ZA200404733B - Polymorphs of clopidogrel hydrogensulfate. - Google Patents
Polymorphs of clopidogrel hydrogensulfate. Download PDFInfo
- Publication number
- ZA200404733B ZA200404733B ZA200404733A ZA200404733A ZA200404733B ZA 200404733 B ZA200404733 B ZA 200404733B ZA 200404733 A ZA200404733 A ZA 200404733A ZA 200404733 A ZA200404733 A ZA 200404733A ZA 200404733 B ZA200404733 B ZA 200404733B
- Authority
- ZA
- South Africa
- Prior art keywords
- clopidogrel hydrogensulfate
- clopidogrel
- solution
- hydrogensulfate
- preparing
- Prior art date
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- FDEODCTUSIWGLK-UHFFFAOYSA-N hydrogen sulfate;hydron;methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5-yl)acetate Chemical compound OS(O)(=O)=O.C1CC=2SC=CC=2CN1C(C(=O)OC)C1=CC=CC=C1Cl FDEODCTUSIWGLK-UHFFFAOYSA-N 0.000 title claims description 355
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- 239000005552 B01AC04 - Clopidogrel Substances 0.000 claims description 83
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 claims description 83
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- 239000003981 vehicle Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 229940057977 zinc stearate Drugs 0.000 description 1
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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US34244001P | 2001-12-18 | 2001-12-18 |
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ZA200404733B true ZA200404733B (en) | 2005-06-15 |
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CN101948474B (zh) * | 2010-10-14 | 2012-03-07 | 山东益康药业有限公司 | 晶i型氯吡格雷硫酸氢盐的制备方法 |
WO2012072824A1 (en) * | 2010-12-03 | 2012-06-07 | Novartis Ag | Pharmaceutical compositions, dosage forms and new forms of the compound of formula (i), and methods of use thereof |
CN103467488B (zh) * | 2013-09-24 | 2015-03-11 | 山东罗欣药业集团股份有限公司 | 一种硫酸氢氯吡格雷的新晶型及其制备方法 |
CN103923100B (zh) * | 2014-04-03 | 2019-05-14 | 浙江华海药业股份有限公司 | 一种硫酸氢氯吡格雷的精制方法 |
CN104045653A (zh) * | 2014-07-15 | 2014-09-17 | 苏州天马精细化学品股份有限公司 | 一种硫酸氢氯吡格雷的纯化方法 |
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