WO2024101428A1 - 生体信号測定器及び状態解析システム - Google Patents

生体信号測定器及び状態解析システム Download PDF

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Publication number
WO2024101428A1
WO2024101428A1 PCT/JP2023/040438 JP2023040438W WO2024101428A1 WO 2024101428 A1 WO2024101428 A1 WO 2024101428A1 JP 2023040438 W JP2023040438 W JP 2023040438W WO 2024101428 A1 WO2024101428 A1 WO 2024101428A1
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WIPO (PCT)
Prior art keywords
reference line
headband
earmuff
biosignal
head
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Ceased
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PCT/JP2023/040438
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English (en)
French (fr)
Japanese (ja)
Inventor
潤一 牛場
森 福田
幸治 森川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Keio University
Lifescapes Inc
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Keio University
Lifescapes Inc
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Application filed by Keio University, Lifescapes Inc filed Critical Keio University
Priority to US19/099,829 priority Critical patent/US20260033770A1/en
Priority to CN202380056375.7A priority patent/CN119604236A/zh
Priority to EP23888773.1A priority patent/EP4616803A4/en
Priority to JP2024557853A priority patent/JPWO2024101428A1/ja
Publication of WO2024101428A1 publication Critical patent/WO2024101428A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/251—Means for maintaining electrode contact with the body
    • A61B5/256—Wearable electrodes, e.g. having straps or bands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/372—Analysis of electroencephalograms
    • A61B5/374—Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods

Definitions

  • the present invention relates to a biosignal measuring device and a condition analysis system.
  • SMR-ERD sensorimotor rhythm-event-related desynchronization
  • SMR-ERD is estimated based on a signal (hereinafter also referred to as the SMR-ERD signal) that indicates the difference between a biosignal measured from an electrode placed on the top of the head and a biosignal measured from an electrode placed on the left motor cortex (or right motor cortex).
  • Patent Document 1 discloses an electroencephalograph in which an earth electrode is placed behind the ear when the electroencephalograph is worn on the head. In this way, by providing the earth electrode at a location on the head that is less susceptible to the influence of bioelectric potentials resulting from brain activity, a stable earth potential can be obtained.
  • Patent Document 1 can measure or analyze brain activity, it cannot measure or analyze muscle activity that occurs around the head, including the masseter and sternocleidomastoid muscles.
  • the present invention was made in consideration of these problems, and its purpose is to provide a biosignal measuring device and condition analysis system that can perform various measurements or analyses that take into account muscle activity occurring around the head, while still having a simpler device configuration.
  • the biosignal measuring device of the present invention comprises a headband having an inverted U-shape and capable of being worn on the head of a person to be measured, a first earmuff provided at one end of the headband and covering one ear of the head when the headband is worn, a second earmuff provided at the other end of the headband and covering the other ear of the head when the headband is worn, a first protruding member extending from a first position on the outer edge of the first earmuff, and a first muff-side electrode portion provided on the tip side of the first protruding member for measuring the biosignal of the person to be measured, and when a straight line parallel to the downward extension direction of the headband and passing through the center of gravity of the planar area formed by the first earmuff is defined as a first reference line in a side view from the first earmuff, and a straight line perpendicular to the first reference line and passing through the center of gravity is defined as a second reference line, the
  • At least the tip of the first protruding member may be configured to extend at an inward and forward incline relative to the first position.
  • the biosignal measuring device may further include a band-side electrode section attached to the headband for measuring the biosignal of the head, and may differentially amplify and output a first biosignal acquired from the band-side electrode section and a second biosignal acquired from the first muff-side electrode section.
  • the biosignal measuring device further includes a second protruding member extending from a second position on the outer edge of the second earmuff, and a second muff-side electrode portion provided on the tip side of the second protruding member for measuring the biosignal of the subject.
  • a straight line parallel to the downward extension direction of the headband and passing through the center of gravity of the planar area formed by the second earmuff is defined as a third reference line in a side view from the second earmuff
  • a straight line perpendicular to the third reference line and passing through the center of gravity is defined as a fourth reference line
  • the second position may be behind the third reference line and below the fourth reference line.
