ES2049663B1 - PROCEDURE FOR OBTAINING FLUCONAZOLE. - Google Patents

PROCEDURE FOR OBTAINING FLUCONAZOLE.

Info

Publication number
ES2049663B1
ES2049663B1 ES9202027A ES9202027A ES2049663B1 ES 2049663 B1 ES2049663 B1 ES 2049663B1 ES 9202027 A ES9202027 A ES 9202027A ES 9202027 A ES9202027 A ES 9202027A ES 2049663 B1 ES2049663 B1 ES 2049663B1
Authority
ES
Spain
Prior art keywords
fluconazole
procedure
obtaining
formula
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9202027A
Other languages
Spanish (es)
Other versions
ES2049663A1 (en
Inventor
Coll Alberto Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro Genesis para la Investigacion SL
Original Assignee
Centro Genesis para la Investigacion SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Genesis para la Investigacion SL filed Critical Centro Genesis para la Investigacion SL
Priority to ES9202027A priority Critical patent/ES2049663B1/en
Publication of ES2049663A1 publication Critical patent/ES2049663A1/en
Application granted granted Critical
Publication of ES2049663B1 publication Critical patent/ES2049663B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE FLUCONAZOL, DE NOMBRE QUIMICO 2-(2,4-DIFLUOROFENIL)-1, 3-BIS-(1-(1H-1,2,4-TRIAZOL-1-IL))- PROPAN-2-OL, DE FORMULA I, BASADO EN LA REACCION DEL COMPUESTO DE FORMULA II FORMULA DONDE M = LI O NA, CON CLORURO DE 2,4-DIFLUOROBENZOILO, EN PRESENCIA DE UN SOLVENTE Y A UNA TEMPERATURA COMPRENDIDA ENTRE 0º Y LA DE EBULLICION DEL SOLVENTE.PROCEDURE FOR OBTAINING FLUCONAZOLE, CHEMICAL NAME 2- (2,4-DIFLUOROPHENYL) -1, 3-BIS- (1- (1H-1,2,4-TRIAZOL-1-IL)) - PROPAN-2-OL , FROM FORMULA I, BASED ON THE REACTION OF THE COMPOUND OF FORMULA II FORMULA WHERE M = LI OR NA, WITH 2,4-DIFLUOROBENZOIL CHLORIDE, IN THE PRESENCE OF A SOLVENT AND A TEMPERATURE INCLUDED BETWEEN 0º AND THE BOILING OF THE SOLVENT.

ES9202027A 1992-10-13 1992-10-13 PROCEDURE FOR OBTAINING FLUCONAZOLE. Expired - Lifetime ES2049663B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9202027A ES2049663B1 (en) 1992-10-13 1992-10-13 PROCEDURE FOR OBTAINING FLUCONAZOLE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202027A ES2049663B1 (en) 1992-10-13 1992-10-13 PROCEDURE FOR OBTAINING FLUCONAZOLE.

Publications (2)

Publication Number Publication Date
ES2049663A1 ES2049663A1 (en) 1994-04-16
ES2049663B1 true ES2049663B1 (en) 1994-12-16

Family

ID=8278395

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202027A Expired - Lifetime ES2049663B1 (en) 1992-10-13 1992-10-13 PROCEDURE FOR OBTAINING FLUCONAZOLE.

Country Status (1)

Country Link
ES (1) ES2049663B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113651762B (en) * 2021-09-03 2023-12-26 上海晋鲁医药科技有限公司 Preparation method of 1-methyl-1H-1, 2, 4-triazole-3-methyl formate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2099818A (en) * 1981-06-06 1982-12-15 Pfizer Ltd Triazoles
GR79307B (en) * 1982-06-09 1984-10-22 Pfizer
ES8604940A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl) 1,3-bis(1H-triazolyl) propan-2-ol prepn.
ES8604938A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl)-1,3-bis(triazolyl) propan-2-ol prepn.
ES8604939A1 (en) * 1985-11-19 1986-03-01 Inke Sa 2-(Difluorophenyl) 1,3-bis (1H-triazolyl) propan-2-ol prepn.
IT1249211B (en) * 1990-06-08 1995-02-20 Ind Chimica Srl Process for the preparation of triazolyl isopropanols, in particular fluconazole

