YU49101A - Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors - Google Patents
Carboxyaryl substituted diphenyl ureas as raf kinase inhibitorsInfo
- Publication number
- YU49101A YU49101A YU49101A YUP49101A YU49101A YU 49101 A YU49101 A YU 49101A YU 49101 A YU49101 A YU 49101A YU P49101 A YUP49101 A YU P49101A YU 49101 A YU49101 A YU 49101A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- kinase inhibitors
- raf kinase
- substituted diphenyl
- diphenyl ureas
- carboxyaryl substituted
- Prior art date
Links
- 235000010290 biphenyl Nutrition 0.000 title 1
- 239000004305 biphenyl Substances 0.000 title 1
- 235000013877 carbamide Nutrition 0.000 title 1
- 125000005026 carboxyaryl group Chemical group 0.000 title 1
- -1 diphenyl ureas Chemical class 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 102000009929 raf Kinases Human genes 0.000 title 1
- 108010077182 raf Kinases Proteins 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 150000003672 ureas Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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- C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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Abstract
Ovaj pronalazak odnosi se na upotrebu grupe aril karbamida u tretiranju raf posredovanih bolesti, i na farmaceutske kompozicije za upotrebu u takvoj terapiji.The present invention relates to the use of an aryl carbamide group in the treatment of Raf-mediated diseases, and to pharmaceutical compositions for use in such therapy.
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US11587799P | 1999-01-13 | 1999-01-13 | |
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US42522899A | 1999-10-22 | 1999-10-22 |
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Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1580188T3 (en) | 2002-02-11 | 2012-02-06 | Bayer Healthcare Llc | Compounds of arylurea as kinase inhibitors |
TW200406374A (en) * | 2002-05-29 | 2004-05-01 | Novartis Ag | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases |
RU2006131045A (en) * | 2004-01-30 | 2008-03-10 | Мерк Патент ГмбХ (DE) | Derivatives of bisaryl urea |
TW200530236A (en) * | 2004-02-23 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Heteroaryl phenylurea |
MY191349A (en) * | 2004-08-27 | 2022-06-17 | Bayer Pharmaceuticals Corp | New pharmaceutical compositions for the treatment of hyper-proliferative disorders |
SI1797037T1 (en) * | 2004-09-29 | 2015-06-30 | Bayer Healthcare Llc | PROCESS FOR THE PREPARATION OF 4-š4-Š(šŠ4-CHLORO-3-(TRIFLUOROMETHYL)PHENYLĆAMINOćCARBONYL)AMINOĆPHENYOXYćN-METHYLPYRIDINE-2-CARBOXAMIDE |
DE102005015253A1 (en) * | 2005-04-04 | 2006-10-05 | Merck Patent Gmbh | New pyrazole derivatives are tyrosine kinase inhibitors useful to treat e.g. solid tumors, diabetic retinopathy, age-related macular degeneration or inflammatory disease, osteoarthritis and rickets |
ES2480440T3 (en) | 2005-12-21 | 2014-07-28 | Bayer Intellectual Property Gmbh | Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders |
WO2008044688A1 (en) * | 2006-10-11 | 2008-04-17 | Daiichi Sankyo Company, Limited | Urea derivative |
EP2136809A4 (en) * | 2007-03-20 | 2012-01-04 | Curis Inc | Raf kinase inhibitors containing a zinc binding moiety |
EP2195286A2 (en) * | 2007-09-10 | 2010-06-16 | Cipla Limited | Process for the preparation of a raf kinase inhibitor and intermediates for use in the process |
CN101372475B (en) * | 2008-03-19 | 2012-01-04 | 南京工业大学 | Aromatic heterocyclic substituted diphenyl urea derivative and application thereof |
CN101298427B (en) * | 2008-06-26 | 2012-03-21 | 中国科学院广州生物医药与健康研究院 | Diaryl urea compound and use thereof |
TW201012467A (en) | 2008-09-16 | 2010-04-01 | Taiho Pharmaceutical Co Ltd | Antitumor agent containing 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]benzoic acid |
CN103254126A (en) * | 2008-09-19 | 2013-08-21 | 苏州泽璟生物制药有限公司 | Deuterated omega-diphenyl carbamide as well as derivative and pharmaceutical composition including compounds |
CN101362717B (en) * | 2008-09-28 | 2013-02-06 | 四川大学 | 4-(4-amidoanilino)-2-(methylcarbamoyl) pyridine, derivates thereof and preparation, application thereof |
