WO2024111582A1 - Peracetic acid measuring device calibration method and peracetic acid meter calibration system - Google Patents

Peracetic acid measuring device calibration method and peracetic acid meter calibration system Download PDF

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Publication number
WO2024111582A1
WO2024111582A1 PCT/JP2023/041818 JP2023041818W WO2024111582A1 WO 2024111582 A1 WO2024111582 A1 WO 2024111582A1 JP 2023041818 W JP2023041818 W JP 2023041818W WO 2024111582 A1 WO2024111582 A1 WO 2024111582A1
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Prior art keywords
peracetic acid
cleaning
meter
concentration
change
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PCT/JP2023/041818
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French (fr)
Japanese (ja)
Inventor
寛昌 赤堀
佳彦 川口
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オリンパス株式会社
株式会社堀場アドバンスドテクノ
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Publication of WO2024111582A1 publication Critical patent/WO2024111582A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/12—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with cooling or rinsing arrangements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2101/00—Chemical composition of materials used in disinfecting, sterilising or deodorising

Definitions

  • the present invention relates to a method for calibrating a peracetic acid measuring device and a peracetic acid meter calibration system.
  • the titration method is susceptible to variability between operators, and requires expert skills in reagent preparation and titration.
  • differences in the performance of the peracetic acid measuring device have a significant effect on the titration accuracy, so an expensive peracetic acid concentration measuring device is required for accurate calibration.
  • the reagents used must be adjusted for each absorbance measurement, requiring operators to perform complex operations and have high skill.
  • the present invention was made in consideration of the above-mentioned problems, and its main objective is to provide a method for accurately calibrating a peracetic acid meter without requiring expensive equipment, advanced operator skills, or complicated operations.
  • the peracetic acid meter calibration method of the present invention is characterized in that the peracetic acid meter is calibrated based on the expected change in peracetic acid concentration when peracetic acid in a sample solution is decomposed by adding a peracetic acid decomposition agent whose reaction constant for the peracetic acid decomposition reaction is known, and the change in the actual value when the sample solution is measured with the peracetic acid meter before and after the addition.
  • the actual value may be a detection value (current value, voltage value, count value, absorbance, etc.) detected by the peracetic acid meter to measure the peracetic acid concentration, or a calculated value calculated based on these (peracetic acid concentration or a value during calculation to calculate the peracetic acid concentration, etc.).
  • the peracetic acid meter calibration method configured in this manner, a peracetic acid decomposition agent with a known reaction constant for the peracetic acid decomposition reaction is added, and the actual values in the sample solution before and after the addition are measured by the peracetic acid meter, which is the object of calibration. Therefore, the peracetic acid meter can be calibrated based on the change in the actual values corresponding to the change in the peracetic acid concentration caused by the addition of the peracetic acid decomposition agent and the theoretical change in the peracetic acid concentration.
  • the peracetic acid meter can be calibrated using a sample solution with an unknown peracetic acid concentration, eliminating the need to calibrate the peracetic acid meter by preparing a peracetic acid formulation with a known concentration as in the conventional method.
  • the peracetic acid decomposition agent can cause a large change in hydrogen peroxide concentration
  • air bubbles are generated when hydrogen peroxide is decomposed, the effect of air bubbles on the measurement by the peracetic acid meter can be reduced by decomposing the hydrogen peroxide first.
  • the decomposition of hydrogen peroxide is carried out using a hydrogen peroxide decomposer
  • the hydrogen peroxide decomposer may include one or more enzymes selected from the group consisting of catalase, peroxidase, and glutathione peroxidase.
  • peracetic acid decomposition agent described above includes one or more selected from the group consisting of thioglycolic acid, glyceryl thioglycolate, methionine, cysteine, methionine derivatives, cysteine derivatives, methionine residue-containing peptides, cysteine residue-containing peptides, cysteamine, thioglycerin, 2-mercapto-4-butanolide, flavonoids, nitrous acid, ascorbic acid, sulfur, platinum, palladium, and halogen elements.
  • the peracetic acid meter may be, for example, a diaphragm type that measures current and/or voltage values.
  • the effects of the present invention are particularly pronounced in applications that require highly accurate calibration of peracetic acid meters, such as medical cleaning and disinfection equipment, food cleaning equipment, or wastewater monitoring equipment.
  • a specific embodiment of the present invention is an endoscope cleaning and disinfecting apparatus that includes a mixture generating means for generating a mixture by mixing a peracetic acid decomposition agent, the reaction constant of which is known for the decomposition reaction of peracetic acid, with a sample solution (cleaning or disinfecting solution) containing peracetic acid, a measuring means for contacting the mixture and measuring the concentration of peracetic acid in the mixture, and a calibration means for calibrating a peracetic acid meter based on the amount of peracetic acid expected to be decomposed by the peracetic acid decomposition agent and the actual value measured by the measuring unit.
  • the endoscope cleaning and disinfecting apparatus may further include a sample solution measuring means for holding a fixed amount of the sample solution, collecting a fixed amount of the sample solution, or measuring the amount of the sample solution, and a peracetic acid decomposition agent measuring means for measuring the amount of the peracetic acid decomposition agent added to the sample solution.
  • the present invention also includes the following inventions.
  • a calculation unit that calculates an expected change in the concentration of peracetic acid when peracetic acid in a sample solution is decomposed by adding a peracetic acid decomposition agent having a known reaction constant for the peracetic acid decomposition reaction, and an amount of change in an actual measurement value when the sample solution is measured with a peracetic acid meter before and after the addition, and a calibration unit that calibrates the peracetic acid meter based on the amount of change in the concentration of peracetic acid and the amount of change in the actual measurement value;
  • a peracetic acid meter calibration program for calibrating a peracetic acid meter based on an expected change in peracetic acid concentration when peracetic acid in a sample solution is decomposed by adding a peracetic acid decomposition agent having a known reaction constant for the peracetic acid decomposition reaction, and an actual change in the value when the sample solution is measured with the peracetic acid meter before and after the addition; and a perace
  • a peracetic acid decomposition agent with a known reaction constant for the peracetic acid decomposition reaction is added, and actual values such as current and/or voltage in the sample solution before and after the addition are measured using a peracetic acid meter, which is the object of calibration. Therefore, the peracetic acid meter can be calibrated based on the change in the actual value corresponding to the change in the peracetic acid concentration caused by the addition of the peracetic acid decomposition agent and the change in the theoretical peracetic acid concentration.
  • the peracetic acid meter can be calibrated using a sample solution with an unknown peracetic acid concentration, eliminating the need to prepare a peracetic acid preparation with a known concentration by titration or absorbance using a peracetic acid concentration measurement device separate from the peracetic acid meter to be calibrated, as in the past.
  • This makes it possible to provide a method for accurately calibrating a peracetic acid meter without requiring expensive equipment, advanced operator skills, or complicated operations.
  • FIG. 1 is an overall schematic diagram of a medical cleaning and disinfecting apparatus according to one embodiment of the present invention
  • FIG. 2 is a functional block diagram of the medical cleaning and disinfecting apparatus according to the present embodiment.
  • 4 is a flow chart showing a procedure for calibrating a peracetic acid meter in the medical cleaning and disinfecting apparatus according to the present embodiment.
  • FIG. 2 is a graph showing the relationship between the peracetic acid concentration and the current value detected by a peracetic acid meter.
  • FIG. 13 is an overall schematic diagram of a medical cleaning and disinfecting apparatus according to another embodiment.
  • FIG. 13 is an overall schematic diagram of a medical cleaning and disinfecting apparatus according to another embodiment.
  • FIG. 13 is an overall schematic diagram of a medical cleaning and disinfecting apparatus according to another embodiment.
  • FIG. 13 is a schematic diagram showing changes in the concentrations of hydrogen peroxide and peracetic acid when a peracetic acid decomposition agent is added to a sample solution (cleaning and disinfecting solution) according to another embodiment.
  • FIG. 13 is a schematic diagram showing changes in the concentrations of hydrogen peroxide and peracetic acid when a peracetic acid decomposition agent is added to a sample solution (cleaning and disinfecting solution) according to another embodiment.
  • the medical cleaning and disinfecting device 100 is for cleaning, disinfecting, and sterilizing medical equipment such as endoscopes, and includes, for example, a cleaning and disinfecting tank 1 and a cleaning and disinfecting liquid supply mechanism 2 that supplies the cleaning and disinfecting tank 1 with a cleaning and disinfecting liquid W for cleaning and/or disinfecting medical equipment, as shown in FIG. 1.
  • the cleaning and disinfecting tank 1 has a space formed inside in which medical instruments, such as endoscopes, which are the objects to be cleaned and/or disinfected, are cleaned and/or disinfected with a cleaning and disinfecting solution W.
  • the cleaning and disinfecting liquid supply mechanism 2 includes a cleaning and disinfecting liquid tank 21, a flow path 22, a pump 23, a valve 24, a sensor unit 25, an information processing unit 26 that processes information from the sensor unit 25, and a cleaning and disinfecting liquid flow control unit 27 that controls the flow of the cleaning and disinfecting liquid W.
  • the cleaning disinfectant tank 21 is a container for containing and storing the cleaning disinfectant W.
  • the cleaning disinfectant W contains peracetic acid.
  • the flow path 22 is composed of, for example, a cleaning disinfectant supply flow path 221 that supplies the cleaning disinfectant W from the cleaning disinfectant tank 21 to the cleaning disinfection tank 1, a discharge flow path 222 that discharges waste liquid from the cleaning disinfection tank 1 to the outside, and a return flow path 223 that returns the cleaning disinfectant W from the cleaning disinfection tank 1 to the cleaning disinfectant tank 21.
  • the return flow path 223 is formed by a common pipe that is partially connected to the discharge flow path 222.
  • a water supply pipe 224 is provided to supply water to the cleaning disinfection tank 1 from the outside.
  • the pump 23 is, for example, a liquid delivery pump such as a diaphragm pump or a peristaltic pump provided on the cleaning/disinfecting liquid supply flow path 221.
  • the valve 24 is, for example, a three-way valve that can switch between a discharge flow path 222 and a return flow path 223 that flow out from the cleaning and disinfection tank 1.
  • the sensor unit 25 includes, for example, a peracetic acid meter 251 and a liquid level sensor 252, as shown in FIG. 2.
  • the peracetic acid meter 251 is, for example, a diaphragm-type polarographic sensor that is positioned so as to come into contact with the cleaning disinfectant W (also called the sample solution because it is the measurement target for the peracetic acid meter) contained in the cleaning disinfectant tank 21, and measures the concentration of peracetic acid in the cleaning disinfectant W.
  • the cleaning disinfectant W also called the sample solution because it is the measurement target for the peracetic acid meter
  • the liquid level sensor 252 detects the water level of the cleaning disinfectant W in the cleaning disinfectant tank 21.
  • the functions of the information processing unit 26 and the cleaning and disinfecting liquid flow control unit 27 are carried out by a dedicated or general-purpose computer CP equipped with a CPU, memory, input/output interface, etc.
  • the medical cleaning and disinfecting apparatus 100 further includes a calibration system 4 that calibrates the peracetic acid meter 251.
  • the calibration system 4 includes a calculation unit 41 that calculates the amount of change in the actual measurement value (current value in this embodiment) based on the signal output from the peracetic acid meter 251 and the amount of change in the theoretical value, which is a current value calculated based on the amount of change in the peracetic acid concentration in the sample solution, a calibration unit 42 that calibrates the peracetic acid meter 251 based on the amount of change in the actual measurement value and the amount of change in the theoretical value calculated by the calculation unit 41, and a decomposition agent addition mechanism 43.
  • the functions of the calculation unit 41 and the calibration unit 42 are performed by the computer CP mentioned above.
  • the decomposing agent adding mechanism 43 adds a peracetic acid decomposing agent that decomposes peracetic acid in the cleaning disinfectant solution W to the cleaning disinfectant solution W, and includes a decomposing agent flow path 431 that guides the decomposing agent to the cleaning disinfectant solution tank 21, and a decomposing agent flow control unit 432 that controls the flow of the peracetic acid decomposing agent flowing through the flow path.
  • the function of the decomposing agent flow control unit 432 is performed by, for example, the above-mentioned computer CP.
  • the decomposition agent flow control unit 432 provided in the decomposition agent addition mechanism 43 is configured to control the flow path 22, the pump 23, the valve 24, and the sensor unit 25 provided in the cleaning disinfection solution supply mechanism 2 described above, and the decomposition agent flow control unit 432 is configured to add the peracetic acid decomposition agent manually added by the user to the cleaning disinfection tank 1 to the cleaning disinfection solution tank 21 via the return flow path 223, which functions as the decomposition agent flow path 431.
  • the sensor unit 25 provided in the cleaning disinfectant supply mechanism 2 may further include a peracetic acid decomposition agent detector 253 that detects the concentration of the peracetic acid decomposition agent in the cleaning disinfectant tank 21.
  • This peracetic acid decomposition agent detector 253 is preferably a device that measures the concentration of peracetic acid decomposition substances (peracetic acid decomposition agent measuring means) to ensure that the entire amount of peracetic acid decomposition agent introduced is reliably mixed with the cleaning disinfectant W.
