CA2051281A1 - Process for the preparation of triazolyl isopropanols - Google Patents

Process for the preparation of triazolyl isopropanols

Info

Publication number
CA2051281A1
CA2051281A1 CA 2051281 CA2051281A CA2051281A1 CA 2051281 A1 CA2051281 A1 CA 2051281A1 CA 2051281 CA2051281 CA 2051281 CA 2051281 A CA2051281 A CA 2051281A CA 2051281 A1 CA2051281 A1 CA 2051281A1
Authority
CA
Canada
Prior art keywords
preparation
isopropanols
triazolyl
fluconazole
halohydrinic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2051281
Other languages
French (fr)
Other versions
CA2051281C (en
Inventor
Fulvio Benigni
Rino Prendin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industriale Chimica SRL
Original Assignee
Industriale Chimica SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industriale Chimica SRL filed Critical Industriale Chimica SRL
Publication of CA2051281A1 publication Critical patent/CA2051281A1/en
Application granted granted Critical
Publication of CA2051281C publication Critical patent/CA2051281C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

An improved method for the preparation of fluconazole is described, by reacting an halohydrinic intermediate with 4-amino-1,2,4-triazole compound of formula II
CA 2051281 1990-06-08 1991-09-13 Process for the preparation of triazolyl isopropanols Expired - Lifetime CA2051281C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02058690A IT1249211B (en) 1990-06-08 1990-06-08 Process for the preparation of triazolyl isopropanols, in particular fluconazole

Publications (2)

Publication Number Publication Date
CA2051281A1 true CA2051281A1 (en) 1993-03-14
CA2051281C CA2051281C (en) 1998-07-07

Family

ID=11169192

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2051281 Expired - Lifetime CA2051281C (en) 1990-06-08 1991-09-13 Process for the preparation of triazolyl isopropanols

Country Status (5)

Country Link
AT (1) AT400145B (en)
CA (1) CA2051281C (en)
ES (1) ES2026416A6 (en)
IT (1) IT1249211B (en)
YU (1) YU48331B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0618198A1 (en) * 1993-03-29 1994-10-05 Teva Pharmaceutical Industries Ltd. Process for the preparation of 1,3-bis (1,2,4-triazol-1-yl)-propan-2-ol derivatives
WO1995008543A1 (en) * 1993-09-23 1995-03-30 Richter Gedeon Vegyészeti Gyár Rt. Novel substituted propane-2-ol derivatives
WO2004000835A1 (en) * 2002-06-24 2003-12-31 Basf Aktiengesellschaft Method for the production of 1,2,4-triazolylmethyl-oxiranes

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2049663B1 (en) * 1992-10-13 1994-12-16 Genesis Para La Investigacion PROCEDURE FOR OBTAINING FLUCONAZOLE.
SI9600165A (en) * 1996-05-21 1997-12-31 Krka Tovarna Zdravil D D Novo Process for preparation of biological active derivative of 1,2,4- triazole and intermediates useful in this process
HU226886B1 (en) * 2001-03-23 2010-01-28 Richter Gedeon Nyrt Novel process for preparing fluconazole monohydrate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79307B (en) * 1982-06-09 1984-10-22 Pfizer
ES8604940A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl) 1,3-bis(1H-triazolyl) propan-2-ol prepn.
ES8604939A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl) 1,3-bis (1H-triazolyl) propan-2-ol prepn.
ES8604938A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl)-1,3-bis(triazolyl) propan-2-ol prepn.
ES8605753A1 (en) * 1985-12-06 1986-04-16 Lazlo Int Sa Di-triazolyl:methyl di:fluoro-phenyl carbinol prepn.

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0618198A1 (en) * 1993-03-29 1994-10-05 Teva Pharmaceutical Industries Ltd. Process for the preparation of 1,3-bis (1,2,4-triazol-1-yl)-propan-2-ol derivatives
US5484936A (en) * 1993-03-29 1996-01-16 Teva Pharmaceutical Industries Ltd. Processes for the preparation of 1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol derivatives
AU683443B2 (en) * 1993-03-29 1997-11-13 Teva Pharmaceutical Industries Ltd. Processes for the preparation of 1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol derivatives
WO1995008543A1 (en) * 1993-09-23 1995-03-30 Richter Gedeon Vegyészeti Gyár Rt. Novel substituted propane-2-ol derivatives
WO2004000835A1 (en) * 2002-06-24 2003-12-31 Basf Aktiengesellschaft Method for the production of 1,2,4-triazolylmethyl-oxiranes
CN100345841C (en) * 2002-06-24 2007-10-31 巴斯福股份公司 Preparation for the production of 1,2,4-triazolymethyl-oxiranes
US7368464B2 (en) 2002-06-24 2008-05-06 Basf Aktiengesellschaft Preparation for the production of 1,2,4-triazolylmethyl-oxiranes

Also Published As

Publication number Publication date
IT9020586A0 (en) 1990-06-07
AT400145B (en) 1995-10-25
IT1249211B (en) 1995-02-20
YU48331B (en) 1998-05-15
IT9020586A1 (en) 1991-12-08
ES2026416A6 (en) 1992-04-16
ATA113291A (en) 1995-02-15
YU101291A (en) 1993-11-16
CA2051281C (en) 1998-07-07

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry