YU58392A - PEPTIDES USED IN THE REGULATION OF IMMUNOLOGICAL AND NERVOUS SYSTEMS - Google Patents
PEPTIDES USED IN THE REGULATION OF IMMUNOLOGICAL AND NERVOUS SYSTEMSInfo
- Publication number
- YU58392A YU58392A YU58392A YU58392A YU58392A YU 58392 A YU58392 A YU 58392A YU 58392 A YU58392 A YU 58392A YU 58392 A YU58392 A YU 58392A YU 58392 A YU58392 A YU 58392A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- pro
- hydroxy
- alkyl
- pentapeptides
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/66—Thymopoietins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Opisani su pentapeptidi koji su sposobni da regulišu funkciju ćelije imunološkog i/ili nervnog sis-tema sisara. Takodje su obezbedjeni farmaceutski preparati koji sadrže peptide i postupci njihove primene. Citirani pentapeptidi imaju formulu: R - V - W - X - Y - Z - R gde je: R vodonik ili C niži alkil ili alkanoil; V je Arg; W je Pro, dehidro Pro ili hidroksi Pro; X je Asp, Ser, Thr, Ala, Asn, Glu Gln; Y je Pro, dehidro Pro ili hidroksi Pro; Z je Phe ili Tyr, po izboru supstituisan sa jednim ili više halogena, nitro ili hidroksi grupa; R je OH ili NR R gde R i R svaki nezavisno se bira iz grupe koju čine H, C alkil ili alkenil normalnog ili račvastog lanca po izboru supstituisan sa aril grupom ili aril supstituisan sa halogenom ili sa C alkil alkenilom normalnog ili račvastog lanca R i R zasebno obuhvata cikličnu metilen grupu od 3-7 atoma ugljenika i gde svi V, W, X, Y i Z su L-amino kiseline ili po izboru jedan ili više V, W, X, Y i Z su D- amino kiseline.Pentapeptides capable of regulating the cell function of the mammalian immune and / or nervous system have been described. Also provided are pharmaceutical compositions containing peptides and methods of administering them. The cited pentapeptides have the formula: R - V - W - X - Y - Z - R wherein: R is hydrogen or C is lower alkyl or alkanoyl; V is Arg; W is Pro, dehydro Pro or hydroxy Pro; X is Asp, Ser, Thr, Ala, Asn, Glu Gln; Y is Pro, dehydro Pro or hydroxy Pro; Z is Phe or Tyr, optionally substituted with one or more halogen, nitro or hydroxy groups; R is OH or NR R wherein R and R are each independently selected from the group consisting of H, C alkyl or alkenyl of the normal or branched chain optionally substituted with an aryl group or aryl substituted with halogen or with C alkyl alkenyl of the normal or branched chain R and R separately comprises a cyclic methylene group of 3-7 carbon atoms and wherein all V, W, X, Y and Z are L-amino acids or optionally one or more V, W, X, Y and Z are D-amino acids.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/708,035 US5215964A (en) | 1991-06-03 | 1991-06-03 | Peptides useful in regulating the immune and nervous systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU58392A true YU58392A (en) | 1995-03-27 |
Family
ID=24844123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU58392A YU58392A (en) | 1991-06-03 | 1992-06-03 | PEPTIDES USED IN THE REGULATION OF IMMUNOLOGICAL AND NERVOUS SYSTEMS |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5215964A (en) |
| EP (1) | EP0517464A1 (en) |
| JP (1) | JPH06501955A (en) |
| CN (1) | CN1068334A (en) |
| AU (1) | AU653838B2 (en) |
| BR (1) | BR9205281A (en) |
| CA (1) | CA2088664A1 (en) |
| CZ (1) | CZ7793A3 (en) |
| FI (1) | FI930342A (en) |
| HU (1) | HUT63856A (en) |
| IE (1) | IE921781A1 (en) |
| IL (1) | IL102065A0 (en) |
| MX (1) | MX9202643A (en) |
| NO (1) | NO930359L (en) |
| NZ (1) | NZ242993A (en) |
| SK (1) | SK4093A3 (en) |
| TW (1) | TW222281B (en) |
| WO (1) | WO1992021366A1 (en) |
| YU (1) | YU58392A (en) |
| ZA (1) | ZA924023B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995003067A1 (en) * | 1993-07-21 | 1995-02-02 | Khavinson Vladimir Khatskelevi | Pharmaceutical with immunomodulating activity |
