YU70899A - Derivati hidrazina - Google Patents

Derivati hidrazina

Info

Publication number
YU70899A
YU70899A YU70899A YU70899A YU70899A YU 70899 A YU70899 A YU 70899A YU 70899 A YU70899 A YU 70899A YU 70899 A YU70899 A YU 70899A YU 70899 A YU70899 A YU 70899A
Authority
YU
Yugoslavia
Prior art keywords
aryl
lower alkyl
signifies
cycloalkyl
alkyl
Prior art date
Application number
YU70899A
Other languages
English (en)
Inventor
Michael John Broadhurst
William Henry Johnson
Daryl Simon Walter
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of YU70899A publication Critical patent/YU70899A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

Derivati hidrazina formule (I) u kojoj Y oznacava CO ili SO2, R1 oznacava nizi alkil, nizi alkenil, nizi cikloalkil, nizi cikloalkil-nizi alkil, aril ili aril-nizi alkil, R2 oznacava nizi alkil, halogen-nizi alkil, aril-nizi alkil, aril-nizi alkenil ili aril kada Y oznacava SO2 i oznacava nizi alkil, halogen-nizi alkil, nizi alkoksi, nizi alkoksikarbonil, acil, nizi cikloalkil, aril, aril-nizi alkil, aril-nizi alkoksi ili NR5R6kada Y oznacava CO, i R3 oznacava vodonik, nizi alkil koji je opciono supstituisan cijan-, amino-, hidroksi-, nizom alkoksi-, nizi alkoksikarbonil-, heterociklil-ili haterociklilkarbonil-grupom, zatim oznacava nizi alkenil, nizi alkinil, nizi cikloalkil, nizi cikloalkil-nizi alkil, aril-nizi alkil, aril-nizi alkenil, aril ili heterociklil, ili R2 i R3 zajedno formiraju ostatak 5-, 6- ili 7-clane ciklicne amidne, ciklicne imidne, ciklicne sulfonamidne ili ciklicne uretanske grupe, R4 oznacava nizi alkil, hidroksi-nizi alkil, nizi alkenil, nizi cikloalkil, nizi cikloalkil-nizi alkil ili grupaciju formule X-aril, X-heteroaril ili -(CH2)1-2CH=CR7R8, X oznacava prostornu grupu, R5 i R6 svaki pojedinacno oznacava vodonik, nizi alkil ili aril-nizi alkil, i R7 i R8 zajedno predstavljaju nizu alkilensku grupu u kojoj je jedna metilenska grupa opciono zamenjena hetero-atomom, i njihove farmaceutski prihvatljive soli inhibiraju ne samo oslobadjanje faktora tumorne nekroze (TNF-α) i transformisuceg faktora rasta (TGF-α) iz celija, vec takodje inhibiraju i proliferaciju keratinocita. Oni se primenjuju kao lekovi, narocito u lecenju zapaljenja, groznice, hemoragije, sepse, reumatoidnog artritisa, osteoartritisa, multiplskleroze ili psorijaze.
YU70899A 1997-06-30 1998-06-18 Derivati hidrazina YU70899A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9713833.3A GB9713833D0 (en) 1997-06-30 1997-06-30 Novel hydrazine derivatives
GBGB9803335.0A GB9803335D0 (en) 1997-06-30 1998-02-17 Novel hydrazine derivatives

Publications (1)

Publication Number Publication Date
YU70899A true YU70899A (sh) 2002-06-19

Family

ID=10815174

Family Applications (1)

Application Number Title Priority Date Filing Date
YU70899A YU70899A (sh) 1997-06-30 1998-06-18 Derivati hidrazina

Country Status (10)

Country Link
KR (1) KR100371122B1 (sh)
AR (1) AR012258A1 (sh)
CO (1) CO4940511A1 (sh)
EA (1) EA199901111A1 (sh)
GB (2) GB9713833D0 (sh)
HR (1) HRP980366A2 (sh)
PE (1) PE86099A1 (sh)
UA (1) UA58561C2 (sh)
YU (1) YU70899A (sh)
ZA (1) ZA985469B (sh)

Also Published As

Publication number Publication date
PE86099A1 (es) 1999-09-17
HRP980366A2 (en) 1999-02-28
GB9713833D0 (en) 1997-09-03
KR20010014331A (ko) 2001-02-26
UA58561C2 (uk) 2003-08-15
KR100371122B1 (ko) 2003-02-05
CO4940511A1 (es) 2000-07-24
ZA985469B (en) 1998-12-30
EA199901111A1 (ru) 2000-08-28
AR012258A1 (es) 2000-09-27
GB9803335D0 (en) 1998-04-15

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