  • the condition analysis system of the present invention includes any one of the biosignal measuring devices described above, and a condition analysis device that performs an analysis process on the biosignal measured by the biosignal measuring device and analyzes the motor intention, cognitive state, or fatigue state of the subject.
  • the present invention makes it possible to perform various measurements or analyses that take into account muscle activity occurring around the head, even with a simpler device configuration.
  • FIG. 1 is an overall configuration diagram of a condition analysis system according to an embodiment of the present invention
  • FIG. 2 is a front view of the headset shown in FIG. 1 .
  • FIG. 2 is a plan view of the headset shown in FIG. 1 .
  • FIG. 2 is a bottom view of the headset shown in FIG. 1 .
  • FIG. 2 is a right side view of the headset shown in FIG. 1 .
  • FIG. 4 is a schematic diagram showing the positional relationship between three electrode portions.
  • FIG. 2 is a diagram illustrating a schematic diagram of the positional relationship between three electrode parts and a target area.
  • FIG. 13 is a diagram showing an example of a time change of an electroencephalogram signal.
  • FIG. 1 is a diagram showing a schematic diagram of an activation region of an SMR-ERD signal.
  • FIG. 1 is a diagram illustrating a highly correlated region of an SMR-ERD signal.
  • FIG. 13 is a diagram showing the basis for determining a target region.
  • FIG. 13 is a view of a subject wearing a headset as seen from the right side.
  • FIG. 2 is a left side view of a subject wearing a headset.
  • ⁇ Overall composition> 1 is a diagram showing the overall configuration of a condition analysis system 10 according to an embodiment of the present invention.
  • This condition analysis system 10 functions as a brain-machine interface system (hereinafter, referred to as a BMI system) that analyzes electroencephalogram signals emitted by a subject 12 and supports the subject 12 in exercising based on the analysis results.
  • the condition analysis system 10 includes a headset 14 (corresponding to a "biological signal measuring instrument"), a condition analysis device 16, and an exercise support device 18.
  • the headset 14 is configured to be able to measure an electrical signal (i.e., a biosignal) that correlates with the condition of the subject 12 when worn on the head H of the subject 12.
  • the headset 14 measures the biosignal via multiple electrodes, and outputs the obtained biosignal to the condition analysis device 16 via wireless or wired communication.
  • the condition analysis device 16 is a computer configured to analyze the condition of the subject 12 (e.g., motor intention, cognitive state, or fatigue state) based on the biosignals measured by the headset 14.
  • the condition analysis device 16 includes an operation unit 22, a presentation unit 23, a sensor controller 24, a processor 26, and a memory 28.
  • the operation unit 22 is configured to allow various operations to be performed by users, including the subject 12 and medical personnel.
  • the operation unit 22 is, for example, an input device including an operation button and a microphone, or an output device including a display panel and a speaker.
  • the presentation unit 23 is an output device that presents information requesting a state of rest (hereinafter also referred to as request information) to the subject 12 in response to a command from the processor 26.
  • the presentation unit 23 is composed of, for example, a display panel, a lamp, a speaker, etc. Examples of the manner in which the request information may be presented include text or audio guidance, turning on a lamp, and outputting various types of sounds.
  • the subject presenting the request information is not limited to the presentation unit 23 of the condition analysis device 16, but may be a person other than the subject 12 (for example, an operator of the condition analysis device 16).
  • the sensor controller 24 is a control circuit that performs various controls on the headset 14.
  • the sensor controller 24 can execute various signal processing including, for example, sampling processing including sensor synchronization, low-pass filter processing, and A/D conversion processing.
  • sampling processing including sensor synchronization, low-pass filter processing, and A/D conversion processing.
  • the sensor controller 24 acquires an electrical signal (i.e., a biosignal) that correlates with the state of the subject 12 at a predetermined sampling interval, and supplies this biosignal to the processor 26.
  • the sampling interval can take any value within the range of 0.5 to several hundred ms.
  • the processor 26 provides overall control over each component of the status analysis device 16.
  • the processor 26 may be a general-purpose processor including a CPU (Central Processing Unit) and an MPU (Micro-Processing Unit), or a dedicated processor including an FPGA (Field Programmable Gate Array) and a GPU (Graphics Processing Unit).
