WO2024073638A3 - Méthodes et compositions pour générer des cellules capillaires vestibulaires de type i - Google Patents

Méthodes et compositions pour générer des cellules capillaires vestibulaires de type i Download PDF

Info

Publication number
WO2024073638A3
WO2024073638A3 PCT/US2023/075477 US2023075477W WO2024073638A3 WO 2024073638 A3 WO2024073638 A3 WO 2024073638A3 US 2023075477 W US2023075477 W US 2023075477W WO 2024073638 A3 WO2024073638 A3 WO 2024073638A3
Authority
WO
WIPO (PCT)
Prior art keywords
hair cells
vestibular hair
compositions
methods
vestibular
Prior art date
Application number
PCT/US2023/075477
Other languages
English (en)
Other versions
WO2024073638A2 (fr
Inventor
Joseph Burns
Noah DRUCKENBROD
Amanda KEDAIGLE
Ryan MCCARTHY
Nivanthika WIMALASENA
Original Assignee
Decibel Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Decibel Therapeutics, Inc. filed Critical Decibel Therapeutics, Inc.
Publication of WO2024073638A2 publication Critical patent/WO2024073638A2/fr
Publication of WO2024073638A3 publication Critical patent/WO2024073638A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des inhibiteurs de Tbx2 qui peuvent être utilisés pour générer des cellules capillaires vestibulaires de type I dans le système vestibulaire. Les inhibiteurs de Tbx2 peuvent être administrés à un sujet seuls ou en combinaison avec un agent de régénération ou un inhibiteur de Sox2 pour convertir des cellules capillaires vestibulaires de type II ou des cellules capillaires vestibulaires régénérées en cellules capillaires vestibulaires de type I.
PCT/US2023/075477 2022-09-30 2023-09-29 Méthodes et compositions pour générer des cellules capillaires vestibulaires de type i WO2024073638A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263412173P 2022-09-30 2022-09-30
US63/412,173 2022-09-30

Publications (2)

Publication Number Publication Date
WO2024073638A2 WO2024073638A2 (fr) 2024-04-04
WO2024073638A3 true WO2024073638A3 (fr) 2024-05-30

Family

ID=90479315

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/075477 WO2024073638A2 (fr) 2022-09-30 2023-09-29 Méthodes et compositions pour générer des cellules capillaires vestibulaires de type i

Country Status (1)

Country Link
WO (1) WO2024073638A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021151018A1 (fr) * 2020-01-24 2021-07-29 Decibel Therapeutics, Inc. Procédés et compositions pour générer des cellules capillaires vestibulaires de type i

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021151018A1 (fr) * 2020-01-24 2021-07-29 Decibel Therapeutics, Inc. Procédés et compositions pour générer des cellules capillaires vestibulaires de type i

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAISER MARINA, WOJAHN IRINA, RUDAT CARSTEN, LÜDTKE TIMO H., CHRISTOFFELS VINCENT M., MOON ANNE, KISPERT ANDREAS, TROWE MARK-OLIVER: "Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse", DEVELOPMENT, THE COMPANY OF BIOLOGISTS LTD., GB, vol. 148, no. 8, 15 April 2021 (2021-04-15), GB , XP093178433, ISSN: 0950-1991, DOI: 10.1242/dev.195651 *
RATZAN EVAN M., MOON ANNE M., DEANS MICHAEL R.: "Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle", DEVELOPMENT, THE COMPANY OF BIOLOGISTS LTD., GB, 19 November 2020 (2020-11-19), GB , XP093178440, ISSN: 0950-1991, DOI: 10.1242/dev.192849 *

Also Published As

Publication number Publication date
WO2024073638A2 (fr) 2024-04-04

Similar Documents

Publication Publication Date Title
WO2019006005A3 (fr) Procédés et compositions pour le traitement du mélanome
NZ592837A (en) Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents
AU2001253039A1 (en) Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
MY198289A (en) Pharmaceutical Composition for use in a Method of Removing Immune Suppression in a Tumor Microenvironment or Stimulating an Immune System Against Cancer Cells
PH12016502254A1 (en) Keratin treatment formulations and methods
IN2012DN02817A (fr)
TN2012000550A1 (en) THE USE OF sGC STIMULATORS, sGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF SYSTEMIC SCLEROSIS (SSc).
DE69533058D1 (de) Speicherplattenanordnung mit redundanter Speicherung und Verfahren zur inkrementalen Redundanzerzeugung während des Datenschreibens auf die Speicherplattenanordnung
TW200737127A (en) Reduced number of channels decoding
NO20080141L (no) Indanderivater som modulatorer av ionekanaler
WO2022221528A3 (fr) Inhibiteurs de kras g12c
AR061772A1 (es) Composicion de alto contenido de ion fluoruro para el cuidado oral y metodo para mantener la actividad anticaries
WO2022217123A3 (fr) Polythérapies comprenant des composés inhibiteurs de cbl-b
EP4389225A3 (fr) Traitements de cancer utilisant des combinaisons d'inhibiteurs erk et mek de type 2
WO2018143552A3 (fr) Composition injectable destinée à prévenir la perte de cheveux ou stimuler la pousse des cheveux
MX2020011817A (es) Metodos para tratar el linfoma.
AU2008321142A8 (en) Heterocyclic derivatives as modulators of ion channels
EP4234701A3 (fr) Régénération de plantes génétiquement modifiées
NZ580533A (en) Cell lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods
TN2017000465A1 (en) The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of digital ulcers (du) concomitant to systemic sclerosis (ssc)
WO2024073638A3 (fr) Méthodes et compositions pour générer des cellules capillaires vestibulaires de type i
PE20200600A1 (es) Composiciones y metodos para promover el crecimiento del cabello con inhibidores de mpc
EP4218753A3 (fr) Composés pour réduire les lésions lipotoxiques
WO2019204332A3 (fr) Inhibiteurs de pak4 et procédés d'utilisation
WO2021187995A3 (fr) Procédé d'obtention de gaules de frêne commun (fraxinus excelsior l.) et milieux appropriés pour une utilisation dans ce procédé