadiazole-5-thione Chemical compound C1[C@@H](C)[C@H](C)CC1(CN)CC1=NOC(=S)N1 RXDXEKHDLCVPDI-HTQZYQBOSA-N 0.000 description 1
- QSQKTUOPGLSZNK-UHFFFAOYSA-N 3-[[1-(aminomethyl)-3,3-dimethylcyclobutyl]methyl]-2h-1,2,4-oxadiazol-5-one Chemical compound C1C(C)(C)CC1(CN)CC1=NOC(=O)N1 QSQKTUOPGLSZNK-UHFFFAOYSA-N 0.000 description 1
- NISSXCGKGSMLOH-UHFFFAOYSA-N 3-[[1-(aminomethyl)cyclohexyl]methyl]-2h-1,2,4-oxadiazole-5-thione Chemical compound N=1OC(=S)NC=1CC1(CN)CCCCC1 NISSXCGKGSMLOH-UHFFFAOYSA-N 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 108090000312 Calcium Channels Proteins 0.000 description 1
- 102000003922 Calcium Channels Human genes 0.000 description 1
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 description 1
- DASRLBOSVBEOQS-SECBINFHSA-N [(1r)-1-(aminomethyl)-3,3-dimethylcyclopentyl]methylphosphonic acid Chemical compound CC1(C)CC[C@@](CN)(CP(O)(O)=O)C1 DASRLBOSVBEOQS-SECBINFHSA-N 0.000 description 1
- DASRLBOSVBEOQS-VIFPVBQESA-N [(1s)-1-(aminomethyl)-3,3-dimethylcyclopentyl]methylphosphonic acid Chemical compound CC1(C)CC[C@](CN)(CP(O)(O)=O)C1 DASRLBOSVBEOQS-VIFPVBQESA-N 0.000 description 1
- DGYBGGKLAOGVTP-HTQZYQBOSA-N [(3r,4r)-1-(aminomethyl)-3,4-dimethylcyclopentyl]methylphosphonic acid Chemical compound C[C@@H]1CC(CN)(CP(O)(O)=O)C[C@H]1C DGYBGGKLAOGVTP-HTQZYQBOSA-N 0.000 description 1
- DDDMKRLWIJLUFH-UHFFFAOYSA-N [1-(aminomethyl)-3,3-dimethylcyclobutyl]methylphosphonic acid Chemical compound CC1(C)CC(CN)(CP(O)(O)=O)C1 DDDMKRLWIJLUFH-UHFFFAOYSA-N 0.000 description 1
- QFLSQUNSWXMJBE-UHFFFAOYSA-N [1-(aminomethyl)cyclohexyl]methylphosphonic acid Chemical compound OP(=O)(O)CC1(CN)CCCCC1 QFLSQUNSWXMJBE-UHFFFAOYSA-N 0.000 description 1
- 239000000048 adrenergic agonist Substances 0.000 description 1
- 229960002430 atomoxetine Drugs 0.000 description 1
- VHGCDTVCOLNTBX-QGZVFWFLSA-N atomoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=CC=C1C VHGCDTVCOLNTBX-QGZVFWFLSA-N 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000000768 catecholaminergic effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000008482 dysregulation Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- JUMYIBMBTDDLNG-OJERSXHUSA-N hydron;methyl (2r)-2-phenyl-2-[(2r)-piperidin-2-yl]acetate;chloride Chemical compound Cl.C([C@@H]1[C@H](C(=O)OC)C=2C=CC=CC=2)CCCN1 JUMYIBMBTDDLNG-OJERSXHUSA-N 0.000 description 1
- 229960001344 methylphenidate Drugs 0.000 description 1
- JUMYIBMBTDDLNG-UHFFFAOYSA-N methylphenidate hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(C(=O)OC)C1CCCC[NH2+]1 JUMYIBMBTDDLNG-UHFFFAOYSA-N 0.000 description 1
- AHDLFZFBRTXUOE-NSHDSACASA-N n-[2-[(1r)-1-(aminomethyl)-3,3-dimethylcyclopentyl]ethyl]methanesulfonamide Chemical compound CC1(C)CC[C@](CN)(CCNS(C)(=O)=O)C1 AHDLFZFBRTXUOE-NSHDSACASA-N 0.000 description 1
- AHDLFZFBRTXUOE-LLVKDONJSA-N n-[2-[(1s)-1-(aminomethyl)-3,3-dimethylcyclopentyl]ethyl]methanesulfonamide Chemical compound CC1(C)CC[C@@](CN)(CCNS(C)(=O)=O)C1 AHDLFZFBRTXUOE-LLVKDONJSA-N 0.000 description 1
- MZLHDSAVPXLKBD-NXEZZACHSA-N n-[2-[(3r,4r)-1-(aminomethyl)-3,4-dimethylcyclopentyl]ethyl]methanesulfonamide Chemical compound C[C@@H]1CC(CN)(CCNS(C)(=O)=O)C[C@H]1C MZLHDSAVPXLKBD-NXEZZACHSA-N 0.000 description 1
- YYJIVWAHSQHIKF-UHFFFAOYSA-N n-[2-[1-(aminomethyl)-3,3-dimethylcyclobutyl]ethyl]methanesulfonamide Chemical compound CC1(C)CC(CN)(CCNS(C)(=O)=O)C1 YYJIVWAHSQHIKF-UHFFFAOYSA-N 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 229940072228 neurontin Drugs 0.000 description 1
- 208000021722 neuropathic pain Diseases 0.000 description 1
- 230000003957 neurotransmitter release Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 210000002442 prefrontal cortex Anatomy 0.000 description 1
- 229940099204 ritalin Drugs 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39214002P | 2002-06-27 | 2002-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200409848B true ZA200409848B (en) | 2005-06-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200409848A ZA200409848B (en) | 2002-06-27 | 2004-12-06 | Method treating attention deficit hyperactivity disorder |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20040006073A1 (zh) |
| EP (1) | EP1515709A2 (zh) |
