ZA200306221B - Novel medicament compositions on the basis of anti-cholinergics and PDE IV inhibitors. - Google Patents
Novel medicament compositions on the basis of anti-cholinergics and PDE IV inhibitors. Download PDFInfo
- Publication number
- ZA200306221B ZA200306221B ZA200306221A ZA200306221A ZA200306221B ZA 200306221 B ZA200306221 B ZA 200306221B ZA 200306221 A ZA200306221 A ZA 200306221A ZA 200306221 A ZA200306221 A ZA 200306221A ZA 200306221 B ZA200306221 B ZA 200306221B
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- ZA
- South Africa
- Prior art keywords
- acid
- inhalable
- pharmaceutical composition
- propellant
- solution
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 51
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title claims description 10
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 title claims description 5
- 239000000812 cholinergic antagonist Substances 0.000 title claims description 5
- 239000003814 drug Substances 0.000 title claims description 4
- 230000001078 anti-cholinergic effect Effects 0.000 title description 2
- 239000013543 active substance Substances 0.000 claims description 46
- 239000000443 aerosol Substances 0.000 claims description 42
- 239000008194 pharmaceutical composition Substances 0.000 claims description 33
- 239000000725 suspension Substances 0.000 claims description 30
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 26
- 150000001875 compounds Chemical class 0.000 claims description 25
- 238000009472 formulation Methods 0.000 claims description 25
- 239000000843 powder Substances 0.000 claims description 25
- 239000003380 propellant Substances 0.000 claims description 25
- 150000003839 salts Chemical class 0.000 claims description 23
- 239000002253 acid Substances 0.000 claims description 18
- -1 polyoxyethylene Polymers 0.000 claims description 18
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 239000007789 gas Substances 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
- 239000004615 ingredient Substances 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims description 12
- 239000002775 capsule Substances 0.000 claims description 11
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 9
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- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 7
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
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- AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims description 5
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- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 5
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- 125000005842 heteroatom Chemical group 0.000 claims description 5
- 125000000623 heterocyclic group Chemical group 0.000 claims description 5
- DPHDSIQHVGSITN-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide Chemical compound C1=C(C(=O)C(=O)NC=2C(=CN=CC=2Cl)Cl)C2=CC(O)=CC=C2N1CC1=CC=C(F)C=C1 DPHDSIQHVGSITN-UHFFFAOYSA-N 0.000 claims description 5
- NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical class CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 claims description 5
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- 150000001298 alcohols Chemical class 0.000 claims description 4
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- CFBUZOUXXHZCFB-OYOVHJISSA-N chembl511115 Chemical compound COC1=CC=C([C@@]2(CC[C@H](CC2)C(O)=O)C#N)C=C1OC1CCCC1 CFBUZOUXXHZCFB-OYOVHJISSA-N 0.000 claims description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- QVDKSPUZWYTNQA-UHFFFAOYSA-N enprofylline Chemical compound O=C1NC(=O)N(CCC)C2=NC=N[C]21 QVDKSPUZWYTNQA-UHFFFAOYSA-N 0.000 claims description 4
- 229950000579 enprofylline Drugs 0.000 claims description 4
- 239000001530 fumaric acid Substances 0.000 claims description 4
- 150000004677 hydrates Chemical class 0.000 claims description 4
- 230000002757 inflammatory effect Effects 0.000 claims description 4
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 claims description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims description 4
- 230000000414 obstructive effect Effects 0.000 claims description 4
- 210000002345 respiratory system Anatomy 0.000 claims description 4
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims description 4
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- 239000003381 stabilizer Substances 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
- G01R31/28—Testing of electronic circuits, e.g. by signal tracer
- G01R31/317—Testing of digital circuits
- G01R31/3181—Functional testing
- G01R31/319—Tester hardware, i.e. output processing circuits
- G01R31/3193—Tester hardware, i.e. output processing circuits with comparison between actual response and known fault free response
