ZA200306549B - Benzophenones as inhibitors of reverse transcriptase. - Google Patents

Benzophenones as inhibitors of reverse transcriptase.

Info

Publication number
ZA200306549B
ZA200306549B ZA200306549A ZA200306549A ZA200306549B ZA 200306549 B ZA200306549 B ZA 200306549B ZA 200306549 A ZA200306549 A ZA 200306549A ZA 200306549 A ZA200306549 A ZA 200306549A ZA 200306549 B ZA200306549 B ZA 200306549B
Authority
ZA
South Africa
Prior art keywords
benzophenones
inhibitors
reverse transcriptase
transcriptase
reverse
Prior art date
Application number
ZA200306549A
Other languages
English (en)
Inventor
Joseph Howing Chan
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of ZA200306549B publication Critical patent/ZA200306549B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/53—X and Y not being nitrogen atoms, e.g. N-sulfonylcarbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
ZA200306549A 2001-03-02 2003-08-21 Benzophenones as inhibitors of reverse transcriptase. ZA200306549B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27295301P 2001-03-02 2001-03-02

Publications (1)

Publication Number Publication Date
ZA200306549B true ZA200306549B (en) 2004-11-22

Family

ID=23041935

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200306549A ZA200306549B (en) 2001-03-02 2003-08-21 Benzophenones as inhibitors of reverse transcriptase.

Country Status (18)

Country Link
US (2) US6995283B2 (xx)
EP (1) EP1363877A2 (xx)
JP (1) JP2004525914A (xx)
KR (1) KR100638954B1 (xx)
CN (1) CN1494528A (xx)
AR (2) AR035436A1 (xx)
AU (1) AU2002254056C1 (xx)
BR (1) BR0207752A (xx)
CA (1) CA2439820A1 (xx)
CZ (1) CZ20032366A3 (xx)
HU (1) HUP0303326A2 (xx)
IL (1) IL157348A0 (xx)
MX (1) MXPA03007883A (xx)
NO (1) NO20033857L (xx)
NZ (1) NZ527864A (xx)
PL (1) PL364658A1 (xx)
WO (1) WO2002070470A2 (xx)
ZA (1) ZA200306549B (xx)

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US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
AR039540A1 (es) 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
BR0313545B1 (pt) 2002-08-09 2021-07-27 Janssen Pharmaceutica Nv processos para a preparação de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]amino]-2-pirimidinil]amino]benzonitrila
AU2003295324B2 (en) 2002-08-23 2008-08-28 Ardea Biosciences,Inc. Non-nucleoside reverse transcriptase inhibitors
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
CA2513527C (en) 2003-02-07 2012-08-14 Janssen Pharmaceutica N.V. Pyrimidine derivatives for the prevention of hiv infection
JP2006521402A (ja) 2003-03-27 2006-09-21 スミスクライン ビーチャム コーポレーション 逆転写酵素阻害剤を調製するための方法
WO2005026114A1 (en) * 2003-09-17 2005-03-24 Pfizer Inc. Hiv protease inhibitors, compositions containing the same and their pharmaceutical uses
US20080132549A1 (en) * 2004-04-14 2008-06-05 Pfizer Inc. Sulphur-Linked Imidazone Compounds for the Treatment of Hiv/Aids
US20060025480A1 (en) * 2004-08-02 2006-02-02 Boehringer Ingelheim International Gmbh Benzoic acid derivatives as non nucleoside reverse transcriptase inhibitors
EP2402011B1 (en) 2004-08-25 2012-11-14 Ardea Biosciences, Inc. S-triazolyl alpha-mercaptoacetanilides as inhibitors of HIV reverse transcriptase
WO2007050087A1 (en) 2004-08-25 2007-05-03 Ardea Biosciences, Inc. N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS
WO2006034583A1 (en) * 2004-09-30 2006-04-06 Boehringer Ingelheim International Gmbh & Co Kg Alkynyl based dervatives of benzophenone as non-nucleoside reverse transcriptase inhibitors
US20090264425A1 (en) * 2004-12-22 2009-10-22 Pfizer Limited Chemical compounds
EP1868587A2 (en) * 2005-04-08 2007-12-26 Abbott Laboratories Pharmaceutical formulations comprising fenofibric acid and/or its salts
AR057455A1 (es) 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
WO2007121415A2 (en) * 2006-04-17 2007-10-25 Smithkline Beecham Corporation Chemical compounds
WO2007121416A2 (en) * 2006-04-17 2007-10-25 Smithkline Beecham Corporation Chemical compounds
AR060492A1 (es) * 2006-04-17 2008-06-18 Smithkline Beecham Corp Compuestos quimicos
SG174016A1 (en) * 2006-07-24 2011-09-29 Korea Res Inst Chem Tech Hiv reverse transcriptase inhibitors
CN101407476B (zh) * 2007-10-12 2012-07-18 中国人民解放军军事医学科学院毒物药物研究所 作为非核苷类hiv逆转录酶抑制剂的间二芳烃-多取代苯胺类化合物、其制备方法及用途
SI2217577T1 (sl) 2007-11-27 2014-11-28 Ardea Biosciences, Inc. Nove spojine in sestavki ter metode uporabe
CN101450911B (zh) * 2007-11-30 2012-02-29 山东轩竹医药科技有限公司 被金刚烷取代的苯甲酸衍生物
CN102219717A (zh) * 2011-04-20 2011-10-19 复旦大学 N-苯基芳基甲酰胺衍生物及其制备方法和用途
CN102212022A (zh) * 2011-04-20 2011-10-12 复旦大学 二苯甲醇衍生物及其制备方法和用途
CN102206177A (zh) * 2011-04-20 2011-10-05 复旦大学 1-萘基苯甲酮衍生物及其制备方法和用途
CN110015963A (zh) * 2019-04-12 2019-07-16 上海优合生物科技有限公司 一种2-氯-6-甲基苯胺的制备方法
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03198050A (ja) * 1989-12-27 1991-08-29 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料

Also Published As

Publication number Publication date
HUP0303326A2 (hu) 2004-01-28
NZ527864A (en) 2004-05-28
WO2002070470A2 (en) 2002-09-12
AU2002254056C1 (en) 2006-04-13
US6995283B2 (en) 2006-02-07
CA2439820A1 (en) 2002-09-12
JP2004525914A (ja) 2004-08-26
PL364658A1 (en) 2004-12-13
US20040122064A1 (en) 2004-06-24
EP1363877A2 (en) 2003-11-26
KR20030086283A (ko) 2003-11-07
CZ20032366A3 (en) 2004-04-14
CN1494528A (zh) 2004-05-05
WO2002070470A3 (en) 2003-03-06
AU2002254056B2 (en) 2005-09-29
NO20033857D0 (no) 2003-09-01
NO20033857L (no) 2003-10-27
US20060009651A1 (en) 2006-01-12
IL157348A0 (en) 2004-02-19
MXPA03007883A (es) 2003-12-04
KR100638954B1 (ko) 2006-10-25
BR0207752A (pt) 2004-03-23
AR035436A1 (es) 2004-05-26
AR043367A2 (es) 2005-07-27

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