ZA200402235B - Bio-sensing platforms for detection and quantitation of biological molecules. - Google Patents

Bio-sensing platforms for detection and quantitation of biological molecules. Download PDF

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Publication number
ZA200402235B
ZA200402235B ZA200402235A ZA200402235A ZA200402235B ZA 200402235 B ZA200402235 B ZA 200402235B ZA 200402235 A ZA200402235 A ZA 200402235A ZA 200402235 A ZA200402235 A ZA 200402235A ZA 200402235 B ZA200402235 B ZA 200402235B
Authority
ZA
South Africa
Prior art keywords
fluorescence
fluorescer
bioconjugate
sample
tether
Prior art date
Application number
ZA200402235A
Other languages
English (en)
Inventor
Sriram Kumaraswamy
David Whitten
Duncan Mcbranch
Frauke Rininsland
Brent Arthur Burdick
Original Assignee
Qtk Biosystems Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qtk Biosystems Llc filed Critical Qtk Biosystems Llc
Publication of ZA200402235B publication Critical patent/ZA200402235B/en

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y20/00Nanooptics, e.g. quantum optics or photonic crystals
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6823Release of bound markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
ZA200402235A 2001-08-23 2002-08-23 Bio-sensing platforms for detection and quantitation of biological molecules. ZA200402235B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31409401P 2001-08-23 2001-08-23

Publications (1)

Publication Number Publication Date
ZA200402235B true ZA200402235B (en) 2005-08-29

Family

ID=23218522

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200402235A ZA200402235B (en) 2001-08-23 2002-08-23 Bio-sensing platforms for detection and quantitation of biological molecules.

Country Status (9)

