ZA200202284B - alphavbeta3 integrin inhibitors. - Google Patents
alphavbeta3 integrin inhibitors. Download PDFInfo
- Publication number
- ZA200202284B ZA200202284B ZA200202284A ZA200202284A ZA200202284B ZA 200202284 B ZA200202284 B ZA 200202284B ZA 200202284 A ZA200202284 A ZA 200202284A ZA 200202284 A ZA200202284 A ZA 200202284A ZA 200202284 B ZA200202284 B ZA 200202284B
- Authority
- ZA
- South Africa
- Prior art keywords
- ylamino
- acid
- phenyl
- compounds
- formula
- Prior art date
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- 108010044426 integrins Proteins 0.000 title claims description 14
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- 239000000203 mixture Substances 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 29
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- 150000003839 salts Chemical class 0.000 claims description 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 17
- 238000006243 chemical reaction Methods 0.000 claims description 16
- 239000004480 active ingredient Substances 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 12
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Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19939980A DE19939980A1 (de) | 1999-08-24 | 1999-08-24 | Inhibitoren des Integrins alphavbeta¶3¶ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200202284B true ZA200202284B (en) | 2003-08-27 |
Family
ID=7919342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200202284A ZA200202284B (en) | 1999-08-24 | 2002-03-20 | alphavbeta3 integrin inhibitors. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6645991B1 (ko) |
| EP (1) | EP1206455A1 (ko) |
| JP (1) | JP2003507457A (ko) |
| KR (1) | KR20020086849A (ko) |
| CN (1) | CN1370146A (ko) |
| AR (1) | AR034692A1 (ko) |
| AU (1) | AU6992500A (ko) |
| BR (1) | BR0013502A (ko) |
| CA (1) | CA2382561A1 (ko) |
| CZ (1) | CZ2002525A3 (ko) |
| DE (1) | DE19939980A1 (ko) |
| HK (1) | HK1049667A1 (ko) |
| HU (1) | HUP0203212A3 (ko) |
| MX (1) | MXPA02001862A (ko) |
| NO (1) | NO20020885D0 (ko) |
| PL (1) | PL352987A1 (ko) |
| SK (1) | SK2272002A3 (ko) |
| WO (1) | WO2001014337A1 (ko) |
| ZA (1) | ZA200202284B (ko) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0008696D0 (en) | 2000-04-07 | 2000-05-31 | Merck Sharp & Dohme | Therapeutic agents |
| UY26780A1 (es) | 2000-06-15 | 2002-01-31 | Pharmacia Corp | Cicloalquil avb3 antagonistas |
| US6531494B1 (en) | 2001-08-29 | 2003-03-11 | Pharmacia Corporation | Gem-substituted αvβ3 antagonists |
| DE10063173A1 (de) * | 2000-12-18 | 2002-06-20 | Merck Patent Gmbh | Harnstoff- und Urethanderivate |
| AU783516B2 (en) | 2001-04-30 | 2005-11-03 | Warner-Lambert Company | Methods, kits and compositions for using pyrrole derivatives |
| KR101085784B1 (ko) * | 2001-10-22 | 2011-11-25 | 더 스크립스 리서치 인스티튜트 | 인테그린 표적화 화합물 |
| WO2005039485A2 (en) * | 2003-08-13 | 2005-05-06 | Chiron Corporation | Gsk-3 inhibitors and uses thereof |
| MXPA06014092A (es) | 2004-06-04 | 2007-03-15 | Scripps Research Inst | Composiciones y metodos para el tratamiento de enfermedades neovasculares. |
| WO2006111925A2 (en) * | 2005-04-18 | 2006-10-26 | Sloan-Kettering Institute For Cancer Research | Inhibition of tumorigenesis by inhibition of a6b4 integrin |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234936A (en) * | 1991-10-24 | 1993-08-10 | American Home Products Corporation | Pyrimidocycloalkanes as a ii antagonists |
