YU46429B - Postupak za dobivanje derivata hinolin karboksilne kiseline - Google Patents

Postupak za dobivanje derivata hinolin karboksilne kiseline

Info

Publication number
YU46429B
YU46429B YU190487A YU190487A YU46429B YU 46429 B YU46429 B YU 46429B YU 190487 A YU190487 A YU 190487A YU 190487 A YU190487 A YU 190487A YU 46429 B YU46429 B YU 46429B
Authority
YU
Yugoslavia
Prior art keywords
general formula
hydrogen atom
group
preparation
carboxylic acid
Prior art date
Application number
YU190487A
Other languages
English (en)
Other versions
YU190487A (en
Inventor
J. Frank
K. Beres
G. Kulcsar
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Publication of YU190487A publication Critical patent/YU190487A/xx
Publication of YU46429B publication Critical patent/YU46429B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

POSTUPAK ZA DOBIVANJE DERIVATA HINOLIN KARBOKSILNE KISELINE, opšte formule I gde R je atom vodonika ili formil grupa R1 predstavlja atom vodonika ili normalnu ili cikličnu alki grupu koja ima 1-4 atoma ugljenika, koja može biti supstituisana halogenim atomom, hidroksi ili amino grupom, ili grupu CH3-NH-, R2 je atom vodonika ili niža alkil grupa i njihovih hidrata i farmaceutski prihvatljivih soli, naznačen time, što reaguje jedinjenje opšte formule II gde R1 i R2 imaju napred data značenja ili njegova kiselina adiciona so, sa piperazinom u dimetil formamidu i u kiseloj sredini na 120-153 stepeni C i, ako se želi, tako dobiveno jedinjenje opšte formule III. gde R1 i R2 imaju napred dato značenje, reaguje sa mineralnom kiselinom ili alkalijom ili podesno se tretira sa hidrazinom, poželjno sa hidrazin hidratom u smeši izopropil alkohola i vode na temperaturi 25-110 stepeni C. Prijava sadrži 1 nezavisni i 1 zavisni zahtev.
YU190487A 1986-10-15 1987-10-15 Postupak za dobivanje derivata hinolin karboksilne kiseline YU46429B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU864292A HU196987B (en) 1986-10-15 1986-10-15 Process for producing quinoline-carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
YU190487A YU190487A (en) 1988-10-31
YU46429B true YU46429B (sh) 1993-10-20

Family

ID=10967565

Family Applications (1)

Application Number Title Priority Date Filing Date
YU190487A YU46429B (sh) 1986-10-15 1987-10-15 Postupak za dobivanje derivata hinolin karboksilne kiseline

Country Status (7)

Country Link
US (1) US4935512A (sh)
EP (1) EP0285655B1 (sh)
JP (1) JPH01501312A (sh)
DD (1) DD263530A5 (sh)
HU (1) HU196987B (sh)
WO (1) WO1988002748A1 (sh)
YU (1) YU46429B (sh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4019023A1 (de) * 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1175836A (en) * 1977-09-20 1984-10-09 Marcel Pesson Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren

Also Published As

Publication number Publication date
HU196987B (en) 1989-02-28
WO1988002748A1 (en) 1988-04-21
HUT45244A (en) 1988-06-28
YU190487A (en) 1988-10-31
DD263530A5 (de) 1989-01-04
EP0285655B1 (en) 1992-04-15
JPH01501312A (ja) 1989-05-11
EP0285655A1 (en) 1988-10-12
US4935512A (en) 1990-06-19

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