ZA200007174B - Method for the treatment of insomnia. - Google Patents
Method for the treatment of insomnia. Download PDFInfo
- Publication number
- ZA200007174B ZA200007174B ZA200007174A ZA200007174A ZA200007174B ZA 200007174 B ZA200007174 B ZA 200007174B ZA 200007174 A ZA200007174 A ZA 200007174A ZA 200007174 A ZA200007174 A ZA 200007174A ZA 200007174 B ZA200007174 B ZA 200007174B
- Authority
- ZA
- South Africa
- Prior art keywords
- substance
- formula
- composition
- treatment
- gabapentin
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 25
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title claims description 14
- 206010022437 insomnia Diseases 0.000 title claims description 14
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims description 38
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 19
- 229960002870 gabapentin Drugs 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims description 10
- 229960001233 pregabalin Drugs 0.000 claims description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 241000124008 Mammalia Species 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
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- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 3
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- 230000000147 hypnotic effect Effects 0.000 description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
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- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 2
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- 206010037764 Radiation myelopathy Diseases 0.000 description 1
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- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 1
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- 239000000938 histamine H1 antagonist Substances 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9216698P | 1998-07-09 | 1998-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200007174B true ZA200007174B (en) | 2002-03-04 |
Family
ID=22231954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200007174A ZA200007174B (en) | 1998-07-09 | 2000-12-04 | Method for the treatment of insomnia. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6306910B1 (ko) |
| EP (1) | EP1094803A2 (ko) |
| JP (1) | JP2002520277A (ko) |
| KR (1) | KR20010071778A (ko) |
| AU (1) | AU765038B2 (ko) |
| BR (1) | BR9911887A (ko) |
| CA (1) | CA2333024C (ko) |
| ID (1) | ID27191A (ko) |
| NO (1) | NO20010117L (ko) |
| NZ (1) | NZ509231A (ko) |
| PL (1) | PL345338A1 (ko) |
| WO (1) | WO2000002546A2 (ko) |
| ZA (1) | ZA200007174B (ko) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998003167A1 (en) | 1996-07-24 | 1998-01-29 | Warner-Lambert Company | Isobutylgaba and its derivatives for the treatment of pain |
| US6992109B1 (en) * | 1999-04-08 | 2006-01-31 | Segal Catherine A | Method for the treatment of incontinence |
| US7164034B2 (en) * | 1999-06-10 | 2007-01-16 | Pfizer Inc. | Alpha2delta ligands for fibromyalgia and other disorders |
| US20080207755A1 (en) * | 2000-05-31 | 2008-08-28 | Pfizer Inc | Alpha 2 Delta Ligands For Fibromyalgia and Other Disorders |
| KR100785182B1 (ko) * | 2000-06-26 | 2007-12-11 | 워너-램버트 캄파니 엘엘씨 | 수면 장애를 위한 가바펜틴 유사체 |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
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Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510381A (en) | 1995-05-15 | 1996-04-23 | Warner-Lambert Company | Method of treatment of mania and bipolar disorder |
-
1999
- 1999-07-01 JP JP2000558806A patent/JP2002520277A/ja active Pending
- 1999-07-01 AU AU49673/99A patent/AU765038B2/en not_active Ceased
- 1999-07-01 ID IDW20010056A patent/ID27191A/id unknown
- 1999-07-01 PL PL99345338A patent/PL345338A1/xx unknown
- 1999-07-01 US US09/743,370 patent/US6306910B1/en not_active Expired - Fee Related
- 1999-07-01 EP EP99933667A patent/EP1094803A2/en not_active Withdrawn
- 1999-07-01 BR BR9911887-4A patent/BR9911887A/pt not_active Application Discontinuation
- 1999-07-01 NZ NZ509231A patent/NZ509231A/en unknown
- 1999-07-01 CA CA002333024A patent/CA2333024C/en not_active Expired - Fee Related
- 1999-07-01 WO PCT/US1999/015058 patent/WO2000002546A2/en not_active Application Discontinuation
- 1999-07-01 KR KR1020017000261A patent/KR20010071778A/ko not_active Application Discontinuation
-
2000
- 2000-12-04 ZA ZA200007174A patent/ZA200007174B/en unknown
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2001
- 2001-01-08 NO NO20010117A patent/NO20010117L/no not_active Application Discontinuation
- 2001-08-03 US US09/921,682 patent/US20020004528A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PL345338A1 (en) | 2001-12-17 |
| AU4967399A (en) | 2000-02-01 |
| KR20010071778A (ko) | 2001-07-31 |
| CA2333024C (en) | 2002-03-26 |
| US20020004528A1 (en) | 2002-01-10 |
| EP1094803A2 (en) | 2001-05-02 |
| AU765038B2 (en) | 2003-09-04 |
| WO2000002546A3 (en) | 2000-06-15 |
| NZ509231A (en) | 2003-08-29 |
| NO20010117D0 (no) | 2001-01-08 |
| NO20010117L (no) | 2001-01-08 |
| ID27191A (id) | 2001-03-08 |
| US6306910B1 (en) | 2001-10-23 |
| JP2002520277A (ja) | 2002-07-09 |
| CA2333024A1 (en) | 2000-01-20 |
| WO2000002546A2 (en) | 2000-01-20 |
| BR9911887A (pt) | 2001-03-27 |
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