  • the peracetic acid decomposition agent contains a peracetic acid decomposition substance that decomposes the peracetic acid contained in the cleaning and disinfecting solution W, and may be a solid such as a powder or tablet, or may be a liquid.
  • peracetic acid decomposition substances include thioglycolic acid, glyceryl thioglycolate, methionine, cysteine, methionine derivatives, cysteine derivatives, methionine residue-containing peptides, cysteine residue-containing peptides, cysteamine, thioglycerin, 2-mercapto-4-butanolide, flavonoids, nitrous acid, ascorbic acid, sulfur, platinum, palladium, and halogen elements.
  • the peracetic acid decomposition agent may contain only one type of peracetic acid decomposition substance, or may contain two or more types.
  • reaction constants for the peracetic acid decomposition reaction can be known from the product information provided by the reagent manufacturer. If necessary, the reaction constants for the reaction conditions desired by each individual can be determined by experiment.
  • the peracetic acid decomposition agent contains a peracetic acid decomposition substance that decomposes only peracetic acid.
  • Peracetic acid decomposition substances that decompose only peracetic acid in cleaning and disinfecting solutions containing peracetic acid that are widely used in the medical cleaning and disinfecting apparatus 100 as described in this embodiment and in food cleaning apparatuses that clean food or equipment used in food production can include, for example, thioglycolic acid, glyceryl thioglycolate, thioglycerin, 2-mercapto-4-butanolide, flavonoids, nitrous acid, sulfur, or halogen elements. These decompose only peracetic acid, whether they are used individually or in combination of two or more types.
  • the cleaning and disinfecting liquid flow control unit 27 closes the valve 24 and issues a command to the pump 23 to supply the cleaning and disinfecting liquid W from the cleaning and disinfecting liquid tank 21 to the cleaning and disinfecting tank 1 to clean and/or disinfect the medical instruments.
  • the liquid level sensor 252 detects from a change in the water level in the cleaning and disinfecting liquid tank 21 that a predetermined amount of cleaning and disinfecting liquid W has been supplied to the cleaning and disinfecting tank 1, the cleaning and disinfecting liquid flow control unit 27 stops the pump 23.
  • the cleaning and disinfecting solution flow control unit 27 opens the valve 24 to recover the used cleaning and disinfecting solution W from the discharge flow path 222 into the cleaning and disinfecting solution tank 21.
  • Water is supplied to the cleaning and disinfecting tank 1 from the water supply pipe 224 to rinse the cleaning and disinfecting solution W remaining in the cleaning and disinfecting tank 1, and all of the rinsing water is discharged to the outside from the discharge flow path 222, completing the cleaning and disinfecting process.
  • the cleaning disinfectant W recovered in the cleaning disinfectant tank 21 after being supplied to the cleaning disinfectant tank 1 and used for cleaning and/or disinfecting medical instruments and the like can be reused if the peracetic acid concentration is within a predetermined concentration range.
  • the peracetic acid concentration of the cleaning disinfectant W recovered in the cleaning disinfectant tank 21 is measured by the peracetic acid meter 251 to confirm whether it can be reused in the next or subsequent cleaning and disinfecting process. If the peracetic acid concentration in the cleaning disinfectant W recovered in the cleaning disinfectant tank 21 falls outside the predetermined concentration range, the cleaning disinfectant W is discharged from the discharge flow path 222 to the outside.
  • the decomposition agent flow control unit 432 adjusts the amount of the cleaning disinfectant W in the cleaning disinfectant tank 21 to a predetermined amount.
  • the liquid level sensor (sample solution measuring means) 252 detects the water level of the cleaning disinfectant tank, and if the water level is lower than a predetermined water level (for example, the minimum water level set in the cleaning disinfectant tank 21), the decomposition agent flow control unit 432 controls the valve 24 to supply water from the water supply pipe 224 via the cleaning disinfection tank 1 and the return flow path 223 to the cleaning disinfectant tank 21 so that the water level in the cleaning disinfectant tank 21 becomes the predetermined water level.
  • a predetermined water level for example, the minimum water level set in the cleaning disinfectant tank 21
  • the decomposition agent flow control unit 432 controls the pump 23 and the valve 24 to discharge the cleaning disinfectant W from the cleaning disinfectant tank 21 via the cleaning disinfectant supply flow path 221, the cleaning disinfectant tank 1, and the discharge flow path 222, so that the water level in the cleaning disinfectant tank 21 becomes the predetermined water level.
  • the peracetic acid meter (measuring means) 251 measures the peracetic acid concentration of the cleaning disinfectant W in the cleaning disinfectant tank 21.
  • a peracetic acid decomposition agent is added to the cleaning and disinfecting liquid tank 21, and the peracetic acid decomposition reaction is started simultaneously with the addition.
  • the user adds a predetermined amount of peracetic acid decomposition agent to the cleaning and disinfection tank 1, and the decomposition agent flow control unit 432 controls the valve 24 to introduce the peracetic acid decomposition agent added to the cleaning and disinfection tank 1 into the cleaning and disinfection liquid tank 21 via the return path 223.
  • the decomposer flow control unit 432 operates the pump 23 to send the cleaning disinfectant W from the cleaning disinfectant tank 21 to the cleaning disinfection tank 1, and repeats the operation of refluxing the cleaning disinfectant W from the cleaning disinfection tank 1 to the cleaning disinfectant tank 21, thereby stirring so that the entire amount of the peracetic acid decomposer added is immediately mixed with the cleaning disinfectant W.
  • the decomposer addition mechanism 43 corresponds to the mixed solution generating means.
  • the peracetic acid meter 251 measures the peracetic acid concentration in the mixture obtained by mixing the cleaning disinfectant W with the peracetic acid decomposition agent.
  • the measurement conditions at this time are preferably as similar as possible to the measurement conditions used when the peracetic acid meter 251 measures the peracetic acid concentration of the cleaning disinfectant W immediately before the peracetic acid decomposition agent is added.
  • the calculation unit 41 calculates the difference between the constant current values in the measurements of the cleaning disinfectant solution W and the mixed solution by the peracetic acid meter 251, and the theoretical amount of peracetic acid decomposed that is expected to be decomposed between these two measurements.
  • the theoretical amount of peracetic acid decomposed is calculated based on, for example, the reaction time and reaction temperature, the amount of cleaning disinfectant solution W in the cleaning disinfectant solution tank 21, the concentration, amount and reaction constant of the added peracetic acid decomposer, etc.
  • the user may input necessary information from this information to the calibration system 4 in advance.
  • the calibration process is completed when the calibration unit (calibration means) 42 calibrates the peracetic acid meter 251 based on the change in the actual current value calculated in this manner and the change in the theoretical current value calculated from the theoretical amount of peracetic acid decomposition.
  • the calibration mode may be automatically selected periodically, or the calibration mode may be selected by the user at any time.
  • the specific method of this calibration is as follows.
  • the current value difference can be converted into the peracetic acid concentration by the following formula (1).
  • C0 represents the reference peracetic acid concentration
  • C represents the peracetic acid concentration of the measurement target solution
  • ⁇ i represents the difference in current value between C0 and C. If the value of C0 and the current value detected when the concentration is C0 are known, the amount of change in the concentration of peracetic acid in the sample solution corresponding to the amount of change in the current value can be calculated from this formula.
  • the relational expression between the amount of change in the current value and the amount of change in the peracetic acid concentration can be determined depending on the type of peracetic acid meter 251 and the environment in which it is used.
  • the change in the peracetic acid concentration calculated from the theoretical amount of peracetic acid decomposed is compared with the change in the peracetic acid concentration converted from the actual current values (actual values) measured before and after the addition of the peracetic acid decomposition agent based on the previously obtained formula (1), and the peracetic acid meter 251 can be calibrated by correcting the deviation between them.
  • C 0 in FIG. 4 indicates the peracetic acid concentration in the sample solution before the addition of the peracetic acid decomposition agent
  • C indicates the peracetic acid concentration after a predetermined time has elapsed since the addition of the peracetic acid decomposition agent.
  • the current value after the addition of the peracetic acid decomposition agent here indicates the current value after a predetermined time has elapsed since the addition of the peracetic acid decomposition agent to the sample solution.
  • a current value when zero water that does not contain peracetic acid is measured may be used to further perform zero point correction for the peracetic acid meter 251.
  • a calibration curve showing the correlation (for example, proportionality) between the amount of change in peracetic acid concentration and the amount of change in current value may be created using the current value when zero water is measured and stored in a storage unit (not shown), and the calibration unit may be configured to calibrate the peracetic acid meter using this calibration curve.
  • the peracetic acid meter 251 that measures the peracetic acid concentration in the cleaning and disinfecting solution W can be calibrated using the cleaning and disinfecting solution W whose peracetic acid concentration is unknown. Therefore, there is no need to use a peracetic acid preparation with a known peracetic acid concentration as in the past.
  • the medical washer/disinfectant 100 in order to reliably disinfect and sterilize medical instruments and the like with the washer/disinfectant, it is necessary to constantly maintain the concentration of peracetic acid in the washer/disinfectant at a standard value or higher.
  • the peracetic acid meter 251 In such a medical cleaning and disinfecting apparatus 100, in order to accurately measure the concentration of peracetic acid contained in the cleaning and disinfecting solution using the peracetic acid meter 251, the peracetic acid meter 251 needs to be calibrated periodically. If the calibration method according to this embodiment is adopted in such a medical cleaning and disinfecting apparatus 100, the burden on the user regarding the maintenance work of the peracetic acid meter 251 can be significantly reduced.
  • the medical cleaning and disinfecting apparatus may further include a temperature control mechanism for adjusting the temperature inside the cleaning and disinfecting solution tank.
  • a temperature control mechanism for adjusting the temperature inside the cleaning and disinfecting solution tank.
  • the cleaning and disinfecting tank 1 is provided with a tray-shaped cleaning and disinfecting tank lower member 11' including a part of its bottom and side surfaces, which prevents medical instruments from being put into the cleaning and disinfecting tank 1, and different cleaning and disinfecting tank lower members 11' may be used for cleaning and disinfecting medical instruments and for calibration.
  • a tray-shaped cleaning and disinfecting tank lower member 11' including a part of its bottom and side surfaces, which prevents medical instruments from being put into the cleaning and disinfecting tank 1, and different cleaning and disinfecting tank lower members 11' may be used for cleaning and disinfecting medical instruments and for calibration.
  • a mark 111' such as a protrusion only to the cleaning and disinfecting tank lower member ' dedicated to the calibration mode, so that the medical cleaning and disinfecting device can distinguish the type of the cleaning and disinfecting tank lower member 11 and select the calibration mode.
  • a cleaning/disinfecting tank lower part 11' dedicated to calibration a predetermined amount of peracetic acid decomposition agent may be placed in the cleaning/disinfecting tank lower part 11' beforehand.
  • the amount of cleaning disinfectant stored in the cleaning disinfectant tank is detected by a liquid level sensor, but for example, as shown in FIG. 6, a temperature sensor 3'' for measuring the temperature of the peracetic acid decomposer may be further provided, and this temperature sensor 3'' may be used to measure the temperature of the peracetic acid decomposer before it is added to the cleaning disinfectant, and the temperature of the mixed solution after the peracetic acid decomposer is added may be measured, thereby calculating the volume of the cleaning disinfectant before the addition of the peracetic acid decomposer from the temperature change of the mixed solution due to the addition of the peracetic acid decomposer.
  • the method for calculating the volume of the cleaning and disinfecting solution is not limited to the above-mentioned method, and the volume may be calculated by measuring the absorbance, conductivity, etc. of the cleaning and disinfecting solution after labeling it with a color or the like.
  • the step of determining the volume of the cleaning disinfectant may be performed after measuring the peracetic acid concentration of the cleaning disinfectant or the mixed solution.
  • a cleaning disinfectant collection section may be provided that collects a predetermined amount of cleaning disinfectant from the cleaning disinfectant tank, and a peracetic acid decomposer may be added to the cleaning disinfectant collected by this cleaning disinfectant collection section.
  • a peracetic acid decomposer may be added to the cleaning disinfectant collected by this cleaning disinfectant collection section.
  • the cleaning disinfectant may be manually collected from the cleaning disinfectant tank by the user.
  • the conditions for measuring the peracetic acid concentration in the cleaning and disinfecting solution or mixed solution using a peracetic acid meter be the same before and after the addition of the peracetic acid decomposition agent, but the conditions do not necessarily have to be the same.
  • the decomposition agent addition mechanism may further include a peracetic acid decomposition agent measuring section and/or a peracetic acid decomposition agent feeding section that automatically adds a predetermined amount of peracetic acid decomposition agent to the cleaning and disinfecting solution.
  • the medical cleaning and disinfecting device may be configured to issue a warning to inform the user that an abnormality has occurred in the peracetic acid meter, etc., if the amount of change in the current value before and after the peracetic acid decomposition agent falls outside a preset threshold value.
  • the hydrogen peroxide may be reduced on the surface of the working electrode of the peracetic acid meter, which may result in the detection of not only a change in current value based on a change in the concentration of peracetic acid, but also a change in current value that includes a change in the concentration of hydrogen peroxide.
  • a peracetic acid decomposer when a peracetic acid decomposer is added to the sample solution and the change in the concentration of peracetic acid in the sample solution is measured, it is believed that the peracetic acid meter can be calibrated more accurately if the decomposer addition mechanism adds a hydrogen peroxide decomposer to the sample solution, taking into account the theoretical change in the hydrogen peroxide concentration.
