WO2024075140A1 - Composition de réhydratation comprenant des électrolytes et contenant un post-biotique et du zinc - Google Patents
Composition de réhydratation comprenant des électrolytes et contenant un post-biotique et du zinc Download PDFInfo
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- WO2024075140A1 WO2024075140A1 PCT/IN2023/050909 IN2023050909W WO2024075140A1 WO 2024075140 A1 WO2024075140 A1 WO 2024075140A1 IN 2023050909 W IN2023050909 W IN 2023050909W WO 2024075140 A1 WO2024075140 A1 WO 2024075140A1
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- WO
- WIPO (PCT)
- Prior art keywords
- zinc
- composition
- rehydrating
- amount
- rehydrating composition
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 71
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims abstract description 34
- 239000011701 zinc Substances 0.000 title claims abstract description 34
- 229910052725 zinc Inorganic materials 0.000 title claims abstract description 34
- 239000003792 electrolyte Substances 0.000 title claims abstract description 17
- 206010012735 Diarrhoea Diseases 0.000 claims description 18
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
- 150000003751 zinc Chemical class 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 230000000813 microbial effect Effects 0.000 claims description 7
- 239000011780 sodium chloride Substances 0.000 claims description 7
- 239000001509 sodium citrate Substances 0.000 claims description 7
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 7
- RNZCSKGULNFAMC-UHFFFAOYSA-L zinc;hydrogen sulfate;hydroxide Chemical compound O.[Zn+2].[O-]S([O-])(=O)=O RNZCSKGULNFAMC-UHFFFAOYSA-L 0.000 claims description 7
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 6
- VNDYJBBGRKZCSX-UHFFFAOYSA-L zinc bromide Chemical compound Br[Zn]Br VNDYJBBGRKZCSX-UHFFFAOYSA-L 0.000 claims description 6
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 6
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 claims description 6
- 229940118149 zinc sulfate monohydrate Drugs 0.000 claims description 6
- 150000001720 carbohydrates Chemical class 0.000 claims description 5
- 235000014633 carbohydrates Nutrition 0.000 claims description 5
- 239000008121 dextrose Substances 0.000 claims description 5
- 239000001103 potassium chloride Substances 0.000 claims description 5
- 235000011164 potassium chloride Nutrition 0.000 claims description 5
- 235000003599 food sweetener Nutrition 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
- 239000005715 Fructose Substances 0.000 claims description 3
- 229930091371 Fructose Natural products 0.000 claims description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
- 240000006024 Lactobacillus plantarum Species 0.000 claims description 3
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 3
- 239000005913 Maltodextrin Substances 0.000 claims description 3
- 229920002774 Maltodextrin Polymers 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 3
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 3
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 3
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 3
- 239000003086 colorant Substances 0.000 claims description 3
- 235000015872 dietary supplement Nutrition 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 3
- 229940035034 maltodextrin Drugs 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000004246 zinc acetate Substances 0.000 claims description 3
- 229960000314 zinc acetate Drugs 0.000 claims description 3
- 229940102001 zinc bromide Drugs 0.000 claims description 3
- 239000011667 zinc carbonate Substances 0.000 claims description 3
- 235000004416 zinc carbonate Nutrition 0.000 claims description 3
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 3
- 229940043825 zinc carbonate Drugs 0.000 claims description 3
- 239000011592 zinc chloride Substances 0.000 claims description 3
- 235000005074 zinc chloride Nutrition 0.000 claims description 3
- 229960001939 zinc chloride Drugs 0.000 claims description 3
- 239000011746 zinc citrate Substances 0.000 claims description 3
- 235000006076 zinc citrate Nutrition 0.000 claims description 3
- 229940068475 zinc citrate Drugs 0.000 claims description 3
- 239000011670 zinc gluconate Substances 0.000 claims description 3
- 235000011478 zinc gluconate Nutrition 0.000 claims description 3
- 229960000306 zinc gluconate Drugs 0.000 claims description 3
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 claims description 3
- 229940007718 zinc hydroxide Drugs 0.000 claims description 3
- 229910021511 zinc hydroxide Inorganic materials 0.000 claims description 3
- 239000011576 zinc lactate Substances 0.000 claims description 3
- 235000000193 zinc lactate Nutrition 0.000 claims description 3
- 229940050168 zinc lactate Drugs 0.000 claims description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
- PCHQDTOLHOFHHK-UHFFFAOYSA-L zinc;hydrogen carbonate Chemical compound [Zn+2].OC([O-])=O.OC([O-])=O PCHQDTOLHOFHHK-UHFFFAOYSA-L 0.000 claims description 3
