YU46663B - PROCESS FOR THE PREPARATION OF CRYSTAL N- (S-3-ALKYL-HEPTANOYL) -D-GAMA-GLUTAMYL-GLYCYL-D-ALANINE - Google Patents

PROCESS FOR THE PREPARATION OF CRYSTAL N- (S-3-ALKYL-HEPTANOYL) -D-GAMA-GLUTAMYL-GLYCYL-D-ALANINE

Info

Publication number
YU46663B
YU46663B YU155987A YU155987A YU46663B YU 46663 B YU46663 B YU 46663B YU 155987 A YU155987 A YU 155987A YU 155987 A YU155987 A YU 155987A YU 46663 B YU46663 B YU 46663B
Authority
YU
Yugoslavia
Prior art keywords
methyl
alkyl
formula
compound
double bond
Prior art date
Application number
YU155987A
Other languages
Serbo-Croatian (sh)
Other versions
YU155987A (en
Inventor
C.W. Murtiasnaw
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1986/001775 external-priority patent/WO1988001613A1/en
Priority claimed from PCT/US1986/001772 external-priority patent/WO1988001612A1/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU155987A publication Critical patent/YU155987A/en
Publication of YU46663B publication Critical patent/YU46663B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

POSTUPAK ZA DOBIJANJE KRISTALNOG N-(S-3-ALKIL-HEPTANOIL)-D-GAMA-GLUTAMIL-GLICIL-D-ALANINA, a drugi je (C1-C6)alkil ili (C6-C8)cikloalkilmetil, naznačen t ime, što obuhvata fazu kuplovanja aktiviranog oblika R-trans-3-metil-4-heptenske kiseline, R-trans-3-etil-4- heptenske kiseline ili S-3-metil-6-heptenske kiseline sa jedinjenjem apsolutne stereohemijske formule pri čemu R6 i R7 su svaki benzil ili jedan R6 i R7 je benzil, a drugi je (C1-C6)alkil ili (C6-C8)cikloalkil-metil radi formiranja jedinjenja apsolutne stereohemijske formule pri čemu jedna ili druga, ali ne obe tačkaste linije predstavljaju dvostruku vezu, R je metil ili etil pod uslovom da kada je dvostruka veza u terminalnom 6,7-položaju R je metil i fazu hidrogenovanja jedinjenja formule (IIIc) radi formiranja jedinjenja formule (I) sa uporednom reakcijom dvostruke veze i hidrogenolizom benzilestarske grupe, kao i kristalizaciju jedinjenja formule (I) u kojoj je R metil, a R4 i R5 su vodonik, iz organskog rastvarača ili grupe rastvarača. Prijava sadrži još 1 zavisan zahtev.A process for the production of CRYSTAL N- (S-3-ALKYL-HEPTANOYL) -D-GAMA-GLUTAMYL-GLYCYL-D-ALANINE, the other being (C1-C6) alkyl or (C6-C8) cycloalkylmethyl, indicated by the name comprising the coupling step of an activated form of R-trans-3-methyl-4-heptenic acid, R-trans-3-ethyl-4-heptenic acid or S-3-methyl-6-heptenic acid with a compound of absolute stereochemical formula wherein R6 and R7 is each benzyl or one R6 and R7 is benzyl and the other is (C1-C6) alkyl or (C6-C8) cycloalkyl-methyl to form compounds of absolute stereochemical formula wherein one or the other but not both dotted lines represent a double bond , R is methyl or ethyl provided that when the double bond is in the terminal 6,7-position R is methyl and the hydrogenation phase of a compound of formula (IIIc) to form a compound of formula (I) with a parallel double bond reaction and hydrogenolysis of a benzyl ester group, as well as crystallization of a compound of formula (I) wherein R is methyl and R 4 and R 5 are hydrogen, from an organic solvent or group is a solvent. The application contains 1 more dependent request.

YU155987A 1986-08-27 1987-08-24 PROCESS FOR THE PREPARATION OF CRYSTAL N- (S-3-ALKYL-HEPTANOYL) -D-GAMA-GLUTAMYL-GLYCYL-D-ALANINE YU46663B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1986/001775 WO1988001613A1 (en) 1986-08-27 1986-08-27 Crystalline n-(s-3-methylheptanoyl)-d-gamma-glutamyl-glycyl-d-alanine, and processes and intermediates therefor
PCT/US1986/001772 WO1988001612A1 (en) 1986-08-27 1986-08-27 Processes and intermediates for n-(s-3-alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-d-alanine

Publications (2)

Publication Number Publication Date
YU155987A YU155987A (en) 1989-02-28
YU46663B true YU46663B (en) 1994-01-20

Family

ID=26773904

Family Applications (1)