  • the decomposition agent adding mechanism may further include a hydrogen peroxide decomposition agent measuring unit and/or a hydrogen peroxide decomposition agent feeding unit that adds a hydrogen peroxide decomposition agent that decomposes hydrogen peroxide to the cleaning and disinfecting solution.
  • the hydrogen peroxide decomposer may be a solid or liquid, so long as it contains a hydrogen peroxide decomposing substance capable of decomposing hydrogen peroxide in a cleaning and disinfecting solution containing peracetic acid used in medical cleaning and disinfecting equipment and food cleaning equipment.
  • the hydrogen peroxide decomposition substance As shown in FIG. 7, it is preferable to use, as the hydrogen peroxide decomposition substance, catalase, peroxidase, glutathione peroxidase, or the like, which does not decompose peracetic acid but can essentially decompose only hydrogen peroxide.
  • the hydrogen peroxide decomposition agent may contain only one of these hydrogen peroxide decomposition substances, or may contain two or more of them.
  • step 1 When hydrogen peroxide is decomposed, oxygen is generated, which generates bubbles. If the generated bubbles adhere to the electrode surface, the sensitivity of the electrode becomes unstable, which may result in poor measurement accuracy. Therefore, as shown in Figures 7 and 8, in step 1, a hydrogen peroxide decomposer is added to decompose hydrogen peroxide in the cleaning and disinfecting solution to remove the generated bubbles, and then in step 2, the peracetic acid concentration is measured in the same manner as in Figure 4, which is preferable because this allows more accurate detection of changes in the peracetic acid concentration due to the addition of a peracetic acid decomposer.
  • the hydrogen peroxide decomposer when hydrogen peroxide is decomposed in advance in this manner, even if the hydrogen peroxide decomposer decomposes some of the peracetic acid in the cleaning and disinfecting solution as shown in FIG. 8, it is perfectly possible to use hydrogen peroxide decomposers other than those mentioned above as long as all of the peracetic acid in the cleaning and disinfecting solution is not decomposed.
  • the hydrogen peroxide decomposer may be added automatically by the decomposer addition mechanism as described above, or may be added manually by the user.
  • the method for calibrating a peracetic acid meter according to the present invention can be applied not only to the above-mentioned medical cleaning and disinfecting apparatus, but also to a peracetic acid meter provided in a food cleaning apparatus, etc. It goes without saying that the method can also be applied to a peracetic acid meter provided in an apparatus that does not use a cleaning and disinfecting solution, such as a wastewater monitoring apparatus, or a peracetic acid meter that is not built into an apparatus.
  • a diaphragm type peracetic acid meter is used has been described, but it goes without saying that the peracetic acid meter does not have to be of the diaphragm type.
  • the peracetic acid meter measures a voltage value as an actual measurement value
  • the relationship between the voltage value and the peracetic acid concentration such as the above-mentioned formula (1), can be obtained in the same manner as in the case of the current value.
  • the effects of the present invention can be achieved even when the actual measured value is not limited to a current value and/or a voltage value, but is an intermediate value used when calculating the peracetic acid concentration based on the current value and/or voltage value.
  • a peracetic acid meter when a peracetic acid meter is used that does not measure a current value and/or a voltage value, but measures the peracetic acid concentration of a sample solution by, for example, absorbance or colorimetry, other indicated values such as absorbance or color wavelength that have a proportional or other correlation with the amount of change in the peracetic acid concentration in the sample solution may be used as the actual measured value.
  • the present invention provides a method for calibrating a peracetic acid meter with high accuracy without requiring expensive equipment, advanced operator skills, or complicated operations.

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Abstract

Provided is a method for highly accurately calibrating a peracetic acid meter without an expensive apparatus, high-level skills of an operator, or complicated operations imposed on the operator. This peracetic acid meter calibration method is for calibrating a peracetic acid meter on the basis of: the change level of peracetic acid concentration envisioned when a peracetic acid degradation agent having a known reaction constant regarding a peracetic acid degradation reaction is added to a sample solution to degrade peracetic acid in the sample solution; and the change level of actual measurement values when measurement is performed by using the peracetic acid meter on the sample solution before and after the addition.

Description

過酢酸測定装置校正方法及び過酢酸計校正システムPeracetic acid measuring device calibration method and peracetic acid meter calibration system
　本発明は、過酢酸測定装置の校正方法及び過酢酸計校正システムに関するものである。 The present invention relates to a method for calibrating a peracetic acid measuring device and a peracetic acid meter calibration system.
　従来の過酢酸計の校正方法としては、特許文献１及び２として挙げたように、校正対象の過酢酸計ではない別の過酢酸濃度測定装置を用いた滴定法や吸光度法によって濃度を既知の状態にした過酢酸製剤を用いる手法が知られている。 　Conventional methods for calibrating a peracetic acid meter, as cited in Patent Documents 1 and 2, are known that use a peracetic acid preparation whose concentration has been made known by a titration method or absorbance method using a peracetic acid concentration measuring device other than the peracetic acid meter being calibrated.
　しかしながら、滴定法は操作者によるばらつきが生じる恐れがあり、試薬作成や滴定操作についての熟練のスキルが求められる。操作者によるばらつきを低減するために、滴定操作を自動で行う過酢酸濃度測定装置を用いる場合には、過酢酸測定装置の性能差が滴定精度に大きく影響するので、精度よく校正するためには高価な過酢酸濃度測定装置が必要である。 However, the titration method is susceptible to variability between operators, and requires expert skills in reagent preparation and titration. When using a peracetic acid concentration measuring device that performs the titration automatically to reduce variability between operators, differences in the performance of the peracetic acid measuring device have a significant effect on the titration accuracy, so an expensive peracetic acid concentration measuring device is required for accurate calibration.
　また、吸光度法においては、使用する試薬を吸光度測定毎に調整する必要があり、操作者には煩雑な操作とスキルが求められる。 In addition, in the absorbance method, the reagents used must be adjusted for each absorbance measurement, requiring operators to perform complex operations and have high skill.
特開平６－１３０５１号公報Japanese Patent Application Laid-Open No. 6-13051 特開２００６－２４２６２９号公報JP 2006-242629 A
　本発明は前述した課題に鑑みてなされたものであり、高価な装置や操作者の高度なスキル及び煩雑な操作を強いることなく、精度よく過酢酸計を校正する方法を提供することを主な目的とする。 The present invention was made in consideration of the above-mentioned problems, and its main objective is to provide a method for accurately calibrating a peracetic acid meter without requiring expensive equipment, advanced operator skills, or complicated operations.
　すなわち、本発明に係る過酢酸計校正方法は、過酢酸分解反応に関する反応定数が既知である過酢酸分解剤を添加して試料溶液中の過酢酸を分解させた場合に想定される過酢酸濃度の変化量と、前記添加の前後において前記試料溶液を過酢酸計で測定した場合の実測値の変化量とに基づいて前記過酢酸計を校正することを特徴とするものである。実測値とは、過酢酸濃度を測定するために過酢酸計によって検出される検出値（電流値、電圧値、カウント値、吸光度等）であっても良いし、これらに基づいて算出される算出値（過酢酸濃度や過酢酸濃度を算出するための計算途中の値等）であっても良い。 In other words, the peracetic acid meter calibration method of the present invention is characterized in that the peracetic acid meter is calibrated based on the expected change in peracetic acid concentration when peracetic acid in a sample solution is decomposed by adding a peracetic acid decomposition agent whose reaction constant for the peracetic acid decomposition reaction is known, and the change in the actual value when the sample solution is measured with the peracetic acid meter before and after the addition. The actual value may be a detection value (current value, voltage value, count value, absorbance, etc.) detected by the peracetic acid meter to measure the peracetic acid concentration, or a calculated value calculated based on these (peracetic acid concentration or a value during calculation to calculate the peracetic acid concentration, etc.).
　このように構成した過酢酸計校正方法によれば、過酢酸分解反応に関する反応定数が既知である過酢酸分解剤を添加して、前記添加前後の試料溶液中の実測値を校正対象である過酢酸計で測定するので、過酢酸分解剤の添加によって変化する過酢酸濃度の変化量に応じた実測値の変化と理論上の過酢酸濃度の変化量とに基づいて前記過酢酸計を校正することができる。
　その結果、過酢酸濃度が未知の試料溶液を用いて過酢酸計を校正することができるので、従来のように濃度が既知の過酢酸製剤を調整して過酢酸計を校正する必要がない。 According to the peracetic acid meter calibration method configured in this manner, a peracetic acid decomposition agent with a known reaction constant for the peracetic acid decomposition reaction is added, and the actual values in the sample solution before and after the addition are measured by the peracetic acid meter, which is the object of calibration. Therefore, the peracetic acid meter can be calibrated based on the change in the actual values corresponding to the change in the peracetic acid concentration caused by the addition of the peracetic acid decomposition agent and the theoretical change in the peracetic acid concentration.
As a result, the peracetic acid meter can be calibrated using a sample solution with an unknown peracetic acid concentration, eliminating the need to calibrate the peracetic acid meter by preparing a peracetic acid formulation with a known concentration as in the conventional method.
　前記過酢酸分解剤によって過酸化水素濃度が大きく変化する場合があるので、過酢酸計によってできるだけ過酢酸の分解による変化量だけを検出するためには、過酢酸分解剤を添加する前に試料溶液中の過酸化水素を分解しておくことが好ましい。また、過酸化水素が分解される際には気泡が発生するので、過酸化水素を先に分解しておくことによって、過酢酸計の測定に対する気泡の影響を減らすことができる。 Because the peracetic acid decomposition agent can cause a large change in hydrogen peroxide concentration, in order to use the peracetic acid meter to detect only the amount of change due to the decomposition of peracetic acid, it is preferable to decompose the hydrogen peroxide in the sample solution before adding the peracetic acid decomposition agent. In addition, since air bubbles are generated when hydrogen peroxide is decomposed, the effect of air bubbles on the measurement by the peracetic acid meter can be reduced by decomposing the hydrogen peroxide first.
　本発明の具体的な実施態様としては、前述した過酸化水素の分解が、過酸化水素分解剤を用いて行われるものであり、前述した過酸化水素分解剤が、カタラーゼ、ペルオキシダーゼ、グルタチオンペルオキシダーゼからなる群のうち１種以上を含むものを挙げることができる。 In a specific embodiment of the present invention, the decomposition of hydrogen peroxide is carried out using a hydrogen peroxide decomposer, and the hydrogen peroxide decomposer may include one or more enzymes selected from the group consisting of catalase, peroxidase, and glutathione peroxidase.
　本発明の具体的な実施態様としては、前述した過酢酸分解剤が、チオグリコール酸、チオグリコール酸グリセリル、メチオニン、システイン、メチオニン誘導体、システイン誘導体、メチオニン残基含有ペプチド、システイン残基含有ペプチド、システアミン、チオグリセリン、２－メルカプト－４－ブタノリド、フラボノイド、亜硝酸、アスコルビン酸、硫黄、白金、パラジウム、ハロゲン元素からなる群より選ばれる１種以上を含むものを挙げることができる。 Specific embodiments of the present invention include those in which the peracetic acid decomposition agent described above includes one or more selected from the group consisting of thioglycolic acid, glyceryl thioglycolate, methionine, cysteine, methionine derivatives, cysteine derivatives, methionine residue-containing peptides, cysteine residue-containing peptides, cysteamine, thioglycerin, 2-mercapto-4-butanolide, flavonoids, nitrous acid, ascorbic acid, sulfur, platinum, palladium, and halogen elements.
　前記過酢酸計としては、例えば、電流値及び／又は電圧値を測定する隔膜式のものを挙げることができる。 The peracetic acid meter may be, for example, a diaphragm type that measures current and/or voltage values.
　医療用洗浄消毒装置、食品用洗浄装置又は排水監視装置等の過酢酸計を高精度で校正することが求められる用途において、本願発明の効果がより顕著に発揮される。 The effects of the present invention are particularly pronounced in applications that require highly accurate calibration of peracetic acid meters, such as medical cleaning and disinfection equipment, food cleaning equipment, or wastewater monitoring equipment.
　本発明の具体的な実施態様としては、過酢酸分解反応に関する反応定数が既知である過酢酸分解剤と、過酢酸を含有する試料溶液（洗浄又は消毒液）とを混合して混合液を生成する混合液生成手段と、前記混合液と接触して前記混合液中の過酢酸濃度を測定する測定手段と、前記過酢酸分解剤によって分解されることが想定される過酢酸の量、及び前記測定部によって測定された実測値に基づいて過酢酸計を校正する校正手段と、を備えた内視鏡洗浄消毒装置を挙げることができる。 A specific embodiment of the present invention is an endoscope cleaning and disinfecting apparatus that includes a mixture generating means for generating a mixture by mixing a peracetic acid decomposition agent, the reaction constant of which is known for the decomposition reaction of peracetic acid, with a sample solution (cleaning or disinfecting solution) containing peracetic acid, a measuring means for contacting the mixture and measuring the concentration of peracetic acid in the mixture, and a calibration means for calibrating a peracetic acid meter based on the amount of peracetic acid expected to be decomposed by the peracetic acid decomposition agent and the actual value measured by the measuring unit.
