YU84101A - Višefazni postupak za proizvodnju mikrokapsula ispunjenih gasom - Google Patents

Višefazni postupak za proizvodnju mikrokapsula ispunjenih gasom

Info

Publication number
YU84101A
YU84101A YU84101A YUP84101A YU84101A YU 84101 A YU84101 A YU 84101A YU 84101 A YU84101 A YU 84101A YU P84101 A YUP84101 A YU P84101A YU 84101 A YU84101 A YU 84101A
Authority
YU
Yugoslavia
Prior art keywords
microcapsules
stage method
producing gas
filled microcapsules
polymerization
Prior art date
Application number
YU84101A
Other languages
English (en)
Inventor
Uwe Budde
Andreas Briel
Georg Rosling
Kai Lovis
Wolfgang Schmidt
Hans-Ulrich Moritz
Michael Gottfried
Jan-Peter Ingwersen
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of YU84101A publication Critical patent/YU84101A/sh

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polymerisation Methods In General (AREA)
  • Medicinal Preparation (AREA)

Abstract

Predmet pronalaska je višestepeni postupak za proizvodnju gasom ispunjenih mikrokapsula. U jednoj fazi postupka sledi polimerizacija supstance koja čini opnu, i iz toga u jednoj prostorno i/ili vremenski odvojenoj fazi postupka stvaranje mikrokapsula procesom nadgradnje. Dok se pri tom polimerizacija izvodi pod umerenim uslovima mešanja stvaranje mikrokapsula sledi pod dispergujućim uslovima.
YU84101A 1999-05-27 2000-05-23 Višefazni postupak za proizvodnju mikrokapsula ispunjenih gasom YU84101A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19925311A DE19925311B4 (de) 1999-05-27 1999-05-27 Mehrstufen-Verfahren zur Herstellung von gasgefüllten Mikrokapseln

Publications (1)

Publication Number Publication Date
YU84101A true YU84101A (sh) 2004-07-15

Family

ID=7910041

Family Applications (1)

Application Number Title Priority Date Filing Date
YU84101A YU84101A (sh) 1999-05-27 2000-05-23 Višefazni postupak za proizvodnju mikrokapsula ispunjenih gasom

Country Status (29)

Country Link
US (1) US6652782B1 (sh)
EP (1) EP1180043B1 (sh)
JP (1) JP2003500458A (sh)
KR (1) KR100681369B1 (sh)
CN (1) CN1189218C (sh)
AT (1) ATE245034T1 (sh)
AU (1) AU766705B2 (sh)
BG (1) BG106137A (sh)
BR (1) BR0011543A (sh)
CA (1) CA2373869A1 (sh)
CZ (1) CZ297351B6 (sh)
DE (2) DE19925311B4 (sh)
DK (1) DK1180043T3 (sh)
EA (1) EA004220B1 (sh)
EE (1) EE200100630A (sh)
ES (1) ES2203496T3 (sh)
HK (1) HK1050492A1 (sh)
HR (1) HRP20010942A2 (sh)
HU (1) HUP0201640A2 (sh)
IL (1) IL146466A0 (sh)
MX (1) MXPA01011998A (sh)
NO (1) NO322312B1 (sh)
NZ (1) NZ515147A (sh)
PL (1) PL195106B1 (sh)
PT (1) PT1180043E (sh)
SK (1) SK16912001A3 (sh)
WO (1) WO2000072888A1 (sh)
YU (1) YU84101A (sh)
ZA (1) ZA200110482B (sh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19952738A1 (de) * 1999-10-27 2001-05-23 Schering Ag Verbesserte Suspensionen von Ultraschallkontrastmitteln
DE10065068A1 (de) * 2000-12-21 2002-07-04 Schering Ag Mehrstufen-Verfahren zur Herstellung von gasgefüllten Mikrokapseln mit definiert enger Größenverteilung durch definierte Fremdbegasung während des Mikrokapselaufbaus
SE0302794D0 (sv) * 2003-10-24 2003-10-24 Per Hansson Novel microparticles for ultrasound contrast imaging and drug delivery
DE602005021057D1 (de) 2004-01-20 2010-06-17 Toronto E Hochfrequenz-ultraschall-darstellung mit kontrastmitteln
CN1984708B (zh) * 2004-06-29 2014-01-29 皇家飞利浦电子股份有限公司 微球体
ITMI20110784A1 (it) * 2011-05-09 2012-11-10 Sipcam Spa Processo per l'ottenimento di microcapsule

