ZA200302523B - Methods of inducing cancer cell death and tumor regression. - Google Patents
Methods of inducing cancer cell death and tumor regression. Download PDFInfo
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- ZA200302523B ZA200302523B ZA200302523A ZA200302523A ZA200302523B ZA 200302523 B ZA200302523 B ZA 200302523B ZA 200302523 A ZA200302523 A ZA 200302523A ZA 200302523 A ZA200302523 A ZA 200302523A ZA 200302523 B ZA200302523 B ZA 200302523B
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
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| US23824000P | 2000-10-05 | 2000-10-05 |
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| US6369138B2 (en) | 1997-07-11 | 2002-04-09 | Bridgestone Corporation | Processability of silica-filled rubber stocks with reduced hysteresis |
| WO2008109417A1 (en) * | 2007-03-02 | 2008-09-12 | Case Western Reserve University | Mgmt inhibitor combinations for the treatment of neoplastic disorders |
| AU2002211427A1 (en) * | 2000-10-05 | 2002-04-15 | Whitehead Institute For Biomedical Research | Effects of combined administration of farnesyl transferase inhibitors and signal transduction inhibitors |
| US20040126755A1 (en) * | 2001-08-29 | 2004-07-01 | Stephan Dietrich A | Gene expression based method for distinguishing metastatic from non-metastatic forms of a tumor, and use in designing therapeutic drugs |
| HUP0402401A2 (hu) * | 2001-11-30 | 2005-03-29 | Schering Corp. | Rák kezelésére szolgáló eljárások egy FPT inhibitor és daganatellenes szerek felhasználásával |
| EP1453513A1 (en) * | 2001-12-03 | 2004-09-08 | Schering Corporation | Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer |
| US20050004008A1 (en) * | 2002-03-01 | 2005-01-06 | Frackelton A. Raymond | SHC proteins as therapeutic targets in proliferative diseases |
| CA2477953A1 (en) * | 2002-03-01 | 2003-09-12 | Roger Williams Hospital | Shc protein-related methods and compositions for the prognosis of breast, prostate and ovarian cancer |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| US7691905B2 (en) * | 2002-12-24 | 2010-04-06 | New York University | Inhibition of melanogenesis and melanoma metastasis with p-aminobenzoic acid (PABA) |
| AU2004289256A1 (en) * | 2003-11-06 | 2005-05-26 | Schering Corporation | Combination of a farnesyl tranferase inhibitor with an antihormonal agent for the treatment of breast cancer |
| US20060205810A1 (en) * | 2004-11-24 | 2006-09-14 | Schering Corporation | Platinum therapeutic combinations |
| US20070148660A1 (en) * | 2005-06-16 | 2007-06-28 | The Regents Of The University Of California | Treatment of maladaptive substance use with H-ras antagonists |
| WO2007042465A2 (en) * | 2005-10-07 | 2007-04-19 | Novartis Ag | Combinati0n of nilotinib with farnesyl transferase inhibitors |
| ATE521893T1 (de) * | 2005-11-11 | 2011-09-15 | Roger Williams Hospital | P66-shc als prädiktiver marker bei der krebsbehandlung |
| CN102274513B (zh) * | 2011-07-06 | 2013-02-20 | 南开大学 | ERK1/2抑制剂通过刺激巨噬细胞干扰素γ表达抑制肿瘤生长 |
| CN102626416B (zh) * | 2012-05-11 | 2013-04-17 | 江苏省人民医院 | 他莫昔芬联合雷帕霉素、人参皂苷Rg3复合物在制备治疗肝癌药物中的应用 |
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| AU665341B2 (en) | 1990-12-18 | 1996-01-04 | Wellcome Foundation Limited, The | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance |
| US5874442A (en) | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
| EP0906099A4 (en) | 1996-04-03 | 2001-02-07 | Merck & Co Inc | METHOD FOR TREATING CANCER |
| JP2000508335A (ja) * | 1996-05-30 | 2000-07-04 | メルク エンド カンパニー インコーポレーテッド | 癌の治療方法 |
| CA2293706C (en) * | 1997-06-17 | 2008-11-18 | Schering Corporation | N-substituted urea inhibitors of farnesyl-protein transferase |
| WO1998057945A1 (en) | 1997-06-17 | 1998-12-23 | Schering Corporation | Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives as farnesyl protein transferase inhibitors |
| US6096757A (en) | 1998-12-21 | 2000-08-01 | Schering Corporation | Method for treating proliferative diseases |
| CA2369895C (en) * | 1999-01-11 | 2010-12-21 | Princeton University | High affinity inhibitors for target validation and uses thereof |
| US6316462B1 (en) * | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
| ES2273688T3 (es) * | 1999-04-14 | 2007-05-16 | Dana-Farber Cancer Institute, Inc. | Procedimiento y composicion para el tratamiento de cancer. |
| US6465448B1 (en) * | 1999-08-13 | 2002-10-15 | Case Western Reserve University | Methoxyamine potentiation of temozolomide anti-cancer activity |
| US7238525B2 (en) * | 2000-06-30 | 2007-07-03 | The Regents Of The University Of California | Strategy for leukemia therapy |
| AU2002211427A1 (en) * | 2000-10-05 | 2002-04-15 | Whitehead Institute For Biomedical Research | Effects of combined administration of farnesyl transferase inhibitors and signal transduction inhibitors |
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Also Published As
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| US20020128280A1 (en) | 2002-09-12 |
| HK1052870A1 (zh) | 2003-10-03 |
| MXPA03003011A (es) | 2003-07-14 |
| NO20031531L (no) | 2003-06-05 |
| CA2424797A1 (en) | 2002-04-11 |
| WO2002028381A3 (en) | 2003-03-27 |
| CN1479630A (zh) | 2004-03-03 |
| HUP0302913A2 (hu) | 2003-12-29 |
| BR0114430A (pt) | 2004-01-06 |
| JP2004510733A (ja) | 2004-04-08 |
| AU1186202A (en) | 2002-04-15 |
| NO20031531D0 (no) | 2003-04-04 |
| CA2424797C (en) | 2009-12-29 |
| US6777415B2 (en) | 2004-08-17 |
| NZ524936A (en) | 2005-08-26 |
| HUP0302913A3 (en) | 2005-05-30 |
| AU2002211862B2 (en) | 2007-03-15 |
| WO2002028381A2 (en) | 2002-04-11 |
| EP1322334A2 (en) | 2003-07-02 |
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