  • CPU Central Processing Unit
  • MPU Micro-Processing Unit
  • FPGA Field Programmable Gate Array
  • GPU Graphics Processing Unit
  • Memory 28 is a non-transitory storage medium including ROM (Read Only Memory) and RAM (Random access memory), and stores the programs and data necessary for processor 26 to control each component.
  • ROM Read Only Memory
  • RAM Random access memory
  • the exercise support device 18 is, for example, an actuator that can be attached to a target part of the subject 12 (arm A in the example shown in this figure).
  • target parts include various body parts that perform extension or flexion movements, such as hands, feet, fingers, knees, and elbows.
  • the exercise support device 18 can be of any configuration, and may be excluded from the condition analysis system 10 if necessary.
  • FIG. 1 is a front view of the headset 14 shown in Figure 1.
  • Figure 3 is a plan view of the headset 14 shown in Figure 1.
  • Figure 4 is a bottom view of the headset 14 shown in Figure 1.
  • Figure 5 is a right side view of the headset 14 shown in Figure 1.
  • FIG. 1 the front-back, left-right, and up-down directions are defined based on the orientation of the head H when the subject 12 is wearing the headset 14 correctly.
  • Figures 2 to 5 show the headset 14 with the five electrodes EL0 to EL4 ( Figure 2) removed, in reality the headset 14 is used with the electrodes EL0 to EL4 attached.
  • the headset 14 comprises a headband 40, an earmuff 42R (corresponding to the "first earmuff”) attached to the right end of the headband 40, and an earmuff 42L (corresponding to the "second earmuff”) attached to the left end of the headband 40.
  • the headband 40 is a band-shaped member having an inverted U-shape, and is made of an insulating material such as resin.
  • the headband 40 is provided with a length adjustment mechanism 44R (corresponding to the "first adjustment mechanism") for adjusting the length of the right side, and a length adjustment mechanism 44L (corresponding to the "second adjustment mechanism”) for adjusting the length of the left side.
  • the length adjustment mechanism 44R is composed of a substantially arc-shaped band body 46 and a slide member 48R that slides and expands from the right end of the band body 46.
  • the length adjustment mechanism 44L is composed of the band body 46 and a slide member 48L that slides and expands from the left end of the band body 46.
  • the central hole Mh0 is provided to allow the electrode EL0 (corresponding to the "central electrode") to be detachably attached.
  • the right hole Mh1 is provided to allow the electrode EL1 (corresponding to the "first electrode") to be detachably attached.
  • the left hole Mh2 is provided to allow the electrode EL2 (corresponding to the "second electrode") to be detachably attached.
  • the electrodes EL0 to EL2 are configured to include metal electrodes used to acquire biosignals. Examples of metal electrodes include silver-silver chloride electrodes, silver electrodes, gold electrodes, and platinum electrodes.
  • the electrodes EL0 to EL2 may be configured to include only one type of electrode having the same material and thickness, or may be configured to include two or more types of electrodes having different materials or thicknesses.
  • FIG. 6 is a diagram showing a schematic diagram of the positional relationship of the three electrodes EL0 to EL2.
  • This diagram shows the curved band body 46 deployed horizontally.
  • Electrode EL0 is located at position P0, which is approximately in the center in the direction in which the band body 46 extends.
  • Electrode EL1 is located at position P1, which is to the right of position P0.
  • Electrode EL2 is located at position P2, which is to the left of position P0 on the band body 46.
  • the distance between the two positions P0 and P1 is D1 (unit: mm) and the distance between the two positions P0 and P2 is D2 (unit: mm)
  • the magnitude relationship may be either D1 > D2 or D1 ⁇ D2.
  • Position P1 is within an allowable region 52 that is set in relation to position P0.
  • This allowable region 52 is a rectangular region that is within a range of 56.2 to 80.0 mm to the right of position P0.
  • distance D1 satisfies the magnitude relationship of 56.2 ⁇ D1 ⁇ 80.0.
  • Position P2 is within an allowable region 54 that is set in relation to position P0.
  • This allowable region 54 is a rectangular region within a range of 56.2 to 80.0 mm to the left of position P0. In other words, distance D2 satisfies the magnitude relationship of 56.2 ⁇ D2 ⁇ 80.0.
  • the right earmuff 42R includes a casing 60R, an ear cup 62R, and a protruding member 64R.