　より具体的には、前記内視鏡洗浄消毒装置が、前記試料溶液を一定量保持する、前記試料溶液を一定量採取する又は前記試料溶液の量を計測する試料溶液計量手段と、前記試料溶液に添加される前記過酢酸分解剤の量を計測する過酢酸分解剤計量手段とをさらに備えたものであってもよい。 More specifically, the endoscope cleaning and disinfecting apparatus may further include a sample solution measuring means for holding a fixed amount of the sample solution, collecting a fixed amount of the sample solution, or measuring the amount of the sample solution, and a peracetic acid decomposition agent measuring means for measuring the amount of the peracetic acid decomposition agent added to the sample solution.
　本発明は、以下の各発明をも含むものである。
　過酢酸分解反応に関する反応定数が既知である過酢酸分解剤を添加して試料溶液中の過酢酸を分解させた場合に想定される過酢酸濃度の変化量と、前記添加の前後において前記試料溶液を過酢酸計で測定した場合の実測値の変化量とを求める演算部と、前記過酢酸濃度の変化量と前記実測値の変化量とに基づいて前記過酢酸計を校正する校正部とを備える、過酢酸計校正システム、
　過酢酸分解反応に関する反応定数が既知である過酢酸分解剤を添加して試料溶液中の過酢酸を分解させた場合に想定される過酢酸濃度の変化量と、前記添加の前後において前記試料溶液を過酢酸計で測定した場合の実測値の変化量とに基づいて前記過酢酸計を校正する、過酢酸計校正プログラム、及び
　過酢酸分解反応に関する反応定数が既知である過酢酸分解剤を含有する、過酢酸計校正キット。 The present invention also includes the following inventions.
a calculation unit that calculates an expected change in the concentration of peracetic acid when peracetic acid in a sample solution is decomposed by adding a peracetic acid decomposition agent having a known reaction constant for the peracetic acid decomposition reaction, and an amount of change in an actual measurement value when the sample solution is measured with a peracetic acid meter before and after the addition, and a calibration unit that calibrates the peracetic acid meter based on the amount of change in the concentration of peracetic acid and the amount of change in the actual measurement value;
A peracetic acid meter calibration program for calibrating a peracetic acid meter based on an expected change in peracetic acid concentration when peracetic acid in a sample solution is decomposed by adding a peracetic acid decomposition agent having a known reaction constant for the peracetic acid decomposition reaction, and an actual change in the value when the sample solution is measured with the peracetic acid meter before and after the addition; and a peracetic acid meter calibration kit containing a peracetic acid decomposition agent having a known reaction constant for the peracetic acid decomposition reaction.
　本発明によれば、過酢酸分解反応に関する反応定数が既知である過酢酸分解剤を添加して、前記添加前後の試料溶液中の電流値及び／又は電圧値等の実測値を校正対象である過酢酸計で測定するので、過酢酸分解剤の添加によって変化する過酢酸濃度の変化量に応じた実測値の変化と理論上の過酢酸濃度の変化量とに基づいて過酢酸計を校正することができる。
　その結果、過酢酸濃度が未知の試料溶液を用いて過酢酸計を校正することができるので、従来のように校正対象である過酢酸計とは別の過酢酸濃度測定装置を用いた滴定法や吸光度法によって濃度が既知の過酢酸製剤を調整する必要がなく、高価な装置や操作者の高度なスキル及び煩雑な操作を強いることなく、精度よく過酢酸計を校正する方法を提供することが可能である。 According to the present invention, a peracetic acid decomposition agent with a known reaction constant for the peracetic acid decomposition reaction is added, and actual values such as current and/or voltage in the sample solution before and after the addition are measured using a peracetic acid meter, which is the object of calibration. Therefore, the peracetic acid meter can be calibrated based on the change in the actual value corresponding to the change in the peracetic acid concentration caused by the addition of the peracetic acid decomposition agent and the change in the theoretical peracetic acid concentration.
As a result, the peracetic acid meter can be calibrated using a sample solution with an unknown peracetic acid concentration, eliminating the need to prepare a peracetic acid preparation with a known concentration by titration or absorbance using a peracetic acid concentration measurement device separate from the peracetic acid meter to be calibrated, as in the past. This makes it possible to provide a method for accurately calibrating a peracetic acid meter without requiring expensive equipment, advanced operator skills, or complicated operations.
本発明の一実施形態に係る医療用洗浄消毒装置の全体摸式図。1 is an overall schematic diagram of a medical cleaning and disinfecting apparatus according to one embodiment of the present invention; 本実施形態に係る医療用洗浄消毒装置の機能ブロック図。FIG. 2 is a functional block diagram of the medical cleaning and disinfecting apparatus according to the present embodiment. 本実施形態に係る医療用洗浄消毒装置における過酢酸計の校正手順を示すフロー。4 is a flow chart showing a procedure for calibrating a peracetic acid meter in the medical cleaning and disinfecting apparatus according to the present embodiment. 過酢酸濃度と過酢酸計によって検出される電流値との関係を示す図。FIG. 2 is a graph showing the relationship between the peracetic acid concentration and the current value detected by a peracetic acid meter. 他の実施形態に係る医療用洗浄消毒装置の全体模式図。FIG. 13 is an overall schematic diagram of a medical cleaning and disinfecting apparatus according to another embodiment. 他の実施形態に係る医療用洗浄消毒装置の全体模式図。FIG. 13 is an overall schematic diagram of a medical cleaning and disinfecting apparatus according to another embodiment. 他の実施形態に係る試料溶液（洗浄消毒液）に過酢酸分解剤を添加した場合の過酸化水素及び過酢酸の濃度の変化の様子を示す模式図。FIG. 13 is a schematic diagram showing changes in the concentrations of hydrogen peroxide and peracetic acid when a peracetic acid decomposition agent is added to a sample solution (cleaning and disinfecting solution) according to another embodiment. 他の実施形態に係る試料溶液（洗浄消毒液）に過酢酸分解剤を添加した場合の過酸化水素及び過酢酸の濃度の変化の様子を示す模式図。FIG. 13 is a schematic diagram showing changes in the concentrations of hydrogen peroxide and peracetic acid when a peracetic acid decomposition agent is added to a sample solution (cleaning and disinfecting solution) according to another embodiment.
　以下に、本発明の一実施形態に係る医療用洗浄消毒装置１００について図面を参照しながら説明する。
＜本実施形態に係る医療用洗浄消毒装置の構成＞ Hereinafter, a medical cleaning and disinfecting apparatus 100 according to one embodiment of the present invention will be described with reference to the drawings.
<Configuration of the medical cleaning and disinfecting apparatus according to this embodiment>
　本実施形態に係る医療用洗浄消毒装置１００は、例えば、内視鏡等の医療機器を洗浄して消毒したり滅菌したりするためのものであり、例えば、図１に示すように、洗浄消毒槽１と、該洗浄消毒槽１に医療器具を洗浄及び／又は消毒する洗浄消毒液Ｗを供給する洗浄消毒液供給機構２とを備えるものである。 The medical cleaning and disinfecting device 100 according to this embodiment is for cleaning, disinfecting, and sterilizing medical equipment such as endoscopes, and includes, for example, a cleaning and disinfecting tank 1 and a cleaning and disinfecting liquid supply mechanism 2 that supplies the cleaning and disinfecting tank 1 with a cleaning and disinfecting liquid W for cleaning and/or disinfecting medical equipment, as shown in FIG. 1.
　洗浄消毒槽１は、その内部に、洗浄及び／又は消毒の対象物である内視鏡等の医療器具を洗浄消毒液Ｗによって洗浄及び／又は消毒するスペースが形成されているものである。 The cleaning and disinfecting tank 1 has a space formed inside in which medical instruments, such as endoscopes, which are the objects to be cleaned and/or disinfected, are cleaned and/or disinfected with a cleaning and disinfecting solution W.
　洗浄消毒液供給機構２は、洗浄消毒液タンク２１と、流路２２と、ポンプ２３と、バルブ２４と、センサユニット２５と、該センサユニット２５からの情報を処理する情報処理部２６と、洗浄消毒液Ｗの流通を制御する洗浄消毒液流通制御部２７とを備えている。 The cleaning and disinfecting liquid supply mechanism 2 includes a cleaning and disinfecting liquid tank 21, a flow path 22, a pump 23, a valve 24, a sensor unit 25, an information processing unit 26 that processes information from the sensor unit 25, and a cleaning and disinfecting liquid flow control unit 27 that controls the flow of the cleaning and disinfecting liquid W.
　洗浄消毒液タンク２１は、洗浄消毒液Ｗを収容し保存しておくための容器である。なお、洗浄消毒液Ｗは過酢酸を含有するものである。 The cleaning disinfectant tank 21 is a container for containing and storing the cleaning disinfectant W. The cleaning disinfectant W contains peracetic acid.
　流路２２は、例えば、洗浄消毒液タンク２１から洗浄消毒槽１へ洗浄消毒液Ｗを供給する洗浄消毒液供給流路２２１と、洗浄消毒槽１からの廃液を外部へ排出する排出流路２２２と、洗浄消毒槽１から洗浄消毒液タンク２１へ洗浄消毒液Ｗを還流させる還流路２２３とからなる。本実施形態においては、還流路２２３は排出流路２２２とその一部が共通の管によって形成されている。本実施形態においては、外部から洗浄消毒槽１に水を供給する給水管２２４が設けられている。 The flow path 22 is composed of, for example, a cleaning disinfectant supply flow path 221 that supplies the cleaning disinfectant W from the cleaning disinfectant tank 21 to the cleaning disinfection tank 1, a discharge flow path 222 that discharges waste liquid from the cleaning disinfection tank 1 to the outside, and a return flow path 223 that returns the cleaning disinfectant W from the cleaning disinfection tank 1 to the cleaning disinfectant tank 21. In this embodiment, the return flow path 223 is formed by a common pipe that is partially connected to the discharge flow path 222. In this embodiment, a water supply pipe 224 is provided to supply water to the cleaning disinfection tank 1 from the outside.
　ポンプ２３は、例えば、前記洗浄消毒液供給流路２２１上に設けられたダイアフラムポンプやペリスタポンプなどの送液ポンプである。 The pump 23 is, for example, a liquid delivery pump such as a diaphragm pump or a peristaltic pump provided on the cleaning/disinfecting liquid supply flow path 221.
　バルブ２４は、例えば、前記洗浄消毒槽１から流れ出る排出流路２２２と還流路２２３とを切り替えることができる３方弁である。 The valve 24 is, for example, a three-way valve that can switch between a discharge flow path 222 and a return flow path 223 that flow out from the cleaning and disinfection tank 1.
　前記センサユニット２５は、例えば、図２に示すように、過酢酸計２５１と液面センサ２５２とを備えるものである。 The sensor unit 25 includes, for example, a peracetic acid meter 251 and a liquid level sensor 252, as shown in FIG. 2.
　過酢酸計２５１は、例えば、隔膜式のポーラログラフセンサであり、前記洗浄消毒液タンク２１内に収容された洗浄消毒液Ｗ（過酢酸計にとっては測定対象であるため試料溶液ともいう。）に触れるように配置されて、洗浄消毒液Ｗ中の過酢酸濃度を測定するものである。 The peracetic acid meter 251 is, for example, a diaphragm-type polarographic sensor that is positioned so as to come into contact with the cleaning disinfectant W (also called the sample solution because it is the measurement target for the peracetic acid meter) contained in the cleaning disinfectant tank 21, and measures the concentration of peracetic acid in the cleaning disinfectant W.
　液面センサ２５２は、洗浄消毒液タンク２１中の洗浄消毒液Ｗの水位を検知するものである。 The liquid level sensor 252 detects the water level of the cleaning disinfectant W in the cleaning disinfectant tank 21.
　情報処理部２６及び洗浄消毒液流通制御部２７は、ＣＰＵ、メモリ、入出力インタフェース等を備えた専用乃至汎用のコンピュータＣＰがその機能を担うものである。 The functions of the information processing unit 26 and the cleaning and disinfecting liquid flow control unit 27 are carried out by a dedicated or general-purpose computer CP equipped with a CPU, memory, input/output interface, etc.
　しかして、本実施形態に係る医療用洗浄消毒装置１００は、前記過酢酸計２５１を校正する校正システム４をさらに備えるものである。 The medical cleaning and disinfecting apparatus 100 according to this embodiment further includes a calibration system 4 that calibrates the peracetic acid meter 251.
　校正システム４は、過酢酸計２５１から出力される信号に基づいて実測値（この実施形態においては電流値）の変化量、及び試料溶液における過酢酸濃度の変化量に基づいて算出される電流値である理論値の変化量を算出する演算部４１と、演算部４１によって算出された実測値の変化量と、理論値の変化量とに基づいて過酢酸計２５１を校正する校正部４２と、分解剤添加機構４３とを備えている。 The calibration system 4 includes a calculation unit 41 that calculates the amount of change in the actual measurement value (current value in this embodiment) based on the signal output from the peracetic acid meter 251 and the amount of change in the theoretical value, which is a current value calculated based on the amount of change in the peracetic acid concentration in the sample solution, a calibration unit 42 that calibrates the peracetic acid meter 251 based on the amount of change in the actual measurement value and the amount of change in the theoretical value calculated by the calculation unit 41, and a decomposition agent addition mechanism 43.
