YU20050409A - Kompozicije oksikodona sa kontrolisanim oslobađanjem - Google Patents

Kompozicije oksikodona sa kontrolisanim oslobađanjem

Info

Publication number
YU20050409A
YU20050409A YU20050409A YUP20050409A YU20050409A YU 20050409 A YU20050409 A YU 20050409A YU 20050409 A YU20050409 A YU 20050409A YU P20050409 A YUP20050409 A YU P20050409A YU 20050409 A YU20050409 A YU 20050409A
Authority
YU
Yugoslavia
Prior art keywords
oxycodone
weight
dosage form
hours
controlled release
Prior art date
Application number
YU20050409A
Other languages
English (en)
Inventor
Benjamin Oshlack
Mark Chasin
John Joseph Minogue
Robert Francis Kaiko
Original Assignee
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of YU20050409A publication Critical patent/YU20050409A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pronalazak se odnosi na cvrst oblik doziranja sa kontrolisanim ispustanjem za oralno davanje, koji sadrzi analgetski efikasnu kolicinu oksikodona ili neke njegove soli u jednoj matrici, pri cemu je brzina rastvaranja oblika doziranja in vitro mereno tzv. Postupkom pomocu lopatica (USP Paddle Method) pri 100 min-1 u 900 ml vodenog rastvora pufera (pH izmedu 1,6 i 7,2) na 37øC, izmedu 12,5 i 42,5% (mas) oksikodona ispustenog posle 1 casa, izmedu 25 i 55% (mas) oksikodona ispustenog posle 2 casa, izmedu 45 i 75% (mas) oksikodona ispustenog posle 4 casa i izmedu 55 i 85% (mas) oksikodona ispustenog posle 6 casova, pri cemu je brzina ispustanja in vitro u sustini nezavisna od pH kada je pH izmedu 1,6 i 7,2. Taj oblik doziranja je izveden u vidu tablete. Pronalazak se takode odnosi na postupak za pripremanje takvog oralnog oblika doziranja.
YU20050409A 1992-11-25 1993-05-21 Kompozicije oksikodona sa kontrolisanim oslobađanjem YU20050409A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21014692A 1992-11-25 1992-11-25

Publications (1)

Publication Number Publication Date
YU20050409A true YU20050409A (sh) 2006-05-25

Family

ID=47559778

Family Applications (3)

Application Number Title Priority Date Filing Date
YU20050409A YU20050409A (sh) 1992-11-25 1993-05-21 Kompozicije oksikodona sa kontrolisanim oslobađanjem
YU20050408A YU20050408A (sh) 1992-11-25 1993-05-21 Kompozicije oksikodona sa kontrolisanim oslobađanjem
YU20050410A YU20050410A (sh) 1992-11-25 1993-05-21 Kompozicije oksikodona sa kontrolisanim oslobađanjem

Family Applications After (2)

Application Number Title Priority Date Filing Date
YU20050408A YU20050408A (sh) 1992-11-25 1993-05-21 Kompozicije oksikodona sa kontrolisanim oslobađanjem
YU20050410A YU20050410A (sh) 1992-11-25 1993-05-21 Kompozicije oksikodona sa kontrolisanim oslobađanjem

Country Status (2)

Country Link
RS (1) RS50053B (sh)
YU (3) YU20050409A (sh)

Also Published As

Publication number Publication date
YU20050410A (sh) 2006-05-25
YU20050408A (sh) 2006-05-25
RS50053B (sr) 2008-11-28
YU70804A (sh) 2005-11-28

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