  • the casing 60R has a cylindrical shape with a bottom that is open at the top, and is made of an insulating material such as resin. It houses a sensor board (not shown). Various electronic components are mounted on this sensor board to acquire the biosignals of the subject 12 and output them to the condition analysis device 16 ( Figure 1).
  • the bottom of the casing 60R is connected to the right end of the headband 40 (i.e., the tip of the sliding member 48R) so as to be able to swing.
  • the ear cup 62R has a disk shape and is made of an insulating material such as resin.
  • the ear cup 62R is provided to cover the opening of the casing 60R.
  • the main surface of the ear cup 62R has an annular uneven portion formed thereon to position the left ear of the subject 12.
  • the protruding member 64R has a curved C-shape and is made of an insulating material such as resin.
  • the protruding member 64R is arranged to extend forward and inward from the outer edge of the casing 60R (position P3 in Figure 5).
  • a hole Mh3 is formed at the tip side of the protruding member 64R. This hole Mh3 is arranged to allow the electrode part EL3 (corresponding to the "first muff side electrode part") to be detachably attached.
  • the left earmuff 42L is composed of a casing 60L, an ear cup 62L, and a protruding member 64L.
  • the casing 60L has a cylindrical shape with a bottom that is open at the top, and is made of an insulating material such as resin. It houses a sensor board (not shown). Various electronic components are mounted on this sensor board to acquire the biosignals of the subject 12 and output them to the condition analysis device 16 ( Figure 1).
  • the bottom of the casing 60L is swingably connected to the left end of the headband 40 (i.e., the tip of the sliding member 48L).
  • the ear cup 62L has a disk shape and is made of an insulating material such as resin.
  • the ear cup 62L is provided to cover the opening of the casing 60L.
  • the main surface of the ear cup 62L has an annular uneven portion formed thereon to position the left ear of the subject 12.
  • the protruding member 64L has a curved C-shape and is made of an insulating material such as resin.
  • the protruding member 64L is arranged to extend rearward and inward from the outer edge of the casing 60L (position P4 in Figure 5).
  • a hole Mh4 is formed at the tip side of the protruding member 64L. This hole Mh4 is provided so that the electrode part EL4 (corresponding to the "second muff side electrode part") can be detached.
  • the center of gravity of the planar area formed by the earmuffs 42R (more specifically, the casing 60R) is defined as O1.
  • a straight line that is parallel to the direction in which the headband 40 extends downward (hereinafter, the first direction) and passes through the center of gravity O1 is defined as a vertical reference line LV (corresponding to the "first reference line”).
  • a straight line that extends in a direction perpendicular to the first direction (hereinafter, the second direction) and passes through the center of gravity O1 is defined as a horizontal reference line LH (corresponding to the "second reference line”).
  • position P3 is forward of the vertical reference line LV and below the horizontal reference line LH.
  • the center of gravity of the planar area formed by the earmuff 42L (more specifically, the casing 60L) is defined as O2.
  • a straight line that is parallel to the first direction in which the headband 40 extends downward and passes through the center of gravity position O1 is defined as the vertical reference line LV (corresponding to the "third reference line”).
  • a straight line that extends in a second direction perpendicular to the first direction and passes through the center of gravity position O2 is defined as the horizontal reference line LH (corresponding to the "fourth reference line”).
  • position P4 is behind the vertical reference line LV and below the horizontal reference line LH.
  • the condition analyzing system 10 in this embodiment is configured as described above. Next, a first effect of the headset 14 constituting a part of the condition analyzing system 10 will be described with reference to Figures 7 to 11 in addition to Figures 1 to 6 described above.
  • the state analysis system 10 is used to identify an individual SMR-ERD frequency (i.e., ISF) specific to the subject 12.
  • SMR-ERD frequency refers to a frequency in the alpha band of 8 to 13 Hz of scalp electroencephalograms measured near the motor cortex at which event-related desynchronization (ERD), a movement-related response, is strong. It is known that the SMR-ERD frequency varies from person to person and fluctuates between 8 and 13 Hz. Therefore, to clearly indicate that it is a frequency specific to an individual, it may be called an individual SMR-ERD frequency (i.e., ISF).