　演算部４１及び校正部４２は、前述したコンピュータＣＰがその機能を担うものである。 The functions of the calculation unit 41 and the calibration unit 42 are performed by the computer CP mentioned above.
　分解剤添加機構４３は、洗浄消毒液Ｗに対して、洗浄消毒液Ｗ中の過酢酸を分解する過酢酸分解剤を添加するものであり、分解剤を洗浄消毒液タンク２１に導く分解剤流路４３１と、該流路を流れる過酢酸分解剤の流通を制御する分解剤流通制御部４３２とを備えるものである。分解剤流通制御部４３２は、例えば、前述したコンピュータＣＰがその機能を担うものである。
　本実施形態においては、分解剤添加機構４３が備える分解剤流通制御部４３２が、前述した洗浄消毒液供給機構２が備える流路２２、ポンプ２３、バルブ２４及びセンサユニット２５を制御するように構成されており、分解剤流通制御部４３２が、洗浄消毒槽１にユーザが手動で投入した過酢酸分解剤を、分解剤流路４３１としての機能を担う還流路２２３を経由して洗浄消毒液タンク２１に添加するように構成されている。 The decomposing agent adding mechanism 43 adds a peracetic acid decomposing agent that decomposes peracetic acid in the cleaning disinfectant solution W to the cleaning disinfectant solution W, and includes a decomposing agent flow path 431 that guides the decomposing agent to the cleaning disinfectant solution tank 21, and a decomposing agent flow control unit 432 that controls the flow of the peracetic acid decomposing agent flowing through the flow path. The function of the decomposing agent flow control unit 432 is performed by, for example, the above-mentioned computer CP.
In this embodiment, the decomposition agent flow control unit 432 provided in the decomposition agent addition mechanism 43 is configured to control the flow path 22, the pump 23, the valve 24, and the sensor unit 25 provided in the cleaning disinfection solution supply mechanism 2 described above, and the decomposition agent flow control unit 432 is configured to add the peracetic acid decomposition agent manually added by the user to the cleaning disinfection tank 1 to the cleaning disinfection solution tank 21 via the return flow path 223, which functions as the decomposition agent flow path 431.
　また、本実施形態においては、洗浄消毒液供給機構２が備えるセンサユニット２５が、洗浄消毒液タンク２１中における過酢酸分解剤の濃度を検知する過酢酸分解剤検出器２５３をさらに備えていても良い。この過酢酸分解剤検出器２５３は、投入された過酢酸分解剤の全量が確実に洗浄消毒液Ｗと混合されたことを確認するために、過酢酸分解物質の濃度を測定するもの（過酢酸分解剤計量手段）であることが好ましい。 In addition, in this embodiment, the sensor unit 25 provided in the cleaning disinfectant supply mechanism 2 may further include a peracetic acid decomposition agent detector 253 that detects the concentration of the peracetic acid decomposition agent in the cleaning disinfectant tank 21. This peracetic acid decomposition agent detector 253 is preferably a device that measures the concentration of peracetic acid decomposition substances (peracetic acid decomposition agent measuring means) to ensure that the entire amount of peracetic acid decomposition agent introduced is reliably mixed with the cleaning disinfectant W.
　前記過酢酸分解剤は、洗浄消毒液Ｗに含まれる過酢酸を分解する過酢酸分解物質を含有するものであり、粉末や錠剤などの固体であっても良いし液体のものであってもよい。過酢酸分解物質の具体例としては、例えば、チオグリコール酸、チオグリコール酸グリセリル、メチオニン、システイン、メチオニン誘導体、システイン誘導体、メチオニン残基含有ペプチド、システイン残基含有ペプチド、システアミン、チオグリセリン、２－メルカプト－４－ブタノリド、フラボノイド、亜硝酸、アスコルビン酸、硫黄、白金、パラジウム又はハロゲン元素等を挙げることができる。過酢酸分解剤は、これら過酢酸分解物質を１種のみ含むものであってもよいし、２種以上含むものであってもよい。 The peracetic acid decomposition agent contains a peracetic acid decomposition substance that decomposes the peracetic acid contained in the cleaning and disinfecting solution W, and may be a solid such as a powder or tablet, or may be a liquid. Specific examples of peracetic acid decomposition substances include thioglycolic acid, glyceryl thioglycolate, methionine, cysteine, methionine derivatives, cysteine derivatives, methionine residue-containing peptides, cysteine residue-containing peptides, cysteamine, thioglycerin, 2-mercapto-4-butanolide, flavonoids, nitrous acid, ascorbic acid, sulfur, platinum, palladium, and halogen elements. The peracetic acid decomposition agent may contain only one type of peracetic acid decomposition substance, or may contain two or more types.
　これら過酢酸分解物質としては、市販のものを使用することができ、試薬メーカーから提供されている製品情報から過酢酸分解反応における反応定数を知ることができるものである。また、必要であれば各自が所望する反応条件における反応定数を実験により求めることができる。 These peracetic acid decomposition substances can be commercially available, and the reaction constants for the peracetic acid decomposition reaction can be known from the product information provided by the reagent manufacturer. If necessary, the reaction constants for the reaction conditions desired by each individual can be determined by experiment.
　前記過酢酸分解剤によって他の物質が分解されることによる電流値の変化をできるだけ減らすために、過酢酸分解剤が過酢酸のみを分解する過酢酸分解物質を含有することがより好ましい。 In order to minimize changes in the current value caused by the decomposition of other substances by the peracetic acid decomposition agent, it is more preferable that the peracetic acid decomposition agent contains a peracetic acid decomposition substance that decomposes only peracetic acid.
　本実施形態で説明したような医療用洗浄消毒装置１００や、食品又は食品製造に係る器具等を洗浄する食品用洗浄装置等において広く用いられている過酢酸を含有する洗浄消毒液において過酢酸のみを分解する過酢酸分解物質としては、例えば、チオグリコール酸、チオグリコール酸グリセリル、チオグリセリン、２－メルカプト－４－ブタノリド、フラボノイド、亜硝酸、硫黄又はハロゲン元素を挙げることができる。これらは１種ずつ使用される場合であっても２種以上併用する場合であっても、過酢酸のみを分解するものである。 Peracetic acid decomposition substances that decompose only peracetic acid in cleaning and disinfecting solutions containing peracetic acid that are widely used in the medical cleaning and disinfecting apparatus 100 as described in this embodiment and in food cleaning apparatuses that clean food or equipment used in food production can include, for example, thioglycolic acid, glyceryl thioglycolate, thioglycerin, 2-mercapto-4-butanolide, flavonoids, nitrous acid, sulfur, or halogen elements. These decompose only peracetic acid, whether they are used individually or in combination of two or more types.
＜本実施形態に係る医療用洗浄消毒装置を用いた洗浄消毒方法及び過酢酸計の校正方法＞
　このように構成した医療用洗浄消毒装置１００について、洗浄消毒液供給機構２及び校正システム４の各機能部の説明を兼ねてその動作の一例を以下に詳述する。 <Cleaning and disinfecting method using the medical cleaning and disinfecting apparatus according to this embodiment and calibration method for the peracetic acid meter>
An example of the operation of the medical cleaning and disinfecting apparatus 100 configured as above will be described in detail below, together with an explanation of each functional part of the cleaning and disinfecting liquid supply mechanism 2 and the calibration system 4.
　まず、本実施形態に係る医療用洗浄消毒装置１００によって医療用器具の洗浄及び／又は消毒を行う場合（洗浄消毒モード）について説明する。
　洗浄消毒液流通制御部２７がバルブ２４を閉状態にし、ポンプ２３に指令を出して洗浄消毒液タンク２１から洗浄消毒槽１に洗浄消毒液Ｗを供給し医療用器具を洗浄及び／又は消毒する。液面センサ２５２が洗浄消毒液タンク２１の水位変化から所定量の洗浄消毒液Ｗが洗浄消毒槽１に供給されたことを検知すると、洗浄消毒液流通制御部２７がポンプ２３を停止する。
　所定時間経過後、洗浄消毒液流通制御部２７はバルブ２４を開いて排出流路２２２から使用済みの洗浄消毒液Ｗを洗浄消毒液タンク２１に回収する。洗浄消毒槽１に給水管２２４から水が供給されて、洗浄消毒槽１に残っている洗浄消毒液Ｗをすすぎ、そのすすぎ水が全て排出流路２２２から外部に排出されて、洗浄消毒工程が終了する。
　なお、洗浄消毒槽１に供給されて医療用器具などの洗浄及び／又は消毒に使用された後、洗浄消毒液タンク２１に回収された洗浄消毒液Ｗは、過酢酸濃度が所定濃度の範囲内のものであれば再度使用することができる。そこで本実施形態においては、過酢酸計２５１によって洗浄消毒液タンク２１に回収された洗浄消毒液Ｗの過酢酸濃度を測定し、次回以降の洗浄消毒工程に再利用できるものであるかどうかを確認するようにしている。そして、洗浄消毒液タンク２１に回収された洗浄消毒液Ｗ中の過酢酸濃度が所定の濃度範囲外のものとなってしまった場合には、洗浄消毒液Ｗを排出流路２２２から外部に排出するようにしてある。 First, a case where medical instruments are cleaned and/or disinfected by the medical cleaning and disinfecting apparatus 100 according to this embodiment (cleaning and disinfecting mode) will be described.
The cleaning and disinfecting liquid flow control unit 27 closes the valve 24 and issues a command to the pump 23 to supply the cleaning and disinfecting liquid W from the cleaning and disinfecting liquid tank 21 to the cleaning and disinfecting tank 1 to clean and/or disinfect the medical instruments. When the liquid level sensor 252 detects from a change in the water level in the cleaning and disinfecting liquid tank 21 that a predetermined amount of cleaning and disinfecting liquid W has been supplied to the cleaning and disinfecting tank 1, the cleaning and disinfecting liquid flow control unit 27 stops the pump 23.
After a predetermined time has elapsed, the cleaning and disinfecting solution flow control unit 27 opens the valve 24 to recover the used cleaning and disinfecting solution W from the discharge flow path 222 into the cleaning and disinfecting solution tank 21. Water is supplied to the cleaning and disinfecting tank 1 from the water supply pipe 224 to rinse the cleaning and disinfecting solution W remaining in the cleaning and disinfecting tank 1, and all of the rinsing water is discharged to the outside from the discharge flow path 222, completing the cleaning and disinfecting process.
The cleaning disinfectant W recovered in the cleaning disinfectant tank 21 after being supplied to the cleaning disinfectant tank 1 and used for cleaning and/or disinfecting medical instruments and the like can be reused if the peracetic acid concentration is within a predetermined concentration range. Therefore, in this embodiment, the peracetic acid concentration of the cleaning disinfectant W recovered in the cleaning disinfectant tank 21 is measured by the peracetic acid meter 251 to confirm whether it can be reused in the next or subsequent cleaning and disinfecting process. If the peracetic acid concentration in the cleaning disinfectant W recovered in the cleaning disinfectant tank 21 falls outside the predetermined concentration range, the cleaning disinfectant W is discharged from the discharge flow path 222 to the outside.
　次に、過酢酸計２５１の校正を行う場合（校正モード）について、図３を用いて説明する。
　まず分解剤流通制御部４３２は、洗浄消毒液タンク２１内の洗浄消毒液Ｗの量が予め定められた所定量となるように調整する。
　具体的な動作例は以下の通りである。液面センサ（試料溶液計量手段）２５２が洗浄消毒液タンクの水位を検知し、該水位が予め決められた所定水位（例えば洗浄消毒液タンク２１において定められた最低水位）よりも小さい場合には、分解剤流通制御部４３２がバルブ２４を制御して給水管２２４から洗浄消毒槽１及び還流路２２３を経由して洗浄消毒液タンク２１に水を供給し、洗浄消毒液タンク２１内の水位が所定水位となるようにする。洗浄消毒液タンク２１の水位が前記所定水位よりも高い場合には、分解剤流通制御部４３２がポンプ２３及びバルブ２４を制御して、洗浄消毒液供給流路２２１、洗浄消毒槽１および排出流路２２２を経由して洗浄消毒液タンク２１から洗浄消毒液Ｗを排出し、洗浄消毒液タンク２１の水位が所定水位となるようにする。 Next, the case where the peracetic acid meter 251 is calibrated (calibration mode) will be described with reference to FIG.
First, the decomposition agent flow control unit 432 adjusts the amount of the cleaning disinfectant W in the cleaning disinfectant tank 21 to a predetermined amount.
A specific example of the operation is as follows: The liquid level sensor (sample solution measuring means) 252 detects the water level of the cleaning disinfectant tank, and if the water level is lower than a predetermined water level (for example, the minimum water level set in the cleaning disinfectant tank 21), the decomposition agent flow control unit 432 controls the valve 24 to supply water from the water supply pipe 224 via the cleaning disinfection tank 1 and the return flow path 223 to the cleaning disinfectant tank 21 so that the water level in the cleaning disinfectant tank 21 becomes the predetermined water level. If the water level in the cleaning disinfectant tank 21 is higher than the predetermined water level, the decomposition agent flow control unit 432 controls the pump 23 and the valve 24 to discharge the cleaning disinfectant W from the cleaning disinfectant tank 21 via the cleaning disinfectant supply flow path 221, the cleaning disinfectant tank 1, and the discharge flow path 222, so that the water level in the cleaning disinfectant tank 21 becomes the predetermined water level.
