YU46319B - PROCESS FOR PREPARATION OF 1- / 3-MERCAPTO- / 2S / -METHYLPROPIONYL / -PYROLIDINE- / 2S / -CARBOXYLIC ACID - Google Patents
PROCESS FOR PREPARATION OF 1- / 3-MERCAPTO- / 2S / -METHYLPROPIONYL / -PYROLIDINE- / 2S / -CARBOXYLIC ACIDInfo
- Publication number
- YU46319B YU46319B YU118187A YU118187A YU46319B YU 46319 B YU46319 B YU 46319B YU 118187 A YU118187 A YU 118187A YU 118187 A YU118187 A YU 118187A YU 46319 B YU46319 B YU 46319B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- pyrolidine
- methylpropionyl
- mercapto
- preparation
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
naznačen time, što reaguje omega-halo-acilprolin formule gde X predstavlja halo, ili njegova so sa tioureom u organskom dipolarnom aprotičnom rastvaračom tako da daje izotiouronijum ili njegov hidrohalid, po izboru posle izolovanja, se hidrolizira i, ako se želi, proizvod formule I se prevodi u so ili se oslobadja iz soli. -Prijava sadrži još 7 zahteva.characterized in that it reacts with an omega-halo-acylproline of formula wherein X represents halo, or a thiourea salt thereof in an organic dipolar aprotic solvent to give isothiouronium or a hydrohalide thereof, optionally after isolation, is hydrolyzed and, if desired, the product of formula I is translated into salt or released from salt. -The application contains 7 more requests.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU862689A HU196959B (en) | 1986-06-27 | 1986-06-27 | Process for producing merkapto-acyl-proline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
YU118187A YU118187A (en) | 1988-04-30 |
YU46319B true YU46319B (en) | 1993-05-28 |
Family
ID=10960651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU118187A YU46319B (en) | 1986-06-27 | 1987-06-24 | PROCESS FOR PREPARATION OF 1- / 3-MERCAPTO- / 2S / -METHYLPROPIONYL / -PYROLIDINE- / 2S / -CARBOXYLIC ACID |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPS6327475A (en) |
KR (1) | KR900007217B1 (en) |
CN (1) | CN87104388A (en) |
AR (1) | AR243159A1 (en) |
AT (2) | AT395012B (en) |
CH (1) | CH673279A5 (en) |
CS (1) | CS276394B6 (en) |
DD (1) | DD263757A5 (en) |
DE (1) | DE3721430A1 (en) |
DK (1) | DK329787A (en) |
ES (1) | ES2004451A6 (en) |
FI (1) | FI87770C (en) |
GR (1) | GR871012B (en) |
HU (1) | HU196959B (en) |
IT (1) | IT1206792B (en) |
NO (1) | NO168941C (en) |
PL (1) | PL153449B1 (en) |
PT (1) | PT85190B (en) |
SE (1) | SE462751B (en) |
SU (1) | SU1650007A3 (en) |
YU (1) | YU46319B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE421551B (en) * | 1980-03-26 | 1982-01-04 | Sandvik Ab | DRILLING TOOL FOR ROTATION AND / OR DRILLING |
HU208954B (en) * | 1990-09-21 | 1994-02-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn |
JPS62125081A (en) * | 1985-11-21 | 1987-06-06 | キングプリンテイング株式会社 | Printing method |
PT928191E (en) * | 1996-09-26 | 2003-01-31 | Meditor Pharmaceuticals Ltd | PHARMACEUTICAL FORMULATIONS UNDERSTANDING S-ALKYLISOYOURONIUM DERIVATIVES |
CN103086939A (en) * | 2011-10-28 | 2013-05-08 | 华中药业股份有限公司 | Recrystallization method of 1-(3-bromo-2-D-methyl propionyl)pyrrolidine-2-carboxylic acid |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
GB2065643B (en) * | 1979-12-13 | 1983-08-24 | Kanegafuchi Chemical Ind | Optically active n-mercaptoalkanoylamino acids |
IE54551B1 (en) * | 1982-01-22 | 1989-11-22 | Ici Plc | Amide derivatives |
KR860001391B1 (en) * | 1984-07-23 | 1986-09-22 | 보령제약 주식회사 | Process for the preparation of pyrolidines |
-
1986
- 1986-04-07 AT AT0091186A patent/AT395012B/en not_active IP Right Cessation
- 1986-06-27 HU HU862689A patent/HU196959B/en unknown
-
1987
- 1987-06-24 YU YU118187A patent/YU46319B/en unknown
- 1987-06-24 CH CH2372/87A patent/CH673279A5/de not_active IP Right Cessation
- 1987-06-24 CN CN198787104388A patent/CN87104388A/en active Pending
- 1987-06-26 GR GR871012A patent/GR871012B/en unknown
- 1987-06-26 KR KR1019870006546A patent/KR900007217B1/en active Pre-grant Review Request
- 1987-06-26 JP JP62159491A patent/JPS6327475A/en active Pending
- 1987-06-26 FI FI872859A patent/FI87770C/en not_active IP Right Cessation
- 1987-06-26 AR AR87307987A patent/AR243159A1/en active
- 1987-06-26 CS CS874794A patent/CS276394B6/en unknown
- 1987-06-26 NO NO872690A patent/NO168941C/en unknown
- 1987-06-26 PT PT85190A patent/PT85190B/en not_active IP Right Cessation
- 1987-06-26 DK DK329787A patent/DK329787A/en not_active Application Discontinuation
- 1987-06-26 SE SE8702654A patent/SE462751B/en not_active IP Right Cessation
- 1987-06-26 PL PL1987266478A patent/PL153449B1/en unknown
- 1987-06-26 AT AT0162087A patent/AT387381B/en not_active IP Right Cessation
- 1987-06-26 SU SU874202836A patent/SU1650007A3/en active
- 1987-06-26 ES ES8702024A patent/ES2004451A6/en not_active Expired
- 1987-06-26 DD DD87304203A patent/DD263757A5/en not_active IP Right Cessation
- 1987-06-26 IT IT8721085A patent/IT1206792B/en active
- 1987-06-29 DE DE19873721430 patent/DE3721430A1/en not_active Withdrawn
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