YU56696A - Polymorphic forms of agent improving growth hormon secretagogue - Google Patents
Polymorphic forms of agent improving growth hormon secretagogueInfo
- Publication number
- YU56696A YU56696A YU56696A YU56696A YU56696A YU 56696 A YU56696 A YU 56696A YU 56696 A YU56696 A YU 56696A YU 56696 A YU56696 A YU 56696A YU 56696 A YU56696 A YU 56696A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- polymorphic forms
- growth hormone
- secretagogue
- phenylmethyloxy
- indole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Ovaj pronalazak se odnosi na polimorfne oblike jedinjenja N-/1(R)-/(1,2-dihidro-1-metansulfonilspiro/3H-indol-3,4'-piperidin/-1'-il)karbonil/-2-(fenilmetiloksi)-etil/-2-amino-2-metilpropanamid metansulffonata koji je agens koji potpomaže izlučivanje hormona rasta koji je korisan kod životinja za hranu za poboljšavanje njihovog rasta i na taj čineći proizvodnju jestivih mesnih proizvoda efikasnijom, i kod ljudi, za tretiranje fizioloških ili medicinskih stanja koja se karakterišu nedostatkom lučenja hormona rasta, i za tretiranje medicinskih stanja koja se poboljšavaju anboličnim efektima hormona rasta. Ovi polimorfni oblici imaju prednosti nad drugim poznatim oblicima N-/1(R)-/(1,2-dihidro-1-metansulfonil-spiro/3H-indol-3,4'-piperidin/-1')karbonil/-2-(fenilmetiloksi)-etil/-2-amino-2-metilpropanamid metansulfonata s obzirom na termodinamičku stabilnost i pogodnost za inkluziju u farmaceutske formulacije. Ovaj pronalazak se takodje odnosi na postupke za dobijanej ovih polimorfnih oblika kao aktivnih komponenti i na upotrebu polimorfnog oblika jedinjenja i njegovih formulacija u tretiranju izvesnih poremećaja.The present invention relates to polymorphic forms of the compound N- [1 (R) - [(1,2-dihydro-1-methanesulfonylspiro [3H-indole-3,4'-piperidin] -1'-yl) carbonyl] -2- (Phenylmethyloxy) -ethyl [-2-amino-2-methylpropanamide methanesulfonate ”which is an agent that promotes the secretion of growth hormone that is useful in food-producing animals to improve their growth and thus make the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a lack of growth hormone secretion, and for the treatment of medical conditions that are enhanced by the anabolic effects of growth hormone. These polymorphic forms have advantages over other known forms of N- (1) (R) - [(1,2-dihydro-1-methanesulfonyl-spiro [3H-indole-3,4'-piperidine] -1 ') carbonyl] -2 - (phenylmethyloxy) -ethyl [-2-amino-2-methylpropanamide methanesulfonate with respect to thermodynamic stability and suitability for inclusion in pharmaceutical formulations. The present invention also relates to methods for preparing these polymorphic forms as active ingredients and to the use of a polymorphic form of a compound and its formulations in the treatment of certain disorders.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US590095P | 1995-10-27 | 1995-10-27 | |
| GBGB9603361.8A GB9603361D0 (en) | 1996-02-16 | 1996-02-16 | Polymorphic forms of a growth hormone secretagogue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU56696A true YU56696A (en) | 1999-09-27 |
Family
ID=26308741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU56696A YU56696A (en) | 1995-10-27 | 1996-10-25 | Polymorphic forms of agent improving growth hormon secretagogue |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1019402A1 (en) |
| JP (1) | JP3204266B2 (en) |
| KR (1) | KR19990067098A (en) |
| CN (1) | CN1067687C (en) |
| AU (1) | AU707946B2 (en) |
| BG (1) | BG102476A (en) |