　洗浄消毒液タンク２１内の洗浄消毒液Ｗの量が所定量に調整された後に、過酢酸計（測定手段）２５１が洗浄消毒液タンク２１中の洗浄消毒液Ｗの過酢酸濃度を測定する。 After the amount of cleaning disinfectant W in the cleaning disinfectant tank 21 has been adjusted to a predetermined amount, the peracetic acid meter (measuring means) 251 measures the peracetic acid concentration of the cleaning disinfectant W in the cleaning disinfectant tank 21.
　次に、洗浄消毒液タンク２１に過酢酸分解剤が添加され、添加と同時に過酢酸分解反応が開始される。
　具体的な添加例の１つとしては、ユーザが洗浄消毒槽１に過酢酸分解剤を所定量投入し、分解剤流通制御部４３２がバルブ２４を制御して洗浄消毒槽１に投入された過酢酸分解剤を、還流路２２３を経由して洗浄消毒液タンク２１に導入する。
　過酢酸分解剤検出器２５３が、洗浄消毒液タンク２１への過酢酸分解剤の流入を検知すると、分解剤流通制御部４３２がポンプ２３を稼働させて、洗浄消毒液タンク２１から洗浄消毒液Ｗを洗浄消毒槽１に送り、洗浄消毒槽１から洗浄消毒液タンク２１に洗浄消毒液Ｗを還流させる操作を繰り返して投入された過酢酸分解剤の全量がすぐさま洗浄消毒液Ｗと混合されるように攪拌する。すなわち、分解剤添加機構４３が混合液生成手段に相当する。 Next, a peracetic acid decomposition agent is added to the cleaning and disinfecting liquid tank 21, and the peracetic acid decomposition reaction is started simultaneously with the addition.
As one specific example of addition, the user adds a predetermined amount of peracetic acid decomposition agent to the cleaning and disinfection tank 1, and the decomposition agent flow control unit 432 controls the valve 24 to introduce the peracetic acid decomposition agent added to the cleaning and disinfection tank 1 into the cleaning and disinfection liquid tank 21 via the return path 223.
When the peracetic acid decomposer detector 253 detects the inflow of peracetic acid decomposer into the cleaning disinfectant tank 21, the decomposer flow control unit 432 operates the pump 23 to send the cleaning disinfectant W from the cleaning disinfectant tank 21 to the cleaning disinfection tank 1, and repeats the operation of refluxing the cleaning disinfectant W from the cleaning disinfection tank 1 to the cleaning disinfectant tank 21, thereby stirring so that the entire amount of the peracetic acid decomposer added is immediately mixed with the cleaning disinfectant W. In other words, the decomposer addition mechanism 43 corresponds to the mixed solution generating means.
　過酢酸分解剤が洗浄消毒液タンク２１に投入されてから所定時間後に、過酢酸計２５１が洗浄消毒液Ｗと過酢酸分解剤とを混合して得た混合液中の過酢酸濃度を測定する。この際の測定条件は、過酢酸分解剤添加直前の過酢酸計２５１による洗浄消毒液Ｗの過酢酸濃度測定時とできるだけ同じ測定条件であることが好ましい。 A predetermined time after the peracetic acid decomposition agent is added to the cleaning disinfectant tank 21, the peracetic acid meter 251 measures the peracetic acid concentration in the mixture obtained by mixing the cleaning disinfectant W with the peracetic acid decomposition agent. The measurement conditions at this time are preferably as similar as possible to the measurement conditions used when the peracetic acid meter 251 measures the peracetic acid concentration of the cleaning disinfectant W immediately before the peracetic acid decomposition agent is added.
　その後、演算部４１が過酢酸計２５１による洗浄消毒液Ｗ及び混合液の測定における定電流値の差と、これら２回の測定の間に分解されることが想定される理論上の過酢酸分解量とを算出する。理論上の過酢酸分解量は、例えば、反応時間や反応温度、洗浄消毒液タンク２１中の洗浄消毒液Ｗの量、添加された過酢酸分解剤の濃度、量及び反応定数等に基づいて算出される。これら情報のうち必要なものについてはユーザが予め校正システム４に対して入力しておくようにしてもよい。 Then, the calculation unit 41 calculates the difference between the constant current values in the measurements of the cleaning disinfectant solution W and the mixed solution by the peracetic acid meter 251, and the theoretical amount of peracetic acid decomposed that is expected to be decomposed between these two measurements. The theoretical amount of peracetic acid decomposed is calculated based on, for example, the reaction time and reaction temperature, the amount of cleaning disinfectant solution W in the cleaning disinfectant solution tank 21, the concentration, amount and reaction constant of the added peracetic acid decomposer, etc. The user may input necessary information from this information to the calibration system 4 in advance.
　このように算出された電流値の実測値の変化量と理論上の過酢酸分解量から算出された電流値の理論値の変化量とに基づいて校正部（校正手段）４２が過酢酸計２５１を校正することによって校正工程が終了する。
期的に校正モードが自動選択されて行われるものとしても良いし、任意の時期にユーザが校正モードを選択することによって行うものとしても良い。 The calibration process is completed when the calibration unit (calibration means) 42 calibrates the peracetic acid meter 251 based on the change in the actual current value calculated in this manner and the change in the theoretical current value calculated from the theoretical amount of peracetic acid decomposition.
The calibration mode may be automatically selected periodically, or the calibration mode may be selected by the user at any time.
　この校正の具体的な方法は以下の通りである。
　過酢酸計２５１による過酢酸濃度の測定時には、以下の式（１）に示すような式により電流値差を過酢酸濃度に換算することができる。
（Ｃ０－Ｃ）／Δｉ（ｐｐｍ／ｎＡ）・・・（１）
　この式（１）中のＣ０は基準となる過酢酸濃度を、Ｃは測定対象液の過酢酸濃度を、ΔｉはＣ０－Ｃ間の電流値の差をそれぞれ表しており、Ｃ０の値と濃度がＣ０である場合に検出される電流値が分かっていればこの式から、電流値の変化量に対応する試料溶液中の過酢酸濃度の変化量を算出することができる。
　この電流値の変化量と過酢酸濃度の変化量との関係式は、過酢酸計２５１の種類や使用環境に応じて決定することができる。 The specific method of this calibration is as follows.
When the peracetic acid concentration is measured by the peracetic acid meter 251, the current value difference can be converted into the peracetic acid concentration by the following formula (1).
(C 0 −C)/Δi(ppm/nA) (1)
In this formula (1), C0 represents the reference peracetic acid concentration, C represents the peracetic acid concentration of the measurement target solution, and Δi represents the difference in current value between C0 and C. If the value of C0 and the current value detected when the concentration is C0 are known, the amount of change in the concentration of peracetic acid in the sample solution corresponding to the amount of change in the current value can be calculated from this formula.
The relational expression between the amount of change in the current value and the amount of change in the peracetic acid concentration can be determined depending on the type of peracetic acid meter 251 and the environment in which it is used.
　そこで、本実施形態に係る校正方法においては、予め求められた式（１）に基づいて、図４に示すように、理論上の過酢酸分解量から算出された過酢酸濃度の変化量（理論上のＣ０－Ｃ）と、過酢酸分解剤の添加前後に測定された実際の各電流値（各実測値）から換算される過酢酸濃度の変化量（実測値としてのＣ０－Ｃ）とを比較し、これらの間のずれを補正することによって過酢酸計２５１を校正することができる。なお、この図４におけるＣ０は、過酢酸分解剤添加前の試料溶液中の過酢酸濃度を、Ｃは過酢酸分解剤を添加してから所定時間経過後の過酢酸濃度をそれぞれ示している。また、ここでの過酢酸分解剤の添加後の電流値とは、試料溶液に過酢酸分解剤を添加してから所定時間経過後の電流値を示している。
　図４の例には記載されていないが、過酢酸を含有しないゼロ水を測定した際の電流値を用いて過酢酸計２５１についてゼロ点補正をさらに行うようにしても良い。また、ゼロ水を測定した際の電流値を用いて過酢酸濃度の変化量と電流値の変化量との間の相関関係（例えば、比例関係）を表す検量線を作成して、図示しない記憶部などに記憶しておき、校正部がこの検量線を用いて過酢酸計を校正するように構成しても良い。 Therefore, in the calibration method according to the present embodiment, as shown in FIG. 4, the change in the peracetic acid concentration calculated from the theoretical amount of peracetic acid decomposed (theoretical C 0 -C ) is compared with the change in the peracetic acid concentration converted from the actual current values (actual values) measured before and after the addition of the peracetic acid decomposition agent based on the previously obtained formula (1), and the peracetic acid meter 251 can be calibrated by correcting the deviation between them. In addition, C 0 in FIG. 4 indicates the peracetic acid concentration in the sample solution before the addition of the peracetic acid decomposition agent, and C indicates the peracetic acid concentration after a predetermined time has elapsed since the addition of the peracetic acid decomposition agent. In addition, the current value after the addition of the peracetic acid decomposition agent here indicates the current value after a predetermined time has elapsed since the addition of the peracetic acid decomposition agent to the sample solution.
4, a current value when zero water that does not contain peracetic acid is measured may be used to further perform zero point correction for the peracetic acid meter 251. Also, a calibration curve showing the correlation (for example, proportionality) between the amount of change in peracetic acid concentration and the amount of change in current value may be created using the current value when zero water is measured and stored in a storage unit (not shown), and the calibration unit may be configured to calibrate the peracetic acid meter using this calibration curve.
＜本実施形態の効果＞
　以上のように構成した医療用洗浄消毒装置１００によれば、洗浄消毒液Ｗ中の過酢酸濃度を測定する過酢酸計２５１を、過酢酸濃度が未知の洗浄消毒液Ｗを用いて校正することができる。
　そのため、従来のように過酢酸濃度が既知の過酢酸製剤を用いる必要がない。
　医療用洗浄消毒装置１００においては、洗浄消毒液による医療器具等を消毒して確実に消毒や滅菌するために洗浄消毒液中の過酢酸濃度を常に基準値以上に保つ必要がある。
　このような医療用洗浄消毒装置１００においては、洗浄消毒液中に含まれる過酢酸の濃度を過酢酸計２５１によって正確に測定するために、過酢酸計２５１を定期的に校正する必要がある。
　このような医療用洗浄消毒装置１００において、本実施形態に係る校正方法を採用すれば、過酢酸計２５１のメンテナンス作業に係るユーザの負担を大幅に低減することができる。 <Effects of this embodiment>
According to the medical cleaning and disinfecting apparatus 100 configured as described above, the peracetic acid meter 251 that measures the peracetic acid concentration in the cleaning and disinfecting solution W can be calibrated using the cleaning and disinfecting solution W whose peracetic acid concentration is unknown.
Therefore, there is no need to use a peracetic acid preparation with a known peracetic acid concentration as in the past.
In the medical washer/disinfectant 100, in order to reliably disinfect and sterilize medical instruments and the like with the washer/disinfectant, it is necessary to constantly maintain the concentration of peracetic acid in the washer/disinfectant at a standard value or higher.
In such a medical cleaning and disinfecting apparatus 100, in order to accurately measure the concentration of peracetic acid contained in the cleaning and disinfecting solution using the peracetic acid meter 251, the peracetic acid meter 251 needs to be calibrated periodically.
If the calibration method according to this embodiment is adopted in such a medical cleaning and disinfecting apparatus 100, the burden on the user regarding the maintenance work of the peracetic acid meter 251 can be significantly reduced.
＜本発明に係る他の実施形態＞
　本発明は前記実施形態に限られたものではない。
　例えば、医療用洗浄消毒装置が洗浄消毒液タンク内の温度を調節する温度調節機構をさらに備えるものとしてもよい。このような構成とすれば、過酢酸計による過酢酸濃度測定中や過酢酸分解反応中の洗浄消毒液の温度をコントロールすることができるので、過酢酸計をより高精度に校正することができる。 <Other embodiments of the present invention>
The present invention is not limited to the above-described embodiment.
For example, the medical cleaning and disinfecting apparatus may further include a temperature control mechanism for adjusting the temperature inside the cleaning and disinfecting solution tank. With this configuration, the temperature of the cleaning and disinfecting solution during the measurement of the peracetic acid concentration by the peracetic acid meter or during the peracetic acid decomposition reaction can be controlled, so that the peracetic acid meter can be calibrated with higher accuracy.
