GR1003725B - Νεες ενωσεις με συνδυασμενη αντιοξειδωτικη και αντιαρρυθμικη δραση - Google Patents

Νεες ενωσεις με συνδυασμενη αντιοξειδωτικη και αντιαρρυθμικη δραση

Info

Publication number
GR1003725B
GR1003725B GR20000100231A GR2000100231A GR1003725B GR 1003725 B GR1003725 B GR 1003725B GR 20000100231 A GR20000100231 A GR 20000100231A GR 2000100231 A GR2000100231 A GR 2000100231A GR 1003725 B GR1003725 B GR 1003725B
Authority
GR
Greece
Prior art keywords
bifunctional agents
agents possessing
antiarrhythmic activity
possessing antioxidant
free radicals
Prior art date
Application number
GR20000100231A
Other languages
English (en)
Inventor
Original Assignee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by filed Critical
Priority to GR20000100231A priority Critical patent/GR1003725B/el
Priority to AU2001267756A priority patent/AU2001267756A1/en
Priority to CA002415523A priority patent/CA2415523A1/en
Priority to US10/332,464 priority patent/US7115657B2/en
Priority to DE60106922T priority patent/DE60106922T2/de
Priority to IL15379101A priority patent/IL153791A0/xx
Priority to PT01945543T priority patent/PT1301504E/pt
Priority to AT01945543T priority patent/ATE281449T1/de
Priority to YUP-1002/02A priority patent/RS49976B/sr
Priority to PCT/GR2001/000030 priority patent/WO2002004438A1/en
Priority to PL363148A priority patent/PL203179B1/pl
Priority to ES01945543T priority patent/ES2231514T3/es
Priority to HU0303137A priority patent/HUP0303137A3/hu
Priority to EP01945543A priority patent/EP1301504B1/en
Publication of GR1003725B publication Critical patent/GR1003725B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αφορά νέες ενώσεις με συνδυασμένη αντιοξειδωτική και αντιαρρυθμική δράση, μεθόδους για τη σύνθεση αυτών και τις εφαρμογές τους στην πρόληψη βλαβών κατά την ισχαιμία-επαναιμάτωση καθώς και διαφόρων διαταραχών που σχετίζονται με τις ελεύθερες ρίζες ή/και τις αρρυθμίες. Οι ενώσεις αυτές αναμένεται να συγκεντρώνονται εκλεκτικά στη μεμβράνη του μυοκαρδίου και να εμφανίζουν την αντιαρρυθμική τους δράση ενώ ταυτόχρονα θα προστατεύουν τα φωσφολιπίδια των μεμβρανών παγιδεύοντας τις ελεύθερες ρίζες. Η παρούσα εφεύρεση περιλαμβάνει ενώσεις του τύπου (Ι)όπου τα R1,R2,R3,R4,R5 και Χ προσδιορίζονται στην περιγραφή της εφεύρεσης.ΰ
GR20000100231A 2000-07-12 2000-07-12 Νεες ενωσεις με συνδυασμενη αντιοξειδωτικη και αντιαρρυθμικη δραση GR1003725B (el)

Priority Applications (14)

Application Number Priority Date Filing Date Title
GR20000100231A GR1003725B (el) 2000-07-12 2000-07-12 Νεες ενωσεις με συνδυασμενη αντιοξειδωτικη και αντιαρρυθμικη δραση
AU2001267756A AU2001267756A1 (en) 2000-07-12 2001-07-04 Bifunctional agents possessing antioxidant and antiarrhythmic activity
CA002415523A CA2415523A1 (en) 2000-07-12 2001-07-04 Bifunctional agents possessing antioxidant and antiarrhythmic activity
US10/332,464 US7115657B2 (en) 2000-07-12 2001-07-04 Bifunctional agents possessing antioxidant and antiarrhythmic activity
DE60106922T DE60106922T2 (de) 2000-07-12 2001-07-04 Bifunktionelle mittel mit antioxydierender und antiarhytmischer wirkung
IL15379101A IL153791A0 (en) 2000-07-12 2001-07-04 Bifunctional agents possessing antioxidant and antiarrhythmic activity
PT01945543T PT1301504E (pt) 2000-07-12 2001-07-04 Agentes bifuncionais possuindo actividade anti-oxidante e antiarritmica
AT01945543T ATE281449T1 (de) 2000-07-12 2001-07-04 Bifunktionelle mittel mit antioxydierender und antiarhytmischer wirkung
YUP-1002/02A RS49976B (sr) 2000-07-12 2001-07-04 Bifunkcionalni agensi koji poseduju antioksidantnu i antiaritmičku aktivnost
PCT/GR2001/000030 WO2002004438A1 (en) 2000-07-12 2001-07-04 Bifunctional agents possessing antioxidant and antiarrhythmic activity
PL363148A PL203179B1 (pl) 2000-07-12 2001-07-04 Pochodne 3,4-dihydro-2H-benzopiranu, ich zastosowanie i środek farmaceutyczny
ES01945543T ES2231514T3 (es) 2000-07-12 2001-07-04 Agentes bidifuncionales que poseen actividad antioxidante y antiarritmica.
HU0303137A HUP0303137A3 (en) 2000-07-12 2001-07-04 Bifunctional agents possessing antioxidant and antiarrhythmic activity
EP01945543A EP1301504B1 (en) 2000-07-12 2001-07-04 Bifunctional agents possessing antioxidant and antiarrhythmic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20000100231A GR1003725B (el) 2000-07-12 2000-07-12 Νεες ενωσεις με συνδυασμενη αντιοξειδωτικη και αντιαρρυθμικη δραση

