ZA200207535B - 4-hydroxyl-1,8-naphthyridine-3-carboxamides as antiviral agents. - Google Patents
4-hydroxyl-1,8-naphthyridine-3-carboxamides as antiviral agents. Download PDFInfo
- Publication number
- ZA200207535B ZA200207535B ZA200207535A ZA200207535A ZA200207535B ZA 200207535 B ZA200207535 B ZA 200207535B ZA 200207535 A ZA200207535 A ZA 200207535A ZA 200207535 A ZA200207535 A ZA 200207535A ZA 200207535 B ZA200207535 B ZA 200207535B
- Authority
- ZA
- South Africa
- Prior art keywords
- methyl
- hydroxy
- composition
- het
- compound
- Prior art date
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- 239000003443 antiviral agent Substances 0.000 title description 5
- PKMFXPIZWVLGFQ-UHFFFAOYSA-N 4-oxo-1h-1,8-naphthyridine-3-carboxamide Chemical class C1=CC=C2C(=O)C(C(=O)N)=CNC2=N1 PKMFXPIZWVLGFQ-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 82
- 239000000203 mixture Substances 0.000 claims description 50
- 125000003118 aryl group Chemical group 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 38
- -1 cyano, phenyl Chemical group 0.000 claims description 26
- 125000005843 halogen group Chemical group 0.000 claims description 25
- 125000001424 substituent group Chemical group 0.000 claims description 22
- 238000002360 preparation method Methods 0.000 claims description 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
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- 241000282414 Homo sapiens Species 0.000 claims description 9
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- 230000037396 body weight Effects 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 6
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- DUDCRNHOLUWPDX-UHFFFAOYSA-N 1,8-naphthyridine-3-carboxamide Chemical compound N1=CC=CC2=CC(C(=O)N)=CN=C21 DUDCRNHOLUWPDX-UHFFFAOYSA-N 0.000 claims description 5
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19097800P | 2000-03-21 | 2000-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200207535B true ZA200207535B (en) | 2003-12-19 |
Family
ID=22703589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200207535A ZA200207535B (en) | 2000-03-21 | 2002-09-19 | 4-hydroxyl-1,8-naphthyridine-3-carboxamides as antiviral agents. |
Country Status (14)
| Country | Link |
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| US (1) | US6413958B2 (zh) |
| EP (1) | EP1265896A1 (zh) |
| JP (1) | JP2003528102A (zh) |
| KR (1) | KR20030013378A (zh) |
| CN (1) | CN1418214A (zh) |
| AR (1) | AR030195A1 (zh) |
| AU (1) | AU2001243241A1 (zh) |
| BR (1) | BR0108845A (zh) |
| CA (1) | CA2399991A1 (zh) |
| HK (1) | HK1054037A1 (zh) |
| MX (1) | MXPA02009250A (zh) |
| NZ (1) | NZ521523A (zh) |
| WO (1) | WO2001070742A1 (zh) |
| ZA (1) | ZA200207535B (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004106334A2 (en) * | 2003-05-28 | 2004-12-09 | Pfizer Products Inc. | Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation |
| US7420059B2 (en) * | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
| NZ587551A (en) * | 2004-06-24 | 2012-01-12 | Vertex Pharma | 5-Amino-phenol derivatives such as 5-amino-2,4-di-tert-butyl-phenol |
| US8513420B2 (en) | 2007-03-19 | 2013-08-20 | Monika Mazik | Amino-naphthyridine derivatives |
| EP1972627A1 (en) * | 2007-03-19 | 2008-09-24 | Technische Universität Carolo-Wilhelmina zu Braunschweig | Amino-napthyridine derivatives |