  • ISF individual SMR-ERD frequency
  • the headset 14 shown in Figures 2 to 6 is used to obtain EEG signals that contain many spectral components of the SMR-ERD frequency.
  • the subject 12 wears the headset 14 on his/her head H. Specifically, the subject 12 holds the headset 14 with both hands and fixes one earmuff 42R to his/her right ear and the other earmuff 42L to his/her left ear.
  • the subject 12 then adjusts the length of the headband 40 using the length adjustment mechanisms 44R, 44L of the headband 40 so that the inner surface 50 of the headband 40 fits the surface of the head H. Through this length adjustment, the positioning of the three electrodes EL0, EL1, EL2 is performed simultaneously.
  • FIG. 7 is a diagram showing a schematic diagram of the positional relationship between the three electrodes EL0-EL2 and the target areas 70R, 70L.
  • the heads H1, H2 of the subjects 12 are each shown as oval in shape.
  • the electrode EL0 is placed on the top of the head regardless of the size of the heads H1, H2.
  • the position of the target area 70R in the right motor cortex differs depending on the size of the heads H1, H2.
  • These target areas 70R, 70L indicate areas where EEG signals containing spectral components at the SMR-ERD frequency (i.e., SMR-ERD signals) can be measured with higher accuracy.
  • EEG signals in the target areas 70R, 70L can be measured simultaneously using the same headset 14, regardless of the "variation" in the size of the heads H1, H2.
  • ⁇ Rationale for target regions 70R and 70L> the basis for determining the positions and sizes of the target regions 70R, 70L shown in Fig. 7 will be described with reference to Figs. 8 to 11.
  • the inventors obtained electroencephalogram data from 82 subjects and analyzed the electroencephalogram data. This electroencephalogram data was obtained using an electroencephalogram measuring device capable of measuring high-density electroencephalograms of 129 channels across the entire head. Through this analysis, it was possible to obtain a detailed distribution of the activation regions of the SMR-ERD signal.
  • Figure 8 shows the change over time in the EEG signal when the subject is at rest.
  • the horizontal axis of the graph shows time (unit: s), and the vertical axis of the graph shows brain potential (unit: ⁇ V).
  • the EEG signal has a complex waveform that fluctuates finely above and below a reference value.
  • FIG. 9 is a diagram showing a schematic diagram of the activation region 72L of the SMR-ERD signal.
  • Each point within the circular region in this diagram indicates the measurement position of the EEG signal on the head H.
  • the three points enclosed by squares indicate, from left to right, the C3, Cz, and C4 positions in the International 10-20 system.
  • Each point enclosed by a triangle corresponds to a measurement position that has been determined to have activation in relation to the EEG signal acquired at the C3 position.
  • the closed curve that envelops all the triangles defines a region that approximates the amount of activation at the C3 position (hereinafter referred to as the "activation region 72L").
  • the ERD value at each measurement position is determined to belong to activation region 72L if it exceeds the threshold value (ERD value - standard deviation) at position C3.
  • Figure 10 is a schematic diagram of a high correlation region 74L of an SMR-ERD signal.
  • Each point within a circular region in this figure indicates the measurement position of the EEG signal on the head H.
  • the three points surrounded by squares indicate, from left to right, the C3, Cz, and C4 positions in the International 10-20 system.
  • Each point surrounded by a circle corresponds to a measurement position that has been determined to have a high time correlation in relation to the EEG signal acquired at the C3 position.
  • the closed curve that envelops all the circles defines a region that approximates the time series signal at the C3 position (hereinafter referred to as the "high correlation region 74L").
  • the correlation coefficient between the time series data of the ERD value at position C3 and the time series data of the ERD value at each measurement position is calculated, and if it exceeds a predetermined threshold (e.g., 0.55), it is determined to belong to the high correlation region 74L.
  • a predetermined threshold e.g., 0.55
  • FIG. 11 is a diagram showing the basis for determining the target region 70L.
  • This figure corresponds to a partial enlargement of the C3 position in Figures 9 and 10.
  • Each point surrounded by a triangle corresponds to a measurement position belonging to the activation region 72L
  • each point surrounded by a circle corresponds to a measurement position belonging to the high correlation region 74L.
  • each point surrounded by both a triangle and a circle belongs to the overlapping region between the activation region 72L and the high correlation region 74L (i.e., the target region 70L).