Application Number Title Priority Date Filing Date
YU155987A YU46663B (en) 1986-08-27 1987-08-24 PROCESS FOR THE PREPARATION OF CRYSTAL N- (S-3-ALKYL-HEPTANOYL) -D-GAMA-GLUTAMYL-GLYCYL-D-ALANINE

Country Status (12)

Country Link
JP (1) JPH0637517B2 (en)
KR (1) KR900004106B1 (en)
CN (1) CN1021436C (en)
DK (1) DK444887A (en)
EG (1) EG18303A (en)
IL (1) IL83657A (en)
MY (1) MY101823A (en)
NZ (1) NZ221570A (en)
PH (1) PH27397A (en)
PL (1) PL156175B1 (en)
PT (1) PT85581B (en)
YU (1) YU46663B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113548977A (en) * 2021-07-12 2021-10-26 广州乐信生物科技有限公司 Process for producing N-methyl-beta-alanine derivative

Also Published As

Publication number Publication date
YU155987A (en) 1989-02-28
IL83657A0 (en) 1988-01-31
IL83657A (en) 1992-03-29
MY101823A (en) 1992-01-31
KR880002896A (en) 1988-05-12
KR900004106B1 (en) 1990-06-15
PT85581A (en) 1987-09-01
PL156175B1 (en) 1992-02-28
CN1021436C (en) 1993-06-30
PH27397A (en) 1993-06-21
CN87105898A (en) 1988-03-09
DK444887D0 (en) 1987-08-26
JPH0637517B2 (en) 1994-05-18
DK444887A (en) 1988-02-28
EG18303A (en) 1992-12-30
NZ221570A (en) 1989-09-27
PT85581B (en) 1990-05-31
PL267444A1 (en) 1988-07-21
JPS6368598A (en) 1988-03-28

Similar Documents

Publication Publication Date Title
ES2131207T3 (en) AMIDAS DERIVATIVES OF VALPROIC ACID AND 2-VALPROENOIC ACID AND ITS USE AS ANTICONVULSIVES.
ATE33838T1 (en) THIAZOLIDE DERIVATIVES, THEIR PRODUCTION AND COMPOSITIONS CONTAINING THEM.
CA2053253A1 (en) New aryl-and heteroarylethenylene derivatives and process for their preparation
ES8103088A1 (en) Spiro-(dihydrobenzofuranpiperidines and -pyrrolidines) and derivatives thereof, methods for their preparation and medicines containing them.
KR910011887A (en) New A-Nor-Steroid-3-carboxylic Acid Derivatives
FI955661A0 (en) Substituted beta-aryl and beta-heteroaryl-alpha-cyanoacrylamide derivatives as tyrosine kinase inhibitors
GB1511463A (en) 1-acylamino methyl-1,2,3,4-tetrahydroisoquinolines
ES473837A1 (en) Isolation of organic acids
ES439430A1 (en) Stilbene derivatives
DE69930616D1 (en) PROCESS FOR SYNTHESIS OF CARBAPENEM ANTIBIOTICS
YU46663B (en) PROCESS FOR THE PREPARATION OF CRYSTAL N- (S-3-ALKYL-HEPTANOYL) -D-GAMA-GLUTAMYL-GLYCYL-D-ALANINE
DK682288A (en) METHOD OF PREPARING QUINOLINCARBOXYL ACID
ATE18226T1 (en) PYRROLO(2,3-D)CARBAZOL DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE.
DK0658211T4 (en) Enzymatic, asymmetric reduction process for the preparation of 4H-thieno (2,3-6) thiopyran derivatives
ES8609195A1 (en) Process for preparing anti-inflammatory cycloalkylidenemethylphenylacetic acid derivatives.
ATE8389T1 (en) AMINO-ALKOXY-PYRAZOLE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM.
DE59108433D1 (en) PHENYLETHANOLAMINE, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
ATE26258T1 (en) PRODUCTION OF PHENYLALANINES BY HYDROGENATION OF PHENYLSERINES.
SE7510787L (en) NEW NITROGENIC, POLYCYCLIC ASSOCIATIONS, SALTS THEREOF AND THEIR OPTICAL ANTIPODS, JUST LIKE THEIR PREPARATION
JPS57146786A (en) Optically active borane compound and preparation of optically active compound using the same
ZA888663B (en) Substituted derivatives of 20,21-dinoreburanamenine,their preparation process and the new intermediates thus obtained,their use as medicaments and the pharmaceutical compositions containing them
ATE29251T1 (en) AMINOPYRIDINECARBONIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
SE7513126L (en) NEW Nitrogen-containing, POLYCYCLIC ASSOCIATIONS JUST SEEN FOR THEIR PREPARATION
CA2039401A1 (en) Preparation of optically active norbornyl amine derivatives
DE69621450D1 (en) SYNTHESIS OF CHIRAL 3-HYDROXY-2-PYRROLIDINONE DERIVATIVES