ZA200208167B - Method and composition for treating cancer by administration of apoptosis-inducing chemotherapeutic agents. - Google Patents

Method and composition for treating cancer by administration of apoptosis-inducing chemotherapeutic agents. Download PDF

Info

Publication number
ZA200208167B
ZA200208167B ZA200208167A ZA200208167A ZA200208167B ZA 200208167 B ZA200208167 B ZA 200208167B ZA 200208167 A ZA200208167 A ZA 200208167A ZA 200208167 A ZA200208167 A ZA 200208167A ZA 200208167 B ZA200208167 B ZA 200208167B
Authority
ZA
South Africa
Prior art keywords
chemotherapeutic
reservoir
microspheres
tumor
composition
Prior art date
Application number
ZA200208167A
Other languages
English (en)
Inventor
Moshe Flashner-Barak
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of ZA200208167B publication Critical patent/ZA200208167B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38Albumins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200208167A 2000-04-10 2002-10-10 Method and composition for treating cancer by administration of apoptosis-inducing chemotherapeutic agents. ZA200208167B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19592000P 2000-04-10 2000-04-10

Publications (1)

Publication Number Publication Date
ZA200208167B true ZA200208167B (en) 2004-02-10

Family

ID=22723363

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200208167A ZA200208167B (en) 2000-04-10 2002-10-10 Method and composition for treating cancer by administration of apoptosis-inducing chemotherapeutic agents.

Country Status (19)

Country Link
US (1) US20020041888A1 (cs)
EP (1) EP1274404A1 (cs)
JP (1) JP2004507451A (cs)
KR (1) KR20030008368A (cs)
CN (1) CN1438882A (cs)
AU (1) AU2001253334A1 (cs)
BR (1) BR0110150A (cs)
CA (1) CA2406484A1 (cs)
CZ (1) CZ20023333A3 (cs)
EA (1) EA200201068A1 (cs)
HU (1) HUP0302296A2 (cs)
IL (1) IL152180A0 (cs)
MX (1) MXPA02009984A (cs)
NO (1) NO20024867L (cs)
PL (1) PL366035A1 (cs)
SK (1) SK14452002A3 (cs)
WO (1) WO2001076567A1 (cs)
YU (1) YU77002A (cs)
ZA (1) ZA200208167B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20020681A1 (it) * 2002-03-29 2003-09-29 Acs Dobfar Spa Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina
ITMI20020680A1 (it) * 2002-03-29 2003-09-29 Acs Dobfar Spa Composizione antitumorale migliorata a base di paclitaxel e metodo per il suo ottenimento
WO2003090722A2 (en) * 2002-04-26 2003-11-06 Teva Pharmaceutical Industries, Ltd. Microparticle pharmaceutical compositions for intratumoral delivery
CN1319525C (zh) * 2004-09-16 2007-06-06 北京圣医耀科技发展有限责任公司 紫杉醇-海藻酸钠微球血管栓塞剂及其制备
US8940311B2 (en) * 2004-10-21 2015-01-27 Tae-Hong Lim In situ controlled release drug delivery system
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
CA3054535A1 (en) 2005-02-18 2006-08-24 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
EP1896007B1 (en) 2005-05-04 2014-03-19 Medigene AG Method of administering a cationic liposomal preparation comprising paclitexel
MX2008011978A (es) 2006-03-22 2009-04-22 Medigene Ag Tratamiento del cancer de seno negativo al triple receptor.
EP2552415B1 (en) 2010-03-29 2016-09-07 Abraxis BioScience, LLC Methods of treating cancer
MX2012011155A (es) 2010-03-29 2012-12-05 Abraxis Bioscience Llc Metodos para mejorar suministros de farmacos y efectividad de agentes terapeuticos.
NZ706745A (en) 2010-06-04 2017-01-27 Abraxis Bioscience Llc Methods of treatment of pancreatic cancer
CN103429267B (zh) 2011-01-09 2016-05-04 Anp科技公司 疏水分子诱导的支化聚合物集合体及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4345588A (en) * 1979-04-23 1982-08-24 Northwestern University Method of delivering a therapeutic agent to a target capillary bed
US4492720A (en) * 1983-11-15 1985-01-08 Benjamin Mosier Method of preparing microspheres for intravascular delivery
HUP9701554D0 (en) * 1997-09-18 1997-11-28 Human Oltoanyagtermeloe Gyogys Pharmaceutical composition containing plazma proteins

Also Published As

Publication number Publication date
YU77002A (sh) 2005-09-19
AU2001253334A1 (en) 2001-10-23
EA200201068A1 (ru) 2003-12-25
EP1274404A1 (en) 2003-01-15
CN1438882A (zh) 2003-08-27
MXPA02009984A (es) 2004-09-10
JP2004507451A (ja) 2004-03-11
PL366035A1 (en) 2005-01-24
NO20024867L (no) 2002-12-06
CA2406484A1 (en) 2001-10-18
SK14452002A3 (sk) 2003-07-01
HUP0302296A2 (hu) 2003-10-28
CZ20023333A3 (cs) 2003-06-18
WO2001076567A1 (en) 2001-10-18
IL152180A0 (en) 2003-05-29
US20020041888A1 (en) 2002-04-11
BR0110150A (pt) 2004-04-27
KR20030008368A (ko) 2003-01-25
NO20024867D0 (no) 2002-10-09

Similar Documents

Publication Publication Date Title
EP1155692B1 (en) Use of Paclitaxel stabilized with albumin for preparing a drug for the treatment of solid tumors and the drug obtained thereby
ZA200208167B (en) Method and composition for treating cancer by administration of apoptosis-inducing chemotherapeutic agents.
Wang et al. Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model
US20090162425A1 (en) Methods and compositions for inhibiting undesirable cellular proliferation by targeted liposome delivery of active agents
KR20140027554A (ko) 약리학적 물질의 조성물 및 그 전달방법
WO2012095543A1 (es) Nanocápsulas con cubierta polimérica
CN109771663B (zh) 一种酸响应性抗癌纳米药物的制备及应用
CA2631243A1 (en) Liposomal compositions
US20220161013A1 (en) Improved delivery of drug therapy to the cns by ultrasound-based opening of the blood-brain barrier
KR100633280B1 (ko) 약제학적 활성 펩티드의 서방형 투여 형태 및 이의 제조 방법
Jeswani et al. Advances in the delivery of cancer therapeutics: a comprehensive review
Naeini et al. Multivesicular liposomes as a potential drug delivery platform for cancer therapy: A systematic review
KR20010005740A (ko) 난소암 치료를 위한 방법과 조성물
US6569459B2 (en) Method of administration of paclitaxel-plasma protein formulation
US20050019386A1 (en) Orally administered pharmaceutical preparation comprising liposomically encapsulated paclitaxel
CN102078301A (zh) 以白蛋白与磷脂为载体的多西他赛纳米制剂及其制备方法
Okumu et al. Implants and injectables
CA2309947A1 (en) Enhanced opening of abnormal brain tissue capillaries
CN1511037A (zh) 非肠道使用的雌莫司汀磷酸盐和白蛋白的制剂
Aparicio-Blanco et al. Managing CNS Tumors: The Nanomedicine Approach
JP2001508810A (ja) 静脈内エストラムスチンリン酸の有効性を高める方法
EP0998279B1 (en) Pharmaceutical injection solution containing taxol
Haque et al. Interstitial chemotherapy and polymer-drug delivery
WO2024098032A1 (en) Use of dianhydrogalactitol in treating ependymoma
US20200121807A1 (en) Anti-Cancer Agents