  • this target region 70L has a circular shape with a diameter of 50 mm (radius 25 mm) centered at the C3 position.
  • the inventor has determined that an SMR-ERD signal can be acquired by arranging the electrode part EL2 within the circular target region 70L with a diameter of 50 mm.
  • the relationship between the left target area 70L and the C3 position is described, but the same applies to the relationship between the right target area 70R and the C4 position.
  • the reason for this is that, in terms of SMR-ERD frequency, there is basically bilateral symmetry in brain function.
  • the inventors have determined that, as above, the SMR-ERD signal can be measured by placing the electrode portion EL1 within the circular target area 70R with a diameter of 50 mm.
  • the dimensional data of the "inter-tragus parietal arc length" of Americans was measured for a total of 3982 people, 1774 men and 2208 women, aged 18 to 88 years.
  • the inter-tragus parietal arc length is the length from one tragus point to the other tragus point via the top of the head, and is measured so as to be perpendicular to the auricular plane. In addition, this length is measured using a tape measure while the person being measured is sitting in a chair.
  • the minimum value of the intertragus parietal arc length in the Japanese human body dimension DB is 316 mm, and the maximum value is 405 mm. If the electrodes EL1 and EL2 are located within a range where the SMR-ERD signal can be measured for both the maximum and minimum values (i.e., target areas 70R and 70L), the SMR-ERD signal can be measured even for intermediate values.
  • the area we want to focus on this time is a 25mm radius area centered on C3 (or C4).
  • C3 or C4
  • the distance between Cz and C3 is equivalent to 20% of the total intertragus parietal arc length.
  • the measurement position by setting the measurement position within the intersection of the two ranges mentioned above, that is, within the range of 56.0 to 88.2 mm, it is possible to measure the SMR-ERD signal for most Japanese people.
  • the above example shows a method for determining the appropriate measurement range for a Japanese population, but a similar method can be used to calculate the appropriate measurement range for other populations (e.g., Chinese, Americans).
  • the minimum value of the intertragus parietal arc length in the Chinese human body dimension DB is 275 mm, and the maximum value is 406 mm.
  • the minimum value of the intertragus parietal arc length in the human body dimension DB for Americans is 298 mm, and the maximum value is 392 mm.
  • the condition analysis system 10 in this embodiment comprises a biosignal measuring device (here, the headset 14) for measuring the biosignals of the subject 12, and a condition analysis device 16 that performs analytical processing on the biosignals measured by the headset 14 and analyzes the motor intention, cognitive state, or fatigue state of the subject 12.
  • a biosignal measuring device here, the headset 14
  • condition analysis device 16 that performs analytical processing on the biosignals measured by the headset 14 and analyzes the motor intention, cognitive state, or fatigue state of the subject 12.
  • the headset 14 comprises a headband 40 having an inverted U-shape and capable of being worn on the head H of the subject 12, and a number of electrodes attached to the headband 40 for measuring biosignals of the head H.
  • the number of electrodes comprises a central electrode (here, electrode EL0) located at a central position P0 in the direction in which the headband 40 extends, a first electrode (here, electrode EL1) located at a position P1 a predetermined distance D1 away from position P0 toward one end of the headband 40, and a second electrode (here, electrode EL2) located at a position P2 a predetermined distance D2 away from position P0 toward the other end of the headband 40.
  • the predetermined distances D1 and D2 are any value between 56.2 and 80.0 mm.
  • the electrodes EL0 to EL2 are positioned to have a positional relationship that takes into account the variation in size of the head H of the subject 12, so that by positioning the electrode EL0 at the top of the head, the remaining electrodes EL1, EL2 can be simultaneously positioned within the desired target regions 70R, 70L.
  • This makes it possible to suppress the decrease in measurement accuracy of the SMR-ERD signal caused by the variation in size of the head H, while still using a simpler device configuration without providing a mechanism for adjusting the positions of the electrodes EL0 to EL2.
  • the headset 14 may further include a first earmuff (here, earmuff 42R) provided at one end of the headband 40 and covering one ear of the head H when the headband 40 is worn, and a second earmuff (here, earmuff 42L) provided at the other end of the headband 40 and covering the other ear of the head H when the headband 40 is worn.