Also Published As

Publication number Publication date
ES2049663A1 (en) 1994-04-16

Similar Documents

Publication Publication Date Title
SE7801088L (en) NEW IMIDAZOLES
YU42770B (en) Process for obtaining 2-(2,4-difluorophenyl)-1,3-bis-(1h-1,2,4-triazol-1-yl)propane-2-oles
ATE134368T1 (en) SUBSTITUTED IMIDAZOLES AND THEIR USE AS AN ANGIOTENSIN II INHIBITOR
SE8305128D0 (en) triazole
AU515134B2 (en) 1-(2-aryl-2-r-ethyl)-1h-1,2,4-triazoles
DE3587790D1 (en) Substituted imidazoles and triazoles.
DK0528922T3 (en) New sulfonyl compounds
GB9010948D0 (en) A thermal shunt for a battery
IT1162369B (en) 1- (2-ARIL-1,3-DIOSSAN-2-IL-METHYL) -1H-IMIDAZOLS AND 1H-1,2,4-TRIAZOLS EQUIPPED WITH ANTI-MUSHROOM ACTIVITIES AND PROCEDURE FOR THEIR PREPARATION
ES2049663B1 (en) PROCEDURE FOR OBTAINING FLUCONAZOLE.
ATE24909T1 (en) ANTIFUNGAL TRIAZOLES.
KR840007589A (en) Method for preparing triazole derivative
DE3368468D1 (en) Immersion oil
ATE5190T1 (en) 1,1-DIPHENYL-2-(1,2,4-TRIAZOLE-1-YL)-AETHANE-1-OLS AS ANTIFUNCTIONAL AGENTS.
IL65924A (en) 1,1-diaryl-2-(1,2,4-triazolyl)ethanes,process for their preparation and biocidal compositions containing them
ES2151077T3 (en) PROCEDURE FOR THE OBTAINING OF 1,3-DISUBSTITUTED IMIDAZOLIDINONES.
YU101291A (en) PROCEDURE FOR THE PREPARATION OF TRIAZOLYL-ISOPROPANOL
ZA829266B (en) Fungicidal alpha-azolylglycols
DE3863079D1 (en) 1- (2,4-DIFLUORPHENYL) -1- (1-FLUORCYCLOPROPYL) -2- (1,2,4-TRIAZOL-1-YL) -ETHAN-1-OL.
ATE130162T1 (en) FUNGICIDAL ACTIVE COMBINATIONS.
ES549022A0 (en) PROCEDURE FOR OBTAINING 2- (2,4-DIFLUOROPHENYL) - 1,3-BIS (1H-1,2,4-TRIAZOL-1-IL) -PROPAN-2-OL.
GB2003466A (en) 1,2,4-triazoles
FI884520A0 (en) 5-MONO-ELLER -DISUBSTITUERADE-3- (PHENYL-ELLER-2-NAPHTHALENYL) -3 - / (1H-IMIDAZOL-1-YLMETHYL-ELLER - (1H-1,2,4-TRIAZOL-1-YLMETHYL)) -2- (METHYL-ELLER-BENZENYL) ISOXAZOLIDINER.
DK161517C (en) 1,1-DIPERFLUORALKYL-2- (1H-1,2,4-TRIAZOL-1-YL) ETHANOL COMPOUNDS AND PHARMACEUTICAL ACCEPTABLE SALTS THEREOF, AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS
TH13660EX (en) Triacol derivatives And a new type of Imidesol, which has a fungicide

Legal Events

Date Code Title Description
FA2A Application withdrawn

Effective date: 19950425