CA2051281A1 - Process for the preparation of triazolyl isopropanols - Google Patents

Process for the preparation of triazolyl isopropanols

Info

Publication number
CA2051281A1
CA2051281A1 CA 2051281 CA2051281A CA2051281A1 CA 2051281 A1 CA2051281 A1 CA 2051281A1 CA 2051281 CA2051281 CA 2051281 CA 2051281 A CA2051281 A CA 2051281A CA 2051281 A1 CA2051281 A1 CA 2051281A1
Authority
CA
Canada
Prior art keywords
preparation
isopropanols
triazolyl
fluconazole
halohydrinic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2051281
Other languages
French (fr)
Other versions
CA2051281C (en
Inventor
Fulvio Benigni
Rino Prendin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industriale Chimica SRL
Original Assignee
Industriale Chimica SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industriale Chimica SRL filed Critical Industriale Chimica SRL
Publication of CA2051281A1 publication Critical patent/CA2051281A1/en
Application granted granted Critical
Publication of CA2051281C publication Critical patent/CA2051281C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

An improved method for the preparation of fluconazole is described, by reacting an halohydrinic intermediate with 4-amino-1,2,4-triazole compound of formula II
CA 2051281 1990-06-08 1991-09-13 Process for the preparation of triazolyl isopropanols Expired - Lifetime CA2051281C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02058690A IT1249211B (en) 1990-06-08 1990-06-08 Process for the preparation of triazolyl isopropanols, in particular fluconazole

Publications (2)

Publication Number Publication Date
CA2051281A1 true CA2051281A1 (en) 1993-03-14
CA2051281C CA2051281C (en) 1998-07-07

Family

ID=11169192

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2051281 Expired - Lifetime CA2051281C (en) 1990-06-08 1991-09-13 Process for the preparation of triazolyl isopropanols

Country Status (5)

Country Link
AT (1) AT400145B (en)
CA (1) CA2051281C (en)
ES (1) ES2026416A6 (en)
IT (1) IT1249211B (en)
YU (1) YU48331B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0618198A1 (en) * 1993-03-29 1994-10-05 Teva Pharmaceutical Industries Ltd. Process for the preparation of 1,3-bis (1,2,4-triazol-1-yl)-propan-2-ol derivatives
WO1995008543A1 (en) * 1993-09-23 1995-03-30 Richter Gedeon Vegyészeti Gyár Rt. Novel substituted propane-2-ol derivatives
WO2004000835A1 (en) * 2002-06-24 2003-12-31 Basf Aktiengesellschaft Method for the production of 1,2,4-triazolylmethyl-oxiranes

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2049663B1 (en) * 1992-10-13 1994-12-16 Genesis Para La Investigacion PROCEDURE FOR OBTAINING FLUCONAZOLE.
SI9600165A (en) * 1996-05-21 1997-12-31 Krka Tovarna Zdravil D D Novo Process for preparation of biological active derivative of 1,2,4- triazole and intermediates useful in this process
CA2439310C (en) 2001-03-23 2009-09-29 Richter Gedeon Vegyeszeti Gyar Rt. Process for preparing fluconazole and its crystal modifications

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79307B (en) * 1982-06-09 1984-10-22 Pfizer
ES8604939A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl) 1,3-bis (1H-triazolyl) propan-2-ol prepn.
ES8604940A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl) 1,3-bis(1H-triazolyl) propan-2-ol prepn.
ES8604938A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl)-1,3-bis(triazolyl) propan-2-ol prepn.
ES8605753A1 (en) * 1985-12-06 1986-04-16 Lazlo Int Sa Di-triazolyl:methyl di:fluoro-phenyl carbinol prepn.

