ZA200205566B - Cyclic quaternary ammonium compounds. - Google Patents

Cyclic quaternary ammonium compounds.

Info

Publication number
ZA200205566B
ZA200205566B ZA200205566A ZA200205566A ZA200205566B ZA 200205566 B ZA200205566 B ZA 200205566B ZA 200205566 A ZA200205566 A ZA 200205566A ZA 200205566 A ZA200205566 A ZA 200205566A ZA 200205566 B ZA200205566 B ZA 200205566B
Authority
ZA
South Africa
Prior art keywords
quaternary ammonium
ammonium compounds
cyclic quaternary
cyclic
compounds
Prior art date
Application number
ZA200205566A
Other languages
English (en)
Inventor
Lewis Liu Leung Choi
Clive P Page
Gregory N Beatch
Original Assignee
Ucb Farchim Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Farchim Sa filed Critical Ucb Farchim Sa
Publication of ZA200205566B publication Critical patent/ZA200205566B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ZA200205566A 1999-12-15 2002-07-11 Cyclic quaternary ammonium compounds. ZA200205566B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2292351 1999-12-15

Publications (1)

Publication Number Publication Date
ZA200205566B true ZA200205566B (en) 2003-11-17

Family

ID=4164887

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200205566A ZA200205566B (en) 1999-12-15 2002-07-11 Cyclic quaternary ammonium compounds.

Country Status (19)

Country Link
US (1) US20030166629A1 (cs)
EP (1) EP1278731A1 (cs)
JP (1) JP2003516966A (cs)
KR (1) KR20020074170A (cs)
CN (1) CN1425005A (cs)
AU (1) AU2334501A (cs)
BG (1) BG106816A (cs)
BR (1) BR0016431A (cs)
CZ (1) CZ20022095A3 (cs)
EE (1) EE200200314A (cs)
HU (1) HUP0301686A2 (cs)
IL (1) IL150179A0 (cs)
IS (1) IS6417A (cs)
MX (1) MXPA02006051A (cs)
NO (1) NO20022870L (cs)
PL (1) PL356032A1 (cs)
WO (1) WO2001044192A1 (cs)
YU (1) YU44102A (cs)
ZA (1) ZA200205566B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010510227A (ja) 2006-11-20 2010-04-02 プレジデント アンド フェロウズ オブ ハーバード カレッジ 痛みおよび痒みの治療方法、組成物およびキット
AU2009223739A1 (en) * 2008-03-11 2009-09-17 President And Fellows Of Harvard College Methods, compositions, and kits for treating pain and pruritis
CA3027255C (en) * 2009-07-10 2022-06-21 The General Hospital Corporation Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
WO2014085154A1 (en) 2012-11-27 2014-06-05 Beth Israel Deaconess Medical Center, Inc. Methods for treating renal disease
WO2015120069A1 (en) 2014-02-04 2015-08-13 Beth Israel Deaconess Medical Center, Inc. Methods and kits for the diagnosis and treatment of pancreatic cancer
CA2994545A1 (en) * 2015-08-03 2017-02-09 President And Fellows Of Harvard College Charged ion channel blockers and methods for use
MA55318A (fr) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Bloqueurs de canaux ioniques chargés et procédés d'utilisation
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN113795248A (zh) 2019-03-11 2021-12-14 诺西恩医疗公司 带电荷的离子通道阻滞剂及其使用方法
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2020185915A1 (en) 2019-03-11 2020-09-17 Nocion Therapeutics, Inc. Ester substituted ion channel blockers and methods for use
CN114828845A (zh) 2019-11-06 2022-07-29 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
EP4054586A4 (en) 2019-11-06 2023-11-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP7708777B2 (ja) 2020-03-11 2025-07-15 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI58632C (fi) * 1978-02-07 1981-03-10 Orion Yhtymae Oy Foerfarande foer framstaellning av anilider med antitussiv verkan

Also Published As

Publication number Publication date
KR20020074170A (ko) 2002-09-28
WO2001044192A1 (en) 2001-06-21
EE200200314A (et) 2003-08-15
IS6417A (is) 2002-06-12
EP1278731A1 (en) 2003-01-29
NO20022870L (no) 2002-08-14
MXPA02006051A (es) 2004-08-23
JP2003516966A (ja) 2003-05-20
US20030166629A1 (en) 2003-09-04
CN1425005A (zh) 2003-06-18
BR0016431A (pt) 2002-10-01
NO20022870D0 (no) 2002-06-14
BG106816A (en) 2003-04-30
IL150179A0 (en) 2002-12-01
YU44102A (sh) 2005-09-19
PL356032A1 (en) 2004-06-14
HUP0301686A2 (hu) 2003-08-28
CZ20022095A3 (cs) 2003-02-12
AU2334501A (en) 2001-06-25

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