　例えば、図５に示すように、洗浄消毒槽１が、その底面及び側面の一部を含むトレー状かつ医療機器を洗浄消毒槽１へ投入できなくする洗浄消毒槽下部部材１１’を備えるものであり、医療機器の洗浄消毒時と校正時において異なる洗浄消毒槽下部部材１１’を使用するものとしてもよい。このように構成しておけば、ユーザが洗浄消毒モードと校正モードとを手動で切り替える場合に、医療機器の洗浄や消毒をするつもりで校正をしてしまい、正しい消毒液濃度が分からなくなってしまったり、校正時に医療機器を洗浄消毒しようとしたりするユーザミスを避けることができる。より確実に過酢酸分解剤の混入を防ぐためには、校正モード専用の洗浄消毒槽下部部材’のみに突起などの目印１１１’を付しておき、医療用洗浄消毒装置が洗浄消毒槽下部部材１１の種類を見分けて、校正モードを選択することができるようにしておくことが好ましい。
　また、校正専用の洗浄消毒槽下部部材１１’を使用する場合には、この洗浄消毒槽下部部材１１’に所定量の過酢酸分解剤を予め入れておくようにしてもよい。 For example, as shown in FIG. 5, the cleaning and disinfecting tank 1 is provided with a tray-shaped cleaning and disinfecting tank lower member 11' including a part of its bottom and side surfaces, which prevents medical instruments from being put into the cleaning and disinfecting tank 1, and different cleaning and disinfecting tank lower members 11' may be used for cleaning and disinfecting medical instruments and for calibration. With this configuration, when a user manually switches between the cleaning and disinfecting mode and the calibration mode, it is possible to avoid user errors such as calibrating the medical instruments while intending to clean or disinfect them, losing track of the correct disinfectant concentration, or trying to clean and disinfect medical instruments during calibration. In order to more reliably prevent the peracetic acid decomposition agent from being mixed in, it is preferable to attach a mark 111' such as a protrusion only to the cleaning and disinfecting tank lower member ' dedicated to the calibration mode, so that the medical cleaning and disinfecting device can distinguish the type of the cleaning and disinfecting tank lower member 11 and select the calibration mode.
When a cleaning/disinfecting tank lower part 11' dedicated to calibration is used, a predetermined amount of peracetic acid decomposition agent may be placed in the cleaning/disinfecting tank lower part 11' beforehand.
　前述した実施形態では洗浄消毒液タンク内に貯留されている洗浄消毒液の量を液面センサによって検知していたが、例えば図６に示すように、過酢酸分解剤の温度を測定する温度センサ３’’をさらに備えるものとし、この温度センサ３’’によって洗浄消毒液に添加する前の過酢酸分解剤の温度を測定し、さらに過酢酸分解剤を添加した後の混合液の温度を測定することによって、過酢酸分解剤の添加による混合液の温度変化から過酢酸分解剤を添加する前の洗浄消毒液の体積を算出するものとしてもよい。 In the above-described embodiment, the amount of cleaning disinfectant stored in the cleaning disinfectant tank is detected by a liquid level sensor, but for example, as shown in FIG. 6, a temperature sensor 3'' for measuring the temperature of the peracetic acid decomposer may be further provided, and this temperature sensor 3'' may be used to measure the temperature of the peracetic acid decomposer before it is added to the cleaning disinfectant, and the temperature of the mixed solution after the peracetic acid decomposer is added may be measured, thereby calculating the volume of the cleaning disinfectant before the addition of the peracetic acid decomposer from the temperature change of the mixed solution due to the addition of the peracetic acid decomposer.
　洗浄消毒液の体積を算出する方法は、前述した方法に限られず、以外にも洗浄消毒液に着色等の標識をしてから、吸光度や導電率等を測定して求めるようにしてもよい。
　また、洗浄消毒液の体積を求める工程は、洗浄消毒液又は混合液の過酢酸濃度測定の後に行うようにしてもよい。 The method for calculating the volume of the cleaning and disinfecting solution is not limited to the above-mentioned method, and the volume may be calculated by measuring the absorbance, conductivity, etc. of the cleaning and disinfecting solution after labeling it with a color or the like.
In addition, the step of determining the volume of the cleaning disinfectant may be performed after measuring the peracetic acid concentration of the cleaning disinfectant or the mixed solution.
　洗浄消毒液タンク内の洗浄消毒液の量が所定量となるように調整するのではなく、洗浄消毒液を洗浄消毒液タンクから所定量採取する洗浄消毒液採取部を備え、この洗浄消毒液採取部によって採取された洗浄消毒液に対して過酢酸分解剤が添加されるものとしてもよい。洗浄消毒液タンクに収容されている洗浄消毒液の量が多い場合には、このように洗浄消毒液を所定量取り出して過酢酸を分解する方が経済的である。洗浄消毒液タンク内からの洗浄消毒液の採取は、ユーザが手動で行うようにしてもよい。 Instead of adjusting the amount of cleaning disinfectant in the cleaning disinfectant tank to a predetermined amount, a cleaning disinfectant collection section may be provided that collects a predetermined amount of cleaning disinfectant from the cleaning disinfectant tank, and a peracetic acid decomposer may be added to the cleaning disinfectant collected by this cleaning disinfectant collection section. When the amount of cleaning disinfectant contained in the cleaning disinfectant tank is large, it is more economical to take out a predetermined amount of cleaning disinfectant in this way and decompose the peracetic acid. The cleaning disinfectant may be manually collected from the cleaning disinfectant tank by the user.
　過酢酸分解剤の添加前後における過酢酸計による洗浄消毒液中又は混合液中の過酢酸濃度測定の条件は同じであることが好ましいが、必ずしも同一条件でなくてもよい。 It is preferable that the conditions for measuring the peracetic acid concentration in the cleaning and disinfecting solution or mixed solution using a peracetic acid meter be the same before and after the addition of the peracetic acid decomposition agent, but the conditions do not necessarily have to be the same.
　分解剤添加機構が、所定量の過酢酸分解剤を自動で洗浄消毒液中に添加する過酢酸分解剤計量部及び／又は過酢酸分解剤投入部をさらに備えるものとしてもよい。 The decomposition agent addition mechanism may further include a peracetic acid decomposition agent measuring section and/or a peracetic acid decomposition agent feeding section that automatically adds a predetermined amount of peracetic acid decomposition agent to the cleaning and disinfecting solution.
　医療用洗浄消毒装置が、過酢酸分解剤の前後における電流値の変化量が予め設定された閾値から外れている場合に過酢酸計等に異常が生じていることをユーザに知らせるための警告を発するものとしてもよい。 The medical cleaning and disinfecting device may be configured to issue a warning to inform the user that an abnormality has occurred in the peracetic acid meter, etc., if the amount of change in the current value before and after the peracetic acid decomposition agent falls outside a preset threshold value.
　試料溶液中に過酸化水素が含有されている場合には、過酢酸計の作用極表面において過酸化水素が還元されることによって、過酢酸の濃度変化に基づく電流値の変化だけでなく、過酸化水素の濃度変化をも含めた電流値の変化が検出されてしまう可能性がある。そこで、例えば図４に示したように、試料溶液に過酢酸分解剤を添加して該試料溶液中の過酢酸濃度の変化量を測定する場合に、分解剤添加機構が試料溶液に過酸化水素分解剤を添加するようにして、過酸化水素濃度の理論上の変化量をも考慮するようにすれば、より精度よく過酢酸計を校正することができると考えられる。 If the sample solution contains hydrogen peroxide, the hydrogen peroxide may be reduced on the surface of the working electrode of the peracetic acid meter, which may result in the detection of not only a change in current value based on a change in the concentration of peracetic acid, but also a change in current value that includes a change in the concentration of hydrogen peroxide. For example, as shown in Figure 4, when a peracetic acid decomposer is added to the sample solution and the change in the concentration of peracetic acid in the sample solution is measured, it is believed that the peracetic acid meter can be calibrated more accurately if the decomposer addition mechanism adds a hydrogen peroxide decomposer to the sample solution, taking into account the theoretical change in the hydrogen peroxide concentration.
　具体的な構成としては、分解剤添加機構が、過酸化水素を分解する過酸化水素分解剤を洗浄消毒液に添加する過酸化水素分解剤計量部及び／又は過酸化水素分解剤投入部をさらに備えるものとしてもよい。
　過酸化水素分解剤は、医療用洗浄消毒装置や食品用洗浄装置に使用される過酢酸を含有する洗浄消毒液中の過酸化水素を分解できる過酸化水素分解物質を含有するものであれば、固体であっても液体であってもよい。 As a specific configuration, the decomposition agent adding mechanism may further include a hydrogen peroxide decomposition agent measuring unit and/or a hydrogen peroxide decomposition agent feeding unit that adds a hydrogen peroxide decomposition agent that decomposes hydrogen peroxide to the cleaning and disinfecting solution.
The hydrogen peroxide decomposer may be a solid or liquid, so long as it contains a hydrogen peroxide decomposing substance capable of decomposing hydrogen peroxide in a cleaning and disinfecting solution containing peracetic acid used in medical cleaning and disinfecting equipment and food cleaning equipment.
　前記過酸化水素分解物質としては、図７に示すように、過酢酸は分解せず、実質的に過酸化水素のみを分解することができるカタラーゼ、ペルオキシダーゼ又はグルタチオンペルオキシダーゼなどを使用することが好ましい。前記過酸化水素分解剤は、これら前記過酸化水素分解物質はいずれか一種のみを含有するものであってもよいし、これらのうちの２種以上を含有するものであってもよい。 As shown in FIG. 7, it is preferable to use, as the hydrogen peroxide decomposition substance, catalase, peroxidase, glutathione peroxidase, or the like, which does not decompose peracetic acid but can essentially decompose only hydrogen peroxide. The hydrogen peroxide decomposition agent may contain only one of these hydrogen peroxide decomposition substances, or may contain two or more of them.
　ところで、過酸化水素が分解される際には酸素が発生するため気泡が発生する。発生した気泡が、電極表面に付着すると電極の感度が不安定となり、測定精度が悪くなってしまう恐れがある。そこで、図７及び図８に示すように、ｓｔｅｐ１として過酸化水素分解剤の添加により洗浄消毒液中の過酸化水素を分解して発生した気泡を除去した後に、ｓｔｅｐ２として、図４の場合と同様にして過酢酸濃度測定を行う方が、過酢酸分解剤の添加による過酢酸濃度の変化をより精度よく検出することができるため好ましい。 When hydrogen peroxide is decomposed, oxygen is generated, which generates bubbles. If the generated bubbles adhere to the electrode surface, the sensitivity of the electrode becomes unstable, which may result in poor measurement accuracy. Therefore, as shown in Figures 7 and 8, in step 1, a hydrogen peroxide decomposer is added to decompose hydrogen peroxide in the cleaning and disinfecting solution to remove the generated bubbles, and then in step 2, the peracetic acid concentration is measured in the same manner as in Figure 4, which is preferable because this allows more accurate detection of changes in the peracetic acid concentration due to the addition of a peracetic acid decomposer.
　また、このように予め過酸化水素を分解する場合には、図８に示すように前記過酸化水素分解剤が、洗浄消毒液中の過酢酸を多少分解するものであっても、洗浄消毒液中の全ての過酢酸が分解されてしまわない限りは、前述した以外の過酸化水素分解物質であっても使用することが十分に可能である。
　前述した過酸化水素分解剤は、前述したように分解剤添加機構によって自動で添加されるようにしても良いし、ユーザが手動で添加するものとしてもよい。 In addition, when hydrogen peroxide is decomposed in advance in this manner, even if the hydrogen peroxide decomposer decomposes some of the peracetic acid in the cleaning and disinfecting solution as shown in FIG. 8, it is perfectly possible to use hydrogen peroxide decomposers other than those mentioned above as long as all of the peracetic acid in the cleaning and disinfecting solution is not decomposed.
The hydrogen peroxide decomposer may be added automatically by the decomposer addition mechanism as described above, or may be added manually by the user.
　本発明に係る過酢酸計の校正方法は、前述したような医療用洗浄消毒装置だけでなく食品用洗浄装置等に備えられた過酢酸計にも適用できる。また、排水監視装置等の洗浄消毒液を使用しない装置に備えられた過酢酸計や装置に組み込まれていない過酢酸計にも適用することができることは言うまでもない。
　前記実施形態においては、隔膜式の過酢酸計を用いる場合について説明したが、過酢酸計は隔膜式のものでなくても良いことは言うまでもない。
　また、過酢酸計が実測値として電圧値を測定するものである場合であっても、電流値の場合と同様に前述した式（１）のような電圧値と過酢酸濃度との関係式を求めることができる。 The method for calibrating a peracetic acid meter according to the present invention can be applied not only to the above-mentioned medical cleaning and disinfecting apparatus, but also to a peracetic acid meter provided in a food cleaning apparatus, etc. It goes without saying that the method can also be applied to a peracetic acid meter provided in an apparatus that does not use a cleaning and disinfecting solution, such as a wastewater monitoring apparatus, or a peracetic acid meter that is not built into an apparatus.
In the above embodiment, the case where a diaphragm type peracetic acid meter is used has been described, but it goes without saying that the peracetic acid meter does not have to be of the diaphragm type.
Furthermore, even if the peracetic acid meter measures a voltage value as an actual measurement value, the relationship between the voltage value and the peracetic acid concentration, such as the above-mentioned formula (1), can be obtained in the same manner as in the case of the current value.