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 claims description 2
- 229940089206 anhydrous dextrose Drugs 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000000310 rehydration solution Substances 0.000 claims description 2
- -1 pH adjusters Substances 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 239000006041 probiotic Substances 0.000 description 5
- 235000018291 probiotics Nutrition 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- 208000005156 Dehydration Diseases 0.000 description 3
- 229940100060 combination of electrolytes Drugs 0.000 description 3
- 230000018044 dehydration Effects 0.000 description 3
- 238000006297 dehydration reaction Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 230000003042 antagnostic effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000002519 immonomodulatory effect Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000008122 artificial sweetener Substances 0.000 description 1
- 235000021311 artificial sweeteners Nutrition 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000741 diarrhetic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000021321 essential mineral Nutrition 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008369 fruit flavor Substances 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 244000005709 gut microbiome Species 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004678 mucosal integrity Effects 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 238000011165 process development Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000019643 salty taste Nutrition 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
Definitions
- the present invention is in field of oral rehydration systems. More particularly, the present invention relates to rehydrating composition of electrolytes along with post biotic and zinc.
- ORS is a simple treatment for dehydration caused by diarrhoea, cholera, too much exposure to heat etc. It is used around the world and specifically in the developing nations where it saves lives of children suffering from dehydration due to diarrhoea, second leading cause of death amongst children.
- Zinc however, with the product has an important role in recovery from the symptoms of diarrhoea.
- the use of zinc with oral rehydration solutions has been shown to affect positive impacts by reducing the duration and severity of diarrheal episodes.
- Overall product gives an additive effect in the treatment of diarrhoea by maintaining mucosal integrity and improving electrolyte balance.
- All 3 products ORS, Zinc and Postbiotics are available separately in market so it is not convenient for administration. According to available evidences, post-biotics do not need the viability in comparison with their parent cells and they exert health effects like live probiotic cells. Also, their preparation and application in various delivery systems is affordable, as discussed in article “Evaluating the Role of Postbiotics as a New Generation of Probiotics in Health and Diseases” by Homayouni-rad et al.
- the object of the invention is to provide a rehydrating composition of electrolytes, zinc and post biotic for diarrhoea and restoring the gut microbial flora.
- the present invention provides a rehydrating composition for diarrhoea and restoring the gut microbial flora.
- the rehydrating composition contains a combination of electrolytes, Zinc and Post Biotics.
- the present invention provides a rehydrating composition
- a rehydrating composition comprising; i.
- the ORS containing the Electrolytes selected from, but not limited to, Sodium Chloride, Potassium Chloride, Sodium Citrate or combinations thereof, in an amount ranging between 0.2 to 0.7 gm/lOOml; ii. Carbohydrates selected from glucose, dextrose, fructose, sucrose, maltodextrin and the like in an amount ranging between 1.2 to 2.5gm/ 100ml; iii. Zinc salts equivalent to zinc in an amount ranging between 2 to 6mg/100ml; and iv. Post biotics in an amount ranging between 25mg-30mg /100ml.
- the rehydrating composition of the present invention may comprise at least one ingredient selected from the group consisting of flavorants, colorants, vitamins, sweeteners, dietary supplements and the like.
- the post biotic Immuno-LP20 is selected from heat killed Lactobacillus plantarum L-137 (HK L-137), which is not viable when administered, however, after reaching the intestine, these heat killed cells release bacterial components with key immune modulating effects and also have antagonizing properties against pathogens.
- HK L-137 heat killed Lactobacillus plantarum L-137
- the zinc salts in the rehydrating composition of the present invention equivalent to the elemental zinc is selected from zinc sulfate, zinc sulfate monohydrate, zinc gluconate, zinc chloride, zinc citrate, zinc bicarbonate, zinc carbonate, zinc hydroxide, zinc lactate, zinc acetate, zinc fluoride, zinc bromide, and zinc sulfonate.
- the rehydrating composition of the present invention is preservative free.
