YU100202A - Bifunkcionalni agensi koji poseduju antioksidantnu i antiaritmičku aktivnost - Google Patents

Bifunkcionalni agensi koji poseduju antioksidantnu i antiaritmičku aktivnost

Info

Publication number
YU100202A
YU100202A YU100202A YUP100202A YU100202A YU 100202 A YU100202 A YU 100202A YU 100202 A YU100202 A YU 100202A YU P100202 A YUP100202 A YU P100202A YU 100202 A YU100202 A YU 100202A
Authority
YU
Yugoslavia
Prior art keywords
bifunctional agents
agents possessing
possessing antioxidant
antiarrhytmic
antiarrhythmic activity
Prior art date
Application number
YU100202A
Other languages
English (en)
Inventor
Maria Koufaki
Theodora Calogeropoulou
Alexandros Makriyannis
Original Assignee
Uni-Pharma Kleon Tsetis Pharmaceutical Laboratoires S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uni-Pharma Kleon Tsetis Pharmaceutical Laboratoires S.A. filed Critical Uni-Pharma Kleon Tsetis Pharmaceutical Laboratoires S.A.
Publication of YU100202A publication Critical patent/YU100202A/sh
Publication of RS49976B publication Critical patent/RS49976B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Predstavljeni pronalazak odnosi se na nove bifunkcionalne agense koji poseduju antioksidantnu i antiaritmičku aktivnost, postupke za sintezu istih i njihove primene u lečenju oštećenja nastalih tokom ishemije i reperfuzije, kao i na široki spektar poremećaja u vezi sa slobodnim radikalima i/ili aritmijama. Ovi bifunkcionalni lekovi treba selektivno da se razdvajaju u membrani i da proizvode njihove antiaritmičke efekte dok u isto vreme treba da pomažu u zaštiti membranskih lipida sakupljanjem slobodnih radikala. Dati pronalazak obuhvata jedinjenja predstavljena pomoću formule (I), u kojoj su R1, R2, R3, R4, R5 dalje definisani.[The present invention relates to novel bifunctional agents possessing antioxidant and antiarrhytmic activity, methods for the synthesis of the same and their applications in treating ischemia-reperfusion injury, as well as a variety of disorders related to free radicals and/or arrhythmias. These bifunctional drugs should preferentially segregate in the membrane and produce their antiarrhytmic effects while, at the same time, help in protecting the membrane lipids by scavenging free radicals. The present invention comprises compounds represented by Formula (I), wherein R1, R2, R3, R4, R5 are further defined.
YUP-1002/02A 2000-07-12 2001-07-04 Bifunkcionalni agensi koji poseduju antioksidantnu i antiaritmičku aktivnost RS49976B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20000100231A GR1003725B (el) 2000-07-12 2000-07-12 Νεες ενωσεις με συνδυασμενη αντιοξειδωτικη και αντιαρρυθμικη δραση

Publications (2)

Publication Number Publication Date
YU100202A true YU100202A (sh) 2006-01-16
RS49976B RS49976B (sr) 2008-09-29

Family

ID=10944322

Country Status (14)

Country Link
US (1) US7115657B2 (sh)
EP (1) EP1301504B1 (sh)
AT (1) ATE281449T1 (sh)
AU (1) AU2001267756A1 (sh)
CA (1) CA2415523A1 (sh)
DE (1) DE60106922T2 (sh)
ES (1) ES2231514T3 (sh)
GR (1) GR1003725B (sh)
HU (1) HUP0303137A3 (sh)
IL (1) IL153791A0 (sh)
PL (1) PL203179B1 (sh)
PT (1) PT1301504E (sh)
RS (1) RS49976B (sh)
WO (1) WO2002004438A1 (sh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101128423A (zh) * 2005-02-25 2008-02-20 伊莱利利公司 新型脂氧化酶抑制剂
AU2011284606A1 (en) * 2010-07-30 2013-03-14 Pharmacellion Ltd Compounds and methods for treating neoplasia
MX2014002087A (es) 2011-08-23 2015-09-07 Vive Crop Prot Inc Formulaciones piretroides.
CN104080333B (zh) 2011-12-22 2017-06-23 维弗作物保护公司 嗜球果伞素配制品
LT2872497T (lt) 2012-07-12 2017-04-25 Khondrion Ip B.V. Chromanilo dariniai, skirti mitochondrinių ligų gydymui
WO2016190852A1 (en) * 2015-05-26 2016-12-01 Stealth Peptides International, Inc. Therapeutic compositions including chromanyl compounds, variants and analogues thereof, and uses thereof
US11517013B2 (en) 2017-08-25 2022-12-06 Vive Crop Protection Inc. Multi-component, soil-applied, pesticidal compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines

Also Published As

Publication number Publication date
PL363148A1 (en) 2004-11-15
RS49976B (sr) 2008-09-29
US7115657B2 (en) 2006-10-03
HUP0303137A2 (hu) 2004-01-28
PL203179B1 (pl) 2009-09-30
ATE281449T1 (de) 2004-11-15
AU2001267756A1 (en) 2002-01-21
HUP0303137A3 (en) 2005-02-28
IL153791A0 (en) 2003-07-31
DE60106922T2 (de) 2005-11-03
EP1301504A1 (en) 2003-04-16
EP1301504B1 (en) 2004-11-03
US20040259763A1 (en) 2004-12-23
ES2231514T3 (es) 2005-05-16
GR1003725B (el) 2001-11-27
DE60106922D1 (de) 2004-12-09
PT1301504E (pt) 2005-02-28
CA2415523A1 (en) 2002-01-17
WO2002004438A1 (en) 2002-01-17

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