ZA200207208B - Azole compounds as therapeutic agents for fungal infections. - Google Patents
Azole compounds as therapeutic agents for fungal infections. Download PDFInfo
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- ZA200207208B ZA200207208B ZA200207208A ZA200207208A ZA200207208B ZA 200207208 B ZA200207208 B ZA 200207208B ZA 200207208 A ZA200207208 A ZA 200207208A ZA 200207208 A ZA200207208 A ZA 200207208A ZA 200207208 B ZA200207208 B ZA 200207208B
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- South Africa
- Prior art keywords
- group
- hydroxy
- amino
- alkoxy
- compound
- Prior art date
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- 206010017533 Fungal infection Diseases 0.000 title claims description 18
- 208000031888 Mycoses Diseases 0.000 title claims description 18
- 239000003814 drug Substances 0.000 title description 9
- 150000003851 azoles Chemical class 0.000 title description 6
- 229940124597 therapeutic agent Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 180
- 125000000217 alkyl group Chemical group 0.000 claims description 157
- 229910052736 halogen Inorganic materials 0.000 claims description 150
- 125000003545 alkoxy group Chemical group 0.000 claims description 149
- 125000001424 substituent group Chemical group 0.000 claims description 116
- 229910052739 hydrogen Inorganic materials 0.000 claims description 114
- -1 carboxyl hydroxy Chemical group 0.000 claims description 100
- 239000001257 hydrogen Substances 0.000 claims description 91
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 91
- 125000005843 halogen group Chemical group 0.000 claims description 83
- 150000002431 hydrogen Chemical group 0.000 claims description 81
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 65
- 150000002367 halogens Chemical class 0.000 claims description 64
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 54
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 47
- 125000003118 aryl group Chemical group 0.000 claims description 44
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 31
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- 125000004423 acyloxy group Chemical group 0.000 claims description 18
- 229940002612 prodrug Drugs 0.000 claims description 16
- 239000000651 prodrug Substances 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 15
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 14
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- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 1
- 229940058690 lanosterol Drugs 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 125000005186 naphthyloxy group Chemical group C1(=CC=CC2=CC=CC=C12)O* 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000327 ocular toxicity Toxicity 0.000 description 1
- 244000039328 opportunistic pathogen Species 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 125000001174 sulfone group Chemical group 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 229960004214 tioconazole Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN198DE2000 IN191188B (en, 2012) | 2000-03-07 | 2000-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200207208B true ZA200207208B (en) | 2003-07-04 |
Family
ID=29727197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200207208A ZA200207208B (en) | 2000-03-07 | 2002-09-09 | Azole compounds as therapeutic agents for fungal infections. |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US6670363B1 (en, 2012) |
| IN (1) | IN191188B (en, 2012) |
| ZA (1) | ZA200207208B (en, 2012) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006076097A2 (en) * | 2004-12-07 | 2006-07-20 | Nektar Therapeutics | Stable non-crystalline formulation comprising losartan |
| AR109545A1 (es) * | 2016-09-29 | 2018-12-19 | Bayer Cropscience Ag | Derivados de triazol |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3262386D1 (en) | 1981-06-06 | 1985-03-28 | Pfizer Ltd | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
| US5023258A (en) | 1989-06-20 | 1991-06-11 | Pfizer Inc. | Triazole antifungal agents |
| US5371181A (en) | 1990-11-28 | 1994-12-06 | Loctite Corporation | Thiol-ene compositions with improved cure speed retention |
| TW218017B (en, 2012) | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd | |
| CA2093481A1 (en) | 1992-04-30 | 1993-10-31 | Gottlieb Schacher | Processing station for carrying out fluorescence polarization measurements in an analyzer |
-
2000
- 2000-03-07 IN IN198DE2000 patent/IN191188B/en unknown
- 2000-05-22 US US09/575,578 patent/US6670363B1/en not_active Expired - Fee Related
-
2002
- 2002-09-09 ZA ZA200207208A patent/ZA200207208B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6670363B1 (en) | 2003-12-30 |
| IN191188B (en, 2012) | 2003-10-04 |
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