JO3101B1 (en) * | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | Benzothiazole derivatives as anticancer agents |
WO2010083649A1 (en) * | 2009-01-22 | 2010-07-29 | 沈阳药科大学 | Bisarylurea derivatives and their use |
EP2531498B1 (en) * | 2010-02-05 | 2016-07-13 | Novartis AG | Compounds and compositions as protein kinase inhibitors |
CN102219733A (en) * | 2010-04-14 | 2011-10-19 | 上海医药工业研究院 | Method for preparing sorafenib |
CN102617458A (en) * | 2010-05-18 | 2012-08-01 | 张南 | Preparation method for anticancer compound |
CN101830847B (en) * | 2010-05-18 | 2012-10-10 | 张南 | Anticancer compound and preparation method thereof |
US9381177B2 (en) * | 2010-10-01 | 2016-07-05 | Bayer Intellectual Property Gmbh | Substituted N-(2-arylamino)aryl sulfonamide-containing combinations |
CN103298808A (en) * | 2011-01-06 | 2013-09-11 | 加拿大贝达药业有限公司 | Novel ureas for the treatment and prevention of cancer |
CN102875460A (en) * | 2012-05-17 | 2013-01-16 | 上海奥博生物医药技术有限公司 | Method for preparing sorafenib |
CN103508961B (en) * | 2012-06-26 | 2015-07-22 | 中美冠科生物技术(太仓)有限公司 | Antitumor drug |
CN103408488A (en) * | 2013-08-13 | 2013-11-27 | 张家港威胜生物医药有限公司 | Optimal synthetic method of sorafenib |
CN103435553A (en) * | 2013-09-16 | 2013-12-11 | 中国药科大学 | Piperazine structure-based aryl formamide Raf kinase inhibitor and preparation method as well as application thereof |
CN104672129B (en) * | 2013-11-26 | 2019-06-25 | 广东东阳光药业有限公司 | A kind of preparation method of carbamide compounds |
CN106866623A (en) | 2014-04-08 | 2017-06-20 | 北大方正集团有限公司 | Polysubstituted pyridine compounds, preparation method, purposes and pharmaceutical composition |
CN104177292A (en) * | 2014-08-08 | 2014-12-03 | 亿腾药业(泰州)有限公司 | Method for industrial production of sorafenib tosylate polymorphic form I |
CA2998647A1 (en) * | 2014-10-03 | 2016-04-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders |
CN105348186B (en) * | 2015-10-15 | 2018-05-22 | 青岛海洋生物医药研究院股份有限公司 | Deuterated substituted bisarylurea compound and preparation method thereof and the application in anti-tumor drug is prepared |
CN105753841B (en) * | 2016-01-18 | 2018-01-05 | 西安交通大学 | A kind of N indazoles substituting thioureido analog derivative and its preparation method and application |
CN105924390B (en) * | 2016-05-19 | 2018-07-10 | 广州南新制药有限公司 | A kind of synthetic method of Mei Tafeini |
CN106699652B (en) * | 2016-11-07 | 2020-11-13 | 天津大学 | Sorafenib alpha-aminobutyrate and preparation method thereof |
CN108264510A (en) | 2017-01-02 | 2018-07-10 | 上海喆邺生物科技有限公司 | A kind of selective depression kinases compound and application thereof |
CN107417604A (en) * | 2017-07-25 | 2017-12-01 | 新发药业有限公司 | Benzamide compound of 4 substituted pyridines 2 and preparation method and application |
JP2022528780A (en) * | 2019-04-12 | 2022-06-15 | ナショナル ヘルス リサーチ インスティトゥーツ | Heterocyclic compounds as kinase inhibitors for therapeutic use |
CN113831491B (en) * | 2021-09-30 | 2023-03-24 | 南昌大学 | Preparation method and adsorption application of pyrimidazole covalent organic framework |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4973675A (en) * | 1989-04-13 | 1990-11-27 | University Of Tennessee Research Center | Hybrid nitrosoureidoanthracyclines having antitumor activity |
US5447987A (en) * | 1993-12-24 | 1995-09-05 | Shin-Etsu Chemical Co., Ltd. | Organopolysiloxane compositions |
US5447957A (en) * | 1994-06-02 | 1995-09-05 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
WO1995033458A1 (en) * | 1994-06-02 | 1995-12-14 | Smithkline Beecham Corporation | Anti-inflammatory compounds |
CA2290520C (en) * | 1997-05-23 | 2009-01-27 | Bayer Corporation | Inhibition of p38 kinase activity by aryl ureas |
JP2002500650A (en) * | 1997-05-23 | 2002-01-08 | バイエル、コーポレイション | RAF kinase inhibitor |
WO1999020617A1 (en) * | 1997-10-21 | 1999-04-29 | Active Biotech Ab | Antiinflammatory thiadiazolyl ureas which act as lfa-1 and mac-1 inhibitors |
KR100704977B1 (en) * | 1997-12-22 | 2007-04-09 | 바이엘 코포레이션 | Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas |
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2005
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