| EP2855479B1 (en) | 2012-04-05 | 2016-03-30 | Boehringer Ingelheim International GmbH | 1,8-naphthyridin-2(1h)-one derivatives as cytomegalovirus inhibitors |
| CA2873861C (en) | 2012-04-05 | 2021-01-19 | Boehringer Ingelheim International Gmbh | Naphthyridinone derivatives as inhibitors of cytomegalovirus dna polymerase |
| CN112996789A (zh) | 2018-09-12 | 2021-06-18 | 诺华股份有限公司 | 抗病毒吡啶并吡嗪二酮化合物 |
| WO2021061898A1 (en) | 2019-09-26 | 2021-04-01 | Novartis Ag | Antiviral pyrazolopyridinone compounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4568649A (en) | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| GB8513639D0 (en) | 1985-05-30 | 1985-07-03 | Ici America Inc | Cinnoline compounds |
| GB8702288D0 (en) | 1987-02-02 | 1987-03-11 | Erba Farmitalia | Cinnoline-carboxamides |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US4959363A (en) | 1989-06-23 | 1990-09-25 | Sterling Drug Inc. | Quinolonecarboxamide compounds, their preparation and use as antivirals. |
| MX9800921A (es) | 1995-08-02 | 1998-05-31 | Chirotech Technology Ltd | Quinolonas y su uso terapeutico. |
| DE69628019T2 (de) | 1995-08-02 | 2004-01-22 | Darwin Discovery Ltd., Slough | Chinolone und deren therapeutische verwendung |
| US6310211B1 (en) | 1996-09-10 | 2001-10-30 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
| KR20000068711A (ko) | 1997-08-06 | 2000-11-25 | 도리이 신이치로 | Ⅳ형 포스포디에스테라제 억제제로서의 1-아릴-1,8-나프틸리딘-4-온 유도체 |
| RU2220960C2 (ru) | 1997-12-22 | 2004-01-10 | Фармация Энд Апджон Компани | 4-гидрокси-3-хинолинкарбоксамиды и гидразиды, фармацевтическая композиция и способ лечения на их основе |
| HUP0002353A3 (en) | 1998-01-29 | 2001-11-28 | Daiichi Asubio Pharma Co Ltd | 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phoshodiesterase iv inhibitory activity and pharmaceutical compositions containing them |
-
2001
- 2001-03-15 CN CN01806468A patent/CN1418214A/zh active Pending
- 2001-03-15 AU AU2001243241A patent/AU2001243241A1/en not_active Abandoned
- 2001-03-15 NZ NZ521523A patent/NZ521523A/en unknown
- 2001-03-15 MX MXPA02009250A patent/MXPA02009250A/es not_active Application Discontinuation
- 2001-03-15 BR BR0108845-9A patent/BR0108845A/pt not_active IP Right Cessation
- 2001-03-15 KR KR1020027012471A patent/KR20030013378A/ko not_active Application Discontinuation
- 2001-03-15 JP JP2001568943A patent/JP2003528102A/ja active Pending
- 2001-03-15 CA CA002399991A patent/CA2399991A1/en not_active Abandoned
- 2001-03-15 EP EP01916184A patent/EP1265896A1/en not_active Withdrawn
- 2001-03-15 WO PCT/US2001/005809 patent/WO2001070742A1/en not_active Application Discontinuation
- 2001-03-15 US US09/808,872 patent/US6413958B2/en not_active Expired - Fee Related
- 2001-03-20 AR ARP010101302A patent/AR030195A1/es unknown
-
2002
- 2002-09-19 ZA ZA200207535A patent/ZA200207535B/en unknown
-
2003
- 2003-09-09 HK HK03106396.4A patent/HK1054037A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1418214A (zh) | 2003-05-14 |
| AR030195A1 (es) | 2003-08-13 |
| CA2399991A1 (en) | 2001-09-27 |
| EP1265896A1 (en) | 2002-12-18 |
| US6413958B2 (en) | 2002-07-02 |
| WO2001070742A1 (en) | 2001-09-27 |
| US20020007066A1 (en) | 2002-01-17 |
| BR0108845A (pt) | 2003-05-06 |
| KR20030013378A (ko) | 2003-02-14 |
| NZ521523A (en) | 2004-05-28 |
| JP2003528102A (ja) | 2003-09-24 |
| HK1054037A1 (zh) | 2003-11-14 |
| AU2001243241A1 (en) | 2001-10-03 |
| MXPA02009250A (es) | 2003-03-12 |
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