  • a first earmuff here, earmuff 42R
  • earmuff 42L earmuff
  • the headband 40 may also include a length adjustment mechanism 44R that adjusts the length from the electrode EL1 to the earmuffs 42R, and a length adjustment mechanism 44L that adjusts the length from the electrode EL2 to the earmuffs 42L. After both ears are covered with the pair of earmuffs 42R, 42L, the length of the headband 40 is adjusted using the pair of length adjustment mechanisms 44R, 44L, thereby further positioning the headband 40 in the left-right direction.
  • the multiple electrode units may include two or more types of electrode units with different thicknesses, and each of the two or more types of electrode units may be configured to be detachable from the headband 40. This allows the electrode units to be replaced as needed while measuring biosignals, and also suppresses any decrease in measurement accuracy of the SMR-ERD signal caused by differences in the thickness of the electrode units.
  • the subject 12 wears the headset 14 on his/her head H. Specifically, the subject 12 holds the headset 14 with both hands and fixes one earmuff 42R to his/her right ear and the other earmuff 42L to his/her left ear.
  • Figure 12 is a view of the subject 12 wearing the headset 14, viewed from the right side.
  • the elastic force of the protruding member 64R provided on the earmuffs 42R acts to press the contact area, and the electrode part EL3 is fixed to the lower part in front of the right ear. This makes it possible to measure electrical signals that correlate with muscle activity occurring around the head H, including, for example, the masseter and sternocleidomastoid muscles.
  • FIG. 13 shows the subject 12 wearing the headset 14, viewed from the left side.
  • the elastic force of the protruding member 64L provided on the earmuff 42L acts to press against the contact area, fixing the electrode EL4 to the lower back of the left ear.
  • the ground potential or earth potential
  • the condition analysis system 10 can perform various measurements or analyses while the subject 12 is wearing the headset 14.
  • electrode EL3 may be used as a reference electrode
  • electrode EL4 may be used as a ground electrode.
  • headset 14 may output a differentially amplified signal between the electrical signal from the other electrodes EL0-EL2 and the electrical signal from electrode EL3. This allows the potential change to be superimposed on the other measurement channels (electrode EL0-EL2) in a phase-inverted form when muscle activity occurs through the differential amplification described above.
  • muscle activity can be more explicitly incorporated as a "signal.”
  • muscle activity is considered to be “noise” in brain activity, the accuracy of brain activity analysis can be improved by excluding the periods in which muscle activity occurs from the analysis target.
  • electrode EL3 may be used as a ground electrode
  • electrode EL4 may be used as a reference electrode.
  • headset 14 may output a differentially amplified signal between the electrical signals from the other electrodes EL0 to EL2 and the electrical signal from electrode EL4. This also makes it possible to superimpose potential changes resulting from muscle activity occurring around the head H onto other measurement channels.
  • the state analysis device 16 may also perform an analysis process on muscle activity occurring around the head H. Examples of the analysis process include (A) quantifying the state of tension of the subject 12, (B) determining whether the subject 12 is in a resting state, and (C) identifying the target section of the electroencephalogram analysis.
  • the biosignal measuring device in this embodiment comprises a headband 40 having an inverted U-shape and capable of being worn on the head H of the subject 12, a first earmuff (here, earmuff 42R) provided at one end of the headband 40 and covering one ear of the head H when the headband 40 is worn, a second earmuff (here, earmuff 42L) provided at the other end of the headband 40 and covering the other ear of the head H when the headband 40 is worn, a first protruding member (here, protruding member 64R) extending from position P3 of the outer edge of the earmuff 42R, and a first muff-side electrode portion (here, electrode portion EL3) provided on the tip side of the protruding member 64R for measuring the biosignal of the subject 12.
  • a straight line that is parallel to the direction in which the headband 40 extends downward and passes through the center of gravity O1 of the planar area formed by the earmuffs 42R is defined as a first reference line (here, the vertical reference line LV)
  • a straight line that is perpendicular to the vertical reference line HV and passes through the center of gravity O2 is defined as a second reference line (here, the horizontal reference line LH)
  • position P3 is forward of the vertical reference line LV and below the horizontal reference line LH.
