ZA200209524B - Liposomal benzoquinazoline thymidylate synthase inhibitor formulation. - Google Patents
Liposomal benzoquinazoline thymidylate synthase inhibitor formulation. Download PDFInfo
- Publication number
- ZA200209524B ZA200209524B ZA200209524A ZA200209524A ZA200209524B ZA 200209524 B ZA200209524 B ZA 200209524B ZA 200209524 A ZA200209524 A ZA 200209524A ZA 200209524 A ZA200209524 A ZA 200209524A ZA 200209524 B ZA200209524 B ZA 200209524B
- Authority
- ZA
- South Africa
- Prior art keywords
- phosphatidylcholine
- liposome
- molar ratio
- btsi
- group
- Prior art date
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- PQIUGRLKNKSKTC-UHFFFAOYSA-N benzo[h]quinazoline Chemical compound N1=CN=C2C3=CC=CC=C3C=CC2=C1 PQIUGRLKNKSKTC-UHFFFAOYSA-N 0.000 title claims description 22
- 239000003734 thymidylate synthase inhibitor Substances 0.000 title claims description 21
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
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| US21059200P | 2000-06-09 | 2000-06-09 |
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| ZA200209524A ZA200209524B (en) | 2000-06-09 | 2002-11-22 | Liposomal benzoquinazoline thymidylate synthase inhibitor formulation. |
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| EP (1) | EP1286661A2 (pt) |
| JP (1) | JP2004503491A (pt) |
| KR (1) | KR100851957B1 (pt) |
| CN (1) | CN1446080A (pt) |
| AU (2) | AU7526901A (pt) |
| BR (1) | BR0111541A (pt) |
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| PL (1) | PL360470A1 (pt) |
| TW (1) | TWI282741B (pt) |
| WO (1) | WO2001095884A2 (pt) |
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| WO2004047802A2 (en) * | 2002-11-26 | 2004-06-10 | Gilead Sciences, Inc. | Liposomal formulations |
| US20090060998A1 (en) * | 2004-01-14 | 2009-03-05 | Gilead Sciences, Inc. | Lipid-based dispersions useful for drug delivery |
| WO2006012502A2 (en) * | 2004-07-23 | 2006-02-02 | Rigel Pharmaceuticals, Inc. | Formulation of insoluble small molecule therapeutics in lipid-based carriers |
| US20070082042A1 (en) * | 2004-08-06 | 2007-04-12 | Deok-Hoon Park | Multiple-layered liposome and preparation method thereof |
| AU2005284909B2 (en) * | 2004-09-13 | 2011-11-17 | Gilead Sciences, Inc. | Delivering iron to an animal |
| WO2006078253A1 (en) * | 2005-01-20 | 2006-07-27 | Osi Pharmaceuticals, Inc. | Method of reclaiming drug compound osi-7904 from liposomal drug manufacturing stream |
| US20060159735A1 (en) * | 2005-01-20 | 2006-07-20 | Nicholas Bonham | Method of reclaiming drug compound from liposomal drug manufacturing stream |
| EP1745788A1 (de) * | 2005-07-22 | 2007-01-24 | KTB Tumorforschungsgesellschaft mbH | Acylglycerophospholipide zur Behandlung von Krebs und Tumorkachexie |
| CN100348194C (zh) * | 2005-07-26 | 2007-11-14 | 康辰医药发展有限公司 | 盐酸洛拉曲克的脂质体制剂及其制备方法 |
| US8246984B2 (en) * | 2005-12-06 | 2012-08-21 | Rigel Pharmaceuticals, Inc. | Formulation of insoluble small molecule therapeutics in lipid-based carriers |
| US9493810B2 (en) * | 2012-06-07 | 2016-11-15 | Pioma, Inc. | 5-ALA for detection of brain tumors |
| WO2014015016A1 (en) * | 2012-07-18 | 2014-01-23 | Onyx Therapeutics, Inc. | Liposomal compositions of epoxyketone-based proteasome inhibitors |
| CN109689104A (zh) | 2016-08-12 | 2019-04-26 | L.E.A.F.控股集团公司 | α和γ-D聚谷氨酸化抗叶酸剂及其用途 |
| CA3090509A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated methotrexate and uses thereof |
| EP3749313A4 (en) | 2018-02-07 | 2022-03-16 | L.E.A.F Holdings Group LLC | ALPHA-POLYGLUTAMATED ANTIFOLATES AND USES THEREOF |
| CN111954531A (zh) | 2018-02-07 | 2020-11-17 | L.E.A.F.控股集团公司 | α聚谷氨酸化培美曲塞及其用途 |
| US11730738B2 (en) | 2018-02-07 | 2023-08-22 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
| EP3752157A4 (en) | 2018-02-14 | 2022-07-06 | L.E.A.F Holdings Group LLC | GAMMA-POLYGLUTAMATED LOMETREXOLE AND USES THEREOF |
| WO2019160736A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pralatrexate and uses thereof |
| CN111971047A (zh) | 2018-02-14 | 2020-11-20 | L.E.A.F.控股集团公司 | γ聚谷氨酸化四氢叶酸及其用途 |
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| US4460577A (en) * | 1977-09-30 | 1984-07-17 | Farmitalia Carlo Erba S.P.A. | Pharmaceutical compositions consisting or consisting essentially of liposomes, and processes for making same |
| US4963367A (en) * | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
| US4755388A (en) * | 1984-11-09 | 1988-07-05 | The Regents Of The University Of California | Liposome-encapsulated 5-fluoropyrimidines and methods for their use |
| US4753788A (en) * | 1985-01-31 | 1988-06-28 | Vestar Research Inc. | Method for preparing small vesicles using microemulsification |
| GB9013615D0 (en) * | 1990-06-19 | 1990-08-08 | Wellcome Found | Pharmaceutical compounds |
| WO1994011030A1 (en) | 1992-11-13 | 1994-05-26 | The Ohio State University Research Foundation | C-glycoside analogues of n-(4-hydroxyphenyl)retinamide-o-glucuronide |
| JPH11199488A (ja) * | 1998-01-09 | 1999-07-27 | Sankyo Co Ltd | 抗腫瘍薬のリポソーム化製剤 |
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| CA2412165A1 (en) | 2001-12-20 |
| IL153230A0 (en) | 2003-07-06 |
| US6689381B2 (en) | 2004-02-10 |
| JP2004503491A (ja) | 2004-02-05 |
| KR100851957B1 (ko) | 2008-08-12 |
| MXPA02012068A (es) | 2004-08-19 |
| AU2001275269B2 (en) | 2006-07-13 |
| BR0111541A (pt) | 2003-07-01 |
| IL153230A (en) | 2009-02-11 |
| KR20030038552A (ko) | 2003-05-16 |
| AU7526901A (en) | 2001-12-24 |
| US20020034538A1 (en) | 2002-03-21 |
| EP1286661A2 (en) | 2003-03-05 |
| US20040057990A1 (en) | 2004-03-25 |
| TWI282741B (en) | 2007-06-21 |
| WO2001095884A2 (en) | 2001-12-20 |
| WO2001095884A3 (en) | 2002-06-13 |
| NZ522842A (en) | 2004-11-26 |
| PL360470A1 (en) | 2004-09-06 |
| CN1446080A (zh) | 2003-10-01 |
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