　さらに言えば、前記実測値として、電流値及び／又は電圧値に限らず、これら電流値及び／又は電圧値に基づいて過酢酸濃度を算出する際の算出途中の値を用いた場合であっても本願発明の効果を奏することができる。また、過酢酸計として、電流値及び／又は電圧値を測定するのではなく、例えば、吸光度や比色法によって試料溶液の過酢酸濃度を測定するものを使用する場合には、吸光度や色の波長などその他の指示値であって、試料溶液中の過酢酸濃度の変化量との間に比例関係などの相関関係を有する指示値を実測値として用いるものとしても良い。 Moreover, the effects of the present invention can be achieved even when the actual measured value is not limited to a current value and/or a voltage value, but is an intermediate value used when calculating the peracetic acid concentration based on the current value and/or voltage value. In addition, when a peracetic acid meter is used that does not measure a current value and/or a voltage value, but measures the peracetic acid concentration of a sample solution by, for example, absorbance or colorimetry, other indicated values such as absorbance or color wavelength that have a proportional or other correlation with the amount of change in the peracetic acid concentration in the sample solution may be used as the actual measured value.
　その他、本発明の趣旨に反しない限りにおいて、種々の変形や実施形態の組合せを行ってもかまわない。 Other modifications and combinations of the embodiments may be made without going against the spirit of the present invention.
　本発明によれば、高価な装置や操作者の高度なスキル及び煩雑な操作を強いることなく、精度よく過酢酸計を校正することができる方法を提供することができる。 The present invention provides a method for calibrating a peracetic acid meter with high accuracy without requiring expensive equipment, advanced operator skills, or complicated operations.
１００・・・医療用洗浄消毒装置
２５１・・・過酢酸計
４　　・・・校正システム
４１　・・・演算部
４２　・・・校正部 100: Medical cleaning and disinfecting apparatus 251: Peracetic acid meter 4: Calibration system 41: Calculation unit 42: Calibration unit

Claims (16)

  1. 　過酢酸分解反応に関する反応定数が既知である過酢酸分解剤を添加して試料溶液中の過酢酸を分解させた場合に想定される過酢酸濃度の変化量と、前記添加の前後において前記試料溶液を過酢酸計で測定した過酢酸濃度又は過酢酸濃度を算出するための値である実測値の変化量とに基づいて前記過酢酸計を校正する、過酢酸計校正方法。 A method for calibrating a peracetic acid meter, which calibrates the peracetic acid meter based on the expected change in the peracetic acid concentration when peracetic acid in a sample solution is decomposed by adding a peracetic acid decomposition agent with a known reaction constant for the peracetic acid decomposition reaction, and the change in the peracetic acid concentration measured by the peracetic acid meter in the sample solution before and after the addition, or the actual measured value that is a value for calculating the peracetic acid concentration.
  2. 　過酢酸を分解する前に過酸化水素を分解する、請求項１に記載の過酢酸計校正方法。 The method for calibrating a peracetic acid meter according to claim 1, in which hydrogen peroxide is decomposed before peracetic acid is decomposed.
  3. 　過酸化水素の分解が過酸化水素分解剤を用いて行われるものであり、
    　前記過酸化水素分解剤が、カタラーゼ、ペルオキシダーゼ、グルタチオンペルオキシダーゼからなる群のうち１種以上を含むものである、請求項２に記載の過酢酸計校正方法。     The decomposition of hydrogen peroxide is carried out using a hydrogen peroxide decomposer,
    3. The method for calibrating a peracetic acid meter according to claim 2, wherein the hydrogen peroxide decomposer includes at least one enzyme selected from the group consisting of catalase, peroxidase, and glutathione peroxidase.
  4. 　前記過酢酸分解剤が、チオグリコール酸、チオグリコール酸グリセリル、メチオニン、システイン、メチオニン誘導体、システイン誘導体、メチオニン残基含有ペプチド、システイン残基含有ペプチド、システアミン、チオグリセリン、２－メルカプト－４－ブタノリド、フラボノイド、亜硝酸、アスコルビン酸、硫黄、白金、パラジウム、ハロゲン元素からなる群より選ばれる１種以上を含む、請求項１に記載の過酢酸計校正方法。 The method for calibrating a peracetic acid meter according to claim 1, wherein the peracetic acid decomposition agent includes at least one selected from the group consisting of thioglycolic acid, glyceryl thioglycolate, methionine, cysteine, methionine derivatives, cysteine derivatives, peptides containing methionine residues, peptides containing cysteine residues, cysteamine, thioglycerin, 2-mercapto-4-butanolide, flavonoids, nitrous acid, ascorbic acid, sulfur, platinum, palladium, and halogen elements.
  5. 　前記過酢酸計が、前記実測値として電流値及び／又は電圧値を測定するものである、請求項１に記載の過酢酸計校正方法。 The method for calibrating a peracetic acid meter according to claim 1, wherein the peracetic acid meter measures a current value and/or a voltage value as the actual measurement value.
  6. 　前記過酢酸計が隔膜式のものである、請求項１に記載の過酢酸計校正方法。 The method for calibrating a peracetic acid meter according to claim 1, wherein the peracetic acid meter is a diaphragm type.
  7. 　前記過酢酸計が、医療用洗浄消毒装置、食品用洗浄装置又は排水監視装置に使用されるものである、請求項１に記載の過酢酸計校正方法。 The method for calibrating a peracetic acid meter according to claim 1, wherein the peracetic acid meter is used in a medical cleaning and disinfection device, a food cleaning device, or a wastewater monitoring device.
  8. 　過酢酸分解反応に関する反応定数が既知である過酢酸分解剤を添加して試料溶液中の過酢酸を分解させた場合に想定される過酢酸濃度の変化量と、前記添加の前後において前記試料溶液を過酢酸計で測定した過酢酸濃度又は過酢酸濃度を算出するための値である実測値の変化量とを求める演算部と、
    　前記過酢酸濃度の変化量と前記実測値の変化量とに基づいて前記過酢酸計を校正する校正部とを備える、過酢酸計校正システム。     A calculation unit that calculates the expected change in the concentration of peracetic acid when peracetic acid in a sample solution is decomposed by adding a peracetic acid decomposition agent having a known reaction constant for the decomposition reaction of peracetic acid, and the change in the concentration of peracetic acid measured by a peracetic acid meter in the sample solution before and after the addition, or the change in the actual measured value that is a value for calculating the concentration of peracetic acid;
    and a calibration unit that calibrates the peracetic acid meter based on an amount of change in the peracetic acid concentration and an amount of change in the actual measured value.
  9. 　過酢酸分解反応に関する反応定数が既知である過酢酸分解剤と、過酢酸を含有する洗浄消毒液と含む混合液を生成する混合液生成部と、
    　前記混合液中の過酢酸濃度を測定する過酢酸計と、
    　前記過酢酸分解剤によって分解されることが想定される過酢酸の量及び前記過酢酸計によって測定された過酢酸濃度又は過酢酸濃度を算出するための値である実測値の変化量に基づいて過酢酸計を校正する校正手段と、を備えた内視鏡洗浄消毒装置。     A mixed solution generating unit that generates a mixed solution containing a peracetic acid decomposing agent having a known reaction constant for a peracetic acid decomposition reaction and a cleaning and disinfecting solution containing peracetic acid;
    A peracetic acid meter for measuring the concentration of peracetic acid in the mixed solution;
    and a calibration means for calibrating the peracetic acid meter based on the amount of peracetic acid expected to be decomposed by the peracetic acid decomposition agent and the peracetic acid concentration measured by the peracetic acid meter or the amount of change in the actual measured value, which is a value for calculating the peracetic acid concentration.
  10. 　前記洗浄消毒液を所定量採取する消毒液採取部を備え、前記消毒液採取部に採取された前記洗浄消毒液に対して前記過酢酸分解剤が添加される請求項９に記載の内視鏡洗浄消毒装置。 The endoscope cleaning and disinfecting apparatus according to claim 9, further comprising a disinfectant collection section for collecting a predetermined amount of the cleaning and disinfecting solution, and the peracetic acid decomposition agent is added to the cleaning and disinfecting solution collected in the disinfectant collection section.
  11. 　前記混合液に添加された前記過酢酸分解剤の量を計測する過酢酸分解剤計量手段とをさらに備えた、請求項１０に記載の内視鏡洗浄消毒装置。 The endoscope cleaning and disinfecting apparatus according to claim 10, further comprising a peracetic acid decomposition agent measuring means for measuring the amount of the peracetic acid decomposition agent added to the mixed liquid.
  12. 　前記過酢酸計が、過酢酸分解剤の添加前後における実測値として電流値を測定するものであり、
    　前記校正手段が、前記電流値を測定した過酢酸計について設定された以下の式（１）に基づいて、電流値の変化量から試料溶液中における過酢酸濃度の変化量を算出するものである、請求項９に記載の内視鏡洗浄消毒装置。
    Figure JPOXMLDOC01-appb-M000001
     （式中のＣ０は過酢酸分解剤の添加前における過酢酸濃度を表す。Ｃは過酢酸分解剤の添加後における過酢酸濃度を表す。Δｉは試料溶液中の過酢酸濃度がＣ０からＣに変化するときの電流値の変化量を表す。）     The peracetic acid meter measures current values as actual values before and after the addition of a peracetic acid decomposer,
    10. The endoscope cleaning and disinfecting apparatus according to claim 9, wherein the calibration means calculates a change in concentration of peracetic acid in the sample solution from a change in the current value based on the following formula (1) set for the peracetic acid meter that measured the current value:
    Figure JPOXMLDOC01-appb-M000001
     (In the formula, C0 represents the concentration of peracetic acid before the addition of the peracetic acid decomposition agent. C represents the concentration of peracetic acid after the addition of the peracetic acid decomposition agent. Δi represents the change in current value when the peracetic acid concentration in the sample solution changes from C0 to C.)
  13. 　前記過酢酸分解剤を添加する前に、試料溶液中に含まれる過酸化水素を分解する過酸化水素分解剤を添加する、請求項９に記載の内視鏡洗浄消毒装置。 The endoscope cleaning and disinfecting apparatus according to claim 9, further comprising: a hydrogen peroxide decomposing agent that decomposes hydrogen peroxide contained in the sample solution, added before the peracetic acid decomposing agent is added.
  14. 　前記過酸化水素分解剤が、カタラーゼ、ペルオキシダーゼ、グルタチオンペルオキシダーゼからなる群のうち１種以上を含むものである、請求項１3に記載の内視鏡洗浄消毒装置。 The endoscope washer/disinfector according to claim 13, wherein the hydrogen peroxide decomposer includes one or more of the group consisting of catalase, peroxidase, and glutathione peroxidase.
  15. 　過酢酸分解反応に関する反応定数が既知である過酢酸分解剤を添加して試料溶液中の過酢酸を分解させた場合に想定される過酢酸濃度の変化量と、前記添加の前後において前記試料溶液を過酢酸計で測定した過酢酸濃度又は過酢酸濃度を算出するための値である実測値の変化量とに基づいて前記過酢酸計を校正する、過酢酸計校正プログラム。 A peracetic acid meter calibration program that calibrates a peracetic acid meter based on the expected change in peracetic acid concentration when peracetic acid in a sample solution is decomposed by adding a peracetic acid decomposition agent with a known reaction constant for the peracetic acid decomposition reaction, and the change in the peracetic acid concentration measured by the peracetic acid meter in the sample solution before and after the addition, or the actual measured value that is a value for calculating the peracetic acid concentration.
  16. 　過酢酸分解反応に関する反応定数が既知である過酢酸分解剤を含有する、過酢酸計校正キット。

          A peracetic acid meter calibration kit containing a peracetic acid decomposition agent with a known reaction constant for the peracetic acid decomposition reaction.
PCT/JP2023/041818 2022-11-22 2023-11-21 Peracetic acid measuring device calibration method and peracetic acid meter calibration system WO2024111582A1 (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5753649A (en) * 1980-09-18 1982-03-30 Oriental Yeast Co Ltd Measuring apparatus of concentration of hydrogen peroxide
JPH0445798A (en) * 1990-06-08 1992-02-14 Hiranuma Sangyo Kk Fractional determination of hydrogen peroxide and peracetic acid
JP2003521710A (en) * 2000-02-07 2003-07-15 ステリス インコーポレイテッド An electrochemical sensor for specific detection of peracetic acid in aqueous solution using pulse amperometry
JP2009207740A (en) * 2008-03-05 2009-09-17 Fujifilm Corp Endoscope cleaning sterilizer and its deodorizing method
WO2018020716A1 (en) * 2016-07-29 2018-02-01 オリンパス株式会社 Endoscope reprocessor
WO2021039392A1 (en) * 2019-08-28 2021-03-04 株式会社堀場アドバンスドテクノ Peracetic acid concentration meter

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5753649A (en) * 1980-09-18 1982-03-30 Oriental Yeast Co Ltd Measuring apparatus of concentration of hydrogen peroxide
JPH0445798A (en) * 1990-06-08 1992-02-14 Hiranuma Sangyo Kk Fractional determination of hydrogen peroxide and peracetic acid
JP2003521710A (en) * 2000-02-07 2003-07-15 ステリス インコーポレイテッド An electrochemical sensor for specific detection of peracetic acid in aqueous solution using pulse amperometry
JP2009207740A (en) * 2008-03-05 2009-09-17 Fujifilm Corp Endoscope cleaning sterilizer and its deodorizing method
WO2018020716A1 (en) * 2016-07-29 2018-02-01 オリンパス株式会社 Endoscope reprocessor
WO2021039392A1 (en) * 2019-08-28 2021-03-04 株式会社堀場アドバンスドテクノ Peracetic acid concentration meter

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