  • position P3 at the base end of protruding member 64R is forward of the vertical reference line LV and below the horizontal reference line LH, so that by covering both ears with a pair of earmuffs 42R, 42L, electrode portion EL3 at the tip end of protruding member 64R is fixed to the lower part of one of the ears on head H.
  • This makes it possible to measure biological signals that correlate with muscle activity occurring around head H, including the masseter and sternocleidomastoid muscles, and allows various measurements and analyses to be performed that take muscle activity into account.
  • At least the tip of the protruding member 64R may be provided to extend at an inward and forward incline with respect to the position P3. This makes it easier for the electrode portion EL3 at the tip side of the protruding member 64R to come into contact with the head H (more specifically, the lower part in front of the ear).
  • the headset 14 may further include band-side electrodes (here, electrodes EL0-EL2) that are attached to the headband 40 and are used to measure biosignals from the head H, and may differentially amplify and output a first biosignal acquired from electrodes EL0-EL2 and a second biosignal acquired from electrode EL3. This allows the potential change to be superimposed on the other electrodes EL0-EL2 in a phase-inverted form when muscle activity occurs through differential amplification.
  • band-side electrodes here, electrodes EL0-EL2
  • the headset 14 further includes a second protruding member (here, protruding member 64L) extending from position P4 on the outer edge of the earmuff 42L, and a second muff-side electrode portion (here, electrode portion EL4) provided on the tip side of the protruding member 64L for measuring the biosignal of the subject 12, position P4 may be behind the vertical reference line LV and below the horizontal reference line LH.
  • the electrode portion EL4 on the tip side of the protruding member 64L is fixed to the lower part behind the other ear of the head H. Taking advantage of the fact that the back of the ear is less susceptible to the influence of bioelectric potentials derived from brain activity, a ground potential (or earth potential) can be obtained from the electrode portion EL4.
  • the ideal arrangement of the electrodes EL0 to EL2 is derived from the activation range of the SMR-ERD signal determined through analysis using the human body dimension database described in Non-Patent Documents 1 to 3. If another signal is targeted, it is expected that the activation range will differ depending on the characteristics of the signal. In this case, a measurement range that is applicable to the majority of people can be set using a similar analysis method based on the activation range determined by analysis.
  • the protruding member 64R is fixed to the front side of the earmuffs 42R, and the protruding member 64L is fixed to the rear side of the earmuffs 42R, but this is not the only possible embodiment.
  • the protruding member 64R may be fixed to the rear side of the earmuffs 42R, and the protruding member 64L may be fixed to the front side of the earmuffs 42R.
  • the configuration of at least one of the protruding members 64R, 64L may be omitted.
  • the protruding members 64R, 64L are fixed to the earmuffs 42R, 42L.
  • the protruding members 64R, 64L may be provided so as to be movable in the circumferential direction relative to the earmuffs 42R, 42L. This makes it easier to adjust the contact points (i.e., measurement points) of the electrode portions EL3, EL4.
  • condition analysis device 16 analyzes biosignals and controls the exercise support device 18, but the system configuration is not limited to this.
  • the analysis unit and the control unit may be provided separately, and configured to be able to exchange necessary data with each other via wired or wireless communication.
  • a cloud-type or on-premise server device may perform the analysis process.
  • the server device is a cloud-type device, the server device may be a group of computers that make up a distributed system.

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PCT/JP2023/040438 2022-11-11 2023-11-09 生体信号測定器及び状態解析システム Ceased WO2024101428A1 (ja)

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US19/099,829 US20260033770A1 (en) 2022-11-11 2023-11-09 Biosignal measurement unit and condition analysis system
CN202380056375.7A CN119604236A (zh) 2022-11-11 2023-11-09 生物体信号测定器以及状态解析系统
EP23888773.1A EP4616803A4 (en) 2022-11-11 2023-11-09 BIOSIGNAL MEASUREMENT UNIT AND STATE ANALYSIS SYSTEM
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JP2019076712A (ja) 2017-10-20 2019-05-23 パナソニック株式会社 脳波計及び脳波測定システム

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JP2019013375A (ja) * 2017-07-05 2019-01-31 ディメンシア・フロント株式会社 脳機能疾病鑑別方法及び該方法を含むプログラムを実行するコンピュータプログラムプロダクト
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