| BR (1) | BR9611229A (en) |
| CA (1) | CA2235371A1 (en) |
| CO (1) | CO4770956A1 (en) |
| CZ (1) | CZ128098A3 (en) |
| EA (1) | EA000528B1 (en) |
| EE (1) | EE9800147A (en) |
| HK (1) | HK1017894A1 (en) |
| HU (1) | HUP9902208A3 (en) |
| IS (1) | IS4721A (en) |
| NO (1) | NO310556B1 (en) |
| NZ (1) | NZ321370A (en) |
| PL (1) | PL327511A1 (en) |
| SK (1) | SK51398A3 (en) |
| TR (1) | TR199800726T2 (en) |
| WO (1) | WO1997015574A1 (en) |
| YU (1) | YU56696A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046333A (en) * | 1996-10-25 | 2000-04-04 | Merck & Co., Inc. | Convergent process for the preparation of a growth hormone secretagogue |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| US20170121385A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO115804B1 (en) * | 1992-12-11 | 2000-06-30 | Merck & Co Inc | Spiropyperidine derivatives, processes for preparation and pharmaceutical compositions thereof |
-
1996
- 1996-10-23 WO PCT/US1996/016955 patent/WO1997015574A1/en not_active Application Discontinuation
- 1996-10-23 CZ CZ981280A patent/CZ128098A3/en unknown
- 1996-10-23 EA EA199800335A patent/EA000528B1/en not_active IP Right Cessation
- 1996-10-23 PL PL96327511A patent/PL327511A1/en unknown
- 1996-10-23 EE EE9800147A patent/EE9800147A/en unknown
- 1996-10-23 AU AU74686/96A patent/AU707946B2/en not_active Expired
- 1996-10-23 BR BR9611229A patent/BR9611229A/en not_active IP Right Cessation
- 1996-10-23 EP EP96936869A patent/EP1019402A1/en not_active Withdrawn
- 1996-10-23 TR TR1998/00726T patent/TR199800726T2/en unknown
- 1996-10-23 JP JP51673797A patent/JP3204266B2/en not_active Expired - Lifetime
- 1996-10-23 KR KR1019980703038A patent/KR19990067098A/en not_active Application Discontinuation
- 1996-10-23 HU HU9902208A patent/HUP9902208A3/en unknown
- 1996-10-23 CA CA002235371A patent/CA2235371A1/en not_active Abandoned
- 1996-10-23 CN CN96199328A patent/CN1067687C/en not_active Expired - Lifetime
- 1996-10-23 SK SK513-98A patent/SK51398A3/en unknown
- 1996-10-23 NZ NZ321370A patent/NZ321370A/en not_active IP Right Cessation
- 1996-10-25 CO CO96056663A patent/CO4770956A1/en unknown
- 1996-10-25 YU YU56696A patent/YU56696A/en unknown
-
1998
- 1998-04-21 IS IS4721A patent/IS4721A/en unknown
- 1998-04-24 NO NO19981867A patent/NO310556B1/en not_active IP Right Cessation
- 1998-05-21 BG BG102476A patent/BG102476A/en unknown
-
1999
- 1999-07-12 HK HK99102961A patent/HK1017894A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA000528B1 (en) | 1999-10-28 |
| AU7468696A (en) | 1997-05-15 |
| HUP9902208A2 (en) | 1999-10-28 |
| CO4770956A1 (en) | 1999-04-30 |
| NO981867D0 (en) | 1998-04-24 |
| CN1067687C (en) | 2001-06-27 |
| IS4721A (en) | 1998-04-21 |
| JP3204266B2 (en) | 2001-09-04 |
| CZ128098A3 (en) | 1998-09-16 |
| PL327511A1 (en) | 1998-12-21 |
| NO981867L (en) | 1998-06-29 |
| HUP9902208A3 (en) | 2001-05-28 |
| WO1997015574A1 (en) | 1997-05-01 |
| NO310556B1 (en) | 2001-07-23 |
| BR9611229A (en) | 1999-05-25 |
| CN1205703A (en) | 1999-01-20 |
| TR199800726T2 (en) | 1998-08-21 |
| EE9800147A (en) | 1998-12-15 |
| BG102476A (en) | 1999-04-30 |
| NZ321370A (en) | 1999-11-29 |
| EA199800335A1 (en) | 1998-12-24 |
| HK1017894A1 (en) | 1999-12-03 |
| AU707946B2 (en) | 1999-07-22 |
| CA2235371A1 (en) | 1997-05-01 |
| KR19990067098A (en) | 1999-08-16 |
| SK51398A3 (en) | 1998-12-02 |
| MX9803351A (en) | 1998-09-30 |
| JPH10512295A (en) | 1998-11-24 |
| EP1019402A1 (en) | 2000-07-19 |
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