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1170569A (en) * 1980-11-17 1984-07-10 Julia S. Rasor Microbubble precursors and methods for their production and use
DE4219724A1 (de) * 1992-06-13 1993-12-16 Schering Ag Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie
HU221485B (en) * 1988-02-05 2002-10-28 Schering Ag Ultrasound contrast media consisting of microparticles and process for producing the same
DE4004430A1 (de) 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
DE4219723A1 (de) 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
DE4232755A1 (de) 1992-09-26 1994-03-31 Schering Ag Mikropartikelpräparationen aus biologisch abbaubaren Mischpolymeren
US6068857A (en) * 1993-09-09 2000-05-30 Schering Aktiengesellchaft Microparticles containing active ingredients, agents containing these microparticles, their use for ultrasound-controlled release of active ingredients, as well as a process for their production
DE4403789A1 (de) * 1994-02-03 1995-08-10 Schering Ag Mittel zur visuellen Markierung von Körpergewebe
NO940711D0 (no) * 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US5820850A (en) * 1995-06-07 1998-10-13 Molecular Biosystems, Inc. Gas-filled amino acid block co-polymer microspheres useful as ultrasound contrast agents
DE19648663A1 (de) 1996-11-14 1998-05-28 Schering Ag Flüssigkeitsgefüllte Mikropartikel mit neuem Wirkungsprinzip und deren Verwendung als Diagnostika und Therapeutika

Also Published As

Publication number Publication date
EE200100630A (et) 2003-02-17
HUP0201640A2 (en) 2002-08-28
AU5962700A (en) 2000-12-18
NZ515147A (en) 2003-07-25
DE50002914D1 (de) 2003-08-21
CZ297351B6 (cs) 2006-11-15
DE19925311A1 (de) 2000-11-30
CA2373869A1 (en) 2000-12-07
NO322312B1 (no) 2006-09-11
EP1180043A1 (de) 2002-02-20
EP1180043B1 (de) 2003-07-16
CN1377284A (zh) 2002-10-30
ES2203496T3 (es) 2004-04-16
CN1189218C (zh) 2005-02-16
BG106137A (bg) 2002-07-31
AU766705B2 (en) 2003-10-23
DE19925311B4 (de) 2004-06-09
EA004220B1 (ru) 2004-02-26
PL195106B1 (pl) 2007-08-31
HK1050492A1 (en) 2003-06-27
NO20015745L (no) 2002-01-08
MXPA01011998A (es) 2002-06-04
CZ20014235A3 (cs) 2002-04-17
NO20015745D0 (no) 2001-11-26
KR100681369B1 (ko) 2007-02-12
EA200101154A1 (ru) 2002-06-27
PT1180043E (pt) 2003-11-28
PL351873A1 (en) 2003-06-30
ATE245034T1 (de) 2003-08-15
KR20020013894A (ko) 2002-02-21
DK1180043T3 (da) 2003-11-10
IL146466A0 (en) 2002-07-25
BR0011543A (pt) 2002-03-05
US6652782B1 (en) 2003-11-25
JP2003500458A (ja) 2003-01-07
ZA200110482B (en) 2003-04-24
HRP20010942A2 (en) 2003-12-31
WO2000072888A1 (de) 2000-12-07
SK16912001A3 (sk) 2002-04-04

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