| GB9425582D0 (en) * | 1994-12-19 | 1995-02-15 | Iaf Biochem Int | Peptides having immunomodulatory activity |
| AU4222200A (en) * | 1999-04-15 | 2000-11-02 | Thymon L.L.C. | Nonextractive method of assaying thymopoietin |
| CN104311640B (en) * | 2014-11-27 | 2017-08-25 | 上海弭阳生物技术有限公司 | One kind is immune to repair 15 peptides, its preparation method and its application |
| WO2017133175A1 (en) * | 2016-02-04 | 2017-08-10 | Nanjing Legend Biotech Co., Ltd. | Engineered mammalian cells for cancer therapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE263994C (en) * | ||||
| DE2639941C2 (en) * | 1976-09-04 | 1984-10-04 | Hoechst Ag, 6230 Frankfurt | Process for the production of phosphine |
| US4397842A (en) * | 1980-03-13 | 1983-08-09 | Ortho Pharmaceutical Corporation | Peptides having thymopoietin-like activity |
| US4505853A (en) * | 1983-11-18 | 1985-03-19 | Ortho Pharmaceutical Corporation | Enzyme-resistant immunomodulatory peptides |
| US4629723A (en) * | 1984-06-27 | 1986-12-16 | Ortho Pharmaceutical Corporation | Potent thymopentin analogs |
| DD263994A1 (en) * | 1987-07-09 | 1989-01-18 | Univ Halle Wittenberg | PROCESS FOR PREPARING OLIGODESOXYRIBONUCLEOTIDES FOR SPLENOPENTINE EXPRESSION |
| DD296084A5 (en) * | 1989-07-27 | 1991-11-21 | Adw | PROCESS FOR THE MANUFACTURE OF HUMAN SPLENINE DERIVATIVES |
| WO1992009628A1 (en) * | 1990-11-23 | 1992-06-11 | Immunodynamics, Inc. | Synthetic immunoactive peptides having immunomodulating and therapeutic activities |
-
1991
- 1991-06-03 US US07/708,035 patent/US5215964A/en not_active Expired - Fee Related
-
1992
- 1992-05-28 HU HU9300278A patent/HUT63856A/en unknown
- 1992-05-28 CA CA002088664A patent/CA2088664A1/en not_active Abandoned
- 1992-05-28 WO PCT/US1992/004484 patent/WO1992021366A1/en not_active Application Discontinuation
- 1992-05-28 BR BR9205281A patent/BR9205281A/en not_active Application Discontinuation
- 1992-05-28 CZ CZ9377A patent/CZ7793A3/en unknown
- 1992-05-28 JP JP5500559A patent/JPH06501955A/en active Pending
- 1992-05-28 SK SK4093A patent/SK4093A3/en unknown
- 1992-05-28 AU AU20125/92A patent/AU653838B2/en not_active Ceased
- 1992-06-01 IL IL102065A patent/IL102065A0/en unknown
- 1992-06-01 EP EP19920305000 patent/EP0517464A1/en not_active Ceased
- 1992-06-02 ZA ZA924023A patent/ZA924023B/en unknown
- 1992-06-02 NZ NZ242993A patent/NZ242993A/en unknown
- 1992-06-03 CN CN92105676A patent/CN1068334A/en active Pending
- 1992-06-03 YU YU58392A patent/YU58392A/en unknown
- 1992-06-03 MX MX9202643A patent/MX9202643A/en unknown
- 1992-07-01 IE IE178192A patent/IE921781A1/en not_active Application Discontinuation
- 1992-07-28 TW TW081105931A patent/TW222281B/zh active
-
1993
- 1993-01-27 FI FI930342A patent/FI930342A/en not_active Application Discontinuation
- 1993-02-02 NO NO93930359A patent/NO930359L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW222281B (en) | 1994-04-11 |
| BR9205281A (en) | 1993-07-27 |
| EP0517464A1 (en) | 1992-12-09 |
| AU653838B2 (en) | 1994-10-13 |
| US5215964A (en) | 1993-06-01 |
| HU9300278D0 (en) | 1993-04-28 |
| AU2012592A (en) | 1993-01-08 |
| IE921781A1 (en) | 1992-12-16 |
| SK4093A3 (en) | 1993-09-09 |
| FI930342A0 (en) | 1993-01-27 |
| ZA924023B (en) | 1993-02-24 |
| NO930359L (en) | 1993-03-18 |
| CA2088664A1 (en) | 1992-12-04 |
| CZ7793A3 (en) | 1993-12-15 |
| IL102065A0 (en) | 1993-01-14 |
| JPH06501955A (en) | 1994-03-03 |
| FI930342A (en) | 1993-01-27 |
| NZ242993A (en) | 1995-09-26 |
| CN1068334A (en) | 1993-01-27 |
| NO930359D0 (en) | 1993-02-02 |
| WO1992021366A1 (en) | 1992-12-10 |
| MX9202643A (en) | 1994-08-31 |
| HUT63856A (en) | 1993-10-28 |
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