ZA200203050B - Novel hydronaphtalene compounds, prepared by a rhodium catalyzed ring opening reaction in the presence of phosphine ligand. - Google Patents

Novel hydronaphtalene compounds, prepared by a rhodium catalyzed ring opening reaction in the presence of phosphine ligand. Download PDF

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Publication number
ZA200203050B
ZA200203050B ZA200203050A ZA200203050A ZA200203050B ZA 200203050 B ZA200203050 B ZA 200203050B ZA 200203050 A ZA200203050 A ZA 200203050A ZA 200203050 A ZA200203050 A ZA 200203050A ZA 200203050 B ZA200203050 B ZA 200203050B
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compound
dihydro
naphthalen
formula
alkyl
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ZA200203050A
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English (en)
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Keith Fagnou
Mark Lautens
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Astrazeneca Ab
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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ZA200203050A 1999-10-29 2002-04-17 Novel hydronaphtalene compounds, prepared by a rhodium catalyzed ring opening reaction in the presence of phosphine ligand. ZA200203050B (en)

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SE9903930A SE9903930D0 (sv) 1999-10-29 1999-10-29 Novel compounds and a novel process for their preparation

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Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
DE602004021358D1 (de) * 2003-03-25 2009-07-16 Fournier Lab Sa Benzosulfonamide derivate, deren verfahren zum herstellung, und deren verwendung zur behandlung von schmerzen
FR2852958B1 (fr) * 2003-03-25 2005-06-24 Fournier Lab Sa Nouveaux derives de benzenesulfonamides et leur utilisation en therapeutique
US7638515B2 (en) 2003-10-08 2009-12-29 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
JP4638438B2 (ja) 2003-10-08 2011-02-23 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト テトラヒドロナフタレン誘導体類、それらの生成方法及び抗−炎症剤としてのそれらの使用
US7662821B2 (en) 2003-10-08 2010-02-16 Bayer Schering Pharma Ag Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US20080153859A1 (en) 2004-04-05 2008-06-26 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
DE102005017316A1 (de) * 2005-04-14 2006-10-19 Schering Ag Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
EP1834948A1 (de) 2006-03-15 2007-09-19 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
EP2070903A1 (en) 2007-12-12 2009-06-17 Laboratorios del Dr. Esteve S.A. Microwave-assisted ring opening reaction
EP2070904A1 (en) 2007-12-12 2009-06-17 Laboratorios Del. Dr. Esteve, S.A. Rhodium-phosphorus complexes and their use in ring opening reactions
KR101229822B1 (ko) 2008-03-04 2013-02-05 연세대학교 산학협력단 혈관신생 억제용 약제학적 조성물
EP2098511A1 (en) * 2008-03-07 2009-09-09 Solvias AG Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring
JP5656364B2 (ja) * 2009-04-20 2015-01-21 株式会社トクヤマ ナフトピラン誘導体の製造方法
CN104744321A (zh) * 2010-01-27 2015-07-01 武田药品工业株式会社 用于抑制由抗癌剂诱导的外周神经障碍的化合物
JP6236785B2 (ja) * 2012-02-28 2017-11-29 株式会社リコー アリールアミン化合物、有機ｅｌ用材料およびその製造方法
CN105399752B (zh) * 2015-11-04 2019-03-15 云南民族大学 一种新型化合物及其制备方法和应用
US11560384B2 (en) 2017-05-04 2023-01-24 University Of Utah Research Foundation Benzonorbornadiene derivatives and reactions thereof
CN108863855B (zh) * 2018-05-29 2020-12-15 云南民族大学 一种合成(1r,2s)-1,2-二氢化萘-1,2-二胺衍生物的方法
CN111471005B (zh) * 2020-05-21 2023-04-07 南方科技大学 一种吲哚-二氢化萘类化合物及其制备方法和应用
CN116459873A (zh) * 2022-01-12 2023-07-21 万华化学集团股份有限公司 一种烯属不饱和化合物羰基化催化剂及其制备方法、应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4031097A (en) * 1997-08-27 1999-03-16 Kyowa Hakko Kogyo Co. Ltd. Process for preparing optically active 1,2-diols

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