YU48331B - PROCEDURE FOR OBTAINING TRIAZOLYL-ISOPROPANOL - Google Patents

PROCEDURE FOR OBTAINING TRIAZOLYL-ISOPROPANOL

Info

Publication number
YU48331B
YU48331B YU101291A YU101291A YU48331B YU 48331 B YU48331 B YU 48331B YU 101291 A YU101291 A YU 101291A YU 101291 A YU101291 A YU 101291A YU 48331 B YU48331 B YU 48331B
Authority
YU
Yugoslavia
Prior art keywords
formula
compound
triazolyl
isopropanol
procedure
Prior art date
Application number
YU101291A
Other languages
Serbo-Croatian (sh)
Other versions
YU101291A (en
Inventor
F. Benigni
R. Prendin
Original Assignee
Industriale Chimica S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industriale Chimica S.R.L. filed Critical Industriale Chimica S.R.L.
Publication of YU101291A publication Critical patent/YU101291A/en
Publication of YU48331B publication Critical patent/YU48331B/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

POSTUPAK ZA DOBIJANJE TRIAZOLIL-IZOPROPANOLA - Postupak za dobijanje jedinjenja formule I ili njegove farmaceutski prihvatljive soli, naznačen time, što se jedinjenje formule II u kojoj je X atom fluora, hlora, broma ili joda, tretira sa 4-amino-1,2,4-triazolom u inertnom rastvaraču, i tako dobijeno intermedijerno jedinjenje III gde X ima gornje značenje, tretira u vodenom ili vodeno-alkoholnom rastvoru sa azotastom kiselinom na hladno ili na sobnoj temperaturi i željeno jedinjenje formule I se izoluje i prečišćava prema uobičajenim postupcima. - Prijava sadrži još 2 zavisna zahteva.A process for the preparation of TRIAZOLYL-ISOPROPANOL - A process for the preparation of a compound of formula I or a pharmaceutically acceptable salt thereof, wherein the compound of formula II wherein X is a fluorine, chlorine, bromine or iodine atom is treated with 4-amino-1,2. 4-triazole in an inert solvent, and thus obtained intermediate compound III where X has the above meaning, is treated in aqueous or aqueous-alcoholic solution with nitric acid at cold or room temperature and the desired compound of formula I is isolated and purified according to the usual methods. - The application contains 2 more dependent requests.

YU101291A 1990-06-08 1991-06-06 PROCEDURE FOR OBTAINING TRIAZOLYL-ISOPROPANOL YU48331B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02058690A IT1249211B (en) 1990-06-08 1990-06-08 Process for the preparation of triazolyl isopropanols, in particular fluconazole

Publications (2)

Publication Number Publication Date
YU101291A YU101291A (en) 1993-11-16
YU48331B true YU48331B (en) 1998-05-15

Family

ID=11169192

Family Applications (1)

Application Number Title Priority Date Filing Date
YU101291A YU48331B (en) 1990-06-08 1991-06-06 PROCEDURE FOR OBTAINING TRIAZOLYL-ISOPROPANOL

Country Status (5)

Country Link
AT (1) AT400145B (en)
CA (1) CA2051281C (en)
ES (1) ES2026416A6 (en)
IT (1) IT1249211B (en)
YU (1) YU48331B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2049663B1 (en) * 1992-10-13 1994-12-16 Genesis Para La Investigacion PROCEDURE FOR OBTAINING FLUCONAZOLE.
IL105200A (en) * 1993-03-29 1997-03-18 Teva Pharma Regiospecific processes for the preparation of 1, 3-bis (1, 2, 4-triazol-1-yl)-propan- 2-ol derivatives
HU212424B (en) * 1993-09-23 1996-06-28 Richter Gedeon Vegyeszet New propan-2-ol derivatives substituted with triazole or imidazole and process for producing them
SI9600165A (en) * 1996-05-21 1997-12-31 Krka Tovarna Zdravil D D Novo Process for preparation of biological active derivative of 1,2,4- triazole and intermediates useful in this process
CA2439310C (en) * 2001-03-23 2009-09-29 Richter Gedeon Vegyeszeti Gyar Rt. Process for preparing fluconazole and its crystal modifications
UA78580C2 (en) 2002-06-24 2007-04-10 Basf Ag A process for the preparation of 1,2,4-triazol-1-yl-methyl-oxiranes and an intermediary compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79307B (en) * 1982-06-09 1984-10-22 Pfizer
ES8604938A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl)-1,3-bis(triazolyl) propan-2-ol prepn.
ES8604939A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl) 1,3-bis (1H-triazolyl) propan-2-ol prepn.
ES8604940A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl) 1,3-bis(1H-triazolyl) propan-2-ol prepn.
ES8605753A1 (en) * 1985-12-06 1986-04-16 Lazlo Int Sa Di-triazolyl:methyl di:fluoro-phenyl carbinol prepn.

Also Published As

Publication number Publication date
ATA113291A (en) 1995-02-15
CA2051281A1 (en) 1993-03-14
IT9020586A1 (en) 1991-12-08
ES2026416A6 (en) 1992-04-16
AT400145B (en) 1995-10-25
CA2051281C (en) 1998-07-07
IT1249211B (en) 1995-02-20
IT9020586A0 (en) 1990-06-07
YU101291A (en) 1993-11-16

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