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
- G01R31/28—Testing of electronic circuits, e.g. by signal tracer
- G01R31/317—Testing of digital circuits
- G01R31/3181—Functional testing
- G01R31/31813—Test pattern generators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
- G01R31/28—Testing of electronic circuits, e.g. by signal tracer
- G01R31/317—Testing of digital circuits
- G01R31/3181—Functional testing
- G01R31/319—Tester hardware, i.e. output processing circuits
- G01R31/31903—Tester hardware, i.e. output processing circuits tester configuration
- G01R31/31905—Interface with the device under test [DUT], e.g. arrangements between the test head and the DUT, mechanical aspects, fixture
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Tests Of Electronic Circuits (AREA)
- Test And Diagnosis Of Digital Computers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10110777A DE10110777A1 (de) | 2001-03-07 | 2001-03-07 | Anordnung und Verfahren zum Testen von integrierten Schaltkreisen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200306221B true ZA200306221B (en) | 2004-07-22 |
Family
ID=7676496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200306221A ZA200306221B (en) | 2001-03-07 | 2003-08-12 | Novel medicament compositions on the basis of anti-cholinergics and PDE IV inhibitors. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6768292B2 (ja) |
| EP (1) | EP1239293B1 (ja) |
| JP (1) | JP2002333466A (ja) |
| DE (2) | DE10110777A1 (ja) |
| ZA (1) | ZA200306221B (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1231608A1 (en) * | 2001-02-07 | 2002-08-14 | STMicroelectronics Limited | Built-in test circuit and method for an integrated circuit |
| DE10110777A1 (de) * | 2001-03-07 | 2002-09-12 | Philips Corp Intellectual Pty | Anordnung und Verfahren zum Testen von integrierten Schaltkreisen |
| WO2002073225A1 (en) * | 2001-03-13 | 2002-09-19 | Koninklijke Philips Electronics N.V. | Integrated circuit testing device with improved reliability |
| KR20060103961A (ko) * | 2001-07-17 | 2006-10-04 | 주식회사 아도반테스토 | 입출력 회로, 및 시험 장치 |
| JP2008505310A (ja) | 2004-06-30 | 2008-02-21 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 回路装置、及び、前記回路装置に設けられたアプリケーション回路の試験方法 |
| FR2962809B1 (fr) * | 2010-07-19 | 2013-03-15 | Thales Sa | Procédé et dispositif pour le test automatique embarque d'un circuit intégré |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3887869A (en) * | 1972-07-25 | 1975-06-03 | Tau Tron Inc | Method and apparatus for high speed digital circuit testing |
| GB8411733D0 (en) * | 1984-05-09 | 1984-06-13 | Gen Electric Co Plc | Integrated circuit testing arrangements |
| JPS6170777U (ja) * | 1984-10-15 | 1986-05-14 | ||
| DE69114183T2 (de) * | 1990-06-07 | 1996-05-30 | Ibm | System zur Reduzierung von Prüfdatenspeichern. |
| JPH04139850A (ja) * | 1990-10-01 | 1992-05-13 | Matsushita Electric Ind Co Ltd | 半導体集積回路装置及びその検査方法 |
| US5166604A (en) * | 1990-11-13 | 1992-11-24 | Altera Corporation | Methods and apparatus for facilitating scan testing of asynchronous logic circuitry |
| US5528600A (en) * | 1991-01-28 | 1996-06-18 | Actel Corporation | Testability circuits for logic arrays |
| US5488612A (en) * | 1993-10-04 | 1996-01-30 | International Business Machines, Corporation | Method and apparatus for field testing field programmable logic arrays |
| US5617531A (en) * | 1993-11-02 | 1997-04-01 | Motorola, Inc. | Data Processor having a built-in internal self test controller for testing a plurality of memories internal to the data processor |
| US6057679A (en) * | 1998-06-12 | 2000-05-02 | Credence Systems Corporation | Integrated circuit tester having amorphous logic for real-time data analysis |
| US6411124B2 (en) * | 2000-04-28 | 2002-06-25 | Altera Corporation | Programmable logic device logic modules with shift register capabilities |
| DE10110777A1 (de) * | 2001-03-07 | 2002-09-12 | Philips Corp Intellectual Pty | Anordnung und Verfahren zum Testen von integrierten Schaltkreisen |
-
2001
- 2001-03-07 DE DE10110777A patent/DE10110777A1/de not_active Withdrawn
-
2002
- 2002-03-04 US US10/090,348 patent/US6768292B2/en not_active Expired - Fee Related
- 2002-03-05 EP EP02100219A patent/EP1239293B1/de not_active Expired - Lifetime
- 2002-03-05 DE DE50204985T patent/DE50204985D1/de not_active Expired - Lifetime
- 2002-03-07 JP JP2002062127A patent/JP2002333466A/ja active Pending
-
2003
- 2003-08-12 ZA ZA200306221A patent/ZA200306221B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE50204985D1 (de) | 2005-12-29 |
| EP1239293A2 (de) | 2002-09-11 |
| EP1239293A3 (de) | 2004-03-10 |
| EP1239293B1 (de) | 2005-11-23 |
| JP2002333466A (ja) | 2002-11-22 |
| US6768292B2 (en) | 2004-07-27 |
| DE10110777A1 (de) | 2002-09-12 |
| US20020144202A1 (en) | 2002-10-03 |
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