Publications (1)

Publication Number Publication Date
GR1003725B true GR1003725B (el) 2001-11-27

Family

ID=10944322

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000100231A GR1003725B (el) 2000-07-12 2000-07-12 Νεες ενωσεις με συνδυασμενη αντιοξειδωτικη και αντιαρρυθμικη δραση

Country Status (14)

Country Link
US (1) US7115657B2 (el)
EP (1) EP1301504B1 (el)
AT (1) ATE281449T1 (el)
AU (1) AU2001267756A1 (el)
CA (1) CA2415523A1 (el)
DE (1) DE60106922T2 (el)
ES (1) ES2231514T3 (el)
GR (1) GR1003725B (el)
HU (1) HUP0303137A3 (el)
IL (1) IL153791A0 (el)
PL (1) PL203179B1 (el)
PT (1) PT1301504E (el)
RS (1) RS49976B (el)
WO (1) WO2002004438A1 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1856040A4 (en) * 2005-02-25 2009-09-23 Lilly Co Eli NEW LIPOXYGENASE INHIBITORS
US20130303500A1 (en) * 2010-07-30 2013-11-14 Medexis S.A. Compounds and methods for treating neoplasia
EP2747556B1 (en) 2011-08-23 2021-08-11 Vive Crop Protection Inc. Pyrethroid formulations
WO2013093578A1 (en) 2011-12-22 2013-06-27 Vive Crop Protection Inc. Strobilurin formulations
CA2878567C (en) 2012-07-12 2021-02-23 Khondrion Ip B.V. Chromanyl derivatives for treating mitochondrial disease
WO2016190852A1 (en) * 2015-05-26 2016-12-01 Stealth Peptides International, Inc. Therapeutic compositions including chromanyl compounds, variants and analogues thereof, and uses thereof
WO2019038642A1 (en) 2017-08-25 2019-02-28 Vive Crop Protection Inc. MULTI-COMPONENT PESTICIDE COMPOSITIONS APPLIED TO SOIL

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293078A1 (en) * 1987-04-27 1988-11-30 The Upjohn Company Pharmaceutically active amines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293078A1 (en) * 1987-04-27 1988-11-30 The Upjohn Company Pharmaceutically active amines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 117, no. 1, 1992, Columbus, Ohio, US; abstract no. 225756k, P.J. SILVER ET AL.: "LOW MOL.WEIGHT ANALOGS OF TROLOX WITH POTENT ANTIOXYDANT ACTIVITY" page 19; XP002163993 *
DRUG DEV . RES., vol. 27, no. 1, 1992, USA, pages 45 - 52 *

Also Published As

Publication number Publication date
HUP0303137A2 (hu) 2004-01-28
EP1301504B1 (en) 2004-11-03
YU100202A (sh) 2006-01-16
PT1301504E (pt) 2005-02-28
ATE281449T1 (de) 2004-11-15
WO2002004438A1 (en) 2002-01-17
CA2415523A1 (en) 2002-01-17
AU2001267756A1 (en) 2002-01-21
PL363148A1 (en) 2004-11-15
RS49976B (sr) 2008-09-29
US7115657B2 (en) 2006-10-03
DE60106922D1 (de) 2004-12-09
DE60106922T2 (de) 2005-11-03
US20040259763A1 (en) 2004-12-23
EP1301504A1 (en) 2003-04-16
IL153791A0 (en) 2003-07-31
ES2231514T3 (es) 2005-05-16
PL203179B1 (pl) 2009-09-30
HUP0303137A3 (en) 2005-02-28

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