YU9092A - AMINO KISELINA DERIVATIVES - Google Patents
AMINO KISELINA DERIVATIVESInfo
- Publication number
- YU9092A YU9092A YU9092A YU9092A YU9092A YU 9092 A YU9092 A YU 9092A YU 9092 A YU9092 A YU 9092A YU 9092 A YU9092 A YU 9092A YU 9092 A YU9092 A YU 9092A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- amino
- lower alkyl
- protected
- carbamoyl
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
DERIVATI AMINO KISELINA, pronalazak predvidja jedinjenja formule gde A predstavlja grupu R1 predstavlja vodonik, amino, zaštićeni amino, acilamino ili niži alkil po potrebi substituisan sa aril, hidroksi, zaštićeni hidroksi, amino, zaštićeni amino, acilamino, maleimido, sukcinimido, naftalimido, 2,3-dihidro-1,3-diokso-1H-benz/d,e/izohinol-2-il, karbok-si, zaštićeni karboksi, karbamoil, mono(niži alkil)karbamoil, di (niži alkil)-karbamoil, di(niži alkil)amino, karboksi-niži alkanoilamino, pirolidino ili morfolion; R2 predstavlja vodonik ili niži alkil po potrebi substituisan sa aril, amino, di(niži alkil)-amino, gvanidino, karboksil, zaštićeni karboksil, karbamoil, mono(niži alkil) karbamoil, di(niži alkil)-karbamoil, di (niži alkoksi)fosfinil, dihidrok-sifosfinil, pirolidino, piperidino ili morfolino; R3 predstavlja vodonik ili niži alkil po potrebi substituisan sa hidroksi, zaštićenim hidroksi, amino ili zaštićenim amino; R4 predstavlja vodonik, hidroksi, niži alkoksi ili benziloksi; i R5 predstavlja vodonik ili halogen i njihove farmaceutski prihvatljive soli. Ova jedinjenja se koriste za proizvodnju lekova za regulisanje li preventivnu degenerativnih bolesti zglobova ili za tretiranje invazionih tumora, ateroskleroze ili multiskleroze. Ona mogu da e proizvedu prema poznatim metodama.AMINO ACID DERIVATIVES, the invention provides compounds of formula wherein A represents a group R 1 represents hydrogen, amino, protected amino, acylamino or lower alkyl optionally substituted with aryl, hydroxy, protected hydroxy, amino, protected amino, acylamino, maleimido, succinimido, naphthalimido, 2 , 3-dihydro-1,3-dioxo-1H-benzyl, e / isoquinol-2-yl, carboxy, protected carboxy, carbamoyl, mono (lower alkyl) carbamoyl, di (lower alkyl) -carbamoyl, di (lower alkyl) amino, carboxy-lower alkanoylamino, pyrrolidino or morpholion; R 2 represents hydrogen or lower alkyl optionally substituted with aryl, amino, di (lower alkyl) -amino, guanidino, carboxyl, protected carboxyl, carbamoyl, mono (lower alkyl) carbamoyl, di (lower alkyl) -carbamoyl, di (lower alkoxy) ) phosphinyl, dihydroxyphosphinyl, pyrrolidino, piperidino or morpholino; R3 represents hydrogen or lower alkyl optionally substituted with hydroxy, protected hydroxy, amino or protected amino; R4 represents hydrogen, hydroxy, lower alkoxy or benzyloxy; and R5 represents hydrogen or halogen and pharmaceutically acceptable salts thereof. These compounds are used in the manufacture of drugs for the regulation or prevention of degenerative joint diseases or for the treatment of invasive tumors, atherosclerosis or multisclerosis. They can be produced according to known methods.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9210090A SI9210090A (en) | 1991-02-01 | 1992-01-29 | Substituated hydroxycarbamoylmethyl- or substituated hydroxyphosphonyl- derivatives of N-/4-methylvaleryl/,3-methyl-L-valinamide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919102194A GB9102194D0 (en) | 1991-02-01 | 1991-02-01 | Amino acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU9092A true YU9092A (en) | 1994-09-09 |
Family
ID=10689370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU9092A YU9092A (en) | 1991-02-01 | 1992-01-29 | AMINO KISELINA DERIVATIVES |
Country Status (8)
| Country | Link |
|---|---|
| KR (1) | KR920016467A (en) |
| BR (1) | BR9200319A (en) |
| GB (2) | GB9102194D0 (en) |
| MX (1) | MX9200282A (en) |
| TW (1) | TW197445B (en) |
| UY (1) | UY23368A1 (en) |
| YU (1) | YU9092A (en) |
| ZA (1) | ZA92516B (en) |
-
1991
- 1991-02-01 GB GB919102194A patent/GB9102194D0/en active Pending
- 1991-10-31 GB GB919123162A patent/GB9123162D0/en active Pending
-
1992
- 1992-01-07 TW TW081100083A patent/TW197445B/zh active
- 1992-01-23 MX MX9200282A patent/MX9200282A/en not_active IP Right Cessation
- 1992-01-24 ZA ZA92516A patent/ZA92516B/en unknown
- 1992-01-29 YU YU9092A patent/YU9092A/en unknown
- 1992-01-31 KR KR1019920001460A patent/KR920016467A/en not_active Application Discontinuation
- 1992-01-31 UY UY23368A patent/UY23368A1/en unknown
- 1992-01-31 BR BR929200319A patent/BR9200319A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX9200282A (en) | 1992-08-01 |
| UY23368A1 (en) | 1992-07-24 |
| KR920016467A (en) | 1992-09-24 |
| BR9200319A (en) | 1992-10-06 |
| GB9123162D0 (en) | 1991-12-18 |
| GB9102194D0 (en) | 1991-03-20 |
| TW197445B (en) | 1993-01-01 |
| ZA92516B (en) | 1992-10-28 |
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