| JP (1) | JP2005534678A (zh) |
| CN (1) | CN1678298A (zh) |
| AU (1) | AU2003239752A1 (zh) |
| BR (1) | BR0312240A (zh) |
| CA (1) | CA2488566A1 (zh) |
| IL (1) | IL165593A0 (zh) |
| MX (1) | MXPA04012922A (zh) |
| PL (1) | PL375090A1 (zh) |
| TW (1) | TW200400025A (zh) |
| WO (1) | WO2004002462A2 (zh) |
| ZA (1) | ZA200409848B (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0934061T6 (en) | 1996-07-24 | 2015-01-26 | Warner Lambert Co | Isobutylgaba and its derivatives for the treatment of pain |
| ES2563304T3 (es) | 2003-04-24 | 2016-03-14 | Incyte Holdings Corporation | Derivados azaespiro alcano como inhibidores de metaloproteasas |
| WO2007143600A2 (en) | 2006-06-05 | 2007-12-13 | Incyte Corporation | Sheddase inhibitors combined with cd30-binding immunotherapeutics for the treatment of cd30 positive diseases |
| AU2008213908B2 (en) * | 2007-02-07 | 2013-07-25 | Gosforth Centre (Holdings) Pty Ltd | Treatment of ADHD |
| AU2007346591A1 (en) * | 2007-02-07 | 2008-08-14 | Gosforth Centre (Holdings) Pty Ltd | Treatment of ADHD |
| EP2331088A4 (en) | 2008-08-06 | 2011-10-12 | Gosforth Ct Holdings Pty Ltd | COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC ILLNESSES |
| EP3452475B1 (en) | 2016-05-06 | 2020-02-26 | Esteve Pharmaceuticals, S.A. | Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| US6197819B1 (en) * | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| US6153650A (en) * | 1996-10-23 | 2000-11-28 | Warner-Lambert Company | Substituted gamma aminobutyric acids as pharmaceutical agents |
| US6518289B1 (en) * | 1997-12-16 | 2003-02-11 | Pfizer, Inc. | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
| PL341231A1 (en) * | 1997-12-16 | 2001-03-26 | Warner Lambert Co | 4(3)-substitute derivatives of 4(3)aminomethyl(thio)pyrane or piperidine derivatives (analogues of garbapentin), their production and application in treating neurological disorders |
| DE69822214T2 (de) * | 1997-12-16 | 2005-03-10 | Warner-Lambert Co. Llc | ((cyclo)alkyl substituierte)-.gamma.-aminobuttersäure derivate (=gaba analoga), deren herstellung und deren verwendung bei der behandlung von neurologischen erkrankungen |
| EP1082306A1 (en) * | 1998-05-26 | 2001-03-14 | Warner-Lambert Company | Conformationally constrained amino acid compounds having affinity for the alpha2delta subunit of a calcium channel |
| HN2000000224A (es) * | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
| US6462084B1 (en) * | 2001-05-14 | 2002-10-08 | Brookhaven Science Associates, Llc | Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG |
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2003
- 2003-06-16 BR BR0312240-9A patent/BR0312240A/pt not_active IP Right Cessation
- 2003-06-16 CN CNA038202131A patent/CN1678298A/zh active Pending
- 2003-06-16 JP JP2004517096A patent/JP2005534678A/ja not_active Withdrawn
- 2003-06-16 IL IL16559303A patent/IL165593A0/xx unknown
- 2003-06-16 WO PCT/IB2003/002666 patent/WO2004002462A2/en not_active Application Discontinuation
- 2003-06-16 EP EP03732941A patent/EP1515709A2/en not_active Withdrawn
- 2003-06-16 MX MXPA04012922A patent/MXPA04012922A/es unknown
- 2003-06-16 PL PL03375090A patent/PL375090A1/xx not_active Application Discontinuation
- 2003-06-16 CA CA002488566A patent/CA2488566A1/en not_active Abandoned
- 2003-06-16 AU AU2003239752A patent/AU2003239752A1/en not_active Abandoned
- 2003-06-23 US US10/602,414 patent/US20040006073A1/en not_active Abandoned
- 2003-06-26 TW TW092117444A patent/TW200400025A/zh unknown
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2004
- 2004-12-06 ZA ZA200409848A patent/ZA200409848B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005534678A (ja) | 2005-11-17 |
| BR0312240A (pt) | 2005-04-12 |
| EP1515709A2 (en) | 2005-03-23 |
| TW200400025A (en) | 2004-01-01 |
| PL375090A1 (en) | 2005-11-14 |
| CA2488566A1 (en) | 2004-01-08 |
| WO2004002462A2 (en) | 2004-01-08 |
| MXPA04012922A (es) | 2005-03-31 |
| WO2004002462A3 (en) | 2004-03-11 |
| AU2003239752A1 (en) | 2004-01-19 |
| IL165593A0 (en) | 2006-01-15 |
| CN1678298A (zh) | 2005-10-05 |
| US20040006073A1 (en) | 2004-01-08 |
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