| US5654322A (en) * | 1992-08-11 | 1997-08-05 | Wakunaga Seiyaku Kabushiki Kaisha | Biphenylmethane derivatives and pharmaceuticals containing the same |
| EP0628559B1 (en) * | 1993-06-10 | 2002-04-03 | Beiersdorf-Lilly GmbH | Pyrimidine compounds and their use as pharmaceuticals |
| PL327626A1 (en) | 1995-12-29 | 1998-12-21 | Smithkline Beecham Corp | Antagonists of vitronectin receptor |
| ES2162676T3 (es) * | 1996-03-29 | 2002-01-01 | Searle & Co | Derivados de fenileno sustituidos en meta y su uso como antagonistas o inhibidores de integrina alfav,beta3. |
| US6177452B1 (en) | 1996-04-03 | 2001-01-23 | Takeda Chemical Industries, Ltd. | Oxazole derivatives, their production and use |
| KR20010041812A (ko) * | 1998-03-10 | 2001-05-25 | 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 | 비트로넥틴 수용체 길항제 |
| PL350998A1 (en) | 1999-03-24 | 2003-02-24 | Anormed Inc | Chemokine recpetor binding heterocyclic compounds |
-
1999
- 1999-08-24 DE DE19939980A patent/DE19939980A1/de not_active Withdrawn
-
2000
- 2000-08-04 JP JP2001518426A patent/JP2003507457A/ja active Pending
- 2000-08-04 BR BR0013502-0A patent/BR0013502A/pt not_active IP Right Cessation
- 2000-08-04 MX MXPA02001862A patent/MXPA02001862A/es unknown
- 2000-08-04 CA CA002382561A patent/CA2382561A1/en not_active Abandoned
- 2000-08-04 US US10/069,187 patent/US6645991B1/en not_active Expired - Fee Related
- 2000-08-04 WO PCT/EP2000/007590 patent/WO2001014337A1/de not_active Application Discontinuation
- 2000-08-04 EP EP00958381A patent/EP1206455A1/de not_active Withdrawn
- 2000-08-04 KR KR1020027001418A patent/KR20020086849A/ko not_active Application Discontinuation
- 2000-08-04 AU AU69925/00A patent/AU6992500A/en not_active Abandoned
- 2000-08-04 CN CN00811880A patent/CN1370146A/zh active Pending
- 2000-08-04 CZ CZ2002525A patent/CZ2002525A3/cs unknown
- 2000-08-04 HU HU0203212A patent/HUP0203212A3/hu unknown
- 2000-08-04 SK SK227-2002A patent/SK2272002A3/sk unknown
- 2000-08-04 PL PL00352987A patent/PL352987A1/xx unknown
- 2000-08-23 AR ARP000104353A patent/AR034692A1/es not_active Application Discontinuation
-
2002
- 2002-02-22 NO NO20020885A patent/NO20020885D0/no not_active Application Discontinuation
- 2002-03-20 ZA ZA200202284A patent/ZA200202284B/en unknown
-
2003
- 2003-03-13 HK HK03101817.6A patent/HK1049667A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20020086849A (ko) | 2002-11-20 |
| US6645991B1 (en) | 2003-11-11 |
| NO20020885L (no) | 2002-02-22 |
| HK1049667A1 (zh) | 2003-05-23 |
| SK2272002A3 (en) | 2002-06-04 |
| MXPA02001862A (es) | 2002-10-23 |
| HUP0203212A2 (hu) | 2003-02-28 |
| BR0013502A (pt) | 2002-05-07 |
| JP2003507457A (ja) | 2003-02-25 |
| EP1206455A1 (de) | 2002-05-22 |
| HUP0203212A3 (en) | 2005-02-28 |
| WO2001014337A1 (de) | 2001-03-01 |
| AU6992500A (en) | 2001-03-19 |
| AR034692A1 (es) | 2004-03-17 |
| PL352987A1 (en) | 2003-09-22 |
| DE19939980A1 (de) | 2001-03-01 |
| NO20020885D0 (no) | 2002-02-22 |
| CA2382561A1 (en) | 2001-03-01 |
| CN1370146A (zh) | 2002-09-18 |
| CZ2002525A3 (cs) | 2002-05-15 |
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