Country Link
US (1) US20030054413A1 (fr)
EP (1) EP1425581A4 (fr)
JP (1) JP2005501248A (fr)
KR (1) KR20040083411A (fr)
CA (1) CA2458405A1 (fr)
IL (1) IL160519A0 (fr)
NO (1) NO20041160L (fr)
WO (1) WO2003019138A2 (fr)
ZA (1) ZA200402235B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050147534A1 (en) * 1998-05-05 2005-07-07 Massachusetts Institute Of Technology Emissive sensors and devices incorporating these sensors
EP1080162B1 (fr) * 1998-05-05 2004-03-10 Massachusetts Institute Of Technology Polymeres emissifs et dispositifs renfermant ces polymeres
US8198096B2 (en) 1998-05-05 2012-06-12 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
EP1437594B1 (fr) * 2001-09-19 2011-01-12 Sekisui Medical Co., Ltd. Polymere luminescent utilisable dans des bioessais
US7462325B2 (en) * 2001-11-30 2008-12-09 Nomadics, Inc. Luminescent polymer particles
US7335478B2 (en) * 2002-04-18 2008-02-26 Kalobios Pharmaceuticals, Inc. Reactivation-based molecular interaction sensors
US7432063B2 (en) * 2002-02-14 2008-10-07 Kalobios Pharmaceuticals, Inc. Methods for affinity maturation
US9371559B2 (en) 2002-06-20 2016-06-21 The Regents Of The University Of California Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US7270956B2 (en) 2002-08-26 2007-09-18 The Regents Of The University Of California Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US10001475B2 (en) 2002-06-20 2018-06-19 The Regents Of The University Of California Light harvesting multichromophore compositions and methods of using the same
CN1675377B (zh) 2002-06-20 2012-10-03 加州大学评议会 利用获取光的多发色团检测和分析多核苷酸的方法和组合物
US7144950B2 (en) * 2003-09-17 2006-12-05 The Regents Of The University Of California Conformationally flexible cationic conjugated polymers
EP1579215A4 (fr) * 2002-11-14 2007-01-17 Qtl Biosystems Llc Procedes de biodetection utilisant des polymeres fluorescents et bioconjugues de type extincteur-chaine-ligand (qtl)
ES2440920T3 (es) 2003-02-13 2014-01-31 The Regents Of The University Of California Métodos y composiciones para la detección y análisis de interacciones de proteínas que se unen a polinucleótidos utilizando multicromóforos captadores de luz
WO2004072266A2 (fr) * 2003-02-13 2004-08-26 Kalobios Inc. Ingenierie de l'affinite des anticorps par un remplacement complementaire en serie guide par epitope
EP1601955B1 (fr) 2003-03-07 2013-01-09 Luxcel Biosciences Limited Sonde sensible a l'oxygène et procède pour mesurer l'absorption d'oxygène
AU2003243850A1 (en) * 2003-06-18 2005-01-04 Bratya Vassilevi Ad Refrigerator and system of refrigerators
US9017766B2 (en) 2003-09-17 2015-04-28 The Regents Of The University Of California Methods and devices comprising soluble conjugated polymers
EP1692703A4 (fr) * 2003-12-12 2007-11-28 Qtl Biosystems Llc Essais, kits et reactifs de superextinction de fluorescence induite par des ions metalliques
US20060088895A1 (en) * 2004-01-30 2006-04-27 Wanders Bart J Systems, methods and reagents for the detection of biological and chemical agents using dynamic surface generation and imaging
EP1716252A1 (fr) * 2004-02-19 2006-11-02 University College Cork-National University of Ireland, Cork Detection de composes actifs sur le plan biologique
DE112005002132T5 (de) * 2004-09-03 2008-03-06 The Regents Of The University Of California, Oakland Lösliche konjugierte Polymere
US8795781B2 (en) * 2004-09-03 2014-08-05 The Regents Of The University Of California Methods and devices utilizing soluble conjugated polymers
WO2006034081A2 (fr) * 2004-09-17 2006-03-30 Massachusetts Institute Of Technology Polymeres destines a la detection d'analytes
EP1824975B9 (fr) * 2004-11-09 2011-04-20 Santaris Pharma A/S Oligonucleotides lna et traitement du cancer
WO2006074482A2 (fr) * 2005-01-10 2006-07-13 The Regents Of The University Of California Procedes et articles pour la detection de polynucleotides specifiques de brin a multichromophores cationiques
EP1838752B1 (fr) 2005-01-10 2017-10-04 The Regents of The University of California Polymeres conjugues cationiques appropries pour la detection de polynucleotides specifiques de brins dans des essais a l'etat solide et homogenes
WO2006075429A1 (fr) * 2005-01-13 2006-07-20 Kyushu Institute Of Technology Particule pour la detection de l’activite enzymatique et procede et outil de detection de l’activite enzymatique l’utilisant
WO2006083932A2 (fr) 2005-01-31 2006-08-10 The Regents Of The University Procedes et compositions permettant de detecter un agregat
KR100704011B1 (ko) * 2005-02-16 2007-04-04 한국과학기술원 금속나노입자와 양자점의 fret에 의한 생체분자특이결합 검출 방법
JP5529382B2 (ja) * 2005-03-01 2014-06-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 固体照明に用いられる多層ポリマー発光ダイオード
US20060292653A1 (en) * 2005-03-18 2006-12-28 Frauke Rininsland Metal mediated fluorescence superquenching assays for detection of phosphorylation and dephosphorylation of quencher-labeled substrates
KR100806669B1 (ko) * 2005-06-23 2008-02-26 김정환 나노 입자-생체 복합체
KR100727413B1 (ko) * 2005-08-26 2007-06-13 경북대학교 산학협력단 의료용 분자 이미징을 위한, 생체 적합성 고분자로 코팅된NIR Q-dot의 제조 방법
JP2009540333A (ja) 2006-06-12 2009-11-19 プレジデント アンド フェロウズ オブ ハーバード カレッジ ナノセンサーおよび関連技術
US8158437B2 (en) * 2006-08-04 2012-04-17 Massachusetts Institute Of Technology Luminescent detection of hydrazine and hydrazine derivatives
WO2008042289A2 (fr) 2006-09-29 2008-04-10 Massachusetts Institute Of Technology Technique synthétique polymérique
US8802447B2 (en) * 2006-10-05 2014-08-12 Massachusetts Institute Of Technology Emissive compositions with internal standard and related techniques
US20090215189A1 (en) 2006-10-27 2009-08-27 Massachusetts Institute Of Technology Sensor of species including toxins and chemical warfare agents
KR100809402B1 (ko) * 2007-01-29 2008-03-05 김정환 나노 입자 표지, 나노 입자 표지를 이용하는 진단 키트, 및진단 방법
KR100914455B1 (ko) * 2007-05-28 2009-08-28 전남대학교산학협력단 양자점을 이용한 생물학적 검출키트 및 방법
US20110039289A1 (en) * 2008-03-14 2011-02-17 Pierre Graves Fluorogenic peptides and their method of production
WO2011038228A1 (fr) * 2009-09-24 2011-03-31 President And Fellows Of Harvard College Nanofils incurvés et détection associée d'espèces
CN104245960B (zh) * 2012-02-21 2018-11-09 美国控股实验室公司 用于生物测定的信号放大的方法和系统
GB2502306A (en) * 2012-05-22 2013-11-27 Univ Singapore Microparticle sensor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0428000A1 (fr) * 1989-11-03 1991-05-22 Abbott Laboratories Substrats fluorogéniques pour la détection de l'activité prothéolytique d'enzymes
GB9310978D0 (en) * 1993-05-27 1993-07-14 Zeneca Ltd Compounds
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5605809A (en) * 1994-10-28 1997-02-25 Oncoimmunin, Inc. Compositions for the detection of proteases in biological samples and methods of use thereof
US6803188B1 (en) * 1996-01-31 2004-10-12 The Regents Of The University Of California Tandem fluorescent protein constructs
WO1998041866A1 (fr) * 1997-03-14 1998-09-24 Merck & Co., Inc. Dosage a haute capacite dans lequel des proteines de fusion sont utilisees
US6251583B1 (en) * 1998-04-27 2001-06-26 Schering Corporation Peptide substrates for HCV NS3 protease assays
US6210896B1 (en) * 1998-08-13 2001-04-03 Us Genomics Molecular motors

Also Published As

Publication number Publication date
EP1425581A2 (fr) 2004-06-09
JP2005501248A (ja) 2005-01-13
KR20040083411A (ko) 2004-10-01
NO20041160L (no) 2004-03-22
CA2458405A1 (fr) 2003-03-06
IL160519A0 (en) 2004-07-25
EP1425581A4 (fr) 2005-03-09
US20030054413A1 (en) 2003-03-20
WO2003019138A2 (fr) 2003-03-06
WO2003019138A3 (fr) 2003-11-06

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