- the pH of the rehydrating composition is in the range of 4.20 to 5.0 and the Osmolarity is 245mOsmol/lit.
- the rehydrating composition of the present invention is ready to drink composition.
- the present invention provides a process for manufacturing the rehydrating composition as depicted in Fig 1.
- Fig 1 Depict the manufacturing process of the rehydrating composition.
- the words “comprising” (and any form of comprising, such as “comprise” and “comprises”), “having” (and any form of having, such as “have” and “has”), “including” (and any form of including, such as “include” and “includes”) or “containing” (and any form of containing, such as “contain” and “contains”), are inclusive or open-ended and do not exclude additional, unrecited elements or process steps.
- the rehydrating composition of the invention comprises a synergistic combination of electrolytes, Zinc and Post Biotics masked with delicious flavour which is suitable for the administration to all age groups including young children. Accordingly, the rehydrating composition of the invention comprises a combination of electrolytes with Zinc in a liquid ready to drink form in contrast to traditional dosage form of taking Zinc tablet supplementation additionally along with ORS.
- the present invention relates to a rehydrating composition
- a rehydrating composition comprising; i.
- the ORS containing the electrolytes selected from, but not limited to, Sodium Chloride, Potassium Chloride, Sodium Citrate or combinations thereof, in an amount ranging between 0.2 to 0.7 gm/lOOml;
- Carbohydrates selected from glucose, dextrose, fructose; sucrose, maltodextrin and the like in an amount ranging between 1.2 to 2.5gm/ 100ml;
- Post biotics in an amount ranging between 25mg to 30mg/100ml.
- the rehydrating composition of the present invention comprise of excipients selected from the group consisting of flavorants, colorants, vitamins, dietary supplements, sweeteners and the like in appropriate amount.
- the flavors mask the salty taste of the rehydration composition and enhance the palatability.
- the sweeteners may compliment the flavours used in the present composition and may include natural or artificial sweeteners.
- the electrolytes of the ORS (Oral rehydrating solution) used in the present composition are as per the World Health Organisation (WHO) guidelines.
- the carbohydrates used in the present composition are in anhydrous form.
- the post biotic Immuno-LP20 is selected from heat killed Lactobacillus plantarum L-137(HK L-137), which is not viable when administered, however, after reaching the intestine, these heat killed cells release bacterial components with key immune modulating effects and also have antagonizing properties against pathogens.
- the advantage of using postbiotics against probiotics is that Post biotics helps in preventing recurrence of diarrhoea and maintains the gut flora.
- the probiotics are live cultures, majority of these live bacteria are destroyed by gastric juices, when consumed, and do not reach the intestine to give the desired effect.
- the zinc salts in the rehydrating composition of the present invention equivalent to the elemental zinc is selected from zinc sulfate, zinc sulfate monohydrate, zinc gluconate, zinc chloride, zinc citrate, zinc bicarbonate, zinc carbonate, zinc hydroxide, zinc lactate, zinc acetate, zinc fluoride, zinc bromide, and zinc sufonate.
- the composition comprises zinc sulphate monohydrate as a source of elemental zinc.
- Zinc is essential mineral that helps in maintaining normal physiological functions of the body. ORS with zinc is widely recommended by UNICEF, WHO for treatment of diarrhoea.
- the rehydrating composition of the present invention is preservative free.
- the pH of the rehydrating composition is in the range of 4.20 to 5.0 and the Osmolarity is 245mOsmol/lit.
- the rehydrating composition of the present invention is ready to drink (RH) composition.
- the present invention discloses a rehydrating composition comprising; i. The ORS containing the Electrolytes, selected from Sodium Chloride in an amount of 0.26g/100ml, Potassium Chloride in an amount of 0.15gm/100ml, Sodium Citrate in an amount of 0.29gm/100ml; ii. Anhydrous dextrose in an amount of 1.35gm/100ml; iii. Zinc sulfate monohydrate equivalent to zinc in an amount of 4mg/100ml; and iv. Immuno-LP20 as Postbiotic in an amount of 25.0mg/100ml.
- the rehydrating composition of the present invention is manufactured by the process known to a person skilled in the art. As a general procedure depicted in Fig 1, all the ingredients may be dry blended together; dispersed in water with agitated; and optionally heated to the appropriate temperature to dissolve all the constituents. The rehydrating composition is then packaged and sterilized to food grade standards as is known in the art.