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0618198A1 (en) * 1993-03-29 1994-10-05 Teva Pharmaceutical Industries Ltd. Process for the preparation of 1,3-bis (1,2,4-triazol-1-yl)-propan-2-ol derivatives
US5484936A (en) * 1993-03-29 1996-01-16 Teva Pharmaceutical Industries Ltd. Processes for the preparation of 1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol derivatives
AU683443B2 (en) * 1993-03-29 1997-11-13 Teva Pharmaceutical Industries Ltd. Processes for the preparation of 1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol derivatives
WO1995008543A1 (en) * 1993-09-23 1995-03-30 Richter Gedeon Vegyészeti Gyár Rt. Novel substituted propane-2-ol derivatives
WO2004000835A1 (en) * 2002-06-24 2003-12-31 Basf Aktiengesellschaft Method for the production of 1,2,4-triazolylmethyl-oxiranes
CN100345841C (en) * 2002-06-24 2007-10-31 巴斯福股份公司 Preparation for the production of 1,2,4-triazolymethyl-oxiranes
US7368464B2 (en) 2002-06-24 2008-05-06 Basf Aktiengesellschaft Preparation for the production of 1,2,4-triazolylmethyl-oxiranes

Also Published As

Publication number Publication date
ATA113291A (en) 1995-02-15
IT9020586A1 (en) 1991-12-08
AT400145B (en) 1995-10-25
YU101291A (en) 1993-11-16
YU48331B (en) 1998-05-15
ES2026416A6 (en) 1992-04-16
IT1249211B (en) 1995-02-20
IT9020586A0 (en) 1990-06-07
CA2051281C (en) 1998-07-07

Similar Documents

Publication Publication Date Title
CA2011428A1 (en) Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
CA2136893A1 (en) Substituted n-piperidino-pyrazole-3-carboxamide
CA2026143A1 (en) Triazole compounds, their production and use
ES8504151A1 (en) 1-Azolyl-2-aryl-3-fluoralkan-2-ols as microbicides.
CA2051281A1 (en) Process for the preparation of triazolyl isopropanols
IE850157L (en) Imidazole and triazole derivatives
IE832184L (en) Derivatives of imidazole and 1, 2, 4-triazole.
CA2158130A1 (en) Process and Intermediates for Preparing Azabicyclo(2.2.2)Octan-3-Imines
CA2081413A1 (en) Preparation of derivatives of 6-trifluoromethyl-1,3,5-triazine
IE41173L (en) Fungicidal triazole derivatives
CA2058888A1 (en) Phenoxyalkylcarboxylic acid derivatives and process of preparing the same
AU8135691A (en) 4-amino-delta4, 6-steroids and their use as 5alpha-reductase inhibitors
CA2172014A1 (en) Preparation of .alpha.-chloroalkyl aryl ketones
ES8602412A1 (en) Emulsifiable concentrates containing azoles.
HUP9901978A2 (en) Process for the preparation of the herbicide ethyl-[alfa,2-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1h-1,2,4-triazol-1-yl]-4-fluoro-phenyl]-propanoate
ES8401479A1 (en) Phenoxypropyltriazolyl ketones and carbinols, process for their preparation and their use as fungicides, and intermediates for their production.
EP0234499A3 (en) Antifungal azolylpropanol derivatives
UA27882C2 (en) METHOD OF OBTAINING ACID CHLORANHYDRIDES
CA2170872A1 (en) Process for the preparation of compounds having ace inhibitory action as well as novel compounds useful as starting materials or intermediates in said process
IE873013L (en) Pyrazoline pesticides
ES2020785A6 (en) Process for obtaining 1,3-bis(1H-1,2,4-triazol-1-yl)- propan-2-one
IE800886L (en) Phenothiazine derivatives
CA2013516A1 (en) Preparation process of new thieno-triazolo-diazepine
IE801024L (en) 6-haloalkylsulphonyloxy penicillanic acid derivatives
DE3270398D1 (en) 5-aryloxy-5-azolyl-3,3-dimethyl-1-penten-4-ones and -ols, process for their preparation and their use as fungicides

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry