YU30202A - Postupak za dobijanje oksazolina iz tetrahidrofurana - Google Patents

Postupak za dobijanje oksazolina iz tetrahidrofurana

Info

Publication number
YU30202A
YU30202A YU30202A YUP30202A YU30202A YU 30202 A YU30202 A YU 30202A YU 30202 A YU30202 A YU 30202A YU P30202 A YUP30202 A YU P30202A YU 30202 A YU30202 A YU 30202A
Authority
YU
Yugoslavia
Prior art keywords
preparation
tetrahydrofurans
oxazolines
disclosed
nelfinavir
Prior art date
Application number
YU30202A
Other languages
English (en)
Inventor
Juliette Kharsa Busse
Scott Edward Zook
Bennett Chaplin Borer
Original Assignee
Agouron Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals Inc. filed Critical Agouron Pharmaceuticals Inc.
Publication of YU30202A publication Critical patent/YU30202A/sh

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Postupci za dobijanje hemijskih intermedijara u sintezi inhibitora HIV-proteaze koji su srodni sa i uključuju nelfinavir mezilat kao što je izloženo. Postupak prema ovom pronalasku sastoji se od konvertovanja derivata tetrahidrofurana u oksazolin da bi se obezbedili ključni intermedijari reakcije za dobijanje nelfinavira. Takodje je izložen postupak za dobijanje kiralnog amino alkohola iz epoksi-tetrahidrofurana.[Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrahydrofuran derivatives (II) into oxazolines (I) to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.
YU30202A 2001-10-21 2000-10-19 Postupak za dobijanje oksazolina iz tetrahidrofurana YU30202A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16069501P 2001-10-21 2001-10-21

Publications (1)

Publication Number Publication Date
YU30202A true YU30202A (sh) 2006-01-16

Family

ID=47747126

Family Applications (1)

Application Number Title Priority Date Filing Date
YU30202A YU30202A (sh) 2001-10-21 2000-10-19 Postupak za dobijanje oksazolina iz tetrahidrofurana

Country Status (1)

Country Link
YU (1) YU30202A (sh)

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