- the rehydrating composition of the present invention is packed in 6- layered aseptic tetra packs.
- the rehydrating composition is stable for a period of 18 months without any added preservative in a ready to drink form.
- the present invention relates to the rehydrating composition for treating diarrhoea and restoring the gut microbial flora. In yet another embodiment, the present invention relates to a method of treating diarrhoea and restoring the gut microbial flora comprising administering the rehydrating composition of the present invention to the subject in need.
- the present invention disclose the ready to drink rehydrating composition packed in 6 layered aseptic tetra pack wherein one tetrapack of 200 ml provides 4 mg of Zinc, 0.52 g of NaCl, 0.3 g of KC1, 0.58 g Sodium Citrate and 2.7 g of Dextrose which is same as per recommendation of WHO.
- the rehydrating composition of the present invention provides exact dosage and Osmolarity of ORS and Zinc which is recommended by WHO through combikit.
- the rehydrating composition of one tetrapack of 200 ml according to the present invention provides 4 mg of Zinc, 0.52 g of NaCl, 0.3 g of KC1, 0.58 g Sodium Citrate and 2.7 g of Dextrose which is same as per recommendation of WHO.
- Postbiotics used in the rehydrating composition helps in preventing recurrence of diarrhoea and maintains the gut flora.
- the rehydrating composition provided in ready to drink liquid form prevents contamination which is generally seen while using contaminated water along with powder ORS that might cause some serious infections specially for infants.
- the rehydrating composition as provided in the present invention has delicious fruit flavour, and easier to carry and thus, suitable for infants and children.
- the rehydrating composition of the invention does not require any cold storage or cold chain.
- the composition can be stored at cool temperatures.
- Each pack of 200ml contains: -
- Each pack of 200ml contains: -
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
La présente invention concerne le domaine des systèmes de réhydratation à administrer par voie orale. Plus particulièrement, la présente invention concerne une composition de réhydratation contenant des électrolytes ainsi qu'un post-biotique et du zinc.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202221057465 | 2022-10-07 | ||
| IN202221057465 | 2022-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2024075140A1 true WO2024075140A1 (fr) | 2024-04-11 |
Family
ID=90609091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2023/050909 WO2024075140A1 (fr) | 2022-10-07 | 2023-10-07 | Composition de réhydratation comprenant des électrolytes et contenant un post-biotique et du zinc |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2024075140A1 (fr) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015175536A1 (fr) * | 2014-05-12 | 2015-11-19 | BiOWiSH Technologies, Inc. | Compositions et méthodes pour améliorer la santé et la nutrition humaine |
| CN112617207A (zh) * | 2020-12-18 | 2021-04-09 | 北京海思未来健康科技有限公司 | 一种含有补液盐和益生菌的组合物 |
| WO2021204644A1 (fr) * | 2020-04-06 | 2021-10-14 | Société des Produits Nestlé S.A. | Complément alimentaire de vitalité |
-
2023
- 2023-10-07 WO PCT/IN2023/050909 patent/WO2024075140A1/fr unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015175536A1 (fr) * | 2014-05-12 | 2015-11-19 | BiOWiSH Technologies, Inc. | Compositions et méthodes pour améliorer la santé et la nutrition humaine |
| WO2021204644A1 (fr) * | 2020-04-06 | 2021-10-14 | Société des Produits Nestlé S.A. | Complément alimentaire de vitalité |
| CN112617207A (zh) * | 2020-12-18 | 2021-04-09 | 北京海思未来健康科技有限公司 | 一种含有补液盐和益生菌的组合物 |
Non-Patent Citations (2)
| Title |
|---|
| ANONYMOUS: "ORAL REHYDRATION SALTS Production of the new ORS", WHO, UNICEF, 1 January 2006 (2006-01-01), XP093160658, Retrieved from the Internet <URL:https://iris.who.int/bitstream/handle/10665/69227/WHO_FCH_CAH_06.1.pdf?sequence=1&isAllowed=y> * |
| MUROSAKI S ET AL.: "Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL -12 production in mice", J ALLERGY CLIN IMMUNOL., vol. 102, no. 1, July 1998 (1998-07-01), pages 57 - 64, XP005687498, DOI: 10.1016/S0091-6749(98)70055-7 * |
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