YU48331B - PROCEDURE FOR OBTAINING TRIAZOLYL-ISOPROPANOL - Google Patents
PROCEDURE FOR OBTAINING TRIAZOLYL-ISOPROPANOLInfo
- Publication number
- YU48331B YU48331B YU101291A YU101291A YU48331B YU 48331 B YU48331 B YU 48331B YU 101291 A YU101291 A YU 101291A YU 101291 A YU101291 A YU 101291A YU 48331 B YU48331 B YU 48331B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- formula
- compound
- triazolyl
- isopropanol
- procedure
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
POSTUPAK ZA DOBIJANJE TRIAZOLIL-IZOPROPANOLA - Postupak za dobijanje jedinjenja formule I ili njegove farmaceutski prihvatljive soli, naznačen time, što se jedinjenje formule II u kojoj je X atom fluora, hlora, broma ili joda, tretira sa 4-amino-1,2,4-triazolom u inertnom rastvaraču, i tako dobijeno intermedijerno jedinjenje III gde X ima gornje značenje, tretira u vodenom ili vodeno-alkoholnom rastvoru sa azotastom kiselinom na hladno ili na sobnoj temperaturi i željeno jedinjenje formule I se izoluje i prečišćava prema uobičajenim postupcima. - Prijava sadrži još 2 zavisna zahteva.A process for the preparation of TRIAZOLYL-ISOPROPANOL - A process for the preparation of a compound of formula I or a pharmaceutically acceptable salt thereof, wherein the compound of formula II wherein X is a fluorine, chlorine, bromine or iodine atom is treated with 4-amino-1,2. 4-triazole in an inert solvent, and thus obtained intermediate compound III where X has the above meaning, is treated in aqueous or aqueous-alcoholic solution with nitric acid at cold or room temperature and the desired compound of formula I is isolated and purified according to the usual methods. - The application contains 2 more dependent requests.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02058690A IT1249211B (en) | 1990-06-08 | 1990-06-08 | Process for the preparation of triazolyl isopropanols, in particular fluconazole |
Publications (2)
Publication Number | Publication Date |
---|---|
YU101291A YU101291A (en) | 1993-11-16 |
YU48331B true YU48331B (en) | 1998-05-15 |
Family
ID=11169192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU101291A YU48331B (en) | 1990-06-08 | 1991-06-06 | PROCEDURE FOR OBTAINING TRIAZOLYL-ISOPROPANOL |
Country Status (5)
Country | Link |
---|---|
AT (1) | AT400145B (en) |
CA (1) | CA2051281C (en) |
ES (1) | ES2026416A6 (en) |
IT (1) | IT1249211B (en) |
YU (1) | YU48331B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2049663B1 (en) * | 1992-10-13 | 1994-12-16 | Genesis Para La Investigacion | PROCEDURE FOR OBTAINING FLUCONAZOLE. |
IL105200A (en) * | 1993-03-29 | 1997-03-18 | Teva Pharma | Regiospecific processes for the preparation of 1, 3-bis (1, 2, 4-triazol-1-yl)-propan- 2-ol derivatives |
HU212424B (en) * | 1993-09-23 | 1996-06-28 | Richter Gedeon Vegyeszet | New propan-2-ol derivatives substituted with triazole or imidazole and process for producing them |
SI9600165A (en) * | 1996-05-21 | 1997-12-31 | Krka Tovarna Zdravil D D Novo | Process for preparation of biological active derivative of 1,2,4- triazole and intermediates useful in this process |
CA2439310C (en) * | 2001-03-23 | 2009-09-29 | Richter Gedeon Vegyeszeti Gyar Rt. | Process for preparing fluconazole and its crystal modifications |
UA78580C2 (en) | 2002-06-24 | 2007-04-10 | Basf Ag | A process for the preparation of 1,2,4-triazol-1-yl-methyl-oxiranes and an intermediary compound |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR79307B (en) * | 1982-06-09 | 1984-10-22 | Pfizer | |
ES8604938A1 (en) * | 1985-11-19 | 1986-03-01 | Inke Sa | 2-(Difluorophenyl)-1,3-bis(triazolyl) propan-2-ol prepn. |
ES8604939A1 (en) * | 1985-11-19 | 1986-03-01 | Inke Sa | 2-(Difluorophenyl) 1,3-bis (1H-triazolyl) propan-2-ol prepn. |
ES8604940A1 (en) * | 1985-11-19 | 1986-03-01 | Inke Sa | 2-(Difluorophenyl) 1,3-bis(1H-triazolyl) propan-2-ol prepn. |
ES8605753A1 (en) * | 1985-12-06 | 1986-04-16 | Lazlo Int Sa | Di-triazolyl:methyl di:fluoro-phenyl carbinol prepn. |
-
1990
- 1990-06-08 IT IT02058690A patent/IT1249211B/en active IP Right Grant
- 1990-11-21 ES ES9002961A patent/ES2026416A6/en not_active Expired - Lifetime
-
1991
- 1991-06-05 AT AT113291A patent/AT400145B/en not_active IP Right Cessation
- 1991-06-06 YU YU101291A patent/YU48331B/en unknown
- 1991-09-13 CA CA 2051281 patent/CA2051281C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATA113291A (en) | 1995-02-15 |
CA2051281A1 (en) | 1993-03-14 |
IT9020586A1 (en) | 1991-12-08 |
ES2026416A6 (en) | 1992-04-16 |
AT400145B (en) | 1995-10-25 |
CA2051281C (en) | 1998-07-07 |
IT1249211B (en) | 1995-02-20 |
IT9020586A0 (en) | 1990-06-07 |